메뉴 건너뛰기




Volumn 29, Issue 1, 2005, Pages 75-87

Pharmacogenomics and systems biology of membrane transporters

Author keywords

Genotype; Pathway; Pharmacogenomics; Phenotype; Polymorphism; Systems biology; Transporter

Indexed keywords

ABSORPTION; CELLS; DISEASE CONTROL; DRUG PRODUCTS; TOXIC MATERIALS;

EID: 26244466980     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:29:1:75     Document Type: Review
Times cited : (11)

References (87)
  • 1
    • 0031000180 scopus 로고    scopus 로고
    • The first genome from the third domain of life
    • Clayton, R.A., White, O., Ketchum, K.A., Venter, J.C. (1997) The first genome from the third domain of life. Nature 29, 459-462.
    • (1997) Nature , vol.29 , pp. 459-462
    • Clayton, R.A.1    White, O.2    Ketchum, K.A.3    Venter, J.C.4
  • 2
  • 4
    • 0032478498 scopus 로고    scopus 로고
    • Microbial genome analyses: Global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities
    • Paulsen, I.T., Sliwinski, M.K., Saier, M.H. Jr. (1998) Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities. J. Mol. Biol. 277, 573-592.
    • (1998) J. Mol. Biol. , vol.277 , pp. 573-592
    • Paulsen, I.T.1    Sliwinski, M.K.2    Saier Jr., M.H.3
  • 5
    • 0032560586 scopus 로고    scopus 로고
    • Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae
    • Paulsen, I.T., Sliwinski, M.K., Nelissen, B., Goffeau, A., Saier, M.H. Jr. (1998) Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae. FEBS Lett. 430, 116-125.
    • (1998) FEBS Lett. , vol.430 , pp. 116-125
    • Paulsen, I.T.1    Sliwinski, M.K.2    Nelissen, B.3    Goffeau, A.4    Saier Jr., M.H.5
  • 6
    • 0343603660 scopus 로고    scopus 로고
    • A functional-phylogenetic classification system for transmembrane solute transporters
    • Saier, M.H. Jr. (2000) A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol. Mol. Biol. Rev. 64, 354-411.
    • (2000) Microbiol. Mol. Biol. Rev. , vol.64 , pp. 354-411
    • Saier Jr., M.H.1
  • 7
    • 0026621245 scopus 로고
    • ABC transporters: From microorganisms to man
    • Higgins, C.F. (1992) ABC transporters: from microorganisms to man. Curr. Opin. Cell Biol. 8, 67-113.
    • (1992) Curr. Opin. Cell Biol. , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 8
    • 0031006578 scopus 로고    scopus 로고
    • Compound missense mutations in the sodium/D-glucose cotransporter result in trafficking defects
    • Martin, M.G., Lostao, M.P., Turk, E., Lam, J., Kreman, M., Wright, E.M. (1997) Compound missense mutations in the sodium/D-glucose cotransporter result in trafficking defects. Gastroenterology 112, 1206-1212.
    • (1997) Gastroenterology , vol.112 , pp. 1206-1212
    • Martin, M.G.1    Lostao, M.P.2    Turk, E.3    Lam, J.4    Kreman, M.5    Wright, E.M.6
  • 9
    • 0033860638 scopus 로고    scopus 로고
    • Heteromeric amino acid transporters explain inherited aminoacidurias
    • Palacin, M., Bertran, J., Zorzano, A. (2000) Heteromeric amino acid transporters explain inherited aminoacidurias. Curr. Opin. Nephrol. Hypertens. 9, 547-553.
    • (2000) Curr. Opin. Nephrol. Hypertens. , vol.9 , pp. 547-553
    • Palacin, M.1    Bertran, J.2    Zorzano, A.3
  • 10
    • 0032912589 scopus 로고    scopus 로고
    • Structure and function of the CFTR chloride channel
    • Sheppard, D.N., Welsh, M.J. (1999) Structure and function of the CFTR chloride channel. Physiol. Rev. 79, S23-45.
    • (1999) Physiol. Rev. , vol.79
    • Sheppard, D.N.1    Welsh, M.J.2
  • 11
    • 0034634741 scopus 로고    scopus 로고
    • Promoter polymorphism of the 5-HT transporter and Alzheimer's disease
    • Hu, M., Retz, W., Baader, M., et al. (2000) Promoter polymorphism of the 5-HT transporter and Alzheimer's disease. Neurosci. Lett. 294, 63-65.
    • (2000) Neurosci. Lett. , vol.294 , pp. 63-65
    • Hu, M.1    Retz, W.2    Baader, M.3
  • 12
    • 0030921878 scopus 로고    scopus 로고
    • Association of a polymorphism in the dopamine-transporter gene with Parkinson's disease
    • Le Couteur, D.G., Leighton, P.W., McCann, S.J., Pond, S. (1997) Association of a polymorphism in the dopamine-transporter gene with Parkinson's disease. Mov. Disord. 12, 760-763.
    • (1997) Mov. Disord. , vol.12 , pp. 760-763
    • Le Couteur, D.G.1    Leighton, P.W.2    McCann, S.J.3    Pond, S.4
  • 13
    • 0034241856 scopus 로고    scopus 로고
    • Association of the dopamine transporter gene with Parkinson's disease in Korean patients
    • Kim, J.W., Kim, D.H., Kim, S.H., and Cha, J.K. (2000) Association of the dopamine transporter gene with Parkinson's disease in Korean patients. J. Korean Med. Sci. 15, 449-451.
    • (2000) J. Korean Med. Sci. , vol.15 , pp. 449-451
    • Kim, J.W.1    Kim, D.H.2    Kim, S.H.3    Cha, J.K.4
  • 14
    • 0033837202 scopus 로고    scopus 로고
    • Variability and validity of polymorphism association studies in Parkinson's disease
    • Tan, E.K., Khajavi, M., Thornby, J.I., Nagamitsu, S., Jankovic, J., and Ashizawa, T. (2000) Variability and validity of polymorphism association studies in Parkinson's disease. Neurology 55, 533-538.
    • (2000) Neurology , vol.55 , pp. 533-538
    • Tan, E.K.1    Khajavi, M.2    Thornby, J.I.3    Nagamitsu, S.4    Jankovic, J.5    Ashizawa, T.6
  • 15
    • 0033801280 scopus 로고    scopus 로고
    • Membrane transporters
    • Lee, V.H. (2000) Membrane transporters. Eur. J. Pharm. Sci. 11, S41-S50.
    • (2000) Eur. J. Pharm. Sci. , vol.11
    • Lee, V.H.1
  • 16
    • 0035996829 scopus 로고    scopus 로고
    • Altered drug disposition of the platelet activating factor antagonist apafant in mdrla knockout mice
    • Leusch, A., Volz, A., Muller, G., et al. (2002) Altered drug disposition of the platelet activating factor antagonist apafant in mdrla knockout mice. Eur. J. Pharm. Sci. 16, 119-128.
    • (2002) Eur. J. Pharm. Sci. , vol.16 , pp. 119-128
    • Leusch, A.1    Volz, A.2    Muller, G.3
  • 17
    • 0033756459 scopus 로고    scopus 로고
    • Transporter-mediated permeation of drugs across the blood-brain barrier
    • Tamai, I. and Tsuji, A. (2000) Transporter-mediated permeation of drugs across the blood-brain barrier. J. Pharm. Sci. 89, 1371-1388.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 1371-1388
    • Tamai, I.1    Tsuji, A.2
  • 18
    • 0032874193 scopus 로고    scopus 로고
    • Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: Importance in the drug delivery to the brain
    • Sugiyama, Y., Kusuhara, H., and Suzuki, H. (1999) Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain. J. Control Release. 62, 179-186.
    • (1999) J. Control Release , vol.62 , pp. 179-186
    • Sugiyama, Y.1    Kusuhara, H.2    Suzuki, H.3
  • 19
    • 0033849976 scopus 로고    scopus 로고
    • Cellular and molecular aspects of drug transport in the kidney
    • Inui, K.I., Masuda, S., and Saito, H. (2000) Cellular and molecular aspects of drug transport in the kidney. Kidney Int. 58, 944-958.
    • (2000) Kidney Int. , vol.58 , pp. 944-958
    • Inui, K.I.1    Masuda, S.2    Saito, H.3
  • 20
    • 0029584879 scopus 로고
    • Biology of membrane transport proteins
    • Sadee, W., Drubbisch, V., and Amidon, G.L. (1995) Biology of membrane transport proteins. Pharm Res. 12, 1823-1837.
    • (1995) Pharm Res. , vol.12 , pp. 1823-1837
    • Sadee, W.1    Drubbisch, V.2    Amidon, G.L.3
  • 21
    • 0033250545 scopus 로고    scopus 로고
    • Multidrug-resistance transporters
    • Silverman, J.A. (1999) Multidrug-resistance transporters. Pharm. Biotechnol. 12, 353-386.
    • (1999) Pharm. Biotechnol. , vol.12 , pp. 353-386
    • Silverman, J.A.1
  • 22
    • 0033254582 scopus 로고    scopus 로고
    • Drug transport and targeting. Intestinal transport
    • Oh, D.M., Han, H.K., and Amidon, G.L. (1999) Drug transport and targeting. Intestinal transport. Pharm. Biotechnol. 12, 59-88.
    • (1999) Pharm. Biotechnol. , vol.12 , pp. 59-88
    • Oh, D.M.1    Han, H.K.2    Amidon, G.L.3
  • 23
    • 0036644903 scopus 로고    scopus 로고
    • Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918
    • Kruijtzer, C. M., Beijnen, J. H., Rosing, H., et al. (2002) Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918. J. Clin. Oncol. 1, 2943-2950.
    • (2002) J. Clin. Oncol. , vol.1 , pp. 2943-2950
    • Kruijtzer, C.M.1    Beijnen, J.H.2    Rosing, H.3
  • 24
    • 0033938105 scopus 로고    scopus 로고
    • Neurotransmitter transporters: Fruitful targets for CNS drug discovery
    • Iversen, L. (2000) Neurotransmitter transporters: fruitful targets for CNS drug discovery. Mol. Psychiatry. 5, 357-362.
    • (2000) Mol. Psychiatry , vol.5 , pp. 357-362
    • Iversen, L.1
  • 25
    • 0032620210 scopus 로고    scopus 로고
    • A mutation in the promoter of the multidrug resistance gene (MDR1) in human hematological malignancies may contribute to the pathogenesis of resistant disease
    • Rund, D., Azar, I., and Shperling, O. (1999) A mutation in the promoter of the multidrug resistance gene (MDR1) in human hematological malignancies may contribute to the pathogenesis of resistant disease. Adv. Exp. Med. Biol. 457, 71-75.
    • (1999) Adv. Exp. Med. Biol. , vol.457 , pp. 71-75
    • Rund, D.1    Azar, I.2    Shperling, O.3
  • 27
    • 84912924789 scopus 로고
    • Multidrug resistance
    • DeVita,V.T.Jr., et al. eds., Lippincott Williams & Wilkins Publishers, Philadelphia
    • Dalton, W.S. and Miller, T.P. (1991) Multidrug resistance, in Cancer: Principles and Practice of Oncolgy.DeVita,V.T.Jr., et al. eds., Lippincott Williams & Wilkins Publishers, Philadelphia, pp. 1-13.
    • (1991) Cancer: Principles and Practice of Oncolgy , pp. 1-13
    • Dalton, W.S.1    Miller, T.P.2
  • 28
    • 0036593544 scopus 로고    scopus 로고
    • Novel animal-health drug targets from ligand-gated chloride channels
    • Raymond, V. and Sattelle, D.B. (2002 ) Novel animal-health drug targets from ligand-gated chloride channels. Nat. Rev. Drug Discov. 1, 427-436.
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 427-436
    • Raymond, V.1    Sattelle, D.B.2
  • 29
    • 0033656073 scopus 로고    scopus 로고
    • The impact of genomics on therapeutic drug development
    • Kennedy, G.C. (2000) The impact of genomics on therapeutic drug development. EXS. 89, 1-10.
    • (2000) EXS , vol.89 , pp. 1-10
    • Kennedy, G.C.1
  • 30
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans, W.E. and Relling, M.V. (1999) Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286, 487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 31
    • 0033403326 scopus 로고    scopus 로고
    • Technologies for detecting genetic polymorphisms in pharmacogenomics
    • Shi, M.M., Bleavins, M.R., and de la Iglesia, F.A. (1999) Technologies for detecting genetic polymorphisms in pharmacogenomics. Mol. Diagn. 4, 343-351.
    • (1999) Mol. Diagn. , vol.4 , pp. 343-351
    • Shi, M.M.1    Bleavins, M.R.2    De La Iglesia, F.A.3
  • 32
    • 85046914149 scopus 로고    scopus 로고
    • Pharmacogenomics: The implementation phase
    • Sadee, W. (2002) Pharmacogenomics: the implementation phase. AAPS PharmSci 4, E5.
    • (2002) AAPS PharmSci. , vol.4
    • Sadee, W.1
  • 33
    • 0033928586 scopus 로고    scopus 로고
    • Impact of genomics on drug discovery and clinical medicine
    • Emilien, G., Ponchon, M., Caldas, C., Isacson, O., and Maloteaux, J.M. (2000) Impact of genomics on drug discovery and clinical medicine. QJM. 93, 391-423.
    • (2000) QJM , vol.93 , pp. 391-423
    • Emilien, G.1    Ponchon, M.2    Caldas, C.3    Isacson, O.4    Maloteaux, J.M.5
  • 34
    • 0033428029 scopus 로고    scopus 로고
    • Impact of pharmacogenomics on the clinical laboratory
    • Hess, P. and Cooper, D. (1999) Impact of pharmacogenomics on the clinical laboratory. Mol. Diagn. 4, 289-298.
    • (1999) Mol. Diagn. , vol.4 , pp. 289-298
    • Hess, P.1    Cooper, D.2
  • 35
    • 0034567052 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics in the discovery and development of medicines
    • Roses, A.D. (2000) Pharmacogenetics and pharmacogenomics in the discovery and development of medicines. Novartis Found Symp. 229, 63-66.
    • (2000) Novartis Found Symp. , vol.229 , pp. 63-66
    • Roses, A.D.1
  • 36
    • 33748428120 scopus 로고    scopus 로고
    • Pharmacogenomics: The genomics of drug response
    • March, R. (2000) Pharmacogenomics: the genomics of drug response. Yeast 17, 16-21.
    • (2000) Yeast , vol.17 , pp. 16-21
    • March, R.1
  • 37
    • 0002150481 scopus 로고
    • Moderne probleme der Human-genetik
    • Vogel, F. (1959) Moderne probleme der Human-genetik. Ergeb. Inn. Med. Kinderheilkd. 12, 52-125.
    • (1959) Ergeb. Inn. Med. Kinderheilkd. , vol.12 , pp. 52-125
    • Vogel, F.1
  • 38
    • 0031035007 scopus 로고    scopus 로고
    • Polymorphisms in drug-metabolizing enzymes: What is their clinical relevance and why do they exist?
    • Nebert, D.W. (1997) Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist? Am. J. Hum. Genet. 60, 265-271.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 265-271
    • Nebert, D.W.1
  • 39
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: A brief overview
    • Kitano H. (2002) Systems biology: a brief overview. Science 295, 1662-1664.
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 40
    • 0032695572 scopus 로고    scopus 로고
    • Association of the dopamine transporter gene (DAT1) with poor methylphenidate response
    • Winsberg, B.G. and Comings, D.E. (1999) Association of the dopamine transporter gene (DAT1) with poor methylphenidate response. J. Am. Acad. Child Adolesc. Psychiatry. 38, 1474-1477.
    • (1999) J. Am. Acad. Child Adolesc. Psychiatry , vol.38 , pp. 1474-1477
    • Winsberg, B.G.1    Comings, D.E.2
  • 41
    • 2542440464 scopus 로고    scopus 로고
    • Interactions between hepatic Mrp4 and Sult2A as revealed by the constitutive androstane receptor and Mrp4 knockout mice
    • Assem, M., Schuetz, E.G., Leggas, M., et al. (2004) Interactions between hepatic Mrp4 and Sult2A as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J. Biol. Chem. 279, 22250-22257.
    • (2004) J. Biol. Chem. , vol.279 , pp. 22250-22257
    • Assem, M.1    Schuetz, E.G.2    Leggas, M.3
  • 42
    • 0142070958 scopus 로고    scopus 로고
    • Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter
    • Flieger, O., Engling, A., Bucala, R., Lue, H., Nickel, W., and Bernhagen, J. (2003) Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter. FEBS Lett. 11, 78-86.
    • (2003) FEBS Lett. , vol.11 , pp. 78-86
    • Flieger, O.1    Engling, A.2    Bucala, R.3    Lue, H.4    Nickel, W.5    Bernhagen, J.6
  • 43
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • Hoffmeyer, S., Burk, O., von Richter, O., et al. (2000) Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl. Acad. Sci. USA 97, 3473-3478.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    Von Richter, O.3
  • 44
    • 0006463359 scopus 로고    scopus 로고
    • Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
    • Lesch, K.P., Bengel, D., Heils, A., et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527-1531.
    • (1996) Science , vol.274 , pp. 1527-1531
    • Lesch, K.P.1    Bengel, D.2    Heils, A.3
  • 45
    • 0031736757 scopus 로고    scopus 로고
    • Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine
    • Smeraldi, E., Zanardi, R., Benedetti, F., Di Bella, D., Perez, J., and Catalano, M. (1998) Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol. Psychiatry. 3, 508-511.
    • (1998) Mol. Psychiatry , vol.3 , pp. 508-511
    • Smeraldi, E.1    Zanardi, R.2    Benedetti, F.3    Di Bella, D.4    Perez, J.5    Catalano, M.6
  • 46
    • 0034677021 scopus 로고    scopus 로고
    • Serotonin transporter gene polymorphism and antidepressant response
    • Kim, D.K., Lim, S.W., Lee, S., et al. (2000) Serotonin transporter gene polymorphism and antidepressant response. Neuroreport. 11, 215-219.
    • (2000) Neuroreport , vol.11 , pp. 215-219
    • Kim, D.K.1    Lim, S.W.2    Lee, S.3
  • 47
    • 0033807374 scopus 로고    scopus 로고
    • Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
    • Pollock, B.G., Ferrell, R.E., Mulsant, B.H., et al. (2000) Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology 23, 587-590.
    • (2000) Neuropsychopharmacology , vol.23 , pp. 587-590
    • Pollock, B.G.1    Ferrell, R.E.2    Mulsant, B.H.3
  • 48
    • 0033984363 scopus 로고    scopus 로고
    • Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene
    • Zanardi, R., Benedetti, F., Di Bella, D., Catalano, M., and Smeraldi, E. (2000) Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. J. Clin. Psychopharmacol. 20, 105-107.
    • (2000) J. Clin. Psychopharmacol. , vol.20 , pp. 105-107
    • Zanardi, R.1    Benedetti, F.2    Di Bella, D.3    Catalano, M.4    Smeraldi, E.5
  • 49
    • 0036325415 scopus 로고    scopus 로고
    • Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome
    • Camilleri, M., Atanasova, E., Carlson, P.J., et al. (2002) Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology 123, 425-432.
    • (2002) Gastroenterology , vol.123 , pp. 425-432
    • Camilleri, M.1    Atanasova, E.2    Carlson, P.J.3
  • 50
    • 0025931429 scopus 로고
    • Nucleoside triphosphates are required to open the CFTR chloride channel
    • Anderson, M.P., Berger, H.A., Rich, D.P., Gregory, R.J., Smith, A.E., and Welsh, M.J. (1991) Nucleoside triphosphates are required to open the CFTR chloride channel. Cell 67, 775-784.
    • (1991) Cell , vol.67 , pp. 775-784
    • Anderson, M.P.1    Berger, H.A.2    Rich, D.P.3    Gregory, R.J.4    Smith, A.E.5    Welsh, M.J.6
  • 51
    • 0026077676 scopus 로고
    • Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel
    • Berger, H.A., Anderson, M.P., Gregory, R.J., et al. (1991) Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel. J. Clin. Invest. 88, 1422-1431.
    • (1991) J. Clin. Invest. , vol.88 , pp. 1422-1431
    • Berger, H.A.1    Anderson, M.P.2    Gregory, R.J.3
  • 52
    • 0033669078 scopus 로고    scopus 로고
    • Support for allelic association of a polymorphic site in the promoter region of the serotonin transporter gene with risk for alcohol dependence
    • Lichtermann, D., Hranilovic, D., Trixler, M., et al. (2000) Support for allelic association of a polymorphic site in the promoter region of the serotonin transporter gene with risk for alcohol dependence. Am. J. Psychiatry. 157, 2045-2047.
    • (2000) Am. J. Psychiatry , vol.157 , pp. 2045-2047
    • Lichtermann, D.1    Hranilovic, D.2    Trixler, M.3
  • 53
    • 0032744001 scopus 로고    scopus 로고
    • Structural, mechanistic and clinical aspects of MRP1
    • Hipfner, D.R., Deeley, R.G., and Cole, S.P. (1999) Structural, mechanistic and clinical aspects of MRP1. Biochim. Biophys. Acta 1461, 359-376.
    • (1999) Biochim. Biophys. Acta , vol.1461 , pp. 359-376
    • Hipfner, D.R.1    Deeley, R.G.2    Cole, S.P.3
  • 55
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • Konig, J., Nies, A.T., Cui, Y., Leier, I., and Keppler, D. (1999) Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim. Biophys. Acta 1461, 377-394.
    • (1999) Biochim. Biophys. Acta , vol.1461 , pp. 377-394
    • Konig, J.1    Nies, A.T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 56
    • 0027978128 scopus 로고
    • A unique gene organization for two cholinergic markers, choline acetyltransferase and a putative vesicular transporter of acetylcholine
    • Bejanin, S., Cervini, R., Mallet, J., and Berrard, S. (1994) A unique gene organization for two cholinergic markers, choline acetyltransferase and a putative vesicular transporter of acetylcholine. J. Biol. Chem. 269, 21944-21947.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21944-21947
    • Bejanin, S.1    Cervini, R.2    Mallet, J.3    Berrard, S.4
  • 57
    • 0028048214 scopus 로고
    • Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus
    • Erickson, J.D., Varoqui, H., Schafer, M.K., et al. (1994) Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus. J. Biol. Chem. 269, 21929-21932.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21929-21932
    • Erickson, J.D.1    Varoqui, H.2    Schafer, M.K.3
  • 58
    • 26244448572 scopus 로고    scopus 로고
    • Protein Data Bank (PDB)
    • Protein Data Bank (PDB): http://www.rcsb.org/pdb/
  • 61
    • 0033071210 scopus 로고    scopus 로고
    • Genotype/Phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease
    • Lewis, R.A., Shroyer, N.F., Singh, N., et al. (1999) Genotype/Phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease. Am. J. Hum. Genet. 64, 422-434.
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 422-434
    • Lewis, R.A.1    Shroyer, N.F.2    Singh, N.3
  • 62
    • 0344364566 scopus 로고    scopus 로고
    • An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis
    • Tokuhiro, S., Yamada, R., Chang, X., et al. (2003) An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet. 35, 341-348.
    • (2003) Nat Genet. , vol.35 , pp. 341-348
    • Tokuhiro, S.1    Yamada, R.2    Chang, X.3
  • 63
    • 0032748555 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics: Why is this relevant to the clinical geneticist?
    • Nebert, D.W. (1999) Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist? Clin Genet. 56, 247-258.
    • (1999) Clin Genet. , vol.56 , pp. 247-258
    • Nebert, D.W.1
  • 64
    • 0033733489 scopus 로고    scopus 로고
    • Pharmacogenetics: A molecular sophistication or a new clinical tool for cardiologists?
    • Dirckx, C., Donati, M.B., and Iacoviello, L. (2000) Pharmacogenetics: a molecular sophistication or a new clinical tool for cardiologists? Ital. Heart J. 1, 662-666.
    • (2000) Ital. Heart J. , vol.1 , pp. 662-666
    • Dirckx, C.1    Donati, M.B.2    Iacoviello, L.3
  • 65
    • 10744220811 scopus 로고    scopus 로고
    • Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial
    • Lerman, C., Shields, P.G., Wileyto, E.P., et al. (2003) Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial. Health Psychol. 22, 541-548.
    • (2003) Health Psychol. , vol.22 , pp. 541-548
    • Lerman, C.1    Shields, P.G.2    Wileyto, E.P.3
  • 66
    • 0031823433 scopus 로고    scopus 로고
    • Genomics and drugs: Finding the optimal drug for the right patient
    • Sadee, W. (1998) Genomics and drugs: finding the optimal drug for the right patient. Pharm. Res. 15, 959-963.
    • (1998) Pharm. Res. , vol.15 , pp. 959-963
    • Sadee, W.1
  • 67
    • 0347185032 scopus 로고    scopus 로고
    • Pharmacogenomics and "individualized drug therapy": High expectations and disappointing achievements
    • Nebert, D.W., Jorge-Nebert, L., and Vesell, E.S. (2003) Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements. Am. J. Pharmacogenomics. 3, 361-370.
    • (2003) Am. J. Pharmacogenomics , vol.3 , pp. 361-370
    • Nebert, D.W.1    Jorge-Nebert, L.2    Vesell, E.S.3
  • 68
    • 0032813808 scopus 로고    scopus 로고
    • Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
    • Brooks-Wilson, A., Marcil, M., Clee, S. M., et al. (1999) Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nature Genet. 22, 336-345.
    • (1999) Nature Genet. , vol.22 , pp. 336-345
    • Brooks-Wilson, A.1    Marcil, M.2    Clee, S.M.3
  • 69
    • 0032813809 scopus 로고    scopus 로고
    • The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
    • Bodzioch, M., Orso, E., Klucken, J., et al. (1999) The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nature Genet. 22, 347-351.
    • (1999) Nature Genet. , vol.22 , pp. 347-351
    • Bodzioch, M.1    Orso, E.2    Klucken, J.3
  • 70
    • 0012119330 scopus 로고    scopus 로고
    • Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration
    • Allikmets, R., Shroyer, N. F., Singh, N., et al. (1997) Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277, 1805-1807.
    • (1997) Science , vol.277 , pp. 1805-1807
    • Allikmets, R.1    Shroyer, N.F.2    Singh, N.3
  • 71
    • 0033804333 scopus 로고    scopus 로고
    • A comprehensive survey of sequence variation in the ABCA4 (ABCR) gene in Stargardt disease and age-related macular degeneration
    • Rivera, A., White, K., Stohr, H., et al. (2000) A comprehensive survey of sequence variation in the ABCA4 (ABCR) gene in Stargardt disease and age-related macular degeneration. Am. J. Hum. Genet. 67, 800-813.
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 800-813
    • Rivera, A.1    White, K.2    Stohr, H.3
  • 72
    • 17644443114 scopus 로고    scopus 로고
    • Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: Evidence for a defect in protein trafficking
    • Dixon, P. H., Weerasekera, N., Linton, K. J., et al. (2000) Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. Hum. Molec. Genet. 9, 1209-1217.
    • (2000) Hum. Molec. Genet. , vol.9 , pp. 1209-1217
    • Dixon, P.H.1    Weerasekera, N.2    Linton, K.J.3
  • 73
    • 0027375464 scopus 로고
    • Abnormal messenger RNA expression and a missense mutation in patients with X-linked adrenoleukodystrophy
    • Cartier, N., Sarde, C.-O., Douar, A.-M., Mosser, J., Mandel, J.-L., and Aubourg, P. (1993) Abnormal messenger RNA expression and a missense mutation in patients with X-linked adrenoleukodystrophy. Hum. Molec. Genet. 2, 1949-1951.
    • (1993) Hum. Molec. Genet. , vol.2 , pp. 1949-1951
    • Cartier, N.1    Sarde, C.-O.2    Douar, A.-M.3    Mosser, J.4    Mandel, J.-L.5    Aubourg, P.6
  • 74
    • 0030060578 scopus 로고    scopus 로고
    • Identification of mutations in the ALD-gene of 20 families with adrenoleukodystrophy/adrenomyeloneuropathy
    • Krasemann, E. W., Meier, V., Korenke, G. C., Hunneman, D. H., and Hanefeld, F. (1996) Identification of mutations in the ALD-gene of 20 families with adrenoleukodystrophy/adrenomyeloneuropathy. Hum. Genet. 97, 194-197.
    • (1996) Hum. Genet. , vol.97 , pp. 194-197
    • Krasemann, E.W.1    Meier, V.2    Korenke, G.C.3    Hunneman, D.H.4    Hanefeld, F.5
  • 75
    • 0028017998 scopus 로고
    • Occipital horn syndrome and a mild Menkes phenotype associated with splice site mutations at the MNK locus
    • Kaler, S. G., Gallo, L. K., Proud, V. K., et al. (1994) Occipital horn syndrome and a mild Menkes phenotype associated with splice site mutations at the MNK locus. Nature Genet. 8, 195-202.
    • (1994) Nature Genet. , vol.8 , pp. 195-202
    • Kaler, S.G.1    Gallo, L.K.2    Proud, V.K.3
  • 76
    • 0028820678 scopus 로고
    • Molecular pathology and haplotype analysis of Wilson disease in Mediterranean populations
    • Figus, A., Angius, A., Loudianos, G., et al. (1995) Molecular pathology and haplotype analysis of Wilson disease in Mediterranean populations. Am. J. Hum. Genet. 57, 1318-1324.
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 1318-1324
    • Figus, A.1    Angius, A.2    Loudianos, G.3
  • 77
    • 0345480774 scopus 로고    scopus 로고
    • Identification of three novel mutations and a high frequency of the arg778-to-leu mutation in Korean patients with Wilson disease
    • Kim, E. K., Yoo, O. J., Song, K. Y., et al. (1998) Identification of three novel mutations and a high frequency of the arg778-to-leu mutation in Korean patients with Wilson disease. Hum. Mutat. 11, 275-278.
    • (1998) Hum. Mutat. , vol.11 , pp. 275-278
    • Kim, E.K.1    Yoo, O.J.2    Song, K.Y.3
  • 78
    • 12244295084 scopus 로고
    • Band 3 Tuscaloosa: pro327-to-arg327 substitution in the cytoplasmic domain of erythrocyte band 3 protein associated with spherocytic hemolytic anemia and partial deficiency of protein 4.2
    • Jarolim, P., Palek, J., Rubin, H. L., Prchal, J. T., Korsgren, C., and Cohen, C. M. (1991) Band 3 Tuscaloosa: pro327-to-arg327 substitution in the cytoplasmic domain of erythrocyte band 3 protein associated with spherocytic hemolytic anemia and partial deficiency of protein 4.2. (Abstract) Blood 78 (suppl.), 252a.
    • (1991) (Abstract) Blood , vol.78 , Issue.SUPPL.
    • Jarolim, P.1    Palek, J.2    Rubin, H.L.3    Prchal, J.T.4    Korsgren, C.5    Cohen, C.M.6
  • 79
    • 0035746511 scopus 로고    scopus 로고
    • Phenotype and genotype variation in primary carnitine deficiency
    • Wang, Y., Korman, S. H., Ye, J., et al. (2001) Phenotype and genotype variation in primary carnitine deficiency. Genet. Med. 3, 387-392.
    • (2001) Genet. Med. , vol.3 , pp. 387-392
    • Wang, Y.1    Korman, S.H.2    Ye, J.3
  • 80
    • 7144253130 scopus 로고    scopus 로고
    • Two frequent missense mutations in Pendred syndrome
    • Van Hauwe, P., Everett, L. A., Coucke, P., et al. (1998) Two frequent missense mutations in Pendred syndrome. Hum. Molec. Genet. 7, 1099-1104.
    • (1998) Hum. Molec. Genet. , vol.7 , pp. 1099-1104
    • Van Hauwe, P.1    Everett, L.A.2    Coucke, P.3
  • 81
    • 0033015606 scopus 로고    scopus 로고
    • Non-syndromic hearing loss associated with enlarged vestibular aqueduct is caused by PDS mutations
    • Usami, S., Abe, S., Weston, M. D., Shinkawa, H., Van Camp, G., and Kimberling, W. J. (1999) Non-syndromic hearing loss associated with enlarged vestibular aqueduct is caused by PDS mutations. Hum. Genet. 104, 188-192.
    • (1999) Hum. Genet. , vol.104 , pp. 188-192
    • Usami, S.1    Abe, S.2    Weston, M.D.3    Shinkawa, H.4    Van Camp, G.5    Kimberling, W.J.6
  • 82
    • 0026602751 scopus 로고
    • Allelic variants of the human putative peptide transporter involved in antigen processing
    • Colonna, M., Bresnahan, M., Bahram, S., Strominger, J. L., and Spies, T. (1992) Allelic variants of the human putative peptide transporter involved in antigen processing. Proc. Nat. Acad. Sci. USA 89, 3932-3936.
    • (1992) Proc. Nat. Acad. Sci. USA , vol.89 , pp. 3932-3936
    • Colonna, M.1    Bresnahan, M.2    Bahram, S.3    Strominger, J.L.4    Spies, T.5
  • 83
    • 0034777332 scopus 로고    scopus 로고
    • Plasmodium falciparum pfcrt and pfmdr1 polymorphisms are associated with the pfdhfr N108 pyrimethamine-resistance mutation in isolates from Ghana
    • Mockenhaupt, F.P., Eggelte, T.A., Till, H., and Bienzle, U. (2001) Plasmodium falciparum pfcrt and pfmdr1 polymorphisms are associated with the pfdhfr N108 pyrimethamine-resistance mutation in isolates from Ghana. Trop. Med. Int. Health 6, 749-755.
    • (2001) Trop. Med. Int. Health , vol.6 , pp. 749-755
    • Mockenhaupt, F.P.1    Eggelte, T.A.2    Till, H.3    Bienzle, U.4
  • 84
    • 0035876910 scopus 로고    scopus 로고
    • Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaounde, Cameroon
    • Basco, L.K. and Ringwald, P. (2001) Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaounde, Cameroon. J. Infect. Dis. 183, 1828-1831.
    • (2001) J. Infect. Dis. , vol.183 , pp. 1828-1831
    • Basco, L.K.1    Ringwald, P.2
  • 85
    • 3042772026 scopus 로고    scopus 로고
    • Identification of functionally variant MDR1 alleles among European Americans and African Americans
    • Kim, R.B., Leake, B.F., Choo, E.F., et al. (2001) Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin. Pharmacol. Ther. 70, 189-199.
    • (2001) Clin. Pharmacol. Ther. , vol.70 , pp. 189-199
    • Kim, R.B.1    Leake, B.F.2    Choo, E.F.3
  • 86
    • 0035929574 scopus 로고    scopus 로고
    • Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans
    • Tirana, R.G., Leake, B.F., Merino, G., and Kim, R.B. (2001) Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. J. Biol. Chem. 276, 35669-35675.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35669-35675
    • Tirana, R.G.1    Leake, B.F.2    Merino, G.3    Kim, R.B.4
  • 87
    • 0032695572 scopus 로고    scopus 로고
    • Association of the dopamine transporter gene (DAT1) with poor methylphenidate response
    • Winsberg, B.G. and Comings, D.E. (1999) Association of the dopamine transporter gene (DAT1) with poor methylphenidate response. J. Am. Acad. Child Adolesc. Psychiatry 38, 1474-1477.
    • (1999) J. Am. Acad. Child Adolesc. Psychiatry , vol.38 , pp. 1474-1477
    • Winsberg, B.G.1    Comings, D.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.