Regulation of innate and acquired immunity in African trypanosomiasis

Parasite Immunology

Volumn 27, Issue 10-11, 2005, Pages 361-371

  Mansfield, J M ^a   Paulnock, D M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

African trypanosomes; Immunoregulation; Trypanosomiasis

Indexed keywords

BETA INTERFERON; DNA; GAMMA INTERFERON; GLYCOSYLPHOSPHATIDYLINOSITOL; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROSTAGLANDIN E2; STAT1 PROTEIN; TOLL LIKE RECEPTOR 9; VARIANT SURFACE GLYCOPROTEIN;

AFRICAN TRYPANOSOMIASIS; ANTIGENIC VARIATION; CPG ISLAND; CYTOKINE RELEASE; HOST PARASITE INTERACTION; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SURVIVAL; TRYPANOSOMIASIS;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENIC VARIATION; B-LYMPHOCYTES; DNA, PROTOZOAN; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; IMMUNITY, NATURAL; LYMPHOCYTE ACTIVATION; MACROPHAGES; T-LYMPHOCYTES; TRYPANOSOMA; TRYPANOSOMIASIS, AFRICAN; VARIANT SURFACE GLYCOPROTEINS, TRYPANOSOMA;

EID: 26244463347     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2005.00791.x     Document Type: Review

References (87)

1. Cross, GA, Wirtz, LE, and Navarro, M. Regulation of VSG expression site transcription and switching in Trypanosoma brucei. Molecular & Biochemical Parasitology 1998; 91:77-91.
2. Borst, P. Antigenic variation and allelic exclusion. Cell 2002; 109:5-8.
3. Navarro, M, and Gull, K. A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei. Nature 2001; 414:759-763.
4. Clayton, CE, Sacks, DL, Ogilvie, BM et al. Membrane fractions of trypanosomes mimic the immunosuppressive and mitogenic effects of living parasites on the host. Parasite Immunol 1979; 1:241-249.
5. Sacks, DL, Selkirk, M, Ogilvie, BM et al. Intrinsic immunosuppressive activity of different trypanosome strains varies with parasite virulence. Nature 1980; 283:476-478.
6. Wellhausen, SR, and Mansfield, JM. Lymphocyte function in experimental African trypanosomiasis. II. Splenic suppressor cell activity. J Immunol 1979; 122:818-824.
7. Wellhausen, SR, and Mansfield, JM. Characteristics of the splenic suppressor cell - target cell interaction in experimental African trypanosomiasis. Cell Immunol 1980; 54:414-424.
8. Mansfield, JM, Levine, RF, Dempsey, WL et al. Lymphocyte function in experimental African trypanosomiasis. IV. Immunosuppression and suppressor cells in the athymic nu/nu mouse. Cell Immunol 1981; 63:210-215.
9. Paulnock, DM, Smith, C, and Mansfield, JM. Antigen presenting cell function in African trypanosomiasis. Alan R Liss; Inc, New York: 1989; 135-144.
10. Mansfield, JM, Davis, TH, and Dubois, ME. Immunobiology of African trypanosomiasis: New paradigms, newer questions, In Black, SJ, and Seed, JR. (ed.), The African Trypanosomes. Kluwer Academic Press; Boston, MA.: 2002; 79-86.
11. Sacks, DL, Bancroft, G, Evans, WH et al. Incubation of trypanosome-derived mitogenic and immunosuppressive products with peritoneal macrophages allows recovery of biological activities from soluble parasite fractions. Infect Immun 1982; 36:160-168.
12. Grosskinsky, CM, and Askonas, BA. Macrophages as primary target cells and mediators of immune dysfunction in African trypanosomiasis. Infect Immun 1981; 33:149-155.
13. Grosskinsky, CM, Ezekowitz, RA, Berton, G et al. Macrophage activation in murine African trypanosomiasis. Infect Immun 1983; 39:1080-1086.
14. Bangs, JD, Doering, TL, Englund, PT et al. Biosynthesis of a variant surface glycoprotein of Trypanosoma brucei. Processing of the glycolipid membrane anchor and N-linked oligosaccharides. Journal of Biological Chemistry 1988; 263:17697-17705.
15. Cross, GA. Glycolipid anchoring of plasma membrane proteins. Annual Review of Cell Biology 1990; 6:1-39.
16. Doering, TL, Masterson, WJ, Englund, PT et al. Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine. J Biol Chem 1989; 264:11168-11173.
17. Ferguson, MA. The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. Journal of Cell Science 1999; 112:2799-2809.
18. Ferguson, MA, Homans, SW, Dwek, RA et al. The glycosylphosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoprotein. Biochemical Society Transactions 1988; 16:265-268.
19. Menon, AK. Structural Analysis of glycosylphosphatidylinositol anchors. Methods in Enzymology 1994; 230:418-442.
20. Hereld, D, Krakow, JL, Bangs, JD et al. A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein. Journal of Biological Chemistry 1986; 261:13813-13819.
21. Mensa Wilmot, K, and Englund, PT. Glycosyl phosphatidylinositol-specific phospholipase C of Trypanosoma brucei: expression in Escherichia coli. Mol Biochem Parasitol 1992; 56:311-321.
22. Bulow, R, Nonnengasser, C, and Overath, P. Release of the variant surface glycoprotein during differentiation of blood-stream to procyclic forms of Trypanosoma brucei. Molecular & Biochemical Parasitology 1989; 32:85-92.
23. Tachado, SD, Gerold, P, Schwarz, R et al. Signal Transduction In Macrophages by Glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania - Activation of Protein Tyrosine Kinases and Protein Kinase C By Inositolglycan and Diacylglycerol Moieties. Proceedings of the National Academy of Sciences of the United States of America 1997; 94:4022-4027.
24. Tachado, SD, and Schofield, L. Glycosylphosphatidylinositol toxin of Trypanosoma brucei regulates IL-1 alpha and TNF-alpha expression in macrophages by protein tyrosine kinase mediated signal transduction. Biochem Biophys Res Commun 1994; 205:984-991.
25. Schofield, L, and Tachado, SD. Regulation of host cell function by glycosylphosphatidylinositols of the parasitic protozoa. Immunology & Cell Biology 1996; 74:555-563.
26. Magez, S, Stijlemans, B, Radwanska, M et al. The glycosylinositol- phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors. Journal of Immunology 1998; 160:1949-1956.
27. Schopf, LR, Filutowicz, H, Bi, X-J et al. Interleukin-4-dependent immunoglobulin G1 isotype switch in the presence of a polarized antigen-specific Th1-cell response to the trypanosome variant surface glycoprotein. Infection and Immunity 1998; 66:1-12.
28. Hertz, CJ, Filutowicz, H, and Mansfield, JM. Resistance to the African trypanosomes is IFN-gamma dependent. Journal of Immunology 1998; 161:6775-6783.
29. Mansfield, JM. T-cell responses to the trypanosome variant surface glycoprotein: A new paradigm? Parasitol Today 1994; 10:267-270.
30. Schleifer, KW, Filutowicz, H, Schopf, LR et al. Characterization of T helper cell responses to the trypanosome variant surface glycoprotein. J Immunol 1993; 150:2910-2919.
31. Schofield, L, McConville, MJ, Hansen, D et al. CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells. Science 1999; 283:225.
32. Coller, SP, Mansfield, JM, and Paulnock, DM. Glycosylinositolphosphate soluble variant surface glycoprotein inhibits IFN-gamma-induced nitric oxide production via reduction in STAT1 phosphorylation in African trypanosomiasis. Journal of Immunology 2003; 171:1466-1472.
33. Paulnock, DM, and Coller, SP. Analysis of macrophage activation in African trypanosomiasis. Journal of Leukocyte Biology 2001; 69:685-690.
34. Paulnock, DM, Demick, KP, and Coller, SP. Analysis of interferon-gamma-dependent and -independent pathways of macrophage activation. Journal of Leukocyte Biology 2000; 67:677-682.
35. De Gee, AL, Sonnenfeld, G, and Mansfield, JM. Genetics of resistance to the African trypanosomes. V. Qualitative and quantitative differences in interferon production among susceptible and resistant mouse strains. J Immunol 1985; 134:2723-2726.
36. Drennan, MB, Stijlemans, B, Van Den Abbeele, J et al. The Induction of a Type 1 Immune Response following a Trypanosoma brucei Infection Is MyD88 Dependent. J Immunol 2005; 175:2501-2509.
37. Carrington, M, Carnall, N, Crow, MS et al. The properties and function of the glycosylphosphatidylinositol-phospholipase C in Trypanosoma brucei. [Review] [57 refs]. Molecular & Biochemical Parasitology 1998; 91:153-164.
38. Webb, H, Carnall, N, Vanhamme, L et al. The GPI-phospholipase C of Trypanosoma brucei is nonessential but influences parasitemia in mice. Journal of Cell Biology 1997; 139:103-114.
39. Namangala, B, De Baetselier, P, Noel, W et al. Alternative versus classical macrophage activation during experimental African trypanosomosis. Journal of Leukocyte Biology 2001; 69:387-396.
40. Namangala, B, de Baetselier, P, Brijs, L et al. Attenuation of Trypanosoma brucei is associated with reduced immunosuppression and concomitant production of Th2 lymphokines. Journal of Infectious Diseases 2000; 181:1110-1120.
41. Shoda, LKM, Kegerreis, KA, Suarez, CE et al. DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T-brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide. Infection & Immunity 2001; 69:2162-2171.
42. De Gee, AL, Levine, RF, and Mansfield, JM. Genetics of resistance to the African trypanosomes. VI. Heredity of resistance and variable surface glycoprotein-specific immune responses. J Immunol 1988; 140:283-288.
43. De Gee, AL, and Mansfield, JM. Genetics of resistance to the African trypanosomes. IV. Resistance of radiation chimeras to Trypanosoma rhodesiense infection. Cell Immunol 1984; 87:85-91.
44. Dempsey, WL, and Mansfield, JM. Lymphocyte function in experimental African trypanosomiasis. V. Role of antibody and the mononuclear phagocyte system in variant-specific immunity. J Immunol 1983; 130:405-411.
45. Levine, RF, and Mansfield, JM. Genetics of resistance to African trypanosomes: role of the H-2 locus in determining resistance to infection with Trypanosoma rhodesiense. Infect Immun 1981; 34:513-518.
46. Dubois, ME, Demick, KP, and Mansfield, JM. Trypanosomes expressing a mosaic variant surface glycoprotein coat escape early detection by the immune system. Infect Immun 2005; 73:2690-2697.
47. Reinitz, DM, and Mansfield, JM. T-cell-independent and T-cell-dependent B-cell responses to exposed variant surface glycoprotein epitopes in trypanosome-infected mice. Infect Immun 1990; 58:2337-2342.
48. Reinitz, DM, and Mansfield, JM. Independent regulation of B cell responses to surface and subsurface epitopes of African trypanosome variable surface glycoproteins. J Immunol 1988; 141:620-626.
49. Blum, G, Ott, M, Cross, A et al. Virulence determinants of Escherichia coli O6 extraintestinal isolates analysed by Southern hybridizations and DNA long range mapping techniques. Microb Pathog 1991; 10:127-136.
50. Carrington, M, and Boothroyd, J. Implications of conserved structural motifs in disparate trypanosome surface proteins. Molecular & Biochemical Parasitology 1996; 81:119-126.
51. Metcalf, D, Elliott, MJ, and Nicola, NA. The excess numbers of peritoneal macrophages in granulocyte-macrophage colony-stimulating factor transgenic mice are generated by local proliferation. J Exp Med 1992; 175:877-884.
52. Metcalf, P, Blum, M, Freymann, D et al. Two variant surface glycoproteins of Trypanosoma brucei of different sequence classes have similar 6 A resolution X-ray structures. Nature 1987; 325:84-86.
53. Fehr, T, Skrastina, D, Pumpens, P et al. T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles. Proceedings of the National Academy of Sciences of the United States of America 1998; 95:9477-9481.
54. Bachmann, MF, and Zinkernagel, RM. The influence of virus structure on antibody responses and virus serotype formation. Immunology Today 1996; 17:553-558.
55. Baltz, T, Giroud, C, Baltz, D et al. Stable expression of two variable surface glycoproteins by cloned Trypanosoma equiperdum. Nature 1986; 319:602-604.
56. Esser, KM, and Schoenbechler, MJ. Expression of two variant surface glycoproteins on individual African trypanosomes during antigen switching. Science 1985; 229:190-193.
57. Seyfang, A, Mecke, D, and Duszenko, M. Degradation, recycling, and shedding of Trypanosoma brucei variant surface glycoprotein. Journal of Protozoology 1990; 37:546-552.
58. Dempsey, WL, and Mansfield, JM. Lymphocyte function in experimental African trypanosomiasis. VI. Parasite-specific immunosuppression. J Immunol 1983; 130:2896-2898.
59. Munoz-Jordan, JL, Davies, KP, and Cross, GA. Stable expression of mosaic coats of variant surface glycoproteins in Trypanosoma brucei. Science 1996; 272:1795-1797.
60. Schleifer, KW, and Mansfield, JM. Innate and acquired resistance to the African trypanosomes: patterns of infection in immunodeficient mouse strains. (In preparation). 2005.
61. Mansfield, JM. Immunobiology of African trypanosomiasis: A revisionist view, In Boothroyd, JC and Komuniecki, R (ed.), Molecular Approaches to Parasitology. Wiley-Liss; New York: 1995; 477-496.
62. Mansfield, JM, and Bagasra, O. Lymphocyte function in experimental African trypanosomiasis. I. B cell responses to helper T cell-independent and -dependent antigens. J Immunol 1978; 120:759-765.
63. Mansfield, JM, and Kreier, JP. Tests for antibody- and cell-mediated hypersensitivity to trypanosome antigens in rabbits infected with Trypanosoma congolense. Infect Immun 1972; 6:62-67.
64. Mansfield, JM, and Wallace, JH. Suppression of cell-mediated immunity in experimental African trypanosomiasis. Infect Immun 1974; 10:335-339.
65. Eardley, DD, and Jayawardena, AN. Suppressor cells in mice infected with Trypanosoma brucei. J Immunol 1977; 119:1029-1033.
66. Jayawardena, AN, Waksman, BH, and Eardley, DD. Activation of distinct helper and suppressor T cells in experimental trypanosomiasis. J Immunol 1978; 121:622-628.
67. Askonas, BA. Macrophages as mediators of immunosuppression in murine African trypanosomiasis. Curr Top Microbiol Immunol 1985; 117:119-127.
68. Borowy, NK, Sternberg, JM, Schreiber, D et al. Suppressive macrophages occurring in murine Trypanosoma brucei infection inhibit T-cell responses in vivo and in vitro. Parasite Immunol 1990; 12:233-246.
69. Sternberg, J, and McGuigan, F. Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection. Eur J Immunol 1992; 22:2741-2744.
70. Schleifer, KW, and Mansfield, JM. Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. J Immunol 1993; 151:5492-5503.
71. Hertz, CJ, and Mansfield, JM. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cellular Immunology 1999; 192:24-32.
72. Millar, AE, Sternberg, J, McSharry, C et al. T-Cell responses during Trypanosoma brucei infections in mice deficient in inducible nitric oxide synthase. Infection and Immunity 1999; 67:3334-3338.
73. Sileghem, M, Darji, A, and De Baetselier, P. In vitro simulation of immunosuppression caused by Trypanosoma brucei. Immunology 1991; 73:246-248.
74. Darji, A, Lucas, R, Magez, S et al. Mechanisms underlying trypanosome-elicited immunosuppression. Ann Soc Belg Med Trop 1992; 1:27-38.
75. Lucas, R, Magez, S, Songa, B et al. A role for TNF during African trypanosomiasis: involvement in parasite control, immunosuppression and pathology. Res Immunol 1993; 144:370-376.
76. Darji, A, Beschin, A, Sileghem, M et al. In Vitro Simulation of Immunosuppression Caused By Trypanosoma Brucei - Active Involvement of Gamma Interferon and Tumor Necrosis Factor in the Pathway of Suppression. Infection & Immunity 1996; 64:1937-1943.
77. Beschin, A, Brys, L, Magez, S et al. Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms. Journal of Leukocyte Biology 1998; 63:429-439.
78. Magez, S, Radwanska, M, Beschin, A et al. Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections. Infection & Immunity 1999; 67:3128-3132.
79. Raes, G, De Baetselier, P, Noel, W et al. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. Journal of Leukocyte Biology 2002; 71:597-602.
80. Bagasra, O, Schell, RF, and Le Frock, JL. Evidence for depletion of Ia+ macrophages and associated immunosuppression in African trypanosomiasis. Infect Immun 1981; 32:188-193.
81. Namangala, B, Brys, L, Magez, S et al. Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophages. Parasite Immunology 2000; 22:361-370.
82. Mansfield, JM, and Olivier, M. Immune evasion by parasites, In Kaufmann, SHE, Sher, A, and Ahmed, R (ed.), Immunology of Infectious Diseases. ASM Press; Washington DC.: 2002: 379-392.
83. Reinitz, DM, Aizenstein, BD, and Mansfield, JM. Variable and conserved structural elements of trypanosome variant surface glycoproteins. Mol Biochem Parasitol 1992; 51:119-132.
84. Carrington, M, Miller, N, Blum, M et al. Variant specific glycoprotein of Trypanosoma brucei consists of two domains each having an independently conserved pattern of cysteine residues. J Mol Biol 1991; 221:823-835.
85. Blum, JL, Down, JA, Gurnett, AM et al. A structural motif in the variant surface glycoproteins of Trypanosoma brucei. Nature 1993; 362:603-609.
86. Beals, TP, and Boothroyd, JC. Sequence divergence among members of a Trypanosome variant surface glycoprotein gene family. J Mol Biol 1992; 225:973-983.
87. Field, MC, and Boothroyd, JC. Sequence divergence in a family of variant surface glycoprotein genes from trypanosomes: coding region hypervariability and downstream recombinogenic repeats. Journal of Molecular Evolution 1996; 42:500-511.