T-cell responses during Trypanosoma brucei infections in mice deficient in inducible nitric oxide synthase

Infection and Immunity

Volumn 67, Issue 7, 1999, Pages 3334-3338

  Millar, Amanda E ^a,c   Sternberg, Jerry ^b   McSharry, Charlie ^a   Wei, Xiao Qing ^a   Liew, F Y ^a   Turner, C Michael R ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; FEMALE; FLOW CYTOMETRY; HELPER CELL; MOUSE; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS;

EID: 0033045566     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.7.3334-3338.1999     Document Type: Article

References (33)

1. Amin, A. R., P. E. Di Cesare, P. Vyas, M. Attur, E. Tzeng, T. R. Billiar, S. A. Stuchin, and S. B. Abramson. 1995. The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase. J. Exp. Med. 182:2097-2102.
2. Askonas, B. A. 1985. Macrophages as mediators of immunosuppression in murine African trypanosomiasis. Curr. Top. Microbiol. Immunol. 117:119-127.
3. + T cells suppresses growth of Trypanosoma brucei brucei and interferon-gamma production in infected rats. Clin. Exp. Immunol. 81:195-199.
4. Bancroft, G. J., A. G. Sutton, A. J. Morris, and B. A. Askonas. 1983. Production of interferons during experimental African trypanosomiasis. Clin. Exp. Immunol. 52:135-143.
5. Borowy, N. K., J. M. Sternberg, D. Schreiber, C. Nonnengasser, and P. Overath. 1990. Suppressive macrophages occurring in murine Trypanosoma brucei infection inhibit T-cell responses in vivo and in vitro. Parasite Immunol. 12:233-246.
6. Darji, A., M. Sileghem, H. Heremans, L. Brys, and P. De Baetselier. 1993. Inhibition of T-cell responsiveness during experimental infections with Trypanosoma brucei: active involvement of endogenous gamma interferon. Infect. Immun. 61:3098-3102.
7. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407-2412.
8. Flynn, J. N., and M. Sileghem. 1991. The role of the macrophage in induction of immunosuppression in Trypanosoma congelense infected cattle. Immunology 74:310-316.
9. Ghiotto, V., R. Brun, L. Jenni, and H. Hecker. 1979. Trypanosoma brucei: morphometric changes and loss of infectivity during transformation of bloodstream forms to procyclic culture forms in vitro. Exp. Parasitol. 48:447-456.
10. Hertz, C. J., and J. M. Mansfield. 1999. IFN-γ-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell. Immunol. 192:24-32.
11. Mabbott, N., and J. Sternberg. 1995. Bone marrow nitric oxide production and development of anemia in Trypanosoma brucei-infected mice. Infect. Immun. 63:1563-1566.
12. Mabbott, N. A., I. A. Sutherland, and J. M. Sternberg. 1994. Trypanosoma brucei is protected from the cytostatic effects of nitric oxide under in vivo conditions. Parasitol. Res. 80:687-690.
13. Mabbott, N. A., I. A. Sutherland, and J. M. Sternberg. 1995. Suppressor macrophages in Trypanosoma brucei infection: nitric oxide is related to both suppressive activity and lifespan in vivo. Parasite Immunol. 17:143-150.
14. McInnes, I. B., B. Leung, X.-Q. Wei, C. G. Gemmell, and F. Y. Liew. 1998. Septic arthritis following Staphylococcus aureus infection in mice lacking inducible nitric oxide synthase. J. Immunol. 160:308-315.
15. McLintock, L. M. L., C. M. R. Turner, and K. Vickerman. 1990. A comparison of multiplication rates in primary and challenge infections of Trypanosoma brucei bloodstream forms. Parasitology 101:49-55.
16. Olsson, T., M. Bakhiet, B. Hojeberg, A, Ljungdahl, C. Edlund, G. Andersson, H. P. Ekre, W. P. Fung-Leung, T. Mak, H. Wigzell, U. Fiszer, and K. Kristensson. 1993. CD8 is critically involved in lymphocyte activation by a T. brucei-released molecule. Cell 72:715-727.
17. Samdani, A. F., C. Newcamp, A. Resink, F. Facchinelti, B. E. Hoffman, V. L. Dawson, and T. M. Dawson. 1997. Differential susceptibility to neurotoxicity mediated by neurotrophins and neural nitric oxide synthase. J. Neurosci. 17:4633-4641.
18. Schleifer, K. W., and J. M. Mansfield. 1993. Suppressor macrophages in African trypanosomiasis inhibit T-cell proliferative responses by nitric oxide and prostaglandins. J. Immunol. 151:5492-5503.
19. Schleifer, K. W., H. Filutowicz, L. R. Schopf, and J. M. Mansfield. 1993. Characterisation of T helper cell responses to the trypanosome variant surface glycoprotein. J. Immunol. 150:2910-2919.
20. Sileghem, M., A. Darji, R. Hamers, M. Van de Winkel, and P. De Baetselier. 1989. Dual role of macrophages in the suppression of interleukin 2 production and interleukin 2 receptor expression in trypanosome-infected mice. Eur. J. Immunol. 19:829-835.
21. Sileghem, M., A. Darji, and P. De Baetselier. 1991. In vitro stimulation of immunosuppression caused by Trypanosoma brucei. Immunology 73:246-248.
22. Sileghem, M., and J. N. Flynn. 1992. Suppression of interleukin 2 secretion and interleukin 2 receptor expression during tsetse-transmitted trypanosomiasis in cattle. Eur. J. Immunol. 22:767-773.
23. Sternberg, J., N. Mabbott, I. Sutherland, and F. Y. Liew. 1994. Inhibition of nitric oxide synthesis leads to reduced parasitemia in murine Trypanosoma brucei infection. Infect. Immun. 62:2135-2137.
24. Sternberg, J. M., and F. McGuigan. 1992. Nitric oxide mediates suppression of T-cell responses in murine Trypanosoma brucei infection. Eur. J. Immunol. 22:2741-2744.
25. Sternberg, J. M. 1998. Immunobiology of African trypanosomiasis. Chem. Immunol. 70:186-199.
26. Sternberg, J. M., N. Njogu-Maina, C. Gichuki, and J. M. Ndung'u. 1998. Nitric oxide production in vervet monkeys (Cercopithecus aethiops) infected with Trypanosoma brucei. Parasite Immunol. 20:395-397.
27. Taylor, K., V. Lutje, and B. Mertens. 1996. Nitric oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression. Infect. Immun. 64:4115-4122.
28. Turner, C. M. R. Unpublished results.
29. Turner, C. M. R. Antigenic variation in Trypanosoma brucei: a holistic view. J. Cell Sci., in press.
30. Turner, C. M. R., and J. D. Barry. 1989. High frequency of antigenic variation in Trypanosoma brucei rhodesiense infections. Parasitology 99:67-75.
31. Turner, C. M. R., N. Aslam, and S. D. Angus. 1996. Inhibition of growth of Trypanosoma brucei parasites in chronic infections. Parasitol. Res. 82:61-66.
32. Vincendeau, P., S. Daulouède, B. Veyret, M. L. Darde, B. Bouteille, and J. P. Lemesre. 1992. Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. Exp. Parasitol. 75:353-360.
33. Wei, X.-Q., I. G. Charles, A. Smith, J. Ure, G.-J. Feng, F.-P. Huang, D. Xu, W. Muller, S. Moncada, and F. Y. Liew. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:408-411.