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Volumn 73, Issue 5, 2005, Pages 2690-2697

Trypanosomes expressing a mosaic variant surface glycoprotein coat escape early detection by the immune system

Author keywords

[No Author keywords available]

Indexed keywords

RIBOSOME DNA; VARIANT SURFACE GLYCOPROTEIN;

EID: 17644405864     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.5.2690-2697.2005     Document Type: Article
Times cited : (42)

References (47)
  • 1
    • 0024404943 scopus 로고
    • Ordered appearance of antigenic variants of African trypanosomes explained in a mathematical model based on a stochastic switch process and immune-selection against putative switch intermediates
    • Agur, Z., D. Abiri, and L. H. Van der Ploeg. 1989. Ordered appearance of antigenic variants of African trypanosomes explained in a mathematical model based on a stochastic switch process and immune-selection against putative switch intermediates. Proc. Natl. Acad. Sci. USA 86:9626-9630.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9626-9630
    • Agur, Z.1    Abiri, D.2    Van Der Ploeg, L.H.3
  • 2
    • 0037101948 scopus 로고    scopus 로고
    • Developmentally regulated trafficking of the lysosomal membrane protein p67 in Trypanosoma brucei
    • Alexander, D. L., K. J. Schwartz, A. E. Balber, and J. D. Bangs. 2002. Developmentally regulated trafficking of the lysosomal membrane protein p67 in Trypanosoma brucei. J. Cell Sci. 115:3253-3263.
    • (2002) J. Cell Sci. , vol.115 , pp. 3253-3263
    • Alexander, D.L.1    Schwartz, K.J.2    Balber, A.E.3    Bangs, J.D.4
  • 3
    • 0030446248 scopus 로고    scopus 로고
    • The influence of virus structure on antibody responses and virus serotype formation
    • Bachmann, M. F., and R. Zinkernagel. 1996. The influence of virus structure on antibody responses and virus serotype formation. Immunol. Today 17:553-558.
    • (1996) Immunol. Today , vol.17 , pp. 553-558
    • Bachmann, M.F.1    Zinkernagel, R.2
  • 4
    • 0022589129 scopus 로고
    • Stable expression of two variable surface glycoproteins by cloned Trypanosoma equiperdum
    • Baltz, T., C. Giroud, D. Baltz, C. Roth, A. Raibaud, and H. Eisen. 1986. Stable expression of two variable surface glycoproteins by cloned Trypanosoma equiperdum. Nature 319:602-604.
    • (1986) Nature , vol.319 , pp. 602-604
    • Baltz, T.1    Giroud, C.2    Baltz, D.3    Roth, C.4    Raibaud, A.5    Eisen, H.6
  • 5
    • 0032129746 scopus 로고    scopus 로고
    • Surface coats and secretory trafficking in African trypanosomes
    • Bangs, J. D. 1998. Surface coats and secretory trafficking in African trypanosomes. Curr. Opin. Microbiol. 1:448-454.
    • (1998) Curr. Opin. Microbiol. , vol.1 , pp. 448-454
    • Bangs, J.D.1
  • 6
    • 0029764290 scopus 로고    scopus 로고
    • A soluble secretory reporter system in Trypanosoma brucei. Studies on endoplasmic reticulum targeting
    • Bangs, J. D., E. M. Brouch, D. M. Ransom, and J. L. Roggy. 1996. A soluble secretory reporter system in Trypanosoma brucei. Studies on endoplasmic reticulum targeting. J. Biol. Chem. 271:18387-18393.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18387-18393
    • Bangs, J.D.1    Brouch, E.M.2    Ransom, D.M.3    Roggy, J.L.4
  • 7
    • 0030791382 scopus 로고    scopus 로고
    • Expression of bloodstream variant surface glycoproteins in procyclic stage Trypanosoma brucei: Role of GPI anchors in secretion
    • Bangs, J. D., D. M. Ransom, M. A. McDowell, and E. M. Brouch. 1997. Expression of bloodstream variant surface glycoproteins in procyclic stage Trypanosoma brucei: role of GPI anchors in secretion. EMBO J. 16:4285-4294.
    • (1997) EMBO J. , vol.16 , pp. 4285-4294
    • Bangs, J.D.1    Ransom, D.M.2    McDowell, M.A.3    Brouch, E.M.4
  • 9
    • 0027412486 scopus 로고
    • A structural motif in the variant surface glycoproteins of Trypanosoma brucei
    • Blum, J. L., J. A. Down, A. M. Gurnett, M. Carrington, M. J. Turner, and D. C. Wiley. 1993. A structural motif in the variant surface glycoproteins of Trypanosoma brucei. Nature 362:603-609.
    • (1993) Nature , vol.362 , pp. 603-609
    • Blum, J.L.1    Down, J.A.2    Gurnett, A.M.3    Carrington, M.4    Turner, M.J.5    Wiley, D.C.6
  • 10
    • 0035946390 scopus 로고    scopus 로고
    • Control of VSG gene expression sites
    • Borst, P., and S. Ulbert. 2001. Control of VSG gene expression sites. Mol. Biochem. Parasitol. 114:17-27.
    • (2001) Mol. Biochem. Parasitol. , vol.114 , pp. 17-27
    • Borst, P.1    Ulbert, S.2
  • 11
    • 0025952503 scopus 로고
    • Variant specific glycoprotein of Trypanosoma brucei consists of two domains each having an independently conserved pattern of cysteine residues
    • Carrington, M., N. Miller, M. Blum, I. Roditi, D. Wiley, and M. Turner. 1991. Variant specific glycoprotein of Trypanosoma brucei consists of two domains each having an independently conserved pattern of cysteine residues. J. Mol. Biol. 221:823-835.
    • (1991) J. Mol. Biol. , vol.221 , pp. 823-835
    • Carrington, M.1    Miller, N.2    Blum, M.3    Roditi, I.4    Wiley, D.5    Turner, M.6
  • 12
    • 0023836943 scopus 로고
    • Physical studies of Trypanosoma brucei variant surface glycoproteins and their antigenic determinants
    • Clarke, M. W., W. D. McCubbin, C. M. Kay, and T. W. Pearson. 1988. Physical studies of Trypanosoma brucei variant surface glycoproteins and their antigenic determinants. Biochemistry 27:405-413.
    • (1988) Biochemistry , vol.27 , pp. 405-413
    • Clarke, M.W.1    McCubbin, W.D.2    Kay, C.M.3    Pearson, T.W.4
  • 13
    • 0032029361 scopus 로고    scopus 로고
    • Regulation of vsg expression site transcription and switching in Trypanosoma brucei
    • Cross, G. A., L. E. Wirtz, and M. Navarro. 1998. Regulation of vsg expression site transcription and switching in Trypanosoma brucei. Mol. Biochem. Parasitol. 91:77-91.
    • (1998) Mol. Biochem. Parasitol. , vol.91 , pp. 77-91
    • Cross, G.A.1    Wirtz, L.E.2    Navarro, M.3
  • 14
    • 0021955575 scopus 로고
    • Genetics of resistance to the African trypanosomes. V. Qualitative and quantitative differences in Interferon production among susceptible and resistant mouse strains
    • De Gee, A. L., G. Sonnenfeld, and J. M. Mansfield. 1985. Genetics of resistance to the African trypanosomes. V. Qualitative and quantitative differences in Interferon production among susceptible and resistant mouse strains. J. Immunol. 134:2723-2726.
    • (1985) J. Immunol. , vol.134 , pp. 2723-2726
    • De Gee, A.L.1    Sonnenfeld, G.2    Mansfield, J.M.3
  • 15
    • 0020687183 scopus 로고
    • Lymphocyte function in experimental African trypanosomiasis. V. Role of antibody and the mononuclear phagocyte system in variant-specific immunity
    • Dempsey, W. L., and J. M. Mansfield. 1983. Lymphocyte function in experimental African trypanosomiasis. V. Role of antibody and the mononuclear phagocyte system in variant-specific immunity. J. Immunol. 130:405-411.
    • (1983) J. Immunol. , vol.130 , pp. 405-411
    • Dempsey, W.L.1    Mansfield, J.M.2
  • 16
    • 0020594397 scopus 로고
    • Lymphocyte function in experimental African trypanosomiasis. VI. Parasite-specific immunosuppression
    • Dempsey, W. L., and J. M. Mansfield. 1983. Lymphocyte function in experimental African trypanosomiasis. VI. Parasite-specific immunosuppression. J. Immunol. 130:2896-2898.
    • (1983) J. Immunol. , vol.130 , pp. 2896-2898
    • Dempsey, W.L.1    Mansfield, J.M.2
  • 17
    • 0037345508 scopus 로고    scopus 로고
    • Antigenic variation and the African trypanosome genome
    • Donelson, J. E. 2003. Antigenic variation and the African trypanosome genome. Acta Trop. 85:391-404.
    • (2003) Acta Trop. , vol.85 , pp. 391-404
    • Donelson, J.E.1
  • 19
    • 0021984625 scopus 로고
    • Expression of two variant surface glycoproteins on individual African trypanosomes during antigen switching
    • Esser, K. M., and M. J. Schoenbechler. 1985. Expression of two variant surface glycoproteins on individual African trypanosomes during antigen switching. Science 229:190-193.
    • (1985) Science , vol.229 , pp. 190-193
    • Esser, K.M.1    Schoenbechler, M.J.2
  • 20
    • 18844462890 scopus 로고    scopus 로고
    • RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei
    • Gunzl, A., T. Bruderer, G. Laufer, B. Schimanski, L. C. Tu, H. M. Chung, P. T. Lee, and M. G. Lee. 2003. RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei. Eukaryot. Cell 2:542-551.
    • (2003) Eukaryot. Cell , vol.2 , pp. 542-551
    • Gunzl, A.1    Bruderer, T.2    Laufer, G.3    Schimanski, B.4    Tu, L.C.5    Chung, H.M.6    Lee, P.T.7    Lee, M.G.8
  • 21
    • 0032534673 scopus 로고    scopus 로고
    • Resistance to the African trypanosomes is IFN-γ dependent
    • Hertz, C. J., H. Filutowicz, and J. M. Mansfield. 1998. Resistance to the African trypanosomes is IFN-γ dependent. J. Immunol. 161:6775-6783.
    • (1998) J. Immunol. , vol.161 , pp. 6775-6783
    • Hertz, C.J.1    Filutowicz, H.2    Mansfield, J.M.3
  • 22
    • 0033602238 scopus 로고    scopus 로고
    • IFN-γ-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis
    • Hertz, C. J., and J. M. Mansfield. 1999. IFN-γ-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell. Immunol. 192:24-32.
    • (1999) Cell. Immunol. , vol.192 , pp. 24-32
    • Hertz, C.J.1    Mansfield, J.M.2
  • 23
    • 0028009258 scopus 로고
    • Axenic culture of African trypanosome bloodstream forms
    • Hirumi, H., and K. Hirumi. 1994. Axenic culture of African trypanosome bloodstream forms. Parasitol. Today 10:80-84.
    • (1994) Parasitol. Today , vol.10 , pp. 80-84
    • Hirumi, H.1    Hirumi, K.2
  • 24
    • 0021768580 scopus 로고
    • Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous transcription in trypanosomes
    • Kooter, J. M., and P. Borst. 1984. Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous transcription in trypanosomes. Nucleic Acids Res. 12:9457-9472.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 9457-9472
    • Kooter, J.M.1    Borst, P.2
  • 25
    • 0014884946 scopus 로고
    • Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose
    • Lanham, S. M., and D. G. Godfrey. 1970. Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose. Exp. Parasitol. 28:521-534.
    • (1970) Exp. Parasitol. , vol.28 , pp. 521-534
    • Lanham, S.M.1    Godfrey, D.G.2
  • 26
    • 0021166854 scopus 로고
    • Genetics of resistance to the African trypanosomes. III. Variant-specific antibody responses of H-2-compatible resistant and susceptible mice
    • Levine, R. F., and J. M. Mansfield. 1984. Genetics of resistance to the African trypanosomes. III. Variant-specific antibody responses of H-2-compatible resistant and susceptible mice. J. Immunol. 133:1564-1569.
    • (1984) J. Immunol. , vol.133 , pp. 1564-1569
    • Levine, R.F.1    Mansfield, J.M.2
  • 27
    • 0028290129 scopus 로고
    • T-cell responses to the trypanosome variant surface glycoprotein: A new paradigm?
    • Mansfield, J. M. 1994. T-cell responses to the trypanosome variant surface glycoprotein: a new paradigm? Parasitol. Today 10:267-270.
    • (1994) Parasitol. Today , vol.10 , pp. 267-270
    • Mansfield, J.M.1
  • 28
    • 0019478711 scopus 로고
    • Lymphocyte function in experimental African trypanosomiasis. IV. Immunosuppression and suppressor cells in the athymic nu/nu mouse
    • Mansfield, J. M., R. F. Levine, W. L. Dempsey, S. R. Wellhausen, and C. T. Hansen. 1981. Lymphocyte function in experimental African trypanosomiasis. IV. Immunosuppression and suppressor cells in the athymic nu/nu mouse. Cell. Immunol. 63:210-215.
    • (1981) Cell. Immunol. , vol.63 , pp. 210-215
    • Mansfield, J.M.1    Levine, R.F.2    Dempsey, W.L.3    Wellhausen, S.R.4    Hansen, C.T.5
  • 29
    • 0023175966 scopus 로고
    • Two variant surface glycoproteins of Trypanosoma brucei of different sequence classes have similar 6 Å esolution X-ray structures
    • Metcalf, P., M. Blum, D. Freymann, M. Turner, and D. C. Wiley. 1987. Two variant surface glycoproteins of Trypanosoma brucei of different sequence classes have similar 6 Å esolution X-ray structures. Nature 325:84-86.
    • (1987) Nature , vol.325 , pp. 84-86
    • Metcalf, P.1    Blum, M.2    Freymann, D.3    Turner, M.4    Wiley, D.C.5
  • 30
    • 0030037305 scopus 로고    scopus 로고
    • Stable expression of mosaic coats of variant surface glycoproteins in Trypanosoma brucei
    • Munoz-Jordan, J. L., K. P. Davies, and G. A. Cross. 1996. Stable expression of mosaic coats of variant surface glycoproteins in Trypanosoma brucei. Science 272:1795-1797.
    • (1996) Science , vol.272 , pp. 1795-1797
    • Munoz-Jordan, J.L.1    Davies, K.P.2    Cross, G.A.3
  • 31
    • 0026503854 scopus 로고
    • Variable and conserved structural elements of trypanosome variant surface glycoproteins
    • Reinitz, D. M., B. D. Aizenstein, and J. M. Mansfield. 1992. Variable and conserved structural elements of trypanosome variant surface glycoproteins. Mol. Biochem. Parasitol. 51:119-132.
    • (1992) Mol. Biochem. Parasitol. , vol.51 , pp. 119-132
    • Reinitz, D.M.1    Aizenstein, B.D.2    Mansfield, J.M.3
  • 32
    • 0023807109 scopus 로고
    • Independent regulation of B cell responses to surface and subsurface epitopes of African trypanosome variable surface glycoproteins
    • Reinitz, D. M., and J. M. Mansfield. 1988. Independent regulation of B cell responses to surface and subsurface epitopes of African trypanosome variable surface glycoproteins. J. Immunol. 141:620-626.
    • (1988) J. Immunol. , vol.141 , pp. 620-626
    • Reinitz, D.M.1    Mansfield, J.M.2
  • 33
    • 0025296687 scopus 로고
    • T-cell-independent and T-cell-dependent B-cell responses to exposed variant surface glycoprotein epitopes in trypanosome-infected mice
    • Reinitz, D. M., and J. M. Mansfield. 1990. T-cell-independent and T-cell-dependent B-cell responses to exposed variant surface glycoprotein epitopes in trypanosome-infected mice. Infect. Immun. 58:2337-2342.
    • (1990) Infect. Immun. , vol.58 , pp. 2337-2342
    • Reinitz, D.M.1    Mansfield, J.M.2
  • 34
    • 0031438790 scopus 로고    scopus 로고
    • Cell density triggers slender to stumpy differentiation of Trypanosoma brucei bloodstream forms in culture
    • Reuner, B., E. Vassella, B. Yutzy, and M. Boshart. 1997. Cell density triggers slender to stumpy differentiation of Trypanosoma brucei bloodstream forms in culture. Mol. Biochem. Parasitol. 90:269-280.
    • (1997) Mol. Biochem. Parasitol. , vol.90 , pp. 269-280
    • Reuner, B.1    Vassella, E.2    Yutzy, B.3    Boshart, M.4
  • 35
    • 0027382922 scopus 로고
    • Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins
    • Schleifer, K. W., and J. M. Mansfield. 1993. Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. J. Immunol. 151:5492-5503.
    • (1993) J. Immunol. , vol.151 , pp. 5492-5503
    • Schleifer, K.W.1    Mansfield, J.M.2
  • 36
    • 0031882516 scopus 로고    scopus 로고
    • Interleukin-4-dependent immunoglobulin G1 isotype switch in the presence of a polarized antigen-specific Th1-cell response to the trypanosome variant surface glycoprotein
    • Schopf, L. R., H. Filutowicz, X. J. Bi, and J. M. Mansfield. 1998. Interleukin-4-dependent immunoglobulin G1 isotype switch in the presence of a polarized antigen-specific Th1-cell response to the trypanosome variant surface glycoprotein. Infect. Immun. 66:451-461.
    • (1998) Infect. Immun. , vol.66 , pp. 451-461
    • Schopf, L.R.1    Filutowicz, H.2    Bi, X.J.3    Mansfield, J.M.4
  • 37
    • 0031967072 scopus 로고    scopus 로고
    • Characterization of a relatively rare class B, type 2 trypanosome variant surface glycoprotein gene
    • Schopf, L. R., and J. M. Mansfield. 1998. Characterization of a relatively rare class B, type 2 trypanosome variant surface glycoprotein gene. J. Parasitol. 84:284.
    • (1998) J. Parasitol. , vol.84 , pp. 284
    • Schopf, L.R.1    Mansfield, J.M.2
  • 38
    • 0025607911 scopus 로고
    • Degradation, recycling, and shedding of Trypanosoma brucei variant surface glycoprotein
    • Seyfang, A., D. Mecke, and M. Duszenko. 1990. Degradation, recycling, and shedding of Trypanosoma brucei variant surface glycoprotein. J. Protozool. 37:546-552.
    • (1990) J. Protozool. , vol.37 , pp. 546-552
    • Seyfang, A.1    Mecke, D.2    Duszenko, M.3
  • 39
    • 0020355378 scopus 로고
    • Cloning of African trypanosomes in mice immunosuppressed by cyclophosphamide treatment
    • Smith, C. J., R. F. Levine, and J. M. Mansfield. 1982. Cloning of African trypanosomes in mice immunosuppressed by cyclophosphamide treatment. Am. J. Trop. Med. Hyg. 31:1098-1102.
    • (1982) Am. J. Trop. Med. Hyg. , vol.31 , pp. 1098-1102
    • Smith, C.J.1    Levine, R.F.2    Mansfield, J.M.3
  • 40
    • 0028895929 scopus 로고
    • Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A redefinition of the TI-2 vs T cell-dependent antigen dichotomy
    • Snapper, C. M., M. R. Kehry, B. E. Castle, and J. J. Mond. 1995. Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A redefinition of the TI-2 vs T cell-dependent antigen dichotomy. J. Immunol. 154:1177-1187.
    • (1995) J. Immunol. , vol.154 , pp. 1177-1187
    • Snapper, C.M.1    Kehry, M.R.2    Castle, B.E.3    Mond, J.J.4
  • 41
    • 0030587171 scopus 로고    scopus 로고
    • A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens
    • Snapper, C. M., and J. J. Mond. 1996. A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens. J. Immunol. 157:2229-2233.
    • (1996) J. Immunol. , vol.157 , pp. 2229-2233
    • Snapper, C.M.1    Mond, J.J.2
  • 42
    • 0028863448 scopus 로고
    • Bacterial lipoproteins may substitute for cytokines in the humoral immune response to T cell-independent type II antigens
    • Snapper, C. M., F. R. Rosas, L. Jin, C. Wortham, M. R. Kehry, and J. J. Mond. 1995. Bacterial lipoproteins may substitute for cytokines in the humoral immune response to T cell-independent type II antigens. J. Immunol. 155:5582-5589.
    • (1995) J. Immunol. , vol.155 , pp. 5582-5589
    • Snapper, C.M.1    Rosas, F.R.2    Jin, L.3    Wortham, C.4    Kehry, M.R.5    Mond, J.J.6
  • 43
    • 0025353396 scopus 로고
    • Regulation of B cell responses to the variant surface glycoprotein molecule in trypanosomiasis. II. Down-regulation of idiotype expression is associated with the appearance of lymphocytes expressing antiidiotypic receptors
    • Theodos, C. M., and J. M. Mansfield. 1990. Regulation of B cell responses to the variant surface glycoprotein molecule in trypanosomiasis. II. Down-regulation of idiotype expression is associated with the appearance of lymphocytes expressing antiidiotypic receptors. J. Immunol. 144:4022-4029.
    • (1990) J. Immunol. , vol.144 , pp. 4022-4029
    • Theodos, C.M.1    Mansfield, J.M.2
  • 44
    • 0030696101 scopus 로고    scopus 로고
    • Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway
    • Vassella, E., B. Reuner, B. Yutzy, and M. Boshart. 1997. Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway. J. Cell Sci. 110:2661-2671.
    • (1997) J. Cell Sci. , vol.110 , pp. 2661-2671
    • Vassella, E.1    Reuner, B.2    Yutzy, B.3    Boshart, M.4
  • 45
    • 0018348985 scopus 로고
    • Lymphocyte function in experimental African trypanosomiasis. II. Splenic suppressor cell activity
    • Wellhausen, S. R., and J. M. Mansfield. 1979. Lymphocyte function in experimental African trypanosomiasis. II. Splenic suppressor cell activity. J. Immunol. 122:818-824.
    • (1979) J. Immunol. , vol.122 , pp. 818-824
    • Wellhausen, S.R.1    Mansfield, J.M.2
  • 46
    • 0018873681 scopus 로고
    • Lymphocyte function in experimental African trypanosomiasis. III. Loss of lymph node cell responsiveness
    • Wellhausen, S. R., and J. M. Mansfield. 1980. Lymphocyte function in experimental African trypanosomiasis. III. Loss of lymph node cell responsiveness. J. Immunol. 124:1183-1186.
    • (1980) J. Immunol. , vol.124 , pp. 1183-1186
    • Wellhausen, S.R.1    Mansfield, J.M.2
  • 47
    • 0034281199 scopus 로고    scopus 로고
    • What is missing in immunology to understand immunity?
    • Zinkernagel, R. M. 2000. What is missing in immunology to understand immunity? Nat. Immunol. 1:181-185.
    • (2000) Nat. Immunol. , vol.1 , pp. 181-185
    • Zinkernagel, R.M.1


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