Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor

Journal of Structural Biology

Volumn 152, Issue 1, 2005, Pages 64-75

  Schormann, Norbert ^a   Pal, Biswajit ^a   Senkovich, Olga ^a   Carson, Mike ^a   Howard, Andrew ^b   Smith, Craig ^a   DeLucas, Lawrence ^a   Chattopadhyay, Debasish ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Chagas' disease; Dihydrofolate; Methotrexate; Pteridine salvage; PTR1; PTR2

Indexed keywords

DIHYDROBIOPTERIN; DIHYDROFOLIC ACID; ENZYME INHIBITOR; LIGAND; METHOTREXATE; OXIDOREDUCTASE; PTERIDINE; PTERIDINE REDUCTASE 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME SUBSTRATE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FOLIC ACID; ISOENZYMES; MACROMOLECULAR SUBSTANCES; METHOTREXATE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NADP; OXIDOREDUCTASES; PROTEIN STRUCTURE, QUATERNARY; PROTOZOAN PROTEINS; SEQUENCE ALIGNMENT; TRYPANOSOMA CRUZI;

LEISHMANIA MAJOR; MAMMALIA; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

EID: 25644437208     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsb.2005.07.008     Document Type: Article

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