A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi

Molecular and Biochemical Parasitology

Volumn 90, Issue 2, 1997, Pages 525-535

  Robello, Carlos ^a   Navarro, Pilar ^a   Castanys, Santiago ^a   Gamarro, Francisco ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

DNA transfection; Drug resistance; Pteridine reductase; Stage specific expression; Trypanosoma cruzi

Indexed keywords

AMINOPTERIN; ENZYME ANTIBODY; FOLIC ACID ANTAGONIST; GLYCOPROTEIN P; METHOTREXATE; OXIDOREDUCTASE; POLYCLONAL ANTIBODY; PYRIMETHAMINE; RECOMBINANT ENZYME; TRIMETHOPRIM;

AMASTIGOTE; AMINO ACID SEQUENCE; ARTICLE; CHROMOSOME; CONTROLLED STUDY; DNA TRANSFECTION; DRUG RESISTANCE; ENZYME PURIFICATION; EPIMASTIGOTE; EXPRESSION VECTOR; GENE ISOLATION; GENETIC ANALYSIS; GENETIC TRANSFECTION; IMMUNOBLOTTING; LEISHMANIA MAJOR; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BLOTTING, WESTERN; CHROMOSOME MAPPING; DRUG RESISTANCE; DRUG RESISTANCE, MULTIPLE; FOLIC ACID ANTAGONISTS; GENE EXPRESSION; GENES, MDR; GENES, PROTOZOAN; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; TRANSFECTION; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

LEISHMANIA MAJOR; LEISHMANIA TARENTOLAE; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0031574462     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(97)00207-7     Document Type: Article

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