Pathogenesis of RA: More than just immune cells;Das immunsystem ist nicht alles

Zeitschrift fur Rheumatologie

Volumn 64, Issue 6, 2005, Pages 396-401

  Muller Ladner U ^a   Pap, T ^b  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Apoptosis; Fibroblasts; Joint destruction; Matrix metalloproteinases; Rheumatoid arthritis; SCID mouse model

Indexed keywords

TRANSCRIPTION FACTOR;

CHRONIC INFLAMMATION; FIBROBLAST; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; INFLAMMATORY CELL; MOLECULAR MECHANICS; OSTEOARTHRITIS; PROTEIN EXPRESSION; PROTO ONCOGENE; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ANIMALS; ARTHRITIS, RHEUMATOID; AUTOIMMUNITY; FIBROBLASTS; HUMANS; SYNOVIAL MEMBRANE; T-LYMPHOCYTES;

EID: 25444432598     PISSN: 03401855     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00393-005-0772-y     Document Type: Review

References (47)

1. Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G (1991) Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. Embo J 10:4025-4031
2. Taylor GA, Carballo E, Lee DM, Lai WS, Thompson MJ, Patel DD, Schenkman DI, Gilkeson GS, Broxmeyer HE, Haynes BF, Blackshear PJ (1996) A pathogenetic role for TNF α in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 4:445-454
3. Dayer JM, Beutler B, Cerami A (1985) Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. J Exp Med 162:2163-2168
4. Brinckerhoff CE, Auble DT (1990) Regulation of collagenase gene expression in synovial fibroblasts. Ann NY Acad Sci 580:355-374
5. van-den BW, van-de LF, Otterness I, Arntz O, Joosten LA (1991) In vivo evidence for a key role of IL-1 in cartilage destruction in experimental arthritis. Agents Actions 32(Suppl)159-163
6. Kurowska M, Rudnicka W, Kontny E, Janicka I, Chorazy M, Kowalczewski J, Ziolkowska M, Ferrari-Lacraz S, Strom TB, Maslinski W (2002) Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. J Immunol 169:1760-1767
7. Bessis N, Boissier MC (2001) Novel pro-inflammatory interleukins: potential therapeutic targets in rheumatoid arthritis. Joint Bone Spine 68:477-481
8. Lubberts E, Koenders MI, van den Berg WB (2005) The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 7:29-37
9. Mulherin D, Fitzgerald O, Bresnihan B (1996) Clinical improvement and radiological deterioration in rheumatoid arthritis: evidence that the pathogenesis of synovial inflammation and articular erosion may differ. Br J Rheumatol 35:1263-1268
10. Cunnane G, Fitzgerald O, Hummel KM, Gay RE, Gay S, Bresnihan B (1999) Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. Rheumatology 38:34-42
11. Buckley CD, Pilling D, Lord JM, Akbar AN, Scheel-Toellner D, Salmon M (2001) Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol 22:199-204
12. Pap T, Müller-Ladner U, Gay RE, Gay S (2000) Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2:361-367
13. Fassbender HG (1983) Histomorphological basis of articular cartilage destruction in rheumatoid arthritis. Coll Relat Res 3:141-155
14. Müller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, Gay S (1996) Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 149:1607-1615
15. Trabandt A, Gay RE, Gay S (1992) Oncogene activation in rheumatoid synovium. APMIS 100:861-875
16. Müller-Ladner U, Gay RE, Gay S (2000) Activation of synoviocytes. Curr Opin Rheumatol 12:186-194
17. Müller-Ladner U, Kriegsmann J, Gay RE, Gay S (1995) Oncoges in rheumatoid synovium. Rheum Dis Clin North Am 21:675-690
18. Morel JC, Park CC, Zhu K, Kumar P, Ruth JH, Koch AE (2002) Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression. J Biol Chem 277:34679-34691
19. Pap T, Nawrath M, Heinrich J, Bosse M, Baier A, Hummel KM, Petrow P, Kuchen S, Michel BA, Gay RE, Müller-Ladner U, Moelling K, Gay S (2004) Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis. Arthritis Rheum 50:2794-2802
20. Yamamoto A, Fukuda A, Seto H, Miyazaki T, Kadono Y, Sawada Y, Nakamura I, Katagiri H, Asano T, Tanaka Y, Oda H, Nakamura K, Tanaka S (2003) Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts. Arthritis Rheum 48:2682-2692
21. Vojtek AB, Der CJ (1998) Increasing complexity of the Ras signaling pathway. J Biol Chem 273:19925-19928
22. Pap T, Aupperle KR, Gay S, Firestein GS, Gay RE (2001) Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion. Arthritis Rheum 44:676-681
23. Pap T, Franz JK, Hummel KM, Jeisy E, Gay R, Gay S (2000) Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction. Arthritis Research 2:59-64
24. Marok R, Winyard PG, Coumbe A, Kus ML, Gaffney K, Blades S, Mapp PI, Morris CJ, Blake DR, Kaltschmidt C, Baeuerle PA (1996) Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum 39:583-591
25. Miagkov AV, Kovalenko DV, Brown CE, Didsbury JR, Cogswell JP, Stimpson SA, Baldwin AS, Makarov SS (1998) NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc Natl Acad Sci USA 95:13859-13864
26. Karin M, Lin A (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3:221-227
27. Makarov SS (2001) NF-kappaB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res 3:200-206
28. Vincenti MP, Coon CI, Brinckerhoff CE (1998) Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1β-stimulated synovial fibroblasts. Arthritis Rheum 41:1987-1994
29. Baier A, Meineckel I, Gay S, Pap T (2003) Apoptosis in rheumatoid arthritis. Curr Opin Rheumatol 15:274-279
30. Zhang HG, Wang Y, Xie JF, Liang X, Liu D, Yang P, Hsu HC, Ray RB, Mountz JD (2001) Regulation of tumor necrosis factor α-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Arthritis Rheum 44:1555-1567
31. Franz JK, Pap T, Hummel KM, Nawrath M, Aicher WK, Shigeyama Y, Müller-Ladner U, Gay RE, Gay S (2000) Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis. Arthritis Rheum 43:599-607
32. Catrina AI, Ulfgren AK, Lindblad S, Grondal L, Klareskog L (2002) Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium. Ann Rheum Dis 61:934-936
33. Schedel J, Gay RE, Kuenzler P, Seemayer C, Simmen B, Michel BA, Gay S (2002) FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis. Arthritis Rheum 46:1512-1518
34. Perlman H, Georganas C, Pagliari LJ, Koch AE, Haines K III, Pope RM (2000) Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability. J Immunol 164:5227-5235
35. el Gabalawy H, Wilkins J (1993) Beta 1 (CD29) integrin expression in rheumatoid synovial membranes: an immunohistologic study of distribution patterns. J Rheumatol 20:231-237
36. Müller-Ladner U, Elices MJ, Kriegsmann J, Strahl D, Gay RE, Firestein GS, Gay S (1997) Alternatively spliced CS-1 fibronectin isoform and its receptor VLA-4 in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry. J Rheumatol 24:1873-1880
37. Pirila L, Aho H, Roivainen A, Konttinen YT, Pelliniemi LJ, Heino J (2001) Identification of α6β1 integrin positive cells in synovial lining layer as type B synoviocytes. J Rheumatol 28:478-484
38. Rinaldi N, Schwarz EM, Weis D, Leppelmann JP, Lukoschek M, Keilholz U, Barth TF (1997) Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins. Ann Rheum Dis 56:45-51
39. Sarkissian M, Lafyatis R (1999) Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts. J Immunol 162:1772-1779
40. Ravanti L, Heino J, Lopez-Otin C, Kahari VM (1999) Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase. J Biol Chem 274:2446-2455
41. Wang AZ, Wang JC, Fisher GW, Diamond HS (1997) Interleukin-1β- stimulated invasion of articular cartilage by rheumatoid synovial fibroblasts is inhibited by antibodies to specific integrin receptors and by collagenase inhibitors. Arthritis Rheum 40:1298-1307
42. Pap T, Schett G, Gay S (2002) Matrix metalloproteinases
43. Müller-Ladner U, Gay RE, Gay S (1996) Cysteine proteinases in arthritis and inflammation. Perspectives in Drug Discovery and Design 6:87-98
44. Rutkauskaite E, Zacharias W, Schedel J, Müller-Ladner U, Mawrin C, Seemayer CA, Alexander D, Gay RE, Aicher WK, Michel BA, Gay S, Pap T (2004) Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 50:1448-1456
45. Rutkauskaite E, Volmer D, Shigeyama Y, Schedel J, Pap G, Müller Ladner U, Meinecke I, Alexander D, Gay RE, Drynda S, Neumann W, Michel BA, Aicher W, Gay S, Pap T (2005) Retroviral gene transfer of an antisense construct against membrane-type matrix metalloproteinase 1 (MT1-MMP) reduces the invasiveness of rheumatoid arthritis synovial fibroblasts. Arthritis Rheum (in press)
46. van der Laan WH, Quax PH, Seemayer CA, Huisman LG, Pieterman E, Grimbergen JM, Verheijen JH, Breedveld FC, Gay RE, Gay S, Huizinga TW, Pap T (2003) Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3. Gene Ther 10:234-242
47. Drynda A, Quax PH, Neumann M, van der Laan WH, Pap G, Drynda S, Meinecke I, Kekow J, Neumann W, Huizinga TW, Naumann M, Konig W, Pap T (2005) Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNFα on fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. J Immunol 174:6524-6531