Effectiveness of anti-folate receptor β antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages

Arthritis and Rheumatism

Volumn 52, Issue 9, 2005, Pages 2666-2675

  Nagayoshi, Ryusaku ^a   Nagai, Taku ^a   Matsushita, Kakushi ^a   Sato, Katsuaki ^a   Sunahara, Nobuhiko ^b   Matsuda, Takemasa ^b   Nakamura, Tadashi ^c   Komiya, Setsuro ^a   Onda, Masanori ^d   Matsuyama, Takami ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b Kagoshima Red Cross Hospital   (Japan)

^c Kumamoto Orthopaedic Hospital   (Japan)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANTIGEN; CD163 ANTIGEN; FOLATE RECEPTOR; FOLATE RECEPTOR BETA ANTIBODY; IMMUNOTOXIN; MONOCLONAL ANTIBODY; PROPIDIUM IODIDE; PSEUDOMONAS EXOTOXIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CROSS LINKING; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVITIS; SYNOVIUM;

ADP RIBOSE TRANSFERASES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; APOPTOSIS; ARTHRITIS, RHEUMATOID; BACTERIAL TOXINS; CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EXOTOXINS; HUMANS; IMMUNOTOXINS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED BALB C; RECEPTORS, CELL SURFACE; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA; VIRULENCE FACTORS;

EID: 25444432235     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21228     Document Type: Article

References (39)

1. Mulherin D, FitzGerald O, Bresnihan B. Synovial tissue macrophage population and articular damage in rheumatoid arthritis. Arthritis Rheum 1996;39:115-24.
2. Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR. Macrophages in rheumatoid arthritis. Arthritis Res 2000;2:189-202.
3. Liu H, Pope RM. Phagocytes: mechanisms of inflammation and tissue destruction. Rheum Dis Clin North Am 2004;30:19-39.
4. Richards PJ, Williams AS, Goodfellow RM, Williams BD. Liposomal clodronate eliminates synovial macrophages, reduces inflammation and ameliorates joint destruction in antigen-induced arthritis. Rheumatology (Oxford) 1999;38:818-25.
5. Barrera P, Blom A, van Lent PL, van Bloois L, Beijnen JH, van Rooijen N, et al. Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis. Arthritis Rheum 2000;43:1951-9.
6. Bondeson J. The mechanisms of action of disease-modifying antirheumatic drugs: a review with emphasis on macrophage signal transduction and the induction of proinflammatory cytokines. Gen Pharmacol 1997;29:127-50.
7. Smith MD, Kraan MC, Slavotinek J, Au V, Weedon H, Parker A, et al. Treatment-induced remission in rheumatoid arthritis patients is characterized by a reduction in macrophage content of synovial biopsies. Rheumatology (Oxford) 2001;40:367-74.
8. Scallon BJ, Moore MA, Trinh H, Knight DM, Ghrayeb J. Chimeric anti-TNFα monoclonal cA2 binds recombinant transmembrane TNFα and activates immune effector functions. Cytokine 1995;7:251-9.
9. Feldmann M, Elliot MJ, Woody JN, Maini RN. Anti-tumor necrosis factor-α therapy of rheumatoid arthritis. Adv Immunol 1997;64:283-350.
10. Nakashima-Matsushita N, Homma T, Yu S, Matsuda T, Sunahara N, Nakamura T, et al. Selective expression of folate receptor β and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum 1999;42:1609-16.
11. Turk MJ, Breur GJ, Widmer WR, Paulos CM, Xu LC, Grote LA, et al. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis Rheum 2002;46:1947-55.
12. Nagayoshi R, Nakamura M, Ijiri K, Yoshida H, Komiya S, Matsuyama T. Ly309887, antifolate via the folate receptor suppresses murine type collagen II-induced arthritis. Clin Exp Rheumatol 2003;21:719-25.
13. Ross JF, Wang H, Behm FG, Mathew P, Wu M, Booth R, et al. Folate receptor type β is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia. Cancer 1999;85:348-57.
14. + cells. Blood 1999;93:3940-8.
15. Pan XQ, Zheng X, Shi G, Wang H, Ratnam M, Lee RJ. Strategy for the treatment of acute myelogenous leukemia based on folate receptor β-targeted liposomal doxorubicin combined with receptor induction using all-trans retinoic acid. Blood 2002;100:594-602.
16. Kreitman RJ. Chimeric fusion protein-Pseudomonas exotoxin-based. Curr Opin Investig Drugs 2001;2:1282-93.
17. Pastan I. Immunotoxins containing Pseudomonas exotoxin A: a short history. Cancer Immunol Immunother 2003;52:338-41.
18. Thepen T, van Vuuren AJ, Kiekens RC, Damen CA, Vooijs WC, van de Winkel JG. Resolution of cutaneous inflammation after local elimination of macrophages. Nat Biotechnol 2000;18:48-51.
19. Bruhl H, Cihak J, Stangassinger M, Schlondorff D, Mack M. Depletion of CCR5-expressing cells with bispecific antibodies and chemokine toxins: a new strategy in the treatment of chronic inflammatory diseases and HIV. J Immunol 2001;166:2420-6.
20. Van Roon JA, van Vuuren AJ, Wijngaarden S, Jacobs KM, Bijlsma JW, Lafeber FP, et al. Selective elimination of synovial inflammatory macrophages in rheumatoid arthritis by an Fey receptor I-directed immunotoxin. Arthritis Rheum 2003;48:1229-38.
21. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
22. Matsuyama T, Nakashima N, Matsuda T, Nakamura H, Uchida S, Abe T. Induction of multinucleated giant cells from rheumatoid arthritis (RA) synovial adherent cells by anti-DR antibody. Clin Exp Immunol 1994;98:257-63.
23. Mizushima S, Nagata S. pEF-BOS. a powerful mammalian expression vector. Nucleic Acids Res 1990;18:5322.
24. Hassan R, Viner JL, Wang QC, Margulies I, Kreitman RJ, Pastan I. Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma. J Immunother 2000;23:473-9.
25. Carroll SF, Collier R. Active site of Pseudomonas aeruginosa exotoxin A: glutamic acid 553 is photolabeled by NAD and shows functional homology with glutamic acid 148 of diphtheria toxin. J Biol Chem 1987;262:8707-11.
26. Graham FL, Prevec L. Manipulation on adenovirus vectors. In: Murray EJ, editor. Gene transfer and expression protocols: methods in molecular biology. Vol. 7. Clifton (NJ): The Humana Press; 1991. p. 109-28.
27. Mayne GC, Borowicz RA, Greeneklee KV, Finlay-Jones JJ, Williams KA, Hart PH. Centrifugation facilitates transduction of green fluorescent protein in human monocytes and macrophages by adenovirus at low multiplicity of infection. J Immunol Methods 2003;278:45-56.
28. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991;139:271-9.
29. Firestein GS, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid arthritis synovium. J Clin Invest 1995;96:1631-8.
30. Piedrahita JA, Oetama B, Bennett GD, van Waes J, Kamen BA, Richardson J, et al. Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Nat Genet 1999;23:228-32.
31. Nakamura M, Nagayoshi R, Ijiri K, Nakashima-Matsushita N, Takeuchi T, Matsuyama T. Nitration and chlorination of folic acid by peroxynitrite and hypochlorous acid, and the selective binding of 10-nitro-folate to folate receptor β. Biochem Biophys Res Commun 2002;297:1238-44.
32. Cauli A, Yanni G, Panayi GS. Interleukin-1, interleukin-1 receptor antagonist and macrophage populations in rheumatoid arthritis synovial membrane. Br J Rheumatol 1997;36:935-40.
33. Elnakat H, Ratnam M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev 2004;56:1067-84.
34. Leamon CP, Reddy JA. Folate-targeted chemotherapy. Adv Drug Deliv Rev 2004;56:1127-41.
35. Nagata S, Onda M, Numata Y, Santora K, Beers R, Kreitman RJ, et al. Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments. Clin Cancer Res 2002;8:2345-55.
36. Onda M, Wang GC, Guo HF, Cheung NK, Pastan I. In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma. Cancer Res 2004;64:1419-24.
37. Kreitman RJ, Pastan I. Targeting Pseudomonas exotoxin to hematologic malignancies. Semin Cancer Biol 1995;6:297-306.
38. Paulos CM, Turk MJ, Breur GJ, Loe PS. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev 2004;56:1205-17.
39. Ravelli A. Macrophage activation syndrome. Curr Opin Rheumatol 2002;14:548-52.