Liposomal clodronate eliminates synovial macrophages, reduces inflammation and ameliorates joint destruction in antigen-induced arthritis

Rheumatology

Volumn 38, Issue 9, 1999, Pages 818-825

  Richards, P J ^a   Williams, A S ^a   Goodfellow, R M ^a   Williams, B D ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Clodronate; Reticuloendothelial system; Small unilamellar vesicles; Synovial macrophages

Indexed keywords

CLODRONIC ACID; LIPOSOME;

ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; INTRAVENOUS DRUG ADMINISTRATION; JOINT DESTRUCTION; KNEE; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNOVIUM;

ANALGESICS, NON-NARCOTIC; ANIMALS; ARTHRITIS, EXPERIMENTAL; CLODRONIC ACID; DISEASE MODELS, ANIMAL; DRUG CARRIERS; LIPOSOMES; MACROPHAGES; MALE; RATS; RATS, INBRED LEW; RETICULOENDOTHELIAL SYSTEM; SYNOVIAL MEMBRANE;

EID: 0032732107     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/38.9.818     Document Type: Article

References (36)

1. Allison AC, Feruga J, Prydz H, Schorlemmer HU. The role of macrophage activation in chronic inflammation. Agents Actions 1978;8:27-35.
2. Firestein GS, Zvaifler NJ. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue Interferon suggest that gamma-interferon is not the primary macrophage activating factor. Arthritis Rheum 1987;30:864-71.
3. Ishikawa H, Ziff M. Electron microscopic observations of immunoreactive cells in the rheumatoid synovial membrane. Arthritis Rheum 1976;19:1-14.
4. Miossec P, Dinarello CA, Ziff M. Interleukin-1 lymphocyte chemotactic activity in rheumatoid arthritis synovial fluid. Arthritis Rheum 1986;29:461-70.
5. Nouri AM, Panayi GS, Goodman SM. Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids. Clin Exp Immunol 1984;55:295-302.
6. Guerne PA, Zuraw BL, Vaughan JH, Carson DA, Lotz M. Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest 1989;83:585-92.
7. Saxne T, Palladino MA Jr, Heinegard D, Talal N, Wollheim FA. Detection of tumour necrosis factor alpha but not tumour necrosis factor beta in rheumatoid arthritis synovial fluid and serum. Arthritis Rheum 1988;31:1041-5.
8. Tetta C, Camussi G, Modena V, Di Vittorio C, Baglioni C. Tumour necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritis. Ann Rheum Dis 1990;49:665-7.
9. Firestein GS, Xu WD, Townsend K et al. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med 1988;168:1573-86.
10. Verschure PJ, Van Noorden CJ, Dijkstra CD. Macrophages and dendritic cells during the early stages of antigen-induced arthritis in rats: immunohistochemical analysis of cryostat sections of the whole knee joint. Scand J Immunol 1989;29:371-81.
11. Dijkstra CD, Dopp EA, Vogels IM, Van Noorden CJ. Macrophages and dendritic cells in antigen-induced arthritis. An immunohistochemical study using cryostat sections of the whole knee joint of rat. Scand J Immunol 1987;26:513-23.
12. Kool J, Gerrits-Boeye MY, Severijnen AJ, Hazenberg MP. Immunohistology of joint inflammation induced in rats by cell wall fragments of Eubacterium aerofaciens. Scand J Immunol 1992;36:497-506.
13. Johnson WJ, Muirhead KA, Meunier PC et al. Macrophage activation I rat models of inflammation and arthritis. Arthritis Rheum 1986;29:1122-30.
14. Henderson B, Rowe FM, Bird CR, Gearing AJH. Production of IL-1 in the joint during the development of antigen-induced arthritis in the rabbit. Clin Exp Immunol 1988;74:371-6.
15. Smith-Oliver T, Noel LS, Stimpson S, Yarnall DP, Conolly KM. Elevated levels of TNF in the joints of adjuvant arthritic rats. Cytokine 1993;5:298-304.
16. Mussener A, Klareskog L, Lorentzen JC, Kleinau S. TNFα dominates cytokine mRNA expression in lymphoid organs of rats developing collagen- and oil-induced arthritis. Scand J Immunol 1995; 42:128-134.
17. Burmester GR, Stuhlmuller B, Rittig M. The monocyte/macrophage system in arthritis - leopard tank or Trojan horse? Scand J Rheumatol 1995;24(suppl. 101):77-82.
18. Naito M, Nagai H, Kawano S et al. Liposomeencapsulated dichloromethylene diphosphonate induces macrophage apoptosis in vivo and in vitro. J Leuk Biol 1996;60:337-44.
19. Van Rooijen N, Sanders A, van den Berg TK. Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine. J Immunol Methods 1996;193:93-9.
20. Schmidt-Weber CB, Rittig M, Buchner E et al. Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes. J Leuk Biol 1996;60:230-44.
21. Frith JC, Monkkonen J, Blackburn GM, Russell RGG, Rogers MJ. Clodronate and liposome-encapsulated clodronate are metabolised to a toxic ATP analog, adenosine 5′-(β, γ-dichloromethylene) triphosphate, by mammalian cells in vitro. J Bone Miner Res 1997;12:1358-67.
22. Selander KS, Monkkonen J, Karhukorpi E-K, Harkonen PL, Hannuniemi R, Vaananen HK. Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. Mol Pharmacol 1996;50:1127-38.
23. Kinne RW, Schmidt-Weber CB, Hoppe R et al. Longterm amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronatecontaining liposomes. Arthritis Rheum 1995;38:1777-90.
24. Love WG, Amos N, Kellaway IW, Williams BD. Specific accumulation of technetium-99m radiolabelled, negative liposomes in the inflamed paws of rats with adjuvant induced arthritis: effect of liposome size. Ann Rheum Dis 1989;48:143-8.
25. Camilleri JP, Williams AS, Amos N. Douglas-Jones AG, Williams BD. Liposomal clodronate depletes synovial macrophages, suppresses inflammation and prevents radiological progression in adjuvant arthritis. Arthritis Rheum 1995;38(suppl. 9):1319.
26. Griffiths RJ. Characterisation and pharmacological sensitivity of antigen arthritis induced by methylated bovine serum albumin in the rat. Agents Actions 1992;35:88-95.
27. Love WG, Camilleri JP, Williams BD. Efficient clodronate entrapment within multilamellar and unilamellar liposomes. J Pharmacol Toxicol Methods 1992;27:185-9.
28. Egensperger R, Kosel S, von Eitzen U, Graeber MB. Microglial activation in Alzheimer disease: association with APOE genotype. Brain Pathol 1998;8:439-47.
29. Kinne RW, Schmidt CB, Buchner E, Hoppe R, Nurnberg E, Emmrich F. Treatment of rat arthritides with clodronate-containing liposomes. Scand J Rheumatol 1995(suppl. 101);24:91-7.
30. Camilleri JP, Williams AS, Amos N, Douglas-Jones AG, Love WG, Williams BD. The effect of free and liposome-encapsulated clodronate on the hepatic mononuclear phagocyte system in the rat. Clin Exp Immunol 1995;99:269-75.
31. Roerdink F, Dijksrta J, Hartman G, Bolscher B, Scherphof G. The involvement of parenchymal, kupffer and endothelial liver cells in the hepatic uptake of intravenously injected liposomes. Effects of lanthanum and gadolinum salts. Biochim Biophys Acta 1981;667:79-89.
32. Senior J, Crawley JCW, Gregoriadis G. Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection. Biochim Biophys Acta 1985;839:1-8.
33. Williams BD, O'Sullivan MM, Saggu GS, Williams KE, Williams LA, Morgan JR. Synovial accumulation of technetium labelled liposome in rheumatoid arthritis. Ann Rheum Dis 1987;46:314-8.
34. Van de Loo FAJ, Joosten LAB, van Lent PLEM, Arntz OJ, van den Berg WB. Role of interleukin-1, tumour necrosis factor a, and interleukin-6 in cartilage proteoglycan metabolism and destruction: effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum 1995;38:164-72.
35. Joosten LA, Helsen MM, van de Loo FA, van den Berg WB. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNFα, anti-IL-1α/β, and IL-1Ra. Arthritis Rheum 1996;39:797-809.
36. Van Lent PLEM, Holthuysen AEM, van den Bersselaar LAM et al. Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis. Arthritis Rheum 1996;39:1545-55.