Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation

Wound Repair and Regeneration

Volumn 10, Issue 1, 2002, Pages 67-76

  Allen, Fred D ^a   Asnes, Clara F ^b   Chang, Philip ^c   Elson, Elliot L ^b   Lauffenburger, Douglas A ^a   Wells, Alan ^c,d  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALPAIN; CALPASTATIN; EPIDERMAL GROWTH FACTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; MOUSE; NONHUMAN; PRIORITY JOURNAL; WOUND CONTRACTION; WOUND HEALING;

ANIMALS; CALPAIN; CELL ADHESION; CELL MOVEMENT; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR MATRIX; FIBROBLASTS; FLAVONOIDS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PLATELET-DERIVED GROWTH FACTOR; WOUND HEALING;

EID: 0036251571     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2002.10701.x     Document Type: Article

References (45)

1. Epidermal growth factor
2. Epidermal growth factor receptor-mediated motility in fibroblasts
3. Chemokine transmodulation of EGF receptor signaling: IP-10 inhibits motility by decreasing EGF-induced calpain activity
4. Epidermal growth factor receptor-mediated cell motility: Phospholipase C activity is required, but MAP kinase activity is not sufficient for induced cell movement
5. Regulation of chemotaxis by the platelet-derived growth factor receptor-β
6. Insulin-like growth factor-1 and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signalling pathways that are distinct from those of proliferation
7. A role for gelsolin in actuating EGF receptor-mediated cell motility
8. Shaping up for shipping out: PLCγ signaling of morphology changes in EGF-stimulated fibroblast migration
9. EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCγ signaling pathway
10. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
11. Increased myosin light chain phosphorylation is not required for growth factor stimulation of collagen matrix contraction
12. Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway
13. Regulation of cell migration by the calcium-dependent protease calpain
14. Regulation of cell movement is mediated by stretch-activated calcium channels
15. Exertion of tractional force requires the coordinated up-regulation of cell contractility and adhesion
16. Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts
17. Cell mechanics studied by a reconstituted model tissue
18. Isometric contraction by fibroblasts and endothelial cells in tissue culture: A quantitative study
19. Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain
20. Balanced mechanical forces and microtubule contribution to fibroblast contraction
21. Quantitative analysis of collagen gel contractile forces generated by dermal fibroblasts and the relationship to cell morphology
22. Tensional homeostasis in dermal fibroblasts: Mechanical responses to mechanical loading in three-dimensional substrates
23. Regulation of cell motility by mitogen-activated protein kinase
24. Variants of 3T3 cells lacking mitogenic response to epidermal growth factor
25. Smooth muscle contractility and protein tyrosine phosphorylation
26. Effect of growth factors on dermal fibroblast contraction in normal skin and hypertrophic scar
27. Physical and biochemical regulation of integrin release during rear detachment of migrating cells
28. Kinetic model for integrin-mediated adhesion release during cell migration
29. Membrane proximal ERK signaling is required for M-calpain activation down-stream of EGF receptor signaling
30. Calpain regulates actin remodeling during cell spreading
31. Differences in the regulation of fibroblast contraction of floating versus stressed collagen matrices
32. Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. A novel role for the calpain inhibitor calpeptin in the inhibition of protein-tyrosine phosphatases
33. Characterization of a functional domain of human calpastatin
34. Fibroblast traction as a mechanism for collagen morphogenesis
35. Connective tissue morphogenesis by fibroblast traction
36. Cell locomotion forces versus cell contraction forces for collagen lattice contraction: An in vitro model of wound contraction
37. Silicone rubber substrata: A new wrinkle in the study of locomotion
38. Traction forces in locomoting cells
39. Cell locomotion and focal adhesions are regulated by substrate flexibility
40. Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in matrix-dependent manner
41. Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration
42. Estimation of cell traction and migration in an isometric cell traction assay
43. Mathematical model for the effects of adhesion and mechanics on cell migration speed
44. Cell migration: A physically integrated molecular process
45. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness