Low toxicity of cationic lipid-based emulsion for gene transfer

Biomaterials

Volumn 25, Issue 27, 2004, Pages 5893-5903

  Choi, Woo Jeong ^a   Kim, Jin Ki ^a   Choi, Sung Hee ^a   Park, Jeong Sook ^a   Ahn, Woong Shick ^b   Kim, Chong Kook ^a  

^a Seoul National University   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Cationic lipids; Emulsion; Gene delivery; Plasmid DNA; Transfection

Indexed keywords

BLOOD; DNA; EMULSIONS; FLUORESCENCE; GENE TRANSFER; LIPIDS; RNA; TOXICITY;

CATIONIC LIPOSOMES; CYTOTOXICITY; SERUM RESISTANCE; TRANSFECTION EFFICIENCY;

BIOMATERIALS;

3BETA [N (N',N' DIMETHYLAMINOETHANE)CARBAMOYL]CHOLESTEROL; CATION; GREEN FLUORESCENT PROTEIN; LIPOSOME; MESSENGER RNA; PLASMID DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DNA TRANSFECTION; DNA TRANSFER; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG STABILITY; EMULSION; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BIOCOMPATIBLE MATERIALS; CATIONS; CELL LINE; CELL SURVIVAL; CHO CELLS; CHOLESTEROL; CRICETINAE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; EMULSIONS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LIPIDS; MICE; MICROSCOPY, CONFOCAL; PHOSPHATIDYLETHANOLAMINES; PLASMIDS; POLYMERASE CHAIN REACTION; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; TRANSFECTION;

CASTOR;

EID: 2542431057     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2004.01.031     Document Type: Article

References (34)

1. Kim C.K., Haider K.H., Lim S.J. Gene medicine. a new field of molecular medicine Arch Pharm Res. 24:2001;1-15
2. Kim C.K., Choi E.J., Choi S.H., Park J.S., Haider K.H., Ahn W.S. Enhanced p53 gene transfer to human ovarian cancer cells using the cationic nonviral vector, DDC. Gynecol Oncol. 90:2003;265-272
3. Zhang Y.M., Rusckowski M., Liu N., Liu C., Hnatowich D.J. Cationic liposomes enhance cellular/nuclear localization of 99mTc-antisense oligonucleotides in target tumor cells. Cancer Biother Radiopharm. 16:2001;411-419
4. Thierry A.R., Lunardi-Iskandar Y., Bryant J.L., Rabinovich P., Gallo R.C., Mahan L.C. Systemic gene therapy. biodistribution and long-term expression of a transgene in mice Proc Nat Acad Sci USA. 92:1995;9742-9746
5. Kabanov A.V. Taking polycation gene delivery systems from in vitro to in vivo. Pharm Sci Technol Today. 2:1999;365-372
6. Reimer D.L., Kong S., Monck M., Wyles J., Tam P., Wasan E.K., Bally M.B. Liposomal lipid and plasmid DNA delivery to B16/BL6 tumors after intraperitoneal administration of cationic liposome DNA aggregates. J Pharmacol Exp Ther. 289:1999;807-815
7. Tousignant J.D., Gates A.K., Ingram L.A., Johnson C.L., Nietupski J.B., Cheng S.H., Eastman S.J., Scheule R.K. Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid. plasmid DNA complexes in mice Hum Gene Ther. 11:2000;2493-2513
8. Loisel S., Le Gall C., Doucet L., Ferec C., Floch V. Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes. Hum Gene Ther. 12:2001;685-696
9. Song Y.K., Liu F., Chu S., Liu D. Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration. Hum Gene Ther. 8:1997;1585-1594
10. Li S., Wu S.P., Whitmore M., Loeffert E.J., Wang L., Watkins S.C., Pitt B.R., Huang L. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors. Am J Physiol. 276:1999;L796-L804
11. Dokka S., Toledo D., Shi X., Castranova V., Rojanasakul Y. Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes. Pharm Res. 17:2000;521-525
12. Liu F., Yang J., Huang L., Liu D. Effect of non-ionic surfactants on the formation of DNA/emulsion complexes and emulsion-mediated gene transfer. Pharm Res. 13:1996;1642-1646
13. Hara T., Liu F., Liu D., Huang L. Emulsion formulations as a vector for gene delivery in vitro and vivo. Adv Drug Deliv Rev. 24:1997;265-271
14. Gao Z.G., Choi H.G., Shin H.J., Park K.M., Lim S.J., Hwang K.J., Kim C.K. Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A. Int J Pharm. 161:1998;75-86
15. Park K.M., Kim C.K. Preparation and evaluation of flurbiprofen-loaded microemulsion for parenteral delivery. Int J Pharm. 181:1999;173-179
16. Yi S.W., Yune T.Y., Kim T.W., Chung H., Choi Y.W., Kwon I.C., Lee E.B., Jeong S.Y. A cationic lipid emulsion/DNA complex as a physically stable and serum-resistant gene delivery system. Pharm Res. 17:2000;314-320
17. Serikawa T., Suzuki N., Kikuchi H., Tanaka K., Kitagawa T. A new cationic liposome for efficient gene delivery with serum into cultured human cells. a quantitative analysis using two independent fluorescent probes Biochim Biophys Acta. 1467:2000;419-430
18. Kim Y.J., Kim T.W., Chung H., Kwon I.C., Sung H.C., Jeong S.Y. The effects of serum on the stability and the transfection activity of the cationic lipid emulsion with various oils. Int J Pharm. 252:2003;241-252
19. Kim J.K., Choi S.H., Kim C.O., Park J.S., Ahn W.S., Kim C.K. Enhancement of polyethylene glycol (PEG)-modified cationic liposome-mediated gene deliveries. effects on serum stability and transfection efficiency J Pharm Pharmacol. 55:2003;453-460
20. Schreier H., Gagne L., Bock T., Erdos G.W., Druzgala P., Conary J.T., Muller B.W. Physicochemical properties and in vitro toxicity of cationic liposome cDNA complexes. Pharm Acta Helv. 72:1997;215-223
21. Delong R., Stephenson K., Loftus T., Fisher M., Alahari S., Nolting A., Juliano R.L. Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery. J Pharm Sci. 86:1997;762-764
22. Kim T.W., Chung H., Kwon I.C., Sung H.C., Jeong S.Y. Optimization of lipid composition in cationic emulsion as in vitro and in vivo transfection agents. Pharm Res. 18:2001;54-60
23. Opawale F.O., Burgess D.J. Influence of interfacial properties of lipophilic surfactants on water-in-oil eEmulsion stability. J Colloid Interface Sci. 197:1998;142-150
24. Liu F., Yang J., Huang L., Liu D. New cationic lipid formulations for gene transfer. Pharm Res. 13:1996;1856-1860
25. Templeton N.S., Lasic D.D., Frederik P.M., Strey H.H., Roberts D.D., Pavlakis G.N. Improved DNA. liposome complexes for increased systemic delivery and gene expression Nat Biotechnol. 15:1997;647-652
26. Sakurai F., Nishioka T., Saito H., Baba T., Okuda A., Matsumoto O., Taga T., Yamashita F., Takakura Y., Hashida M. Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice. the role of the neutral helper lipid Gene Ther. 8:2001;677-686
27. Hofland H.E., Shephard L., Sullivan S.M. Formation of stable cationic lipid, DNA complexes for gene transfer. Proc Nat Acad Sci USA. 93:1996;7305-7309
28. Escriou V., Ciolina C., Lacroix F., Byk G., Scherman D., Wils P. Cationic lipid-mediated gene transfer. effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes Biochim Biophys Acta. 1368:1998;276-288
29. Powell E.E., Kroon P.A. Measurement of mRNA by quantitative PCR with a nonradioactive label. J Lipid Res. 33:1992;609-614
30. Kim C.K., Lim S.J. Liposome immunoassay (LIA) with antigen-coupled liposomes containing alkaline phosphatase. J Immunol Methods. 159:1993;101-106
31. Liu S., Ishida T., Kiwada H. Effect of serum components from different species on destabilizing hydrogenated phosphatidylcholine-based liposome. Biol Pharm Bull. 20:1997;874-880
32. Liu S., Ishida T., Kiwada H. Characterization of bovine serum factor triggering the lysis of liposome via complement activation. Biol Pharm Bull. 21:1998;390-397
33. Gao H., Hui K.M. Synthesis of a novel series of cationic lipids that can act as efficient gene delivery vehicles through systematic heterocyclic substitution of cholesterol derivatives. Gene Ther. 8:2001;855-863
34. Mohr L., Yoon S.K., Eastman S.J., Chu Q., Scheule R.K., Scaglioni P.P., Geissler M., Heintges T., Blum H.E., Wands J.R. Cationic liposome-mediated gene delivery to the liver and to hepatocellular carcinomas in mice. Hum Gene Ther. 12:2001;799-809