A cationic lipid emulsion/DNA complex as a physically stable and serum- resistant gene delivery system

Pharmaceutical Research

Volumn 17, Issue 3, 2000, Pages 314-320

  Yi, Sun Woo ^a,b   Yune, Tae Young ^a   Kim, Tae Woo ^a   Chung, Hesson ^a   Choi, Young Wook ^b   Kwon, Ick Chan ^a   Lee, Eunhee Bae ^a   Jeong, Seo Young ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

Cationic lipids; Gene transfer; Lipid emulsions; Poly(ethylene glycol); Transfection

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; DEOXYRIBONUCLEASE I; DNA; EMULSIFYING AGENT; LIPID EMULSION; OIL; POLYASPARTIC ACID; SOYBEAN OIL;

ANIMAL CELL; ARTICLE; CERCOPITHECIDAE; COMPLEX FORMATION; CONTROLLED STUDY; EMULSION; GENE; GENE TARGETING; GENE TRANSFER; MONKEY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; CATIONS; CHOLINE O-ACETYLTRANSFERASE; COS CELLS; DEOXYRIBONUCLEASES; ELECTROPHORESIS; EMULSIONS; GENE TRANSFER TECHNIQUES; GLYCEROL; PEPTIDES; PLASMIDS; POLYETHYLENE GLYCOLS; SOYBEAN OIL; TRANSFECTION; WATER;

EID: 0033998938     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007553106681     Document Type: Article

References (24)

1. 1. X. Gao and L. Huang. A novel cationic liposome reagent for efficient transfection of mammalian cell. Biochem. Biophys. Res. Commun. 179:280-285 (1991).
2. 2. J. H. Felgner, R. Kumar, C. N. Sridhar, C. J. Wheeler, Y. J. Tsai, R. Border, P. Ramsey, M. Martin, and P. L Felgner. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem. 269:2550-2561 (1994).
3. 3. Y. K. Song, F. Liu, S. Chu, and D. Liu. Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration. Hum. Gene Ther. 8:1585-1594 (1997).
4. 4. A. R. Thierry, P. Rabinovich, B. Peng, L. C. Mahan, J. L. Bryant, and R. C. Gallo. Characterization of liposome-mediated gene delivery: expression, stability and pharmacokinetics of plasmid DNA. Gene Ther. 4:226-237 (1997).
5. 5. P. L. Felgner, T. R. Gadek, M. Holm, R. Roman, H. W. Chan, M. Wenz, J. P. Northrop, G. M. Ringold, and M. Danielsen. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA 84:7413-7417 (1987).
6. 6. P. L. Felgner and G. M. Ringold. Cationic liposome-mediated transfection. Nature 337:387-388 (1989).
7. 7. B. Sternberg, F. L. Sorgi, and L. Huang. New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy. FEBS Lett. 356:361-366 (1994).
8. 8. J. Zabner. Cationic lipids used in gene transfer. Adv. Drug Del. Rev. 27:17-28 (1997).
9. 9. K. Hong, W. Zheng, A. Baker, and D. Papahadjopoulos. Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery. FEBS Lett. 400:233-237 (1997).
10. 10. E. Dodds, M. G. Dunckley, K. Naujoks, U. Michaelis, and G. Dickson. Lipofection of cultured mouse muscle cells: a direct comparison of Lipofectamine and DOSPER. Gene Ther. 5:542-551 (1998).
11. 11. V. Escriou, C. Ciolina, F. Lacroix, G. Byk, D. Scherman, and P. Wils. Cationic lipid-mediated gene transfer: effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes. Biochim. Biophys. Acta 1368:276-288 (1998).
12. 12. H. E. Hofland, L. Shephard, and S. M. Sullivan. Formation of stable cationic lipid/DNA complexes for gene transfer. Proc. Natl. Acad. Sci. USA 93:7305-7309 (1996).
13. 13. O. Zelphati, C. Nguyen, M. Ferrari, J. Felgner, Y. Tsai, and P. L. Felgner. Stable and monodisperse lipoplex formulations for gene delivery. Gene Ther. 5:1272-1282 (1998).
14. 14. S. Benita and M. Y. Levy. Submicron emulsions as colloidal drug carders for intravenous administration: comprehensive physicochemical characterization. J. Pharm. Sci. 82:1069-1079 (1993).
15. 15. Y. Mizushima. Lipid microspheres as novel drug carriers. Drugs Exp. Clin. Res. 11:595-600 (1985).
16. 16. M. Singh and L. J. Ravin. Parenteral emulsions as drug carrier systems. J. Parenter. Sci. Technol. 40:34-41 (1986).
17. 17. F. Liu, J. Yang, L. Huang, and D. Liu. New cationic lipid formulations for gene transfer. Pharm. Res. 13:1856-1860 (1996).
18. 18. G. Hulman. The pathogenesis of fat embolism. J. Pathol. 176:3-9 (1995).
19. 19. D. M. Lidgate, T. Trattner, R. M. Shultz, and R. Maskiewicz. Sterile filtration of a parenteral emulsion. Pharm. Res. 9:860-863 (1992).
20. 20. J. J. Wheeler, K. F. Wong, S. M. Ansell, D. Masin, and M. B. Bally. Polyethylene glycol modified phospholipids stabilize emulsions prepared from triacylglycerol. J. Pharm. Sci. 83:1558-1564 (1994).
21. 21. D. Clausse. Research techniques utilizing emulsions. In P. Becher (ed), Encyclopedia of emulsion technology. Vol. 2 Basic theory, Marcel Dekker. Inc., New York and Basel, 1983, pp. 77-157.
22. 22. A. De Maio and T. G. Buchman. Mammalian liver contains an activity which mimics bacterial chloramphenicol acetyltransferase. Biochim. Biophys. Acta 1087:303-308 (1990).
23. 23. M. M. Bradford. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254 (1976).
24. 24. Y. Xu and F. C. Szoka. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 35:5616-5623 (1996).