Aberrant iron accumulation and oxidized status of erythroid-specific δ-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts

Blood

Volumn 101, Issue 3, 2003, Pages 1188-1193

  Harigae, Hideo ^a,b   Nakajima, Osamu ^a,b   Suwabe, Naruyoshi ^a,b   Yokoyama, Hisayuki ^a,b   Furuyama, Kazumichi ^a,b   Sasaki, Takeshi ^a,b   Kaku, Mitsuo ^a,b   Yamamoto, Masayuki ^a,b   Sassa, Shigeru ^a,b  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; IRON;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; ELECTRON MICROSCOPY; ERYTHROBLAST; ERYTHROID CELL; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC CODE; IN VIVO STUDY; IRON METABOLISM; IRON STORAGE; MOUSE; NONHUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0037307754     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-01-0309     Document Type: Article

References (31)

1. Ponka P. Tissue-specific regulation of iron metabolism and heme synthesis: distinct control in erythroid cells. Blood. 1997;89:1-25.
2. Chen JJ, London IM. Regulation of protein synthesis by heme-regulated elF-2 α kinase [review]. Trends Biochem Sci. 1995;20:105-108.
3. Muta K, Krantz SB. Inhibition of heme synthesis induces apoptosis in human erythroid progenitor cells. J Cell Physiol. 1995;163:38-50.
4. Cox TC, Bawden MJ, Abraham NG, et al. Erythroid 5-aminolevulinate synthase is located in the X chromosome. Am J Hum Genet. 1990;46:107-111.
5. Bottomley SS, May BK, Cox TC, Cotter PD, Bishop DF. Molecular defects of erythroid 5-aminolevulinate synthase in X-linked sideroblastic anemia. J Bioenerg Biomembr. 1995;27:161-168.
6. Harigae H, Furuyama K, Kudo K, et al. A novel mutation of the erythroid-specific δ-aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemia. Am J Hematol. 1999;62:112-114.
7. Harigae H, Furuyama K, Kimura A, et al. A novel mutation of the erythroid-specific δ-aminolevulinate synthase gene in a patient with X-linked sideroblastic anemia. Br J Haematol. 1999;106:175-177.
8. Riddle RD, Yamamoto M, Engel JD. Expression of δ-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes. Proc Natl Acad Sci U S A. 1989;86:792-796.
9. Kappas A, Sassa S, Galbraith RA, Nordmann Y. The porphyria. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Basis of Inherited Disease. Vol 7. New York, NY: McGraw-Hill; 1995:2103-2159.
10. Nakajima O, Takahashi S, Harigae H, et al. Heme deficiency in the erythroid lineage causes differentiation arrest and cytoplasmic iron overload. EMBO J. 1999;18:6282-6289.
11. Nakano T, Kodama H, Honjo T. In vitro development of primitive and definitive erythrocytes from different precursors. Science. 1996;272:722-724.
12. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorophorm extraction. Anal Biochem. 1987;162:156-159.
13. Ikuta K, Kina T, MacNeil I, et al. A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell. 1990;62:863-874.
14. Sassa S. Sequential induction of hemepathway enzymes during erythroid differentiation of mouse Friend leukemia virus-infected cells. J Exp Med. 1976;143:305-315.
15. Chan JY, Kwong M, Lo M, Emerson R, Kuypers FA. Reduced oxidative-stress response in red blood cells from p45NFE2-deficient mice. Blood. 2001;97:2151-2158.
16. Nagai T, Harigae H, Ishihara H, et al. Transcription factor GATA-2 is expressed in erythroid, early myeloid, and CD34+ human leukemia-derived cell lines. Blood. 1994;84:1074-1084.
17. Miwa Y, Atsumi T, Imai N, Ikawa Y. Primitive erythropoiesis of mouse teratocarcinoma stem cells PCC3/A/1 in serum-free medium. Development. 1991;111:543-549.
18. Hangae H, Suwabe N, Weinstock PH, et al. Deficient heme and globin synthesis in embryonic stem cells lacking the erythroid-specific δ-aminolevulinate synthase gene. Blood. 1998;91:798-805.
19. Mitani K, Fujita H, Sassa S, Kappas A. Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells. Biochem Biophys Res Commun. 1990;166:1429-1434.
20. Linpisarn S, Satoh K, Mikami T, Orimo H, Shinjo S, Yoshino Y. Effects of iron on lipid peroxidation. Int J Hematol. 1991;54:181-188.
21. Fleming MD, Campagna DR, Haslett JN, Trenor CC III, Andrews NC. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev. 2001;15:652-657.
22. Amenomori T, Tomonaga M, Jinnai I, et al. Cytogenetic and cytochemical studies on progenitor cells of primary acquired sideroblastic anemia (PASA): involvement of multipotent myeloid stem cells in PASA clone and mosaicism with normal clone. Blood. 1987;70:1367-1372.
23. Takaku F, Mizoguchi H, Suda T, Kubota K, Miura Y. Erythroid precursor cells in primary acquired and secondary sideroblastic anemia. Exp Hematol. 1980;8:225-234.
24. Fujita H, Yamamoto M, Yamagami T, Hayashi N, Sassa S. Erythroleukemia differentiation. Distinctive responses of the erythroid-specific and the nonspecific δ-aminolevulinate synthase mRNA. J Biol Chem. 1991;266:17494-17502.
25. Sassa S, Granick S. Induction of δ-aminolevulinic acid synthase in chick embryo liver cells in culture. Proc Natl Acad Sci U S A. 1970;67:517-522.
26. Granick S, Sinclair P, Sassa S, Grieninger G. Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition. J Biol Chem. 1975;250:9215-9225.
27. Tyrrell DL, Marks GS. Drug-induced porphyrin biosynthesis. Effect of protohemin on the transcriptional and post-transcriptional phases of δ-aminolevulinic acid synthase induction. Biochem Pharmacol. 1972;21:2077-2093.
28. Andrews NC. Disorders of iron metabolism. N Engl J Med. 1999;341:1986-1995.
29. Gutteridge JM, Halliwell B, Treffry A, Harrison PM, Blake D. Effect of ferritin-containing fractions with different iron loading on lipid peroxidation. Biochem J. 1983;209:557-560.
30. O'Connell MJ, Ward RJ, Baum H, Peters TJ. The role of iron in ferritin- and haemosiderin-mediated lipid peroxidation in liposomes. Biochem J. 1985;229:135-139.
31. Shalev O, Repka T, Goldfarb A, et al. Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassemic and sickle red blood cells both in vitro and in vivo. Blood. 1995;86:2008-2013.