Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure

Endocrinology

Volumn 140, Issue 6, 1999, Pages 2592-2601

  Mann, Rachel J ^a   Keri, Ruth A ^a   Nilson, John H ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; ESTRADIOL; LUTEINIZING HORMONE; PROGESTERONE;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ANOVULATION; ARTICLE; CONTROLLED STUDY; DECIDUALIZATION; EMBRYO; EMBRYO RESORPTION; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; HORMONE SUBSTITUTION; MOUSE; NONHUMAN; OOCYTE MATURATION; OVARIECTOMY; OVARY POLYCYSTIC DISEASE; PREGNANCY DISORDER; PRIORITY JOURNAL; SUPEROVULATION; TRANSGENIC MOUSE;

EID: 0033279007     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.6.6927     Document Type: Article

References (42)

1. Hypersecretion of luteinizing hormone: A significant cause of infertility and miscarriage
2. The prognostic value of basal luteinizing hormone: Follicle stimulating hormone ratio in the treatment of patients with polycystic ovarian syndrome by assisted reproduction techniques
3. Luteinizing hormone: Its role, mechanism of action, and detrimental effects when hypersecreted during the follicular phase
4. Hypersecretion of luteinising hormone, infertility and miscarriage
5. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism
6. Epidemiology of infertility and polycystic ovarian disease: Endocrinological and demographic studies
7. Polycystic ovary syndrome: A changing perspective
8. Insulin resistance and polycystic ovarian syndrome
9. On the paradox of insulin-induced hyperandrogenism in insulin-resistant states
10. Heterogeneity of the polycystic ovary syndrome: Clinical, endocrine and ultrasound features in 556 patients
11. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion
12. Common problems in induction of ovulation
13. Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors
14. Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology
15. Chronically elevated luteinizing hormone depletes primordial follicles in the mouse ovary
16. Ovarian follicle atresia: A hormonally controlled apoptotic process
17. On the action of intraovarian injection of androgen on follicle and corpus luteum maturation in women
18. The endocrinology of conception
19. The mammalian ovum
20. Increase in androgen: Estrogen ratio specifically during low-dose follicle-stimulating hormone therapy for polycystic ovary syndrome
21. cdc2 kinase
22. The Mouse (Its Reproduction and Development)
23. 125I
24. Relationship between the developmental programs controlling nuclear and cytoplasmic maturation of mouse oocytes
25. Requirement for progesterone priming and its long-term effects on implantation in the mouse
26. Minimal progesterone support required for the maintenance of pregnancy in mice
27. Blastocyst's state of activity determines the "window" of implantation in the receptive mouse uterus
28. Immunolocalization of estrogen receptor protein in the mouse blastocyst during normal and delayed implantation
29. The induction of implantation in the mouse after ovariectomy
30. Physiological action of progesterone in target tissues
31. Implantation and the placenta: Key pieces of the development puzzle
32. Histological and histochemical analysis of the formation of implantation chambers in the mouse uterus
33. The ovarian androgen producing cells: A review of structure/function relationships
34. Fetal death in mice lacking 5α-reductase type I caused by estrogen excess
35. Experimental foetal death: The surviving placenta
36. Pharmacodynamic and biological effects of anti-estrogens in different models
37. The pharmacology and clinical uses of tamoxifen
38. A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
39. The effects of the antihormones RU486 and tamoxifen on fetoplacental development and placental bed vascularisation in the rat: A model for intrauterine fetal growth retardation
40. Induction of calcium-dependent nitric oxide synthases by sex hormones
41. Induction of nitric oxide synthases early in pregnancy
42. Vascular aspects of oestrogen