Microbial compounds induce the expression of pro-inflammatory cytokines, chemokines and human β-defensin-2 in vaginal epithelial cells

Microbes and Infection

Volumn 7, Issue 9-10, 2005, Pages 1117-1127

  Pivarcsi, Andor ^a   Nagy, Istvan ^a   Koreck, Andrea ^a   Kis, Kornelia ^a   Kenderessy Szabo, Anna ^a   Szell, Marta ^a   Dobozy, Attila ^a   Kemeny, Lajos ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Antimicrobial peptides; Female reproductive tract; Fungal infections; Innate immunity; Toll like receptors (TLRs)

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIUM LIPOPOLYSACCHARIDE; BETA DEFENSIN 2; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; ZYMOSAN;

ARTICLE; BACTERIAL CELL WALL; CANDIDA ALBICANS; CELL LINE; CHEMOTAXIS; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FEMALE GENITAL SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMORAL IMMUNITY; INNATE IMMUNITY; MICROORGANISM; MYCOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; UPREGULATION; VAGINA EPITHELIUM;

BETA-DEFENSINS; CANDIDA ALBICANS; CELL LINE; CHEMOKINES; CYTOKINES; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; NF-KAPPA B; PEPTIDOGLYCAN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; VAGINA; ZYMOSAN;

BACTERIA (MICROORGANISMS); CANDIDA ALBICANS; NEGIBACTERIA; POSIBACTERIA;

EID: 24944511233     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2005.03.016     Document Type: Article

References (59)

1. B. Beutler, K. Hoebe, X. Du, and R.J. Ulevitch How we detect microbes and respond to them: the Toll-like receptors and their transducers J. Leukoc. Biol. 74 2003 479 485
2. O. Takeuchi, K. Hoshino, and S. Akira Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection J. Immunol. 165 2000 5392 5396
3. S. Akira, and K. Takeda Toll-like receptor signalling Nat. Rev. Immunol. 4 2004 499 511
4. G. Zhang, and S. Ghosh Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity J. Clin. Invest. 107 2001 13 19
5. M.G. Netea, C. Van der Graaf, J.W. Van der Meer, and B.J. Kullberg Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system J. Leukoc. Biol. 75 2004 749 755
6. C.J. Hertz, Q. Wu, E.M. Porter, Y.J. Zhang, K.-H. Weismuller, P.J. Godowski, T. Ganz, S.H. Randell, and R.L. Modlin Activation of toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human {beta} defensin-2 J Immunol. 171 2003 6820 6826
7. S.N. Vogel, K.A. Fitzgerald, and M.J. Fenton TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression Mol. Interv. 3 2003 466 477
8. A. Pivarcsi, I. Nagy, and L. Kemeny Innate immunity in the skin how keratinocytes fight against pathogens, Curr. Immunol. Rev. 1 2005 29 42
9. C. Pasare, and R. Medzhitov Toll-like receptors: linking innate and adaptive immunity Microbes Infect. 6 2004 1382 1387
10. M. Strus, M. Malinowska, and P.B. Heczko In vitro antagonistic effect of Lactobacillus on organisms associated with bacterial vaginosis J. Reprod. Med. 47 2002 41 46
11. F. Nomanbhoy, C. Steele, J. Yano, and P.L. Fidel Jr. Vaginal and oral epithelial cell anti-candida activity Infect. Immun. 70 2002 7081 7088
12. C. Steele, H. Ozenci, W. Luo, M. Scott, and P.L. Fidel Jr. Growth inhibition of Candida albicans by vaginal cells from naive mice Med. Mycol. 37 1999 251 259
13. N. Rajan, D.L. Pruden, H. Kaznari, Q. Cao, B.E. Anderson, J.L. Duncan, and A.J. Schaeffer Characterization of an immortalized human vaginal epithelial cell line J. Urol. 163 2000 616 622
14. A. Pivarcsi, L. Bodai, B. Rethi, A. Kenderessy-Szabo, A. Koreck, M. Szell, Z. Beer, Z. Bata-Csorgoo, M. Magocsi, E. Rajnavolgyi, A. Dobozy, and L. Kemeny Expression and function of Toll-like receptors 2 and 4 in human keratinocytes Int. Immunol. 15 2003 721 730
15. S. Akira, K. Takeda, and T. Kaisho Toll-like receptors: critical proteins linking innate and acquired immunity Nat. Immunol. 2 2001 675 680
16. S. Thoma-Uszynski, S. Stenger, O. Takeuchi, M.T. Ochoa, M. Engele, P.A. Sieling, P.F. Barnes, M. Rollinghoff, P.L. Bolcskei, M. Wagner, S. Akira, M.V. Norgard, J.T. Belisle, P.J. Godowski, B.R. Bloom, and R.L. Modlin Induction of direct antimicrobial activity through mammalian toll-like receptors Science 291 2001 1544 1547
17. S.H. Rhee, and D. Hwang Murine Toll-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase J. Biol. Chem. 275 2000 34035 34040
18. T. Ganz Defensins: antimicrobial peptides of innate immunity Nat. Rev. Immunol. 3 2003 710 720
19. H.L. Pahl Activators and target genes of Rel/NF-kappaB transcription factors Oncogene 18 1999 6853 6866
20. C.A. Spiegel Vaginitis/vaginosis Clin. Lab. Med. 9 1989 525 533
21. K. Deb, M.M. Chaturvedi, and Y.K. Jaiswal Comprehending the role of LPS in Gram-negative bacterial vaginosis: ogling into the causes of unfulfilled child-wish Arch. Gynecol. Obstet. 270 2004 133 146
22. D. Subtil, V. Denoit, F. Le Goueff, M.O. Husson, D. Trivier, and F. Puech The role of bacterial vaginosis in preterm labor and preterm birth: a case-control study Eur. J. Obstet. Gynecol. Reprod. Biol. 101 2002 41 46
23. C.C. Tebes, C. Lynch, and J. Sinnott The effect of treating bacterial vaginosis on preterm labor Infect. Dis. Obstet. Gynecol. 11 2003 123 129
24. K. Takeda, T. Kaisho, and S. Akira Toll-like receptors Annu. Rev. Immunol. 21 2003 335 376
25. L.E. Yauch, M.K. Mansour, S. Shoham, J.B. Rottman, and S.M. Levitz Involvement of CD14, toll-like receptors 2 and 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo Infect. Immun. 72 2004 5373 5382
26. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
27. A. Aderem, and R.J. Ulevitch Toll-like receptors in the induction of the innate immune response Nature 406 2000 782 787
28. I. Sugawara, H. Yamada, C. Li, S. Mizuno, O. Takeuchi, and S. Akira Mycobacterial infection in TLR2 and TLR6 knockout mice Microbiol. Immunol. 47 2003 327 336
29. S.S. Mambula, K. Sau, P. Henneke, D.T. Golenbock, and S.M. Levitz Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus J. Biol. Chem. 277 2002 39320 39326
30. S.M. Levitz Interactions of Toll-like receptors with fungi Microbes Infect. 6 2004 1351 1355
31. S. Bellocchio, C. Montagnoli, S. Bozza, R. Gaziano, G. Rossi, S.S. Mambula, A. Vecchi, A. Mantovani, S.M. Levitz, and L. Romani The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo J. Immunol. 172 2004 3059 3069
32. A. Meier, C.J. Kirschning, T. Nikolaus, H. Wagner, J. Heesemann, and F. Ebel Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages Cell. Microbiol. 5 2003 561 570
33. E. Villamon, D. Gozalbo, P. Roig, J.E. O'Connor, D. Fradelizi, and M.L. Gil Toll-like receptor-2 is essential in murine defenses against Candida albicans infections Microbes Infect. 6 2004 1 7
34. P.A. Pioli, E. Amiel, T.M. Schaefer, J.E. Connolly, C.R. Wira, and P.M. Guyre Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract Infect. Immun. 72 2004 5799 5806
35. R.N. Fichorova, A.O. Cronin, E. Lien, D.J. Anderson, and R.R. Ingalls Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling J. Immunol. 168 2002 2424 2432
36. R.M. Strieter, S.L. Kunkel, H.J. Showell, D.G. Remick, S.H. Phan, P.A. Ward, and R.M. Marks Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta Science 243 1989 1467 1469
37. A. Harada, N. Sekido, T. Akahoshi, T. Wada, N. Mukaida, and K. Matsushima Essential involvement of interleukin-8 (IL-8) in acute inflammation J. Leukoc. Biol. 56 1994 559 564
38. G. Godaly, G. Bergsten, L. Hang, H. Fischer, B. Frendeus, A.C. Lundstedt, M. Samuelsson, P. Samuelsson, and C. Svanborg Neutrophil recruitment, chemokine receptors, and resistance to mucosal infection J. Leukoc. Biol. 69 2001 899 906
39. G. Godaly, A.E. Proudfoot, R.E. Offord, C. Svanborg, and W.W. Agace Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration Infect. Immun. 65 1997 3451 3456
40. R.N. Fichorova, P.J. Desai, F.C. Gibson III, and C.A. Genco Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells Infect. Immun. 69 2001 5840 5848
41. D.J. Anderson, J.A. Politch, L.D. Tucker, R. Fichorova, F. Haimovici, R.E. Tuomala, and K.H. Mayer Quantitation of mediators of inflammation and immunity in genital tract secretions and their relevance to HIV type 1 transmission AIDS Res. Hum. Retroviruses 14 1998 S43 S49
42. T. Sasaki, R. Kano, H. Sato, Y. Nakamura, S. Watanabe, and A. Hasegawa Effects of staphylococci on cytokine production from human keratinocytes Br. J. Dermatol. 148 2003 46 50
43. C. Perez, I. Albert, K. DeFay, N. Zachariades, L. Gooding, and M. Kriegler A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact Cell 63 1990 251 258
44. R.A. Black, C.T. Rauch, C.J. Kozlosky, J.J. Peschon, J.L. Slack, M.F. Wolfson, B.J. Castner, K.L. Stocking, P. Reddy, S. Srinivasan, N. Nelson, N. Boiani, K.A. Schooley, M. Gerhart, R. Davis, J.N. Fitzner, R.S. Johnson, R.J. Paxton, C.J. March, and D.P. Cerretti A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells Nature 385 1997 729 733
45. R.I. Lehrer, and T. Ganz Defensins of vertebrate animals Curr. Opin. Immunol. 14 2002 96 102
46. T. Ganz Defensins and host defense Science 286 1999 420 421
47. J. Harder, J. Bartels, E. Christophers, and J.M. Schroder A peptide antibiotic from human skin Nature 387 1997 861
48. H.Y. Lee, A. Andalibi, P. Webster, S.K. Moon, K. Teufert, S.H. Kang, J.D. Li, M. Nagura, T. Ganz, and D.J. Lim Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae BMC Infect. Dis. 4 2004 12
49. K. Midorikawa, K. Ouhara, H. Komatsuzawa, T. Kawai, S. Yamada, T. Fujiwara, K. Yamazaki, K. Sayama, M.A. Taubman, H. Kurihara, K. Hashimoto, and M. Sugai Staphylococcus aureus susceptibility to innate antimicrobial peptides, {beta}-defensins and CAP18, expressed by human keratinocytes Infect. Immun. 71 2003 3730 3739
50. D. Yang, Q. Chen, O. Chertov, and J.J. Oppenheim Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells J. Leukoc. Biol. 68 2000 9 14
51. J.J. Oppenheim, A. Biragyn, L.W. Kwak, and D. Yang Roles of antimicrobial peptides such as defensins in innate and adaptive immunity Ann. Rheum. Dis. 62 2003 ii17 ii21
52. D. Yang, A. Biragyn, L.W. Kwak, and J.J. Oppenheim Mammalian defensins in immunity: more than just microbicidal Trends Immunol. 23 2002 291 296
53. A. Iwasaki, and R. Medzhitov Toll-like recepor control of the adaptive immune responses Nat. Immunol. 5 2004 987 995
54. C.A. Janeway Jr., and R. Medzhitov Innae immune recognition Annu. Rev. Immunol. 20 2002 197 216
55. F. Mercurio, and A.M. Manning Multiple signals converging on NF-kappaB Curr. Opin. Cell Biol. 11 1999 226 232
56. V. Ayyavoo, A. Mahboubi, S. Mahalingam, R. Ramalingam, S. Kudchodkar, W.V. Williams, D.R. Green, and D.B. Weiner HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B Nat. Med. 3 1997 1117 1123
57. T. Matsusaka, K. Fujikawa, Y. Nishio, N. Mukaida, K. Matsushima, T. Kishimoto, and S. Akira Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8 Proc. Natl. Acad. Sci. USA 90 1993 10193 10197
58. Y. Tsutsumi-Ishii, and I. Nagaoka NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation J. Leukoc. Biol. 71 2002 154 162
59. K. Deb, M.M. Chatturvedi, and Y.K. Jaiswal Gram-negative bacterial endotoxin- induced infertility: a birds eye view Gynecol. Obstet. Invest. 57 2004 224 232