Toll-like receptor-2 is essential in murine defenses against Candida albicans infections

Microbes and Infection

Volumn 6, Issue 1, 2004, Pages 1-7

  Villamón, Eva ^a   Gozalbo, Daniel ^a   Roig, Patricia ^a   O'Connor, José Enrique ^a   Fradelizi, Didier ^b   Gil, M Luisa ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b INSTITUT COCHIN   (France)

Author keywords

Candida albicans; Macrophages; TLR2

Indexed keywords

MACROPHAGE MIGRATION INHIBITION FACTOR; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; FEMALE; FUNGUS HYPHAE; MALE; MOUSE; MYCOSIS; NEUTROPHIL; NONHUMAN; PERITONEAL CAVITY; PHAGOCYTOSIS; PRIORITY JOURNAL; SURVIVAL; WILD TYPE; YEAST;

ANIMALIA; CANDIDA; CANDIDA ALBICANS; MURINAE;

EID: 1642452662     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2003.09.020     Document Type: Article

References (32)

1. Vincent J.L., Anaissie E., Bruining H., Demajo W., El-Ebiary M., Haber J., Hiramatsu Y., Nitenberg G., Nyström P.O., Pittet D., Rogers T., Sandven P., Sganga G., Schaller M.D., Solomkin J. Epidemiology, diagnosis and treatment of systemic Candida infections in surgical patients under intensive care. Intensive Care Med. 24:1998;206-216.
2. Garber G. An overview of fungal infections. Drugs. 61:(Suppl. 1):2001;1-12.
3. Netea M.G., Block W.L., Kullerg B.J., Bemelmans M., Vogels M.T.E., Buurman W.A., Van der Meer J.W.M. Pharmacological inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice. J. Infect. Dis. 171:1995;393-399.
4. Steinshamn S., Waage A. Tumor necrosis factor and interleukin-6 in Candida albicans infection in normal and granulocytopenic mice. Infect. Immun. 60:1992;4003-4008.
5. Netea M.G., Van Tits L.J.H., Curfs J.H.A.J., Amiot F., Meis J.F.G.M., Van der Meer J.W.M., Kullberg B.J. Increased susceptibility of TNF-α lymphotoxin-α double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida. J. Immunol. 163:1999;1498-1505.
6. Steinshamn S., Bemelmans M.H.A., Van Tits L.H.J., Bergh K., Buurman W.A., Waage A. TNF receptors in murine Candida albicans infection: evidence for an important role of TNF receptor p55 in antifungal defense. J. Immunol. 157:1996;2155-2159.
7. Traynor T.R., Huffnagle G.B. Role of chemokines in fungal infections. Med. Mycol. 39:2001;41-50.
8. Szabo S.J., Sullivan B.M., Peng S.L., Glimcher L.H. Molecular mechanisms regulating TH1 immune responses. Annu. Rev. Immunol. 21:2003;713-758.
9. Altamura M., Casale D., Pepe M., Tafaro A. Immune responses to fungal infections and therapeutic implications. Curr. Drug Targeting Immune Endocrinol. Metabol. Disord. 1:2001;189-197.
10. Romani L., Bistoni F., Puccetti P. Fungi, dendritic cells and receptors: a host perspective of fungal virulence. Trends Microbiol. 10:2002;508-514.
11. Takeda K., Kaisho T., Akira S. Toll-like receptors. Annu. Rev. Immunol. 21:2003;335-376.
12. Netea M.G., Van der Graaf C.A.A., Vonk A.G., Verschueren I., Van der Meer J.W.M., Kullberg B.J. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J. Infect. Dis. 185:2002;1483-1489.
13. Morré S.A., Murillo L.S., Spaargaren J., Fennema H.S.A., Peña A.S. Role of the toll-like receptor 4 Asp299Gly polymorphism in susceptibility to Candida albicans infection. J. Infect. Dis. 186:2002;1377-1379.
14. Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K., Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 11:1999;443-451.
15. Gil-Navarro I., Gil M.L., Casanova M., O'Connor J.E., Martínez J.P., Gozalbo D. The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase of Candida albicans is a surface antigen. J. Bacteriol. 179:1997;4992-4999.
16. Gozalbo D., Gil-Navarro I., Azorín I., Renau-Piqueras J., Martínez J.P., Gil M.L. The cell wall-associated glyceraldehyde-3- phosphate dehydrogenase of Candida albicans is also a fibronectin and laminin binding protein. Infect. Immun. 66:1998;2052-2059.
17. Calderone R.A. Candida and Candidiasis. 2001;ASM Press, New York.
18. Chiani P., Bromuro C., Torosantucci A. Defective induction of interleukin-12 in human monocytes by germ-tube forms of Candida albicans. Infect. Immun. 68:2000;5628-5634.
19. Liu L., Kang K., Takahara M., Cooper K.D., Ghannoum M.A. Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: inhibitory role of C. albicans germination. Infect. Immun. 69:2001;4695-4697.
20. Underhill D.M., Ozinsky A., Hajjar A.M., Stevens A., Wilson C.B., Bassetti M., Aderem A. The toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature. 401:1999;811-815.
21. Gantner B.N., Simmons R.M., Canavera S.J., Akira S., Underhill D.M. Collaborative induction of inflammatory response by dectin-1 and toll-like receptor 2. J. Exp. Med. 197:2003;1107-1117.
22. Chaffin W.L., López-Ribot J.L., Casanova M., Gozalbo D., Martínez J.P. Cell wall and secreted proteins of Candida albicans: identification, function, and expression. Microbiol. Mol. Biol. Rev. 62:1998;130-180.
23. Martínez J.P., Gil M.L., López-Ribot J.L., Chaffin W.L. Serologic response to cell wall mannoproteins and proteins of Candida albicans. Clin. Microbiol. Rev. 11:1998;121-141.
24. Wolpe S., Cerami A. Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines. FASEB J. 3:1989;2565-2573.
25. Bazzoni F., Beutler B. The tumor necrosis factor ligand and receptor families. New Engl. J. Med. 334:1996;1717-1725.
26. Strieter R.M., Kunkel S.L. Crystal R.G., Wests J.B. Chemokines, The Lung. 1997;155 Lippincott-Raven, Philadelphia.
27. Ingalls R.R., Arnaout M.A., Golenbock D.T. Outside-in signaling by lipopolysaccharide through a tailless integrin. J. Immunol. 159:1997;433-438.
28. Vasquez-Torres A., Balish E. Macrophages in resistance to candidiasis. Microbiol. Mol. Biol. Rev. 61:1997;170-192.
29. Cambi A., Gijzen K., De Vries I.J.M., Torensma R., Joosten B., Adema G. J., Netea M.G., Kullberg B.J., Romani L., Figdor C.G. The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur. J. Immunol. 33:2003;532-538.
30. Mummidi S., Catano G., Lam L., Hoefle A., Telles V., Begum K., Jimenez F., Ahuja S.S., Ahuja S.K. Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. J. Biol. Chem. 276:2001;33196-33212.
31. Lee S.J., Zheng N.Y., Clavijo M., Nussenzweig M.C. Normal host defense during systemic candidiasis in mannose receptor-deficient mice. Infect. Immun. 71:2003;437-445.
32. Haugland R.P. Handbook of Fluorescent Probes and Research Products. eighth ed :2001;Molecular Probes. Inc.