Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12

Apoptosis

Volumn 10, Issue 5, 2005, Pages 1043-1062

  Brecht, K ^a,c   Simonen, M ^a   Heim, J ^a,b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^c TRIEMLI HOSPITAL   (Switzerland)

Author keywords

Alpha globin; Apoptosis; Caspases; Heme

Indexed keywords

ALPHA GLOBIN; ANTISENSE OLIGONUCLEOTIDE; APOPTOSIS INDUCING FACTOR; BETA GLOBIN; CASPASE 3; CASPASE 8; CASPASE 9; CISPLATIN; CYTOCHROME C; CYTOKINE; GREEN FLUORESCENT PROTEIN; HEME; HEMOGLOBIN; INTERLEUKIN 3; PROTEIN BAX;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CONTROLLED STUDY; DOWN REGULATION; ENRICHMENT CULTURE; ENZYME ACTIVITY; ERYTHROID CELL; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXYGEN TRANSPORT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; B-LYMPHOCYTES; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASES; CELL LINE; CISPLATIN; CYCLOHEXIMIDE; CYTOCHROMES C; DOXORUBICIN; GLOBINS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HEMATOPOIETIC STEM CELLS; HEME; HUMANS; INTERLEUKIN-3; K562 CELLS; MICE; NIH 3T3 CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; STAUROSPORINE; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 24644508859     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-005-0617-9     Document Type: Article

References (61)

1. Adachi-Yamada T, O'Connor MB. Mechanisms for removal of developmentally abnormal cells: cell competition and morphogenetic apoptosis. J Biochem (Tokyo) 2004; 136(1): 13-17.
2. Khanna KK, Lavin MF. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 1993; 8(12): 3307-3312.
3. Selvakumaran M, Lin HK, Miyashita T, Wang HG, Krajewski S, Reed JC, et al. Immediate early up-regulation of bax expression by p53 but not TGF beta 1: A paradigm for distinct apoptotic pathways. Oncogene 1994; 9(6): 1791-1798.
4. Boatright KM, Salvesen GS. Mechanisms of caspase activation. Curr Opin Cell Biol 2003; 15(6): 725-731.
5. Kuwana T, Smith JJ, Muzio M, Dixit V, Newmeyer DD, Kornbluth S. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J Biol Chem 1998; 273(26): 16589-16594.
6. Shelton JG, Steelman LS, Lee JT, Knapp SL, Blalock WL, Moye PW, et al. Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. Oncogene 2003; 22(16): 2478-2492.
7. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282(5392): 1318-1321.
8. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96(6): 857-868.
9. Muirhead H, Cox JM, Mazzarella L, Perutz MF. Structure and function of haemoglobin. 3. A three-dimensional fourier synthesis of human deoxyhaemoglobin at 5.5 Angstrom resolution. J Mol Biol 1967; 28(1): 117-156.
10. Rabbitts TH. Bacterial cloning of plasmids carrying copies of rabbit globin messenger RNA. Nature 1976; 260(5548): 221-225.
11. Hardison RC. A brief history of hemoglobins: Plant, animal, protist, and bacteria. Proc Natl Acad Sci USA 1996; 93(12): 5675-5679.
12. Fessas P, Loukopoulos D, Kaltsoya A. Peptide analysis of the inclusions of erythroid cells in beta-thalassemia. Biochim Biophys Acta 1966; 124(2): 430-432.
13. Kihm AJ, Kong Y, Hong W, Russell JE, Rouda S, Adachi K, et al. An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature 2002; 417(6890): 758-763.
14. Wride MA, Mansergh FC, Adams S, Everitt R, Minnema SE, Rancourt DE, et al. Expression profiling and gene discovery in the mouse lens. Mol Vis 2003; 9: 360-96:360-396.
15. Brachat A, Pierrat B, Brungger A, Heim J. Comparative microarray analysis of gene expression during apoptosis-induction by growth factor deprivation or protein kinase C inhibition. Oncogene 2000; 19(44): 5073-5082.
16. Devireddy LR, Teodoro JG, Richard FA, Green MR. Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 2001; 293(5531): 829-834.
17. Brachat A, Pierrat B, Xynos A, Brecht K, Simonen M, Brungger A et al. A microarray-based, integrated approach to identify novel regulators of cancer drug response and apoptosis. Oncogene 2002; 21(54): 8361-8371.
18. Taketani S, Immenschuh S, Go S, Sinclair PR, Stockert RJ, Liem HH, et al. Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors. Hepatology 1998; 27(3): 808-814.
19. Mahadevappa M, Warrington JA. A high-density probe array sample preparation method using 10- to 100-fold fewer cells. Nat Biotechnol 1999; 17(11): 1134-1136.
20. Jung M, Sabat R, Kratzschmar J, Seidel H, Wolk K, Schonbein C, et al. Expression profiling of IL-10-regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL-10 therapy. Eur J Immunol 2004; 34(2): 481-493.
21. Sassa S. Sequential induction of heme pathway enzymes during erythroid differentiation of mouse Friend leukemia virus-infected cells. J Exp Med 1976; 143(2): 305-315.
22. Worthington RE, Bossie-Codreanu J, Van Zant G. Quantitation of erythroid differentiation in vitro using a sensitive colorimetric assay for hemoglobin. Exp Hematol 1987; 15(1): 85-92.
23. Swift, Lorens, Achacoso, Nolan. Retroviral transduction. Current Protocols in Immunology 1999, Unit 10, 28(Suppl).
24. Coyle B, Freathy C, Gant TW, Roberts RA, Cain K. Characterization of the transforming growth factor-beta 1-induced apoptotic transcriptome in FaO hepatoma cells. J Biol Chem 2003; 278(8): 5920-5928.
25. Burmester T, Weich B, Reinhardt S, Hankeln T. A vertebrate globin expressed in the brain. Nature 2000; 407(6803): 520-523.
26. Burmester T, Ebner B, Weich B, Hankeln T. Cytoglobin: A novel globin type ubiquitously expressed in vertebrate tissues. Mol Biol Evol 2002; 19(4): 416-421.
27. Rutherford T, Clegg JB, Higgs DR, Jones RW, Thompson J, Weatherall DJ. Embryonic erythroid differentiation in the human leukemic cell line K562. Proc Natl Acad Sci USA 1981; 78(1): 348-352.
28. Bertrand R, Solary E, O'Connor P, Kohn KW, Pommier Y. Induction of a common pathway of apoptosis by staurosporine. Exp Cell Res 1994; 211(2): 314-321.
29. Abreu-Martin MT, Vidrich A, Lynch DH, Targan SR. Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-alpha and ligation of Fas antigen. J Immunol 1995; 155(9): 4147-4154.
30. Johnson BW, Boise LH. Bcl-2 and caspase inhibition cooperate to inhibit tumor necrosis factor-alpha-induced cell death in a Bcl-2 cleavage-independent fashion. J Biol Chem 1999; 274(26): 18552-18558.
31. Fulda S, Meyer E, Debatin KM. Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. Cancer Res 2000; 60(14): 3947-3956.
32. Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003; 22(47): 7265-7279.
33. Jiang S, Cai J, Wallace DC, Jones DP. Cytochrome c-mediated apoptosis in cells lacking mitochondrial DNA. Signaling pathway involving release and caspase 3 activation is conserved. J Biol Chem 1999; 274(42): 29905-29911.
34. Shibahara S, Muller RM, Taguchi H. Transcriptional control of rat heme oxygenase by heat shock. J Biol Chem 1987; 262(27): 12889-12892.
35. Aries A, Trentesaux C, Ottolenghi S, Jardillier JC, Jeannesson P, Doubeikovski A. Activation of erythroid-specific promoters during anthracycline-induced differentiation of K562 cells. Blood 1996; 87(7): 2885-2890.
36. Mc Gee MM, Campiani G, Ramunno A, Fattorusso C, Nacci V, Lawler M et al. Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl. J Pharmacol Exp Ther 2001; 296(1): 31-40.
37. Dedoussis GV, Mouzaki A, Theodoropoulou M, Menounos P, Kyrtsonis MC, Karameris A et al. Endogenous interleukin 6 conveys resistance to cis-diamminedichloroplatinum-mediated apoptosis of the K562 human leukemic cell line. Exp Cell Res 1999; 249(2): 269-278.
38. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998; 94(4): 481-490.
39. McKearn JP, McCubrey J, Fagg B. Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors. Proc Natl Acad Sci USA 1985; 82(21): 7414-7418.
40. Ahmed MM. Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors. Curr Cancer Drug Targets 2004; 4(1): 43-52.
41. Morceau F, Chenais B, Gillet R, Jardillier J C, Jeannesson P, Trentesaux C. Transcriptional and posttranscriptional regulation of erythroid gene expression in anthracycline-induced differentiation of human erythroleukemic cells. Cell Growth Differ 1996; 7(8): 1023-1029.
42. Scholander Pf. Oxygen transport through hemoglobin solutions. Science 1960; 131: 585-90: 585-590.
43. Yoshida E, Ohmura S, Sugiki M, Anai K, Maruyama M. A novel function of extraerythrocytic hemoglobin: Identification of globin as a stimulant of plasminogen activator biosynthesis in human fibroblasts. Thromb Haemost 2001; 86(6): 1521-1527.
44. Spadaccini A, Tilbrook PA, Sarna MK, Crossley M, Bieker JJ, Klinken SP. Transcription factor erythroid Kruppel-like factor (EKLF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation. J Biol Chem 1998; 273(37): 23793-23798.
45. Yuan J, Bunyaratvej A, Fucharoen S, Fung C, Shinar E, Schrier SL. The instability of the membrane skeleton in thalassemic red blood cells. Blood 1995; 86(10): 3945-3950.
46. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282(5392): 1318-1321.
47. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91(2): 231-241.
48. Bojes HK, Feng X, Kehrer JP, Cohen GM. Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3 withdrawal: Relationship to caspase activity and the loss of glutathione. Cell Death Differ 1999; 6(1): 61-70.
49. Zou H, Li Y, Liu X, Wang X. An APAF-1.cytochrome c multimetric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 1999; 274(17): 11549-11556.
50. Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC et al. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem 2004; 279(2): 1513-1525.
51. Johnson DE. Regulation of survival pathways by IL-3 and induction of apoptosis following IL-3 withdrawal. Front Biosci 1998; 3: d313-24: d313-d324.
52. Kumar S. Inhibition of apoptosis by the expression of antisense Nedd2. FEBS Lett 1995; 368(1): 69-72.
53. Lassus P, Opitz-Araya X, Lazebnik Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 2002; 297(5585): 1352-1354.
54. Troy CM, Shelanski ML. Caspase-2 redux. Cell Death Differ 2003; 10(1): 101-107.
55. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 1999; 144(2): 281-292.
56. Porter AG, Janicke RU. Emerging roles of caspase-3 in apoptosis. Cell Death Differ 1999; 6(2): 99-104.
57. Eskes R, Desagher S, Antonsson B, Martinou JC. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol 2000; 20(3): 929-935.
58. Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, Green DR. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem 1999; 274(4): 2225-2233.
59. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 1996; 87(4): 619-628.
60. Murphy KM, Ranganathan V, Farnsworth ML, Kavallaris M, Lock RB. Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells. Cell Death Differ 2000; 7(1): 102-111.
61. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 1996; 86(1): 147-157.