Genotoxic effects of 2-trans-hexenal in human buccal mucosa cells in vivo

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 390, Issue 1-2, 1997, Pages 161-165

  Dittberner, Ulrike ^a   Schmetzer, Beate ^a   Gölzer, Petra ^a   Eisenbrand, Gerhard ^a   Zankl, Heinrich ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

Author keywords

2 trans Hexenal; Buccal mucosa; Human; Micronuclei in vivo

Indexed keywords

ALDEHYDE DERIVATIVE;

ADULT; ARTICLE; CHEEK MUCOSA; CONTROLLED STUDY; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; MICRONUCLEUS; MUTAGENICITY; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0030913851     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(97)00013-X     Document Type: Article

References (21)

1. Feron, V.J., H.P. Til, F. de Vrijer, R.A. Woutersen, F.R. Cassee and P.J. van Bladeren (1991) Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment, Mutation Res., 259, 363-385.
2. Dürr, P., U. Schobinger and M. Zellweger (1981) Das Aroma in Apfelmaische bei deren Verflüssigung durch Pektinasen und Zellulasen, Lebensm.-Wiss.-Technol., 14, 268-272.
3. Skobeleva, N.I., A.A. Bezzubov, T.A. Petrova and M.A. Bokuchava (1979) Aroma-forming substances in black tea, Appl. Biochem. Microbiol., 15, 682-687.
4. Marnett, L.J., H.K. Hurd, M.C. Hollstein, D.E. Levin, H. Esterbauer and B.N. Ames (1985) Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA 104, Mutation Res., 148, 25-34.
5. Schuhmacher, J. (1990) Untersuchungen zur Genotoxizität und zum Metabolismus aromawirksamer α,β-ungesättigter Aldehyde, Dissertation, Universität Kaiserslautern.
6. 2,7,8 bis-cyclic adducts, Chem. Res. Toxicol., 5, 802-808.
7. Canonero, R., A. Marteki, U.M. Marinari and G. Brambilla (1990) Mutation induction in Chinese hamster lung V79 cells by five alk-2-enals produced by lipid peroxidation, Mutation Res., 244, 153-156.
8. Dittberner, U., G. Eisenbrand and H. Zankl (1995) Genotoxic effects of the α,β-unsaturated aldehydes 2-trans-butenal, 2-trans-hexenal and 2-trans,6-cis-nonadienal, Mutation Res., 335, 259-265.
9. Stich, H.F., J.R. Curtis and B.B. Parida (1982) Application of the micronucleus test to exfoliated cells of high cancer risk groups: tobacco chewers, Int. J. Cancer, 30, 553-559.
10. Stich, H.F., W. Stich and B.B. Parida (1982) Elevated frequency of micronucleated cells in the buccal mucosa of individuals at high risk for oral cancer: betel quid chewers, Cancer Lett., 17, 125-134.
11. Stich, H.F., M.P. Rosin and M.O. Vallejera (1984) Reduction with vitamin A and beta-carotene administration of proportion of micronucleated buccal mucosa cells in asian betel nut and tobacco chewers, Lancet, 2, 1204-1206.
12. Stich, H.F., W. Stich, M.P. Rosin and M.O. Vallejera (1984) Use of the micronucleus test to monitor the effect of vitamin A, beta-carotene and canthaxanthin of the buccal mucosa of betel nut/tobacco chewers, Int. J. Cancer, 34, 745-750.
13. Picker, J.D. and D.P. Fox (1986) Do curried foods produce micronuclei in buccal epithelial cells?, Mutation Res., 171, 185-188.
14. Sarto, F., S. Finotto, L. Giocomelli, D. Mazzotti, R. Tomanin and A.G. Levis (1987) The micronucleus assay in exfoliated cells of the human buccal mucosa, Mutagenesis, 2, 11-17.
15. Rosin, M.P. (1992) The use of the micronucleus test on exfoliated cells to identify anti-clastogenic action in humans: a biological marker for the efficacy of chemopreventive agents, Mutation Res., 267, 265-276.
16. Heddle, J.A., M.C. Dimino, M. Hayashi, F. Romagna, M.D. Shelby, J.D. Tucker, P. Vanparys and J.T. MacGregor (1991) Micronuclei as an index of cytogenetic damage: past, present and future, Environ. Mol. Mutagen., 18, 277-291.
17. Lutz, D., E. Eder, T. Neudecker and D. Henschler (1982) Structure mutagenicity relationship in α,β-unsaturated carbonylic compounds and their corresponding allylic alcohols, Mutation Res., 93, 305-315.
18. Gabriel, L., A. Miglietta and M.U. Dianzani (1985) 4-Hydroxyalkenals interaction with purified microtubular protein, Chem.-Biol. Interact., 56, 201-212.
19. Winter, C. (1986) Formation of cyclic adducts of desoxyguanosine with aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro, Cancer Res., 46, 5682-5686.
20. Eder, E., C. Deininger, T. Neudecker and D. Deininger (1992) Mutagenicity of β-alkyl substituted acrolein congeners in the Salmonella typhimurium strain TA 100 and genotoxicity testing in the SOS chromotest, Environ. Mol. Mutagen., 19, 338-345.
21. Livingston, G.K., R.N. Reed, B.L. Oson and J.E. Lockey (1990) Induction of nuclear aberrations by smokeless tobacco in epithelial cells of human oral mucosa, Environ. Mol. Mutagen., 15, 136-144.