A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation

European Journal of Biochemistry

Volumn 263, Issue 2, 1999, Pages 410-419

  Supino Rosin, Lia ^b   Yoshimura, Akihiko ^b   Altaratz, Hanna ^b   Neumann, Drorit ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b NONE

Author keywords

Chimeras; Degradation; Endoplasmic reticulum; Epidermal growth factor receptor; Erythropoietin receptor

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERYTHROPOIETIN RECEPTOR;

ANIMAL CELL; ARTICLE; CATTLE; CELL DIFFERENTIATION; CELL MATURATION; ENDOPLASMIC RETICULUM; ERYTHROPOIESIS; HORMONE RECEPTOR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN TRANSPORT;

ANIMALS; BREFELDIN A; CELL LINE; COS CELLS; ENDOPLASMIC RETICULUM; KINETICS; MICE; MUTAGENESIS; PROTEIN SYNTHESIS INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ERYTHROPOIETIN; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

ANIMALIA; BOS TAURUS;

EID: 0000311479     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00516.x     Document Type: Article

References (56)

1. 1. Yoshimura, A. & Misawa, H. (1998). Physiology and function of the erythropoietin receptor. Curr. Opin. Hematol. 5, 171-176.
2. 2. Youssoufian, H., Longmore, G., Neumann, D., Yoshimura, A. & Lodish, H.F. (1993). Structure, function, and activation of the erythropoietin receptor. Blood 81, 2223-2236.
3. 3. Witthuhn, B.A., Quelle, F.W., Silvennoinen, O., Yi, T., Tang, B., Miura, O. & Ihle, J.N. (1993). JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74, 227-236.
4. 4. Watowich, S.S., Yoshimura, A., Longmore, G.D., Hilton, D.J., Yoshimura, Y. & Lodish, H.F. (1992). Homodimerization and constitutive activation of the erythropoietin receptor. Proc. Natl Acad. Sci. USA 89, 2140-2144.
5. 5. Ohashi, H., Maruyama, K., Liu, Y.C. & Yoshimura, A. (1994). Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases. Proc. Natl Acad. Sci. USA 91, 158-162.
6. 6. Heberlein, C., Fischer, K.D., Stoffel, M., Nowock, J., Ford, A., Tessmer, U. & Stocking, C. (1992). The gene for erythropoietin receptor is expressed in multipotential hematopoietic and embryonal stem cells: evidence for differentiation stage-specific regulation. Mol. Cell. Biol. 12, 1815-1826.
7. 7. Winter, S.S., Howard, T. & Ware, R.E. (1996). Regulation of expression of the human erythropoietin receptor gene. Blood Cells Mol. Dis. 22, 214-224.
8. 8. Hilton, D.J., Watowich, S.S., Murray, P.J. & Lodish, H.F. (1995). Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoictin receptor. Proc. Natl Acad. Sci. USA 92, 190-194.
9. 9. Sawyer, S.T. & Hankins, W.D. (1993). The functional form of the erythropoietin receptor is a 78-kDa protein: correlation with cell surface expression, endocytosis, and phosphorylation. Proc. Natl Acad. Sci. USA 90, 6849-6853.
10. 10. Yoshimura, A.A.D., D.A. & Lodish, H.F. (1990). Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism. Proc. Natl Acad. Sci. USA 87, 4139-4143.
11. 11. Neumann, D., Wikstrom, L., Watowich, S.S. & Lodish, H.F. (1993). Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes. J. Biol. Chem. 268, 13639-13649.
12. 12. Watowich, S.S., Hilton, D.J. & Lodish, H.F. (1994). Activation and inhibition of erythropoietin receptor function: role of receptor dimerization. Mol. Cell. Biol. 14, 3535-3549.
13. 13. Neumann, D., Yuk, M.H., Lodish, H.F. & Lederkremer, G.Z. (1996). Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms. Biochem. J. 313, 391-399.
14. 14. Levin, I., Cohen, J., Supino-Rosin, L., Yoshimura, A., Watowich, S.S. & Neumann, D. (1998). Identification of a cytoplasmic motif in the erythropoietin receptor required for receptor internalization. FEBS Lett. 427, 164-170.
15. 15. Cohen, J., Altaratz, H., Zick, Y., Klingmuller, U. & Neumann, D. (1997). Phosphorylation of erythropoietin receptors in the endoplasmic reticulum by pervanadate-mediated inhibition of tyrosine phosphatases. Biochem. J. 327, 391-397.
16. 16. Sawyer, S.T. & Penta, K. (1996). Association of JAK2 and STAT5 with erythropoietin receptors. Role of receptor phosphorylation in erythropoietin signal transduction. J. Biol. Chem. 271, 32430-32437.
17. 17. Subtil, A., Delepierre, M. & Dautry-Varsat, A. (1997). An alpha-helical signal in the cytosolic domain of the interleukin 2 receptor beta chain mediates sorting towards degradation after endocytosis. J. Cell Biol. 136, 583-595.
18. 18. Blagoveshchenskaya, A.D., Norcott, J.P. & Cutler, D.F. (1998). Lysosomal targeting of P-selectin is mediated by a novel sequence within its cyloplasmic tail. J. Biol. Chem. 273, 2729-2737.
19. 19. Marks, M.S., Woodruff, L., Ohno, H. & Bonifacino, J.S. (1996). Protein targeting by tyrosine-and di-leucine-based signals: evidence for distinct saturabie components. J. Cell Biol. 135, 341-354.
20. 20. Opresko, L.K., Chang, C.P., Will, B.H., Burke, P.M., Gill, G.N. & Wiley, H.S. (1995). Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain. J. Biol. Chem. 270, 4325-4333.
21. 21. Ward, C.L., Omura, S. & Kopito, R.R. (1995). Degradation of CFTR by the ubiquitin-proteasome pathway. Cell 83, 121-127.
22. 22. Govers, R., van Kerkhof, P., Schwartz, A.L. & Strous, G.J. (1997). Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor. EMBO J. 16, 4851-4858.
23. 23. Dittrich, E., Haft, C.R., Muys, L., Heinrich, P.C. & Graeve, L. (1996). A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. J. Biol. Chem. 271, 5487-5494.
24. 24. Hamer, I., Haft, C.R., Paccaud, J.P., Maeder, C., Taylor, S. & Carpentier, J.L. (1997). Dual role of a dileucine motif in insulin receptor endocytosis. J. Biol. Chem. 272, 21685-21691.
25. 25. Mukherjee, S., Ghosh, R.N. & Maxfield, F.R. (1997). Endocytosis Physiol. Rev. 77, 759-803.
26. 26. Honing, S. & Hunziker, W. (1995). Cytoplasmic determinants involved in direct lysosomal sorting, endocytosis, and basolateral targeting of rat lgp120 (lamp-I) in MDCK cells. J. Cell Biol. 128, 321-332.
27. 27. Sandoval, I.V. & Bakke, O. (1994). Targeting proteins to endosomes and lysosomes. Trends Cell Biol. 4, 292-297.
28. 28. Morelon, E. & Dautry-Varsat, A. (1998). Endocytosis of the common cytokine receptor gammac chain. Identification of sequences involved in internalization and degradation. J. Biol. Chem. 273, 22044-22051.
29. 29. Green, S.A., Setiadi, H., McEver, R.P. & Kelly, R.B. (1994). The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes. J. Cell Biol. 124, 435-448.
30. 30. Kurten, R.C., Cadena, D.L. & Gill, G.N. (1996). Enhanced degradation of EGF receptors by a sorting nexin, SNXI. Science 272, 1008-1010.
31. 31. Felder, S., Miller, K., Moehren, G., Ullrich, A., Schlessinger, J. & Hopkins, C.R. (1990). Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body. Cell 61, 623-634.
32. 32. Ekstrand, A.J., Liu, L., He, J., Hamid, M.L., Longo, N., Collins, V.P. & James, C.D. (1995). Altered subcellular location of an activated and tumour-associated epidermal growth factor receptor. Oncogene 10, 1455-1460.
33. 33. Verheijden, G.F., Moolenaar, W.H. & Ploegh, H.L. (1992). Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells. Biochem. J. 282, 115-121.
34. 34. Carlin, C.R. & Knowles, B.B. (1984). Biosynthesis of the epidermal growth factor receptor in human epidermoid carcinoma-derived A431 cells. J. Biol. Chem. 259, 7902-7908.
35. 35. Letourneur, F. & Klausner, R.D. (1992). A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell 69, 1143-1157.
36. 36. Maruyama, K., Miyata, K. & Yoshimura, A. (1994). Proliferation and erythroid differentiation through the cytoplasmic domain of the erythropoietin receptor. J. Biol. Chem. 269, 5976-5980.
37. 37. Iwatsuki, K., Endo, T., Misawa, H., Yokouchi, M., Matsumoto, A., Ohtsubo, M., Mori, K.J. & Yoshimura, A. (1997). STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line. J. Biol. Chem. 272, 8149-8152.
38. 38. Collins, M.K., Downward, J., Miyajima, A., Maruyama, K., Arai, K. & Mulligan, R.C. (1988). Transfer of functional EGF receptors to an IL3-dependent cell line. J. Cell Physiol. 137, 293-298.
39. 39. D'Andrea, A.D., Lodish, H.F. & Wong, G.G. (1989). Expression cloning of the murine erythropoietin receptor. Cell 57, 277-285.
40. 40. Hobert, M. & Carlin, C. (1995). Cytoplasmic juxtamembrane domain of the human EGF receptor is required for basolateral localization in MDCK cells. J. Cell Physiol. 162, 434-446.
41. 41. Aruffo, A. & Seed, B. (1987). Molecular cloning of aCD28 cDNA by a high-efficiency COS cell expression system. Proc: Natl Acad. Sci. USA 84, 8573-8577.
42. 42. Senanayake, S.D. & Brian, D.A. (1995). Precise large deletions by the PCR-based overlap extension method. Mol. Biotechnol. 4, 13-15.
43. 43. Damen, J.E., Mui, A.L., Puil, L., Pawson, T. & Krystal, G. (1993). Phosphatidylinositol 3-kinase assoc+iates, via its Src homology 2 domains, with the activated erythropoietin receptor. Blood 81, 3204-3210.
44. 44. D'Andrea, A., Yoshimura, A., Youssoufian, H., Zon, L.I., Koo, J.W. & Lodish, H.F. (1991). The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains. Mol. Cell. Biol. 11, 1980-1987.
45. 45. Klausner, R.D., Donaldson, J.G. & Lippincott-Schwartz, J. (1992). Brefeldin A: insights into the control of membrane traffic and organelle structure. J. Cell Biol. 116, 1071-1080.
46. 46. Tokunaga, F., Shirotani, H., Hara, K., Kozuki, D., Omura, S. & Koide, T. (1997). Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors FEBS Lett. 412, 65-69. (erratum FEBS Lett. 415, 351)
47. 47. Jensen, T.J., Loo, M.A., Pind, S., Williams, D.B., Goldberg, A.L. & Riordan, J.R. (1995). Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell 83, 129-135.
48. 48. Bogyo, M., Gaczynska, M. & Ploegh, H.L. (1997). Proteasome inhibitors and antigen presentation. Biopolymers 43, 269-280.
49. 49. Fenteany, G., Standaert, R.F., Lane, W.S., Choi, S., Corey, E.J. & Schreiber, S.L. (1995). Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268, 726-731.
50. 50. Chin, H., Nakamura, N., Kamiyama, R., Miyasaka, N., Ihle, J.N. & Miura, O. (1996). Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. Blood 88, 4415-4425.
51. 51. Lankford, S.P., Cosson, P., Bonifacino, J.S. & Klausner, R.D. (1993). Transmembrane domain length affects charge-mediated retention and degradation of proteins within the endoplasmic reticulum. J. Biol. Chem. 268, 4814-4820.
52. 52. Hobert, M.E., Kil, S.J., Medof, M.E. & Carlin, C.R. (1997). The cytoplasmie juxtamembrane domain of the epidermal growth factor receptor contains a novel autonomous basolateral sorting determinant. J. Biol. Chem. 272, 32901-32909.
53. 53. Galcheva-Gargova, Z., Theroux, S.J. & Davis, R.J. (1995). The epidermal growth factor receptor is covalently linked to ubiquitin. Oncogene 11, 2649-2655.
54. 54. Strous, G.J., van Kerkhof, P., Covers, R., Ciechanover, A. & Schwartz, A.L. (1996). The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J. 15, 3806-3812.
55. 55. Hiller, M.M., Finger, A., Schweiger, M. & Wolf, D.H. (1996). ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway. Science 273, 1725-1728.
56. 56. Yoshimura, A., Longmore, G. & Lodish, H.F. (1990). Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity. Nature 348, 647-649.