-
1
-
-
0028883828
-
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
-
West of Scotland Coronary Prevention Study Group
-
Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995; 333:1301-1307.
-
(1995)
N Engl J Med
, vol.333
, pp. 1301-1307
-
-
Shepherd, J.1
Cobbe, S.M.2
Ford, I.3
-
2
-
-
0027987849
-
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
-
Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344:1383-1389.
-
(1994)
Lancet
, vol.344
, pp. 1383-1389
-
-
-
3
-
-
0032554676
-
Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS)
-
West of Scotland Coronary Prevention Study Group. Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation. 1998; 97:1440-1445.
-
(1998)
Circulation
, vol.97
, pp. 1440-1445
-
-
-
5
-
-
0036251153
-
SREBPs: Activators of complete program of cholesterol and fatty acid synthesis in the liver
-
Horton JD, Goldstein JL, Brown MS. SREBPs: activators of complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002;109:1125-1131.
-
(2002)
J Clin Invest
, vol.109
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
6
-
-
0036322869
-
Isoprenoids as mediators of the biological effects of statins
-
Liao JK. Isoprenoids as mediators of the biological effects of statins. J Clin Invest. 2002;110:285-288.
-
(2002)
J Clin Invest
, vol.110
, pp. 285-288
-
-
Liao, J.K.1
-
7
-
-
0034994075
-
Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I
-
Martin G, Duez H, Blanquart C, et al. Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I. J Clin Invest. 2001;107:1423-1432.
-
(2001)
J Clin Invest
, vol.107
, pp. 1423-1432
-
-
Martin, G.1
Duez, H.2
Blanquart, C.3
-
9
-
-
0034186204
-
Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients
-
Paolisso G, Barbagallo M, Petrella G, et al. Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients. Atherosclerosis. 2000;150:121-127.
-
(2000)
Atherosclerosis
, vol.150
, pp. 121-127
-
-
Paolisso, G.1
Barbagallo, M.2
Petrella, G.3
-
10
-
-
0033581607
-
First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104
-
Suzuki M, Yanagawa Y, Iwasaki H, et al. First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104. Bioorg Med Chem Lett. 1999;9:2977-2982.
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 2977-2982
-
-
Suzuki, M.1
Yanagawa, Y.2
Iwasaki, H.3
-
11
-
-
0034840928
-
Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors
-
Suzuki M, Iwasaki H, Fujikawa Y, Kitahara M, Sakashita M, Sakoda R. Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors. Bioorg Med Chem. 2001;9:2727-2743.
-
(2001)
Bioorg Med Chem
, vol.9
, pp. 2727-2743
-
-
Suzuki, M.1
Iwasaki, H.2
Fujikawa, Y.3
Kitahara, M.4
Sakashita, M.5
Sakoda, R.6
-
12
-
-
2442682741
-
-
Japanese source
-
-
-
-
13
-
-
0012908222
-
Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
Aoki T, Nishimura H, Nakagawa S, et al. Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 1997;47:904-909.
-
(1997)
Arzneimittelforschung
, vol.47
, pp. 904-909
-
-
Aoki, T.1
Nishimura, H.2
Nakagawa, S.3
-
14
-
-
0022549920
-
A receptor-mediated pathway for cholesterol homeostasis
-
Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science. 1986; 232:34-47.
-
(1986)
Science
, vol.232
, pp. 34-47
-
-
Brown, M.S.1
Goldstein, J.L.2
-
15
-
-
0033613147
-
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
-
Brown MS, Goldstein JL. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci U S A. 1999;96: 11041-11048.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 11041-11048
-
-
Brown, M.S.1
Goldstein, J.L.2
-
16
-
-
0035028119
-
Effect of NK-104, an HMG-CoA reductase inhibitor on lipid metabolism in HepG2 cells
-
Nakagawa S, Tanabe S, Tamaki T, et al. Effect of NK-104, an HMG-CoA reductase inhibitor on lipid metabolism in HepG2 cells. Jpn Pharmacol Ther. 2001;29:51-57.
-
(2001)
Jpn Pharmacol Ther
, vol.29
, pp. 51-57
-
-
Nakagawa, S.1
Tanabe, S.2
Tamaki, T.3
-
17
-
-
0034570787
-
Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells
-
Morikawa S, Umetani M, Nakagawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7:138-144.
-
(2000)
J Atheroscler Thromb
, vol.7
, pp. 138-144
-
-
Morikawa, S.1
Umetani, M.2
Nakagawa, S.3
-
18
-
-
0032822196
-
Hypolipidemic effect of NK-104, a potent HMG-CoA reductase inhibitor, in guinea pigs
-
Suzuki H, Aoki T, Tamaki T, Sato F, Kitahara M, Saito Y. Hypolipidemic effect of NK-104, a potent HMG-CoA reductase inhibitor, in guinea pigs. Atherosclerosis. 1999;146:259-270.
-
(1999)
Atherosclerosis
, vol.146
, pp. 259-270
-
-
Suzuki, H.1
Aoki, T.2
Tamaki, T.3
Sato, F.4
Kitahara, M.5
Saito, Y.6
-
19
-
-
0035139148
-
Hypolipidemic effect of NK-104 and other 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in guinea pigs
-
Suzuki H, Yamazaki H, Aoki T, et al. Hypolipidemic effect of NK-104 and other 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in guinea pigs. Arzneimittelforschung. 2001;51:38-45.
-
(2001)
Arzneimittelforschung
, vol.51
, pp. 38-45
-
-
Suzuki, H.1
Yamazaki, H.2
Aoki, T.3
-
20
-
-
0030859045
-
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and hepatic apolipoprotein B secretion
-
Huff MW, Burnett JR. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and hepatic apolipoprotein B secretion. Curr Opin Lipidol. 1997;8: 138-145.
-
(1997)
Curr Opin Lipidol
, vol.8
, pp. 138-145
-
-
Huff, M.W.1
Burnett, J.R.2
-
21
-
-
0032799925
-
NK-104, a potent new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, enhances posttranslational catabolism of apolipoprotein B-100 and inhibits secretion of apolipoprotein B-100 and triacylglycerols from HepG2 cells
-
Yanagita T, Hara E, Yotsumoto H, et al. NK-104, a potent new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, enhances posttranslational catabolism of apolipoprotein B-100 and inhibits secretion of apolipoprotein B-100 and triacylglycerols from HepG2 cells. Curr Ther Res. 1999;60:423-434.
-
(1999)
Curr Ther Res
, vol.60
, pp. 423-434
-
-
Yanagita, T.1
Hara, E.2
Yotsumoto, H.3
-
22
-
-
12644301168
-
Multiple-dose pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an inhibitor of HMG-CoA reductase, in healthy subjects
-
Cilla DD Jr, Whitfield LR, Gibson DM, Sedman AJ, Posvar EL. Multiple-dose pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an inhibitor of HMG-CoA reductase, in healthy subjects. Clin Pharmacol Ther. 1996;60:687-695.
-
(1996)
Clin Pharmacol Ther
, vol.60
, pp. 687-695
-
-
Cilla Jr., D.D.1
Whitfield, L.R.2
Gibson, D.M.3
Sedman, A.J.4
Posvar, E.L.5
-
23
-
-
0031818309
-
NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery
-
Kitahara M, Kanaki T, Toyoda K, et al. NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery. Jpn J Pharmacol. 1998;77:117-128.
-
(1998)
Jpn J Pharmacol
, vol.77
, pp. 117-128
-
-
Kitahara, M.1
Kanaki, T.2
Toyoda, K.3
-
24
-
-
0042009914
-
Plaque-stabilizing effect of pitavastatin in Watanabe Heritable Hyperlipidemic (WHHL) rabbits
-
Suzuki H, Kobayashi H, Sato F, Yonemitsu Y, Nakashima Y, Sueishi K. Plaque-stabilizing effect of pitavastatin in Watanabe Heritable Hyperlipidemic (WHHL) rabbits. J Atheroscler Thromb. 2003;10:109-116.
-
(2003)
J Atheroscler Thromb
, vol.10
, pp. 109-116
-
-
Suzuki, H.1
Kobayashi, H.2
Sato, F.3
Yonemitsu, Y.4
Nakashima, Y.5
Sueishi, K.6
-
25
-
-
17344385356
-
The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC
-
Morikawa S, Takabe W, Mataki C, et al. The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC. J Atheroscler Thromb. 2002;9(4):178-183.
-
(2002)
J Atheroscler Thromb
, vol.9
, Issue.4
, pp. 178-183
-
-
Morikawa, S.1
Takabe, W.2
Mataki, C.3
-
26
-
-
0041319490
-
Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells
-
Markle RA, Han J, Summers BD, et al. Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells. J Cell Biochem. 2003;90(1):23-32.
-
(2003)
J Cell Biochem
, vol.90
, Issue.1
, pp. 23-32
-
-
Markle, R.A.1
Han, J.2
Summers, B.D.3
-
27
-
-
0034837148
-
Assessment of drug-drug interactions: Concepts and approaches
-
Weaver RJ. Assessment of drug-drug interactions: concepts and approaches. Xenobiotica. 2001;31:499-538.
-
(2001)
Xenobiotica
, vol.31
, pp. 499-538
-
-
Weaver, R.J.1
-
28
-
-
0002549759
-
Studies on the metabolic fate of NK-104, a new inhibitor HMG-CoA reductase (4): Interspecies variation in laboratory animals and humans
-
Fujino H, Kojima J, Yamada Y, et al. Studies on the metabolic fate of NK-104, a new inhibitor HMG-CoA reductase (4): interspecies variation in laboratory animals and humans. Xenobio Metabol Dispos. 1999;14:79-91.
-
(1999)
Xenobio Metabol Dispos
, vol.14
, pp. 79-91
-
-
Fujino, H.1
Kojima, J.2
Yamada, Y.3
-
29
-
-
0141997153
-
Effect of biliary excretion on the pharmacokinetics of pitavastatin in dogs
-
Kojima J, Ohshima T, Yoneda M, Sawada H. Effect of biliary excretion on the pharmacokinetics of pitavastatin in dogs. Xenobio Metabol Dispos. 2001; 16:497-502.
-
(2001)
Xenobio Metabol Dispos
, vol.16
, pp. 497-502
-
-
Kojima, J.1
Ohshima, T.2
Yoneda, M.3
Sawada, H.4
-
30
-
-
0000332988
-
Studies on the metabolic fate of NK-104, a new inhibitor HMG-CoA reductase (1): Absorption, distribution, metabolism and excretion in rats
-
Kimata H, Fujino H, Koide T, et al. Studies on the metabolic fate of NK-104, a new inhibitor HMG-CoA reductase (1): Absorption, distribution, metabolism and excretion in rats. Xenobio Metabol Dispos. 1998;13:484-498.
-
(1998)
Xenobio Metabol Dispos
, vol.13
, pp. 484-498
-
-
Kimata, H.1
Fujino, H.2
Koide, T.3
-
31
-
-
0027392882
-
+-independent multispecific anion transporter mediates active transport of pravastatin into rat liver
-
+-independent multispecific anion transporter mediates active transport of pravastatin into rat liver. Am J Physiol. 1993;264:36-44.
-
(1993)
Am J Physiol
, vol.264
, pp. 36-44
-
-
Yamazaki, M.1
Suzuki, H.2
Sugiyama, Y.3
-
32
-
-
2442676360
-
Uptake mechanism of pitavastatin, a new inhibitor of HMG-CoA reductase, in rat hepatocytes
-
Shimada S, Fujino H, Kojima J, et al. Uptake mechanism of pitavastatin, a new inhibitor of HMG-CoA reductase, in rat hepatocytes. Drug Metab Pharmacokin. 2003;18:245-251.
-
(2003)
Drug Metab Pharmacokin
, vol.18
, pp. 245-251
-
-
Shimada, S.1
Fujino, H.2
Kojima, J.3
-
33
-
-
84990240607
-
Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase - Effect of cMOAT deficiency on hepatobiliary excretion in rats and of mdr1a/b gene disruption on tissue distribution in mice
-
Fujino H, Yamada I, Shimada S, et al. Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase - effect of cMOAT deficiency on hepatobiliary excretion in rats and of mdr1a/b gene disruption on tissue distribution in mice. Drug Metabol Pharmacokin. 2002;17:449-456.
-
(2002)
Drug Metabol Pharmacokin
, vol.17
, pp. 449-456
-
-
Fujino, H.1
Yamada, I.2
Shimada, S.3
-
34
-
-
0030862073
-
Biliary excretion of pravastatin in rats: Contribution of the excretion pathway mediated by cMOAT
-
Yamazaki M, Akiyama S, Sugiyama Y, et al. Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by cMOAT. Drug Metab Dispos. 1997;25:1123-1129.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 1123-1129
-
-
Yamazaki, M.1
Akiyama, S.2
Sugiyama, Y.3
-
35
-
-
0037232458
-
Interaction between several medicines and statins
-
Fujino H, Saito T, Tsunenari Y, et al. Interaction between several medicines and statins. Arzneimittelforschung. 2003;53:145-153.
-
(2003)
Arzneimittelforschung
, vol.53
, pp. 145-153
-
-
Fujino, H.1
Saito, T.2
Tsunenari, Y.3
-
36
-
-
0037235204
-
Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: Human UDP-glucuronosyltransferase enzymes involved in lactonization
-
Fujino H, Yamada I, Shimada S, et al. Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003;33:27-41.
-
(2003)
Xenobiotica
, vol.33
, pp. 27-41
-
-
Fujino, H.1
Yamada, I.2
Shimada, S.3
-
37
-
-
0031736655
-
Metabolism and drug interactions 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor in transplant patients: Are the statins mechanistcally similar?
-
Christians U, Jacobsen W, Floren L. Metabolism and drug interactions 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor in transplant patients: are the statins mechanistcally similar? Pharmacol Ther. 1998;80:1-34.
-
(1998)
Pharmacol Ther
, vol.80
, pp. 1-34
-
-
Christians, U.1
Jacobsen, W.2
Floren, L.3
-
38
-
-
0036233667
-
Glucuronidation of statins in animals and humans: A novel mechanism of statin lactonization
-
Prueksaritanont T, Subramanian R, Fang X. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos. 2002;30:505-512.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 505-512
-
-
Prueksaritanont, T.1
Subramanian, R.2
Fang, X.3
-
39
-
-
0033783036
-
Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atrovastatin
-
Jacobsen W, Kuhn B, Soldner A. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atrovastatin. Drug Metab Dispos. 2000;28:1369-1378.
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 1369-1378
-
-
Jacobsen, W.1
Kuhn, B.2
Soldner, A.3
-
40
-
-
2442705171
-
-
Japanese source
-
-
-
-
41
-
-
2442643806
-
-
Japanese source
-
-
-
-
42
-
-
0141997152
-
-
Geriat Med. 2001;39:849-860.
-
(2001)
Geriat Med
, vol.39
, pp. 849-860
-
-
-
43
-
-
2442682740
-
-
Japanese source
-
-
-
-
44
-
-
2442710077
-
-
Japanese source
-
-
-
-
45
-
-
0033846824
-
Plasma concentrations of active simvastatin acid are increased by gemfibrozil
-
Backman JT, Kyrklund C, Kivisto KT, Wang JS, Neuvonen PJ. Plasma concentrations of active simvastatin acid are increased by gemfibrozil. Clin Pharmacol Ther. 2000;68:122-129.
-
(2000)
Clin Pharmacol Ther
, vol.68
, pp. 122-129
-
-
Backman, J.T.1
Kyrklund, C.2
Kivisto, K.T.3
Wang, J.S.4
Neuvonen, P.J.5
-
46
-
-
0025365041
-
Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy
-
Pierce LR, Wysowski DK, Gross TP. Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. JAMA. 1990;264:71-75.
-
(1990)
JAMA
, vol.264
, pp. 71-75
-
-
Pierce, L.R.1
Wysowski, D.K.2
Gross, T.P.3
-
47
-
-
2442702692
-
-
Japanese source
-
-
-
-
48
-
-
0030868487
-
Specific CYP3A4 inhibitors in grapefruit juice: Furocoumarin dimers as components of drug interaction
-
Fukuda K, Ohta T, Ohshima Y, Ohashi N, Yoshikawa M, Yamazoe Y. Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction. Pharmacogenetics. 1997;7:391-396.
-
(1997)
Pharmacogenetics
, vol.7
, pp. 391-396
-
-
Fukuda, K.1
Ohta, T.2
Ohshima, Y.3
Ohashi, N.4
Yoshikawa, M.5
Yamazoe, Y.6
-
49
-
-
0031790854
-
Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in Caco-2 cells
-
Takanaga H, Ohnishi A, Matsuo H, Sawada Y. Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in Caco-2 cells. Biol Pharm Bull. 1998;21:1062-1066.
-
(1998)
Biol Pharm Bull
, vol.21
, pp. 1062-1066
-
-
Takanaga, H.1
Ohnishi, A.2
Matsuo, H.3
Sawada, Y.4
-
50
-
-
0242645646
-
Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin
-
Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Clin Pharmacol Ther. 1999;66:118-127.
-
(1999)
Clin Pharmacol Ther
, vol.66
, pp. 118-127
-
-
Lilja, J.J.1
Kivisto, K.T.2
Neuvonen, P.J.3
|