Hypolipidemic effect of NK-104 and other 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in guinea pigs

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 1, 2001, Pages 38-45

  Suzuki, H ^a   Yamazaki, H ^a   Aoki, T ^a   Tamaki, T ^a   Sato, F ^a   Kitahara, M ^a   Saito, Y ^a  

^a KOWA COMPANY LTD   (Japan)

Author keywords

(+) Monocalcium bis (3r,5s,6e) 7 2 cyclopropyl 4 (4 fiuorophenyl) 3 quinolyl 3,5 dihydroxy 6 heptenoate ; CAS 147526 32 7; HMG CoA reductase inhibitor; NK 104, endoplasmic reticulum, guinea pig, hypolipidemic effect; Statins

Indexed keywords

APOLIPOPROTEIN E; ATORVASTATIN; CARRIER PROTEIN; CERIVASTATIN; CHOLESTEROL; CHOLESTEROL ESTER; DIACYLGLYCEROL ACYLTRANSFERASE; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; LIVER ENZYME; PITAVASTATIN; PRAVASTATIN; SIMVASTATIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENDOPLASMIC RETICULUM; GUINEA PIG; HYPOLIPEMIA; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; MALE; MICROSOME; NONHUMAN;

EID: 0035139148     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300000     Document Type: Article

References (26)

1. Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
2. Studies on the metabolic fate of NK-104, a new inhibitor of HMG-CoA reductase (4): Interspecies variation in laboratory animals and humans
3. Effects of NK-104, a new hydroxymethylglutaryl-coenzyme A reductase inhibitor, on low-density lipoprotein cholesterol in heterozygous familial hypercholesterolemia
4. Hypolipidemic effect of NK-104, a potent HMG-CoA reductase inhibitor, in guinea pigs
5. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
6. Isolation of plasma membrane, Golgi apparatus, and endoplasmic reticulum fractions from single homogenates of mouse liver
7. Role of acyl CoA: Cholesterol acyltransferase in cholesterol absorption and its inhibition by 57- 118 in the rabbit
8. Diacylglycerol acyltransferase from rat liver microsomes separation and acyldonor specificity
9. Localization of intracellular triacylglycerol and cholesterol ester transfer activity in rat tissues
10. Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin
11. Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: Reduction of MRNA levels for interleukin-1β, interleukin-6, cyclo-oxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor α (PPARα) in primary endothelial cells
12. The evolving role of statins in the management of atherosclerosis
13. Effect of NK-104, a new synthetic HMG-CoA reductase inhibitor, on triglyceride secretion and fatty acid oxidation in rat liver
14. Immunological quantitation and localization of ACAT-1 and ACAT- 2 in human liver and small intestine
15. Tissue-specific expression and cholesterol regulation of acylcoenzyme A: Cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro
16. Activation of acyl-coenzyme A: Cholesterol acyltransferase activity by cholesterol is not due to altered miRNA levels in HepG 2 cells
17. Recombinant acyl-CoA: Cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner
18. Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription
19. Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: Insulin negatively regulates MTP gene expression
20. Inhibition of translocation of nascent apolipoprotein B across the endoplasmic reticulum membrane is associated with selective inhibition of the synthesis of apolipoprotein B
21. The amino-terminal domain of apoB does not undergo retrograde translocation from the ER to the cytosol: Proteasomal degradation of nascent apoB begins at the carboxyl-terminus of the protein while apoB is still in its original translocon
22. Role of lipid synthesis, chaperone proteins and proteasomes in the assembly and secretion of apoprotein B-containing lipoproteins from cultured liver cells
23. Evidence for triacylglycerol synthesis in the lumen of microsomes via a lipolysis-esterification pathway involving carnitine acyltransferases
24. The activity of microsomal triglyceride transfer protein is essential for accumulation of triglyceride within microsomes in McA-RH 7777 cells. A unified model for the assembly of very low density lipoproteins
25. Comparison of statins in hypertriglyceridemia
26. Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients