Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Arzneimittel-Forschung/Drug Research

Volumn 47, Issue 8, 1997, Pages 904-909

  Aoki, Taro ^a   Nishimura, Hiroki ^a   Nakagawa, Shunji ^a   Kojima, Junji ^a   Suzuki, Hideo ^a   Tamaki, Taro ^a   Wada, Yasushi ^a   Yokoo, Nobuo ^a   Sato, Fumiyasu ^a   Kimata, Hideki ^a   Kitahara, Masaki ^b   Toyoda, Kyomi ^b   Sakashita, Mitsuaki ^b   Saito, Yasushi ^c  

^a KOWA COMPANY LTD   (Japan)

^b NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

(+)Monocalcium bis (3R,5S,6E) 7 2 cyclopropyl 4 (4 fluorophenyl) 3 quinolyl 3; 5 dihydroxy 6 heptenoate ; Antihyperlipidemic agents; CAS 147526 32 7; HMG CoA reductase inhibitors; Hypolipidemic effects; NK 104; Pharmacology; Sterol synthesis

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PITAVASTATIN; PRAVASTATIN; SIMVASTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOG; DRUG ACTIVITY; DRUG POTENCY; INTRAPERITONEAL DRUG ADMINISTRATION; LIPID METABOLISM; MALE; NONHUMAN; RAT; STEROL METABOLISM; STEROL SYNTHESIS; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTILIPEMIC AGENTS; DOGS; ENZYME INHIBITORS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINETICS; LIPIDS; LIVER; LOVASTATIN; MALE; PRAVASTATIN; QUINOLINES; RATS; RATS, WISTAR; SIMVASTATIN; STEROLS;

EID: 0012908222     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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