Modeling and interactions of Aspergillus fumigatus lanosterol 14-α demethylase 'A' with azole antifungals

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 11, 2004, Pages 2937-2950

  Gollapudy, Reena ^a   Ajmani, Subhash ^a   Kulkarni, Sudhir A ^a  

^a VLife Sciences Technologies   (India)

Author keywords

Antifungal azoles; Aspergillus fumigatus; Docking; Molecular modeling; Mycobacterium tuberculosis

Indexed keywords

2 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 4 [4 (2,2,3,3 TETRAFLUOROPROPOXY)PHENYL] 1,2,4 TRIAZOL 3(2H) ONE; ANTIFUNGAL AGENT; FLUCONAZOLE; ITRACONAZOLE; J1 114; KETOCONAZOLE; OXICONAZOLE; PYRROLE DERIVATIVE; RAVUCONAZOLE; SANKYO; SCH 43427; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG; VORICONAZOLE;

ARTICLE; ASPERGILLUS FUMIGATUS; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; DRUG TARGETING; ENZYME STRUCTURE; MODEL; MYCOBACTERIUM TUBERCULOSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; AZOLES; BINDING SITES; COMPUTATIONAL BIOLOGY; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; FUNGAL PROTEINS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT;

ASPERGILLUS; ASPERGILLUS FUMIGATUS; FUNGI; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 2442514053     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.034     Document Type: Article

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