New inhibitors of thrombin and other trypsin-like proteases: Hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain

Biochemistry

Volumn 36, Issue 43, 1997, Pages 13180-13186

  Lee, Sheng Lian ^a   Alexander, Richard S ^a   Smallwood, Angela ^a   Trievel, Raymond ^a,b   Mersinger, Lawrence ^a   Weber, Patricia C ^a,c   Kettner, Charles ^a  

^a DUPONT COMPANY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; CHYMOTRYPSIN; KALLIKREIN; PHENYLALANINE; THROMBIN INHIBITOR; THROMBOPLASTIN; TRYPSIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD CLOTTING; CRYSTAL STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMIDES; BINDING SITES; BORONIC ACIDS; CRYSTALLOGRAPHY, X-RAY; CYANIDES; HUMANS; HYDROGEN BONDING; MACROMOLECULAR SUBSTANCES; OLIGOPEPTIDES; PHENYLALANINE; PROLINE; PROTEIN BINDING; SERINE ENDOPEPTIDASES; THROMBIN; TRYPSIN INHIBITORS;

EID: 0030783589     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970912m     Document Type: Article

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