Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus

Neuroscience

Volumn 115, Issue 2, 2002, Pages 515-524

  Jung, B P ^a,c   Zhang, G ^a   Ho, W ^a,c   Francis, J ^a,b   Eubanks, J H ^a,b,c,d  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d NONE   (Canada)

Author keywords

Chromatin; Epigenetics; Neurodegeneration; Stroke; Transcription factor

Indexed keywords

METHYL CPG BINDING PROTEIN; METHYL CPG BINDING PROTEIN 1; METHYL CPG BINDING PROTEIN 2; METHYL GROUP; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; BRAIN ISCHEMIA; CONTROLLED STUDY; DENTATE GYRUS; DISEASE ACTIVITY; DNA BINDING; FOREBRAIN; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIPPOCAMPUS; MALE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; TRANSIENT ISCHEMIC ATTACK;

AGE FACTORS; ANIMALS; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA-BINDING PROTEINS; GENE EXPRESSION; HIPPOCAMPUS; ISCHEMIC ATTACK, TRANSIENT; MALE; METHYL-CPG-BINDING PROTEIN 2; NERVE DEGENERATION; RATS; RATS, WISTAR; REPRESSOR PROTEINS; RNA, MESSENGER;

EID: 0037146613     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00383-4     Document Type: Article

References (40)

1. Akins P.T., Liu P.K., Hsu C.Y. Immediate early gene expression in response to cerebral ischemia. Friend or foe? Stroke. 27:1996;1682-1687.
2. Bird A., Wolffe A.P. Methylation-induced repression - belts, braces, and chromatin. Cell. 99:1999;451-454.
3. Boyes J., Bird A. Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein. EMBO J. 11:1992;327-333.
4. Cedar H. DNA methylation and gene activity. Cell. 53:1988;3-4.
5. Cross S.H., Bird A.P. CpG islands and genes. Curr. Opin. Genet. Dev. 5:1995;309-314.
6. Cross S.H., Meehan R., Nan X., Bird A. A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nat. Genet. 16:1997;256-259.
7. Endres M., Meisel A., Biniszkiewicz D., Namura S., Prass K., Ruscher K., Lipski A., Jaenisch R., Moskowitz M.A., Dirnagl U. DNA methyltransferase contributes to delayed ischemic brain injury. J. Neurosci. 20:2000;3175-3181.
8. Feng Q., Cao R., Xia L., Erdjument-Bromage H., Tempst P., Zhang Y. Identification and functional characterization of the p66/p68 components of the MeCP1 complex. Mol. Cell. Biol. 22:2002;536-546.
9. Feng Q., Zhang Y. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev. 15:2001;827-832.
10. Francis J., Jung B.P., Zhang G., Cheng J., Ho W., Burnham W.M., Eubanks J.H. Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Neuroscience. 113:2001;79-87.
11. Francis J., Zhang Y., Ho W., Wallace M.C., Zhang L., Eubanks J.H. Decreased hippocampal expression, but not functionality, of GABA(B) receptors after transient cerebral ischemia in rats. J. Neurochem. 72:1999;87-94.
12. Frantseva M.V., Perez-Velazquez J.L., Tsoraklidis G., Mendonca A.J., Adamchik Y., Mills L.R., Carlen P.L., Burnham W.M. Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy. Neuroscience. 97:2000;431-543.
13. Goto K., Ishige A., Sekiguchi K., Iizuka S., Sugimoto A., Yuzurihara M., Aburada M., Hosoya E., Kogure K. Effects of cycloheximide on delayed neuronal death in rat hippocampus. Brain Res. 534:1990;299-302.
14. Hendrich B., Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol. Cell. Biol. 18:1998;6538-6547.
15. Hendrich B., Guy J., Ramsahoye B., Wilson V.A., Bird A. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev. 15:2001;710-723.
16. Hendrich B., Hardeland U., Ng H.H., Jiricny J., Bird A. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature. 401:1999;301-304.
17. Hsu J.C., Takagi N., Zhang Y., Gurd J.W., Wallace M.C., Zhang L., Eubanks J.H. Decreased expression and functionality of nmda receptor complexes persist in the ca1, but not in the dentate gyrus after transient cerebral ischemia. J. Cereb. Blood Flow Metab. 18:1998;768-775.
18. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:1982;57-69.
19. Lewis J.D., Meehan R.R., Henzel W.J., Maurer-Fogy I., Jeppesen P., Klein F., Bird A. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell. 69:1992;905-914.
20. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 79:1999;1431-1568.
21. MacManus J.P., Linnik M.D. Gene expression induced by cerebral ischemia: an apoptotic perspective. J. Cereb. Blood Flow Metab. 17:1997;815-832.
22. Maldonado E., Hampsey M., Reinberg D. Repression: targeting the heart of the matter. Cell. 99:1999;455-458.
23. Meehan R.R., Lewis J.D., McKay S., Kleiner E.L., Bird A.P. Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell. 58:1989;499-507.
24. Nan X., Ng H.H., Johnson C.A., Laherty C.D., Turner B.M., Eisenman R.N., Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP-2 involves a histone deacetylase complex. Nature. 393:1998;386-389.
25. Ng H.H., Jeppesen P., Bird A. Active repression of methylated genes by the chromosomal protein MBD1. Mol. Cell. Biol. 20:2000;1394-1406.
26. Ng H.H., Zhang Y., Hendrich B., Johnson C.A., Turner B.M., Erdjument-Bromage H., Tempst P., Reinberg D., Bird A. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat. Genet. 23:1999;58-61.
27. Petito C., Feldmann E., Pulsinelli W.A., Plum F. Delayed hippocampal damage in humans following cardio-respiratory arrest. Neurology. 37:1987;1281-1286.
28. Pulsinelli W.A., Brierley J.B. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke. 10:1979;267-272.
29. Pulsinelli W.A., Brierley J., Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11:1982;491-498.
30. Razin A. CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J. 17:1998;4905-4908.
31. Shahbazian M.D., Antalffy B., Armstrong D.L., Zoghbi H.Y. Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum. Mol. Genet. 11:2002;115-124.
32. Shigeno T., Yamasaki Y., Kato G., Kusaka K., Mima T., Takakura K., Graham D.I., Furukawa S. Reduction of delayed neuronal death by inhibition of protein synthesis. Neurosci. Lett. 120:1990;117-119.
33. Shinno K., Zhang L., Eubanks J.H., Carlen P.L., Wallace M.C. Transient ischemia induces an early decrease of synaptic transmission in CA1 neurons of rat hippocampus: electrophysiological study in brain slices. J. Cereb. Blood Flow Metab. 17:1997;955-966.
34. Simmons D., Arriza J., Swanson L. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radio-labeled single-stranded RNA probes. J. Histotechnol. 12:1989;169-181.
35. Struhl K. Fundamentally different logic of gene regulation in eukaryotes and prokaryotes. Cell. 98:1999;1-4.
36. Tatematsu K.I., Yamazaki T., Ishikawa F. MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. Genes Cells. 5:2000;677-688.
37. Tortosa A., Rivera R., Ferrer I. Dose-related effects of cycloheximide on delayed neuronal death in the gerbil hippocampus after bilateral transitory forebrain ischemia. J. Neurol. Sci. 121:1994;10-17.
38. Wigle D., Ho W., Lo D., Francis J., Eubanks J.H., Wallace M.C. Altered expression levels of SEF-2 and p112 in the rat hippocampus after transient cerebral ischemia: identification by mRNA differential display. J. Cereb. Blood Flow Metab. 19:1999;435-442.
39. Zhang L., Hsu J.C., Takagi N., Gurd J.W., Wallace M.C., Eubanks J.H. Transient global ischemia alters NMDA receptor expression in rat hippocampus: correlation with decreased immunoreactive protein levels of the NR2A/2B subunits, and an altered NMDA receptor functionality. J. Neurochem. 69:1997;1983-1994.
40. Zhang Y., Ng H., Erdjument-Bromage H., Tempst P., Bird A., Reinberg D. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13:1999;1924-1935.