-
1
-
-
0035939903
-
Delineation of prognostic biomarkers in prostate cancer
-
Dhanasekaran SM, Barrette TR, Ghosh D, et al. Delineation of prognostic biomarkers in prostate cancer. Nature 2001;412:822-6.
-
(2001)
Nature
, vol.412
, pp. 822-826
-
-
Dhanasekaran, S.M.1
Barrette, T.R.2
Ghosh, D.3
-
2
-
-
0141569009
-
Myc-driven murine prostate cancer shares molecular features with human prostate tumors
-
Ellwood-Yen K, Graeber TG, Wongvipat J, et al. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell 2003;4:223-38.
-
(2003)
Cancer Cell
, vol.4
, pp. 223-238
-
-
Ellwood-Yen, K.1
Graeber, T.G.2
Wongvipat, J.3
-
3
-
-
0024595556
-
Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors
-
van Lohuizen M, Verbeek S, Krimpenfort P, et al. Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell 1989;56:673-82.
-
(1989)
Cell
, vol.56
, pp. 673-682
-
-
Van Lohuizen, M.1
Verbeek, S.2
Krimpenfort, P.3
-
4
-
-
0025863346
-
Identification of cooperating oncogenes in e mu-myc transgenic mice by provirus tagging
-
van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 1991;65:737-52.
-
(1991)
Cell
, vol.65
, pp. 737-752
-
-
Lohuizen, M.1
Verbeek, S.2
Scheijen, B.3
Wientjens, E.4
Van Der Gulden, H.5
Berns, A.6
-
5
-
-
0026525243
-
Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally related
-
Lilly M, Le T, Holland P, Hendrickson SL. Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally related. Oncogene 1992;7:727-32.
-
(1992)
Oncogene
, vol.7
, pp. 727-732
-
-
Lilly, M.1
Le, T.2
Holland, P.3
Hendrickson, S.L.4
-
6
-
-
0030953788
-
The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells
-
Sakai I, Kraft AS. The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells. J Biol Chem 1997;272:12350-8.
-
(1997)
J Biol Chem
, vol.272
, pp. 12350-12358
-
-
Sakai, I.1
Kraft, A.S.2
-
7
-
-
0027057533
-
Interleukin 2 and tumor necrosis factor α are complementary for proliferation of the hematopoietic stem cell line LyD9
-
Saito Y, Tada H, Nazarea M, Honjo T. Interleukin 2 and tumor necrosis factor α are complementary for proliferation of the hematopoietic stem cell line LyD9. Growth Factors 1992;7:297-303.
-
(1992)
Growth Factors
, vol.7
, pp. 297-303
-
-
Saito, Y.1
Tada, H.2
Nazarea, M.3
Honjo, T.4
-
8
-
-
0035964820
-
Pim-1 translocates sorting nexin 6/ TRAF4-associated factor 2 from cytoplasm to nucleus
-
Ishibashi Y, Maita H, Yano M, et al. Pim-1 translocates sorting nexin 6/ TRAF4-associated factor 2 from cytoplasm to nucleus. FEBS Lett 2001;506:33-8.
-
(2001)
FEBS Lett
, vol.506
, pp. 33-38
-
-
Ishibashi, Y.1
Maita, H.2
Yano, M.3
-
9
-
-
0036697292
-
Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1
-
Xu LG, Wu M, Hu J, Zhai Z, Shu HB. Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1. J Leukoc Biol 2002;72:410-6.
-
(2002)
J Leukoc Biol
, vol.72
, pp. 410-416
-
-
Xu, L.G.1
Wu, M.2
Hu, J.3
Zhai, Z.4
Shu, H.B.5
-
10
-
-
0030609009
-
r 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells
-
r 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells. Cancer Res 1997;57:5348-55.
-
(1997)
Cancer Res
, vol.57
, pp. 5348-5355
-
-
Lilly, M.1
Kraft, A.2
-
11
-
-
0042626302
-
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
-
Fox CJ, Hammerman PS, Cinalli RM, Master SR, Chodosh LA, Thompson CB. The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev 2003;17:1841-54.
-
(2003)
Genes Dev
, vol.17
, pp. 1841-1854
-
-
Fox, C.J.1
Hammerman, P.S.2
Cinalli, R.M.3
Master, S.R.4
Chodosh, L.A.5
Thompson, C.B.6
-
12
-
-
0242580961
-
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
-
Yan B, Zemskova M, Holder S, et al. The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J Biol Chem 2003;278:45358-67.
-
(2003)
J Biol Chem
, vol.278
, pp. 45358-45367
-
-
Yan, B.1
Zemskova, M.2
Holder, S.3
-
13
-
-
0033536203
-
The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway
-
Lilly M, Sandholm J, Cooper JJ, Koskinen PJ, Kraft A. The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway. Oncogene 1999;18:4022-31.
-
(1999)
Oncogene
, vol.18
, pp. 4022-4031
-
-
Lilly, M.1
Sandholm, J.2
Cooper, J.J.3
Koskinen, P.J.4
Kraft, A.5
-
14
-
-
0033451992
-
Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
-
Shirogane T, Fukada T, Muller JM, Shima DT, Hibi M, Hirano T. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 1999;11:709-19.
-
(1999)
Immunity
, vol.11
, pp. 709-719
-
-
Shirogane, T.1
Fukada, T.2
Muller, J.M.3
Shima, D.T.4
Hibi, M.5
Hirano, T.6
-
16
-
-
0033959911
-
Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)
-
Koike N, Maita H, Taira T, Ariga H, Iguchi-Ariga SM. Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1). FEBS Lett 2000;467:17-21.
-
(2000)
FEBS Lett
, vol.467
, pp. 17-21
-
-
Koike, N.1
Maita, H.2
Taira, T.3
Ariga, H.4
Iguchi-Ariga, S.M.5
-
17
-
-
0033603454
-
Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway
-
Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y. Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J Biol Chem 1999;274:18659-66.
-
(1999)
J Biol Chem
, vol.274
, pp. 18659-18666
-
-
Mochizuki, T.1
Kitanaka, C.2
Noguchi, K.3
Muramatsu, T.4
Asai, A.5
Kuchino, Y.6
-
18
-
-
0037133208
-
Pim serine/threonine kinases regulate the stability of Socs-1 protein
-
Chen XP, Losman JA, Cowan S, et al. Pim serine/threonine kinases regulate the stability of Socs-1 protein. Proc Natl Acad Sci U S A 2002;99:2175-80.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 2175-2180
-
-
Chen, X.P.1
Losman, J.A.2
Cowan, S.3
-
19
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002;16:1472-87.
-
(2002)
Genes Dev
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
20
-
-
0036830256
-
Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells
-
Grunwald V, DeGraffenried L, Russel D, Friedrichs WE, Ray RB, Hidalgo M. Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells. Cancer Res 2002;62:6141-5.
-
(2002)
Cancer Res
, vol.62
, pp. 6141-6145
-
-
Grunwald, V.1
Degraffenried, L.2
Russel, D.3
Friedrichs, W.E.4
Ray, R.B.5
Hidalgo, M.6
-
21
-
-
0033153166
-
Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
-
Gingras AC, Gygi SP, Raught B, et al. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev 1999;13:1422-37.
-
(1999)
Genes Dev
, vol.13
, pp. 1422-1437
-
-
Gingras, A.C.1
Gygi, S.P.2
Raught, B.3
-
22
-
-
0035498939
-
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
-
Gingras AC, Raught B, Gygi SP, et al. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev 2001;15:2852-64.
-
(2001)
Genes Dev
, vol.15
, pp. 2852-2864
-
-
Gingras, A.C.1
Raught, B.2
Gygi, S.P.3
-
23
-
-
0037373346
-
The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation
-
Wang X, Li W, Parra JL, Beugnet A, Proud CG. The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol Cell Biol 2003;23:1546-57.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 1546-1557
-
-
Wang, X.1
Li, W.2
Parra, J.L.3
Beugnet, A.4
Proud, C.G.5
-
24
-
-
2942544833
-
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells
-
Avdulov S, Li S, Michalek V, et al. Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 2004;5:553-63.
-
(2004)
Cancer Cell
, vol.5
, pp. 553-563
-
-
Avdulov, S.1
Li, S.2
Michalek, V.3
-
25
-
-
0037192868
-
The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites
-
Herbert TP, Tee AR, Proud CG. The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. J Biol Chem 2002;277:11591-6.
-
(2002)
J Biol Chem
, vol.277
, pp. 11591-11596
-
-
Herbert, T.P.1
Tee, A.R.2
Proud, C.G.3
-
26
-
-
0032520009
-
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
-
Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev 1998;12:502-13.
-
(1998)
Genes Dev
, vol.12
, pp. 502-513
-
-
Gingras, A.C.1
Kennedy, S.G.2
O'Leary, M.A.3
Sonenberg, N.4
Hay, N.5
-
27
-
-
0345268731
-
Pim-1 protein kinase is nuclear in Burkitt's lymphoma: Nuclear localization is necessary for its biologic effects
-
Ionov Y, Le X, Tunquist BJ, et al. Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects. Anticancer Res 2003;23:167-78.
-
(2003)
Anticancer Res
, vol.23
, pp. 167-178
-
-
Ionov, Y.1
Le, X.2
Tunquist, B.J.3
-
28
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov DD, Ali SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004;14:1296-302.
-
(2004)
Curr Biol
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
-
29
-
-
0029808294
-
Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
-
Di Como CJ, Arndt KT. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev 1996;10:1904-16.
-
(1996)
Genes Dev
, vol.10
, pp. 1904-1916
-
-
Di Como, C.J.1
Arndt, K.T.2
-
30
-
-
0026504296
-
A single gene encodes two isoforms of the p70 S6 kinase: Activation upon mitogenic stimulation
-
Reinhard C, Thomas G, Kozma SC. A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation. Proc Natl Acad Sci USA 1992;89:4052-6.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4052-4056
-
-
Reinhard, C.1
Thomas, G.2
Kozma, S.C.3
-
31
-
-
15744396300
-
Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase l required for its mammalian target of rapamycin-dependent regulation
-
Schalm SS, Tee AR, Blenis J. Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase l required for its mammalian target of rapamycin-dependent regulation. J Biol Chem 2005;280:11101-6.
-
(2005)
J Biol Chem
, vol.280
, pp. 11101-11106
-
-
Schalm, S.S.1
Tee, A.R.2
Blenis, J.3
-
32
-
-
2342489456
-
eIF-4E expression and its role in malignancies and metastases
-
De Benedetti A, Graff JR. eIF-4E expression and its role in malignancies and metastases. Oncogene 2004;23:3189-99.
-
(2004)
Oncogene
, vol.23
, pp. 3189-3199
-
-
De Benedetti, A.1
Graff, J.R.2
-
33
-
-
0028207001
-
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family
-
Jefferies HB, Reinhard C, Kozma SC, Thomas G. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc Natl Acad Sci U S A 1994;91:4441-5.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 4441-4445
-
-
Jefferies, H.B.1
Reinhard, C.2
Kozma, S.C.3
Thomas, G.4
-
34
-
-
0034306997
-
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
-
Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 2000;14:2501-14.
-
(2000)
Genes Dev
, vol.14
, pp. 2501-2514
-
-
Sears, R.1
Nuckolls, F.2
Haura, E.3
Taya, Y.4
Tamai, K.5
Nevins, J.R.6
-
35
-
-
2942650133
-
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
-
Welcker M, Orian A, Jin J, et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 2004;101:9085-90.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9085-9090
-
-
Welcker, M.1
Orian, A.2
Jin, J.3
-
36
-
-
2342526543
-
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
-
Yeh E, Cunningham M, Arnold H, et al. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol 2004;6:308-18.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 308-318
-
-
Yeh, E.1
Cunningham, M.2
Arnold, H.3
-
37
-
-
0033006919
-
eIF4E activity is regulated at multiple levels
-
Raught B, Gingras AC. eIF4E activity is regulated at multiple levels. Int J Biochem Cell Biol 1999;31:43-57.
-
(1999)
Int J Biochem Cell Biol
, vol.31
, pp. 43-57
-
-
Raught, B.1
Gingras, A.C.2
-
38
-
-
0034624746
-
Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1
-
Tan A, Bitterman P, Sonenberg N, Peterson M, Polunovsky V. Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1. Oncogene 2000;19:1437-47.
-
(2000)
Oncogene
, vol.19
, pp. 1437-1447
-
-
Tan, A.1
Bitterman, P.2
Sonenberg, N.3
Peterson, M.4
Polunovsky, V.5
-
39
-
-
0035856918
-
c-Myc regulates mammalian body size by controlling cell number but not cell size
-
Trumpp A, Refaeli Y, Oskarsson T, et al. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 2001;414:768-73.
-
(2001)
Nature
, vol.414
, pp. 768-773
-
-
Trumpp, A.1
Refaeli, Y.2
Oskarsson, T.3
-
40
-
-
8544263854
-
Lymphocyte transformation by Pim-2 is dependent on nuclear factor-κB activation
-
Hammerman PS, Fox CJ, Cinalli RM, et al. Lymphocyte transformation by Pim-2 is dependent on nuclear factor-κB activation. Cancer Res 2004;64:8341-8.
-
(2004)
Cancer Res
, vol.64
, pp. 8341-8348
-
-
Hammerman, P.S.1
Fox, C.J.2
Cinalli, R.M.3
-
41
-
-
17344381954
-
Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast
-
Duvel K, Santhanam A, Garrett S, Schneper L, Broach JR. Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast. Mol Cell 2003;11:1467-78.
-
(2003)
Mol Cell
, vol.11
, pp. 1467-1478
-
-
Duvel, K.1
Santhanam, A.2
Garrett, S.3
Schneper, L.4
Broach, J.R.5
-
42
-
-
0037799220
-
Protein phosphatase 2A regulates the stability of Pim protein kinases
-
Losman JA, Chen XP, Vuong BQ, Fay, S, Rothman PB. Protein phosphatase 2A regulates the stability of Pim protein kinases. J Biol Chem 2003;278:4800-5.
-
(2003)
J Biol Chem
, vol.278
, pp. 4800-4805
-
-
Losman, J.A.1
Chen, X.P.2
Vuong, B.Q.3
Fay, S.4
Rothman, P.B.5
-
43
-
-
1442310493
-
Identification of specific PP2A complexes involved in human cell transformation
-
Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC. Identification of specific PP2A complexes involved in human cell transformation. Cancer Cell 2004;5:127-36.
-
(2004)
Cancer Cell
, vol.5
, pp. 127-136
-
-
Chen, W.1
Possemato, R.2
Campbell, K.T.3
Plattner, C.A.4
Pallas, D.C.5
Hahn, W.C.6
-
44
-
-
2642527835
-
Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway
-
Thyrell L, Hjortsberg L, Arulampalam V, et al. Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. J Biol Chem 2004;279:24152-62.
-
(2004)
J Biol Chem
, vol.279
, pp. 24152-24162
-
-
Thyrell, L.1
Hjortsberg, L.2
Arulampalam, V.3
-
45
-
-
0037115394
-
Constitutive activation of Akt/ protein kinase B in melanoma leads to up-regulation of nuclear factor-κB and tumor progression
-
Dhawan P, Singh AB, Ellis DL, Richmond A. Constitutive activation of Akt/ protein kinase B in melanoma leads to up-regulation of nuclear factor-κB and tumor progression. Cancer Res 2002;62:7335-42.
-
(2002)
Cancer Res
, vol.62
, pp. 7335-7342
-
-
Dhawan, P.1
Singh, A.B.2
Ellis, D.L.3
Richmond, A.4
-
46
-
-
2542451727
-
Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion
-
Zhang HM, Rao JN, Guo X, et al. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. J Biol Chem 2004;279:22539-47.
-
(2004)
J Biol Chem
, vol.279
, pp. 22539-22547
-
-
Zhang, H.M.1
Rao, J.N.2
Guo, X.3
-
47
-
-
0141705466
-
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin
-
El-Hashemite N, Walker V, Zhang H, Kwiatkowski DJ. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res 2003;63:5l73-7.
-
(2003)
Cancer Res
, vol.63
-
-
El-Hashemite, N.1
Walker, V.2
Zhang, H.3
Kwiatkowski, D.J.4
-
48
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002;4:648-57.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
49
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 1999;344 Pt 2:427-31.
-
(1999)
Biochem J
, vol.344
, Issue.PART 2
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
50
-
-
0030632044
-
Phosphorylation site substrate specificity determinants for the Pim-1 protooncogene-encoded protein kinase
-
Palaty CK, Clark-Lewis I, Leung D, Pelech SL. Phosphorylation site substrate specificity determinants for the Pim-1 protooncogene-encoded protein kinase. Biochem Cell Biol 1997;75:153-62.
-
(1997)
Biochem Cell Biol
, vol.75
, pp. 153-162
-
-
Palaty, C.K.1
Clark-Lewis, I.2
Leung, D.3
Pelech, S.L.4
-
52
-
-
0035964367
-
Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
-
Mills GB, Lu Y, Kohn EC. Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci USA 2001;98:10031-3.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10031-10033
-
-
Mills, G.B.1
Lu, Y.2
Kohn, E.C.3
-
53
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A 2001;98:10314-9.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
-
54
-
-
0842304369
-
Mammalian target of rapamycin inhibition as therapy for hematologic malignancies
-
Panwalkar A, Verstovsek S, Giles FJ. Mammalian target of rapamycin inhibition as therapy for hematologic malignancies. Cancer 2004;100:657-66.
-
(2004)
Cancer
, vol.100
, pp. 657-666
-
-
Panwalkar, A.1
Verstovsek, S.2
Giles, F.J.3
-
55
-
-
0036735346
-
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
-
Shi Y, Gera J, Hu L, et al. Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res 2002;62:5027-34.
-
(2002)
Cancer Res
, vol.62
, pp. 5027-5034
-
-
Shi, Y.1
Gera, J.2
Hu, L.3
-
56
-
-
0032126505
-
Frequent inactivation of PTEN in prostate cancer cell lines and xenografts
-
Vlietstra RJ, van Alewijk DC, Hermans KG, van Steenbrugge GJ, Trapman J. Frequent inactivation of PTEN in prostate cancer cell lines and xenografts. Cancer Res 1998;58:2720-3.
-
(1998)
Cancer Res
, vol.58
, pp. 2720-2723
-
-
Vlietstra, R.J.1
Van Alewijk, D.C.2
Hermans, K.G.3
Van Steenbrugge, G.J.4
Trapman, J.5
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