Development of a generic dual-reporter gene assay for screening G-protein-coupled receptors

Journal of Biomolecular Screening

Volumn 10, Issue 5, 2005, Pages 437-446

  Kent, Toby C ^a,c   Thompson, Kevin S J ^b   Naylor, Louise H ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b Akubio Ltd   (United Kingdom)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Drug discovery; G protein coupled receptor; High throughput screening; Intracellular signaling; Multiplexed; Reporter gene

Indexed keywords

ALPHA INTERMEDIN; CARBACHOL; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HS 024; LUCIFERASE; PHENYLEPHRINE; PHORBOL 13 ACETATE 12 MYRISTATE; PRAZOSIN; PROPYLNORAPOMORPHINE; REMOXIPRIDE;

ARTICLE; CELL STRAIN HEK293; CHIMERA; CYCLIC AMP RESPONSIVE ELEMENT; HIGH THROUGHPUT SCREENING; LIGAND BINDING; LUCIFERASE GENE; PRIORITY JOURNAL; REPORTER GENE;

ANIMALS; BIOTECHNOLOGY; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FIREFLIES; GENE LIBRARY; GENES, REPORTER; GENETIC TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LIGANDS; LUCIFERASES; RECEPTORS, CELL SURFACE; RECEPTORS, DOPAMINE D2; RECEPTORS, G-PROTEIN-COUPLED; RESPONSE ELEMENTS; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

RENILLA LUCIFERASE;

EID: 24144452791     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087057105275033     Document Type: Article

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