A constitutively active mutant of the α1B-adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins Gqα and G11α than the wild-type receptor

Biochemical Journal

Volumn 320, Issue 1, 1996, Pages 79-86

  Lee, Tae Weon ^a   Wise, Alan ^a   Cotecchia, Susanna ^b   Milligan, Graeme ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1B ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; MUTANT PROTEIN; NORADRENALIN; PHENYLEPHRINE;

ANIMAL CELL; ARTICLE; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; DNA TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; CRICETINAE; DNA, COMPLEMENTARY; DOWN-REGULATION; GTP-BINDING PROTEINS; HUMANS; INOSITOL PHOSPHATES; KINETICS; NOREPINEPHRINE; PHENYLEPHRINE; POLYMERASE CHAIN REACTION; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; TRANSFECTION;

ANIMALIA; CRICETINAE;

EID: 0029822338     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3200079     Document Type: Article

References (34)

1. Milligan, G., Svoboda, P. and Brown, C. M. (1994) Biochem. Pharmacol. 48, 1059-1071
2. Bylund, D. B. (1992) FASEB J. 6, 832-839
3. Samama, P., Cotecchia, S., Costa, T. and Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 4625-4636
4. Pei, G., Samama, P., Lohse, M., Wang, M., Codina, J. and Lefkowitz, R. J. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 2699-2702
5. Cotecchia, S., Exum, S., Caron, M. G. and Lefkowitz, R. J. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 2896-2900
6. Kjelsberg, M. A., Cotecchia, S., Ostrowski, J., Caron, M. G. and Lefkowitz, R. J. (1993) J. Biol. Chem. 267, 1633-1639
7. Allen, L. F., Lefkowitz, R. J., Caron, M. G. and Cotecchia, S. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 11354-11358
8. Dohlman, H. G., Thorner, J., Caron, M. G. and Lefkowitz, R. J. (1991) Annu. Rev. Biochem. 60, 653-688
9. Milligan, G. (1993) Trends Pharmacol. Sci. 14, 413-418
10. Wise, A., Lee, T. W., MacEwan, D. J. and Milligan, G. (1995) J. Biol. Chem. 270, 17196-17203
11. Plevin, R., Palmer, S., Gardner, S. D. and Wakelam, M. J. O. (1990) Biochem. J. 268, 605-610
12. MacNulty, E. E., McClue, S. J., Carr, I. C., Jess, T., Wakelam, M. J. O. and Milligan, G. (1992) J. Biol. Chem. 267, 2149-2156
13. Mitchell, F. M., Mullaney, I., Godfrey, P. P., Arkinstall, S. J., Wakelam, M. J. O. and Milligan, G. (1991) FEBS Lett. 287, 171-174
14. Shah, B. H. and Milligan, G. (1994) Mol. Pharmacol. 48, 1-7
15. McKenzie, F. R. and Milligan, G. (1990) Biochem. J. 267, 391-398
16. Cotecchia, S., Lattion, A. L., Daviani, D. and Cavilli, A. (1995) Biochem. Soc. Trans. 20, 121-125
17. Shenker, A., Laue, L., Kosugi, S., Merendino, Jr., J. J., Minegishi, T. and Cutler, Jr., G. B. (1993) Nature (London) 365, 652-654
18. Parma, J., Duprez, L., Van Sande, J., Cochaux, P., Gervy, C., Mockel, J., Dumont, J. and Vassart, G. (1993) Nature (London) 365, 649-651
19. Raymond, J. R. (1994) Am. J. Physiol. 266, F163-F174
20. Coughlin, S. R. (1994) Curr. Opin. Cell. Biol. 6, 191-197
21. Lefkowitz, R. J., Cotecchia, S., Samama, P. and Costa, T. (1993) Trends Pharmacol. Sci. 14, 303-307
22. Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., Johnson, T. D., Bond, R. A. and Lefkowitz, R. J. (1994) Science 264, 582-586
23. Adie, E. J. and Milligan, G. (1994) Biochem. J. 303, 803-808
24. Chidiac, P., Hebert, T. E., Valiquette, M., Dennis, M. and Bouvier, M. (1994) Mol. Pharmacol. 45, 490-499
25. Samama, P., Pei, G., Costa, T., Cotecchia, S. and Lefkowitz, R. J. (1994) Mol. Pharmacol. 45, 390-394
26. Milligan, G., Bond, R. A. and Lee, M. (1995) Trends Pharmacol. Sci. 16, 10-13
27. Gether, U., Lin, S. S. and Kobilka, B. K. (1995) J. Biol. Chem. 270, 28268-28275
28. Mitchell, F. M., Buckley, N. J. and Milligan, G. (1993) Biochem. J. 293, 495-499
29. Shah, B. H., MacEwan, D. J. and Milligan, G. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 1886-1890
30. van de Westerlo, E., Yang, J., Logsdon, C. and Williams, J. A. (1995) Biochem. J. 310, 559-563
31. Levis, M. J. and Bourne, H. R. (1992) J. Cell. Biol. 119, 1297-1307
32. Mullaney, I., Shah, B. H., Wise, A. and Milligan, G. (1995) J. Neurochem. 65, 545-553
33. Adie, E. J. and Milligan, G. (1994) Biochem. J. 300, 709-715
34. MacEwan, D. J., Kim, G. D. and Milligan, G. (1995) Mol. Pharmacol. 48, 316-325