Effect of cyanidin 3-O-β-glucopyranoside on hepatic stellate cell proliferation and collagen synthesis induced by oxidative stress

Digestive and Liver Disease

Volumn 37, Issue 5, 2005, Pages 342-348

  Bendia, E ^a   Benedetti, A ^a   Baroni, G S ^a   Candelaresi, C ^a   Macarri, G ^a   Trozzi, L ^a   Di Sario, A ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Cell proliferation; Hepatic stellate cells; Intracellular pathways of signal transduction; Liver fibrosis; Na+ H+ exchanger; Oxidative stress

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1; CYANIDIN 3 O BETA GLUCOPYRANOSIDE; GLUCOPYRANOSIDE; HYDROPEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRILOTRIACETATE IRON; PROTEIN KINASE B; PROTON; S6 KINASE; SODIUM ION; UNCLASSIFIED DRUG; ANTHOCYANIN; CYANIDIN-3-O-BETA-GLUCOPYRANOSIDE; MITOGEN ACTIVATED PROTEIN KINASE 3; SODIUM PROTON EXCHANGE PROTEIN;

ARTICLE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; LIVER CELL; MALE; NONHUMAN; NORTHERN BLOTTING; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTON SODIUM EXCHANGE; RAT; SPECTROFLUOROMETRY; STELLATE CELL; WESTERN BLOTTING; ANIMAL; CYTOLOGY; LIVER; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTHOCYANINS; BLOTTING, NORTHERN; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; LIVER; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER; SPECTROMETRY, FLUORESCENCE;

EID: 24044534509     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2004.11.008     Document Type: Article

References (43)

1. Amorini A.M., Fazzina G., Lazzarino G., Tavazzi B., Di Pierro D., Santucci R., et al. Activity and mechanism of the antioxidant properties of cyanidin-3-O-beta-glucopyranoside. Free Radic Res 35 (2001) 953-966
2. Tsuda T., Horio F., and Osawa T. Dietary cyanidin 3-O-beta-d-glucoside increases ex vivo oxidation resistance of serum in rats. Lipids 33 (1998) 583-588
3. Tsuda T., Ohshima K., Kawakishi S., and Osawa T. Oxidation products of cyanidin-O-beta-d-glucoside with a free radical initiator. Lipids 31 (1996) 1259-1263
4. Bedossa P., Houglum K., Trautwein C., Holstege A., and Chojkier M. Stimulation of collagen α1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis. Hepatology 19 (1994) 1262-1271
5. Friedman S.L. Molecular regulation of hepatic fibrosis: an integrated cellular response to tissue injury. J Biol Chem 275 (2000) 2247-2250
6. Bissell D.M., Arenson D.M., Maher J.J., and Roll F.J. Support of cultured hepatocytes by a laminin-rich gel: evidence for a functionally significant subendothelial matrix in normal rat liver. J Clin Invest 79 (1987) 801-812
7. Maher J.J., Bissell D.M., Friedman S.L., and Roll F.J. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. J Clin Invest 82 (1988) 450-459
8. Friedman S.L., Roll J.F., Boyles J., and Bissell D.M. Hepatic lipocytes: the principal collagen producing cells of normal rat liver. Proc Natl Acad Sci U S A 82 (1985) 8681-8685
9. Svegliati-Baroni G., D'Ambrosio L., Curto P., Casini A., Mancini R., Jezequel A.M., et al. Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology 23 (1996) 1189-1199
10. Geerts A., Lazou J.M., De Bleser P., and Wisse E. Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon-tetrachloride-injured rat liver. Hepatology 13 (1991) 1193-1202
11. Milani S., Herbst H., Schuppan D., Kim K.Y., Riechen E.O., and Stein H. Cellular localization of type I, III and IV procollagen gene transcripts in normal and fibrotic human liver. Am J Pathol 137 (1990) 59-70
12. Friedman S.L., Roll J.F., Boyles J., Arenson D.M., and Bissell D.M. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem 264 (1989) 10756-10762
13. Friedman S.L. Cytokines and fibrogenesis. Semin Liver Dis 19 (1999) 129-140
14. Pinzani M., Gesualdo L., Sabbah G.M., and Abboud H.E. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA syntehsis and growth of cultured rat liver fat-storing cells. J Clin Invest 84 (1989) 1786-1793
15. Svegliati-Baroni G., Ridolfi F., Di Sario A., Casini A., Marucci L., Gaggiotti G., et al. Insulin and IGF-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology 29 (1999) 1743-1751
16. Svegliati Baroni G., D'Ambrosio L., Ferretti G., Casini A., Di Sario A., Salzano R., et al. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology 27 (1998) 720-726
17. Di Sario A., Svegliati Baroni G., Bendia E., D'Ambrosio L., Ridolfi F., Marileo J.R., et al. Characterization of ion transport mechanisms regulating intracellular pH in hepatic stellate cells. Am J Physiol 273 (1997) G39-G48
18. + activation by platelet-derived growth factor in rat hepatic stellate cells. Gastroenterology 116 (1999) 1155-1166
19. + exchange activity in human hepatic stellate cells: effect of platelet-derived growth factor, insulin-like growth factor 1 and insulin. J Hepatol 34 (2001) 378-385
20. + exchanger reduces rat hepatic stellate cell activity and liver fibrosis: an in vitro and in vivo study. Gastroenterology 120 (2001) 545-556
21. + exchange inhibition by cariporide reduces liver fibrosis in the rat. Hepatology 37 (2003) 256-266
22. Lee K.S., Buck M., Houglum K., and Chojkier M. Activation of hepatic stellate cells by TGFβ and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96 (1995) 2461-2468
23. Svegliati Baroni G., Saccomanno S., van Goor H., Jansen P., Benedetti A., and Moshage H. Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver 21 (2001) 1-12
24. + exchanger modulates the fibrogenic effect of oxidative stress in hepatic stellate cells. J Hepatol 30 (1999) 868-875
25. Parola M., Pinzani M., Casini A., Albano E., Poli G., Gentilini A., et al. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen α1(I) gene expression in human liver fat-storing cells. Biochem Biophys Res Commun 194 (1993) 1044-1050
26. Morel I., Lescoat G., Cillard J., Pasdeloup N., Brissot P., and Cillard P. Kinetic evaluation of free malondialdehyde and enzyme leakage as indices of iron damage in rat hepatocyte cultures. Biochem Pharmacol 39 (1990) 1647-1655
27. Bacon B.R., Tavill A.S., Brittenham G.M., Park C.H., and Recknagel R.O. Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 71 (1983) 429-439
28. Amorini A.M., Fazzina G., Lazzarino G., Tavazzi B., Di Pierro D., Santucci R., et al. Activity and mechanism of the antioxidant properties of cyanidin-3-O-beta-glucopyranoside. Free Radic Res 35 (2001) 953-966
29. Fimognari C., Berti F., Nusse M., Cantelli-Forti G., and Hrelia P. Induction of apoptosis in two human leukemia cell lines as well as differentiation in human promyelocytic cells by cyanidin-3-O-beta-glucopyranoside. Biochem Pharmacol 67 (2004) 2047-2056
30. Prior R.L. Fruit and vegetables in the prevention of cellular oxidative damage. Am J Clin Nutr 78 (2003) S570-S578
31. Heil J., and Reiffersheid G. Detection of mammalian carcinogens with an immunological DNA synthesis-inhibition test. Carcinogenesis 13 (1992) 2389-2394
32. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of the bacteriophage T. Nature 227 (1970) 680-685
33. Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 76 (1979) 4350-4353
34. Chomczynski P., and Sacchi N. Single step-method of RNA isolation by acid guanidium thyocianate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156-159
35. Casini A., Pinzani M., Milani S., Grappone C., Galli G., Jezequel A.M., et al. Regulation of extracellular matrix synthesis by transforming growth factor beta 1 in human fat-storing cells. Gastroenterology 105 (1993) 245-253
36. Danielson P.E., Forss-Petter S., Brown M.A., Calavetta L., Douglass J., Milner R.J., et al. P1B15: a cDNA clone of the rat mRNA encoding cyclophilin. DNA Res 7 (1988) 261-267
37. Schreck R., and Baeuerle P.A. A role for oxygen radicals as second messengers. Trends Cell Biol 1 (1991) 39-42
38. Sen C.K., and Packer L. Antioxidant and redox regulation of gene transcription. FASEB J 10 (1996) 709-720
39. 2 for platelet derived growth factor signal trasduction. Science 270 (1995) 296-299
40. Gonzalez-Rubia M., Voit S., Rodriguez-Puyol D., Weber M., and Marx M. Oxidative stress induces tyrosin phosphorylation of PDGF alpha-and beta-receptor and pp60c-src in mesangial cells. Kidney Int 50 (1996) 164-173
41. Kawada N., Seki S., and Kuroki T. Effect of antioxidants, resveratrol, quercetin and n-acetylcisteine on the functions of cultured rat hepatic stellate cell and Kuppfer cells. Hepatology 27 (1998) 1265-1274
42. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochem Biophys Acta 988 (1989) 73-97
43. Marra F., Pinzani M., De Franco R., Laffi G., and Gentilini P. Involvement of phosphatidilinositol 3-kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells. FEBS Lett 376 (1995) 141-145