Functional analysis of human hematopoietic stem cell gene expression using zebrafish

PLoS Biology

Volumn 3, Issue 8, 2005, Pages

  Eckfeldt, Craig E ^a   Mendenhall, Eric M ^a   Flynn, Catherine M ^a   Wang, Tzu Fei ^a   Pickart, Michael A ^b   Grindle, Suzanne M ^c   Ekker, Stephen C ^b   Verfaillie, Catherine M ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Minnesota Medical School Minneapolis   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CD33 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; COMPLEMENTARY DNA; STEM CELL FACTOR; TRANSCRIPTOME; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA; NERVE PROTEIN; PHOSPHOPROTEIN; RHODAMINE 123; SPRY1 PROTEIN, HUMAN; SPRY4 PROTEIN, ZEBRAFISH; ZEBRAFISH PROTEIN;

ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; CYTOLOGY; EMBRYO; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; NONHUMAN; ONTOGENY; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRY4 GENE; UMBILICAL CORD BLOOD; ZEBRA FISH; ANIMAL; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; DNA MICROARRAY; FETUS BLOOD; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENETICS; GENOMICS; METABOLISM; METHODOLOGY; MULTIGENE FAMILY; PHYSIOLOGY; PRENATAL DEVELOPMENT;

DANIO RERIO;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD34; ANTIGENS, CD38; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; FETAL BLOOD; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENOMICS; HEMATOPOIETIC STEM CELLS; HUMANS; MEMBRANE PROTEINS; MULTIGENE FAMILY; NERVE TISSUE PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPROTEINS; RHODAMINE 123; RNA, MESSENGER; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 23944463968     PISSN: 15449173     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pbio.0030254     Document Type: Article

References (52)

1. Morrison SJ, Uchida N, Weissman IL (1995) The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol 11: 35-71.
2. Krause DS (2002) Regulation of hematopoietic stem cell fate. Oncogene 21: 3262-3269.
3. Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, et al. (1995) Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9: 1753-1765.
4. Antonchuk J, Sauvageau G, Humphries RK (2001) HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation. Exp Hematol 29: 1125-1134.
5. Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, et al. (2002) Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood 100: 862-868.
6. Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, et al. (2000) Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med 6: 1278-1281.
7. Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423: 409-414.
8. Murdoch B, Chadwick K, Martin M, Shojaei F, Shah KV, et al. (2003) Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci U S A 100: 3422-3427.
9. Bhardwaj G, Murdoch B, Wu D, Baker DP, Williams KP, et al. (2001) Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol 2: 172-180.
10. Terskikh AV, Miyamoto T, Chang C, Diatchenko L, Weissman IL (2003) Gene expression analysis of purified hematopoietic stem cells and committed progenitors. Blood 102: 94-101.
11. Park IK, He Y, Lin F, Laerum OD, Tian Q, et al. (2002) Differential gene expression profiling of adult murine hematopoietic stem cells. Blood 99: 488-498.
12. Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, et al. (2002) A stem cell molecular signature. Science 298: 601-604.
13. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA (2002) "Stemness": Transcriptional profiling of embryonic and adult stem cells. Science 298: 597-600.
14. Fortunel NO, Otu HH, Ng HH, Chen J, Mu X, et al. (2003) Comment on "'Stemness': Transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature." Science 302: 393.
15. Bhatia M, Wang JC, Kapp U, Bonnet D, Dick JE (1997) Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A 94: 5320-5325.
16. Shojaei F, Gallacher L, Bhatia M (2004) Differential gene expression of human stem progenitor cells derived from early stages of in utero human hematopoiesis. Blood 103: 2530-2540.
17. Liu H, Verfaillie CM (2002) Myeloid-lymphoid initiating cells (ML-IC) are highly enriched in the rhodamine-c-kit(+)CD33(-)CD38(-) fraction of umbilical cord CD34(+) cells. Exp Hematol 30: 582-589.
18. Cheng T, Rodrigues N, Shen H, Yang Y, Dombkowski D, et al. (2000) Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287: 1804-1808.
19. Seidel MG, Look AT (2001) E2A-HLF usurps control of evolutionarily conserved survival pathways. Oncogene 20: 5718-5725.
20. Buonamici S, Chakraborty S, Senyuk V, Nucifora G (2003) The role of EVI1 in normal and leukemic cells. Blood Cells Mol Dis 31: 206-212.
21. Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, et al. (1994) The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell 78: 45-57.
22. Zhou Y, Lim KC, Onodera K, Takahashi S, Ohta J, et al. (1998) Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J 17: 6689-6700.
23. Travis A, Amsterdam A, Belanger C, Grosschedl R (1991) LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]. Genes Dev 5: 880-894.
24. Bigas A, Martin DI, Milner LA (1998) Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol Cell Biol 18: 2324-2333.
25. Hashizume H, Hamalainen H, Sun Q, Sucharczuk A, Lahesmaa R (2003) Downregulation of mafB expression in T-helper cells during early differentiation in vitro. Scand J Immunol 57: 28-34.
26. Geiman TM, Muegge K (2000) Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes. Proc Natl Acad Sci U S A 97: 4772-4777.
27. Birve A, Sengupta AK, Beuchle D, Larsson J, Kennison JA, et al. (2001) Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development 128: 3371-3379.
28. Ruzinova MB, Benezra R (2003) Id proteins in development, cell cycle and cancer. Trends Cell Biol 13: 410-418.
29. Hoyle CF, Sherrington P, Hayhoe FG (1988) Translocation (3;6)(q21;p21) in acute myeloid leukemia with abnormal thrombopoiesis and basophilia. Cancer Genet Cytogenet 30: 261-267.
30. Sonoki T, Harder L, Horsman DE, Karran L, Taniguchi I, et al. (2001) Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood 98: 2837-2844.
31. Nagarajan L, Louie E, Tsujimoto Y, ar-Rushdi A, Huebner K, et al. (1986) Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias. Proc Natl Acad Sci U S A 83: 2556-2560.
32. Ekker SC (2000) Morphants: A new systematic vertebrate functional genomics approach. Yeast 17: 302-306.
33. Ackermann GE, Paw BH (2003) Zebrafish: A genetic model for vertebrate organogenesis and human disorders. Front Biosci 8: d1227-1253.
34. Liao W, Ho CY, Yan YL, Postlethwait J, Stainier DY (2000) Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development 127: 4303-4313.
35. Thisse C, Zon LI (2002) Organogenesis - Heart and blood formation from the zebrafish point of view. Science 295: 457-462.
36. Nasevicius A, Ekker SC (2000) Effective targeted gene "knockdown" in zebrafish. Nat Genet 26: 216-220.
37. Galloway JL, Wingert RA, Thisse C, Thisse B, Zon LI (2005) Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell 8: 109-116.
38. Haffter P, Granato M, Brand M, Mullins MC, Hammerschmidt M, et al. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123: 1-36.
39. Pickart MA, Sivasubbu S, Nielsen AL, Shriram S, King RA, et al. (2004) Functional genomics tools for the analysis of zebrafish pigment. Pigment Cell Res 17: 461-470.
40. Golling G, Amsterdam A, Sun Z, Antonelli M, Maldonado E, et al. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nat Genet 31: 135-140.
41. Leung AY, Mendenhall EM, Kwan TT, Liang R, Eckfeldt C, et al. (2005) Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev Biol 277: 235-254.
42. Hammerschmidt M, Pelegri F, Mullins MC, Kane DA, van Eeden FJ, et al. (1996) Dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development 123: 95-102.
43. Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr, Medzhitov R, et al. (2002) IRAK-M is a negative regulator of toll-like receptor signaling. Cell 110: 191-202.
44. Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, et al. (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99: 23-33.
45. Gilmour DT, Lyon GJ, Carlton MB, Sanes JR, Cunningham JM, et al. (1998) Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J 17: 1860-1870.
46. Chida K, Hara T, Hirai T, Konishi C, Nakamura K, et al. (2003) Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis. Cancer Res 63: 2404-2408.
47. Brun AC, Bjornsson JM, Magnusson M, Larsson N, Leveen P, et al. (2004) Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood 103: 4126-4133.
48. Furthauer M, Reifers F, Brand M, Thisse B, Thisse C (2001) Sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. Development 128: 2175-2186.
49. Thompson MA, Ransom DG, Pratt SJ, MacLennan H, Kieran MW, et al. (1998) The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev Biol 197: 248-269.
50. Kim HJ, Bar-Sagi D (2004) Modulation of signalling by Sprouty: A developing story. Nat Rev Mol Cell Biol 5: 441-450.
51. Brekken RA, Sage EH (2001) SPARC, a matricellular protein: At the crossroads of cell-matrix communication. Matrix Biol 19: 816-827.
52. Marin F, Charnay P (2000) Hindbrain patterning: FGFs regulate Krox20 and mafB/kr expression in the otic/preotic region. Development 127: 4925-4935.