F-DIO obesity-prone rat is insulin resistant before obesity onset

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 289, Issue 3 58-3, 2005, Pages

  Levin, Barry E ^a,b   Magnan, Christophe ^c   Migrenne, Stephanie ^c   Chua Jr , Streamson C ^d   Dunn Meynell, Ambrose A ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Development; Diabetes; Neuropeptide Y; Orexin; Proopiomelanocortin

Indexed keywords

DEXAMETHASONE; GLUCOSE; INSULIN; LEPTIN; MESSENGER RNA; NEUROPEPTIDE Y; OREXIN; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CALORIC INTAKE; CALORIC RESTRICTION; CONTROLLED STUDY; DIABETES MELLITUS; DIET; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HYPERINSULINEMIA; HYPOTHALAMUS NUCLEUS; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; MALE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; PRIORITY JOURNAL; RAT; RAT STRAIN;

ANIMALS; ARCUATE NUCLEUS; BLOOD GLUCOSE; DIET; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE; HYPOGLYCEMIC AGENTS; HYPOTHALAMIC AREA, LATERAL; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; NEUROPEPTIDES; OBESITY; PHENOTYPE; PRO-OPIOMELANOCORTIN; RATS; RATS, INBRED F344; RATS, INBRED STRAINS;

EID: 23944462602     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00216.2005     Document Type: Article

References (52)

1. American Physiological Society. Guiding principals for research involving animals and human beings. Am J Physiol Regul Intgr Comp Physiol 283: R281-R283, 2002.
2. Appel NM, Track NS, and Van Loon GR. Autonomic and endocrine participation in opioid peptide-induced hyperglycemia. J Auton Nerv Syst 20: 221-231, 1987.
3. Bouchard C and Perusse L. Genetics of obesity. Annu Rev Nutr 13: 337-354, 1993.
4. Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Urban PC, Klein R, Krone W, Muller-Wieland D, and Kahn CR. Role of brain insulin receptor in control of body weight and reproduction. Science 289: 2122-2125, 2000.
5. Clegg DJ, Benoit SC, Air EL, Jackman A, Tso P, D'Alessio D, Woods SC, and Seeley RJ. Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology 144: 2941-2946, 2003.
6. Cleyy DJ, Benoit SC, Reed JA, Woods SC, and Levin HE. Reduced anorexic effects of insulin in obesity-prone rats and rats fed a moderate fat diet. Am J Physiol Regul Integr Comp Physiol 288: R981-R986, 2005.
7. Cooper SJ, Jackson A, and Kirkham TC. Endorphins and food intake: kappa opioid receptor agonists and hyperphagia. Pharmacol Biochem Behav 23: 889-901, 1985.
8. Cruciani-Guglielmacci C, Hervalet A, Douared L, Sanders NM, Levin BE, Ktorza A, and Magnan C. Beta oxidation in the brain is required for the effects of nonesterified fatty acids on glucose-induced insulin secretion in rats. Diabetologia 47: 2032-2038, 2004.
9. Dohrian AD, Davies MJ, Prewitt RL, and Laulerio TJ. Development of hypertension in a rat model of diet-induced obesity. Hypertension 35: 1009-1015, 2000.
10. Dorner G, Mohnike A, and Thoelke M. Further evidence for the dependence of diabetes prevalence on nutrition in perinatal life. Exp Clin Endocrinol 84: 129-133, 1984.
11. El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, and Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105: 1827-1832, 2000.
12. Fan W, Dinulescu DM, Butler AA, Zhou J, Marks DL, and Cone RD. The central melanocortin system can directly regulate scrum insulin levels. Endocrinology 141: 3072-3079, 2000.
13. Hiyuchi H, Yang HY, and Sabol SL. Rat neuropeptide Y precursor gene expression, mRNA structure, tissue distribution, and regulation by glucocorticoids, cyclic AMP, and phorbol ester. J Biol Chem 263: 6288-6295, 1988.
14. Jones AP and Friedman MI. Obesity and adipocyte abnormalities in offspring of rats undernourished during pregnancy. Science. 215: 1518-1519, 1982.
15. Jones AP, Simson EL, and Friedman MI. Gestational undernutrition and the development of obesity in rats. J Nutr 114: 1484-1492, 1984.
16. Levin BE. Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. Am J Physiol Regul Integr Comp Physiol 276: R382-R387, 1999.
17. Levin BE and Dunn-Meynell A. A defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 282: R46-R54, 2002.
18. Levin BE and Dunn-Meynell A. A dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 272: R1365-R1370, 1997.
19. Levin BE and Dunn-Meynell A. A Maternal obesity alters adiposity and monoamine function in genetically predisposed offspring. Am J Physiol Regul Integr Comp Physiol 283: R1087-R1093, 2002.
20. Levin BE and Dunn-Meynell A. A reduced central leptin sensitivity in rats with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 283: R941-R948, 2002.
21. Levin BE and Dunn-Meynell A. A sibutramine alters the central mechanisms regulating the defended body weight in diet-induced obese rats. Am J Physiol Regul Intger Comp Physiol 279: R2222-R2228, 2000.
22. Levin BE, Dunn-Meynell AA, Balkan B, and Keesey RE. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 273: R725-R730, 1997.
23. Levin BE, Dunn-Meynell AA, and Banks WA. Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol Regul Integr Comp Physiol 286: R143-R150, 2004.
24. Levin BE, Dunn-Meynell AA, McMinn JE, Cunningham-Bussel A, and Chua SC Jr. A new obesity-prone, glucose intolerant rat strain (F. DIO). Am J Physiol Regul Integr Comp Physiol 285: R1184-R1191, 2003.
25. Levin BE, Dunn-Meynell AA, Ricci MR, and Cummings DE. Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats. Am J Physiol Endocrinol Metab 285: E949-E957, 2003.
26. Levin BE and Govek E. Gestational obesity accentuates obesity in obesity-prone progeny. Am J Physiol Regul Integr Comp Physiol 275: R1374-R1379, 1998.
27. Levin BE, Hogan S, and Sullivan AC. Initiation and perpetuation of obesity and obesity resistance in rats. Am J Physiol Regul Integr Comp Physiol 256: R766-R771, 1989.
28. Levin BE, Richard D, Michel C, and Servatius R. Differential stress responsivity in diet-induced obese and resistant rats. Am J Physiol Regul Integr Comp Physiol 279: R1357-R1364, 2000.
29. Levitt NS, Lindsay RS, Holmes MC, and Seckl JR. Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology 64: 412-418, 1996.
30. Lopez M, Seoane L, Garcia MC, Lago F, Casanueva FF, Senaris R, and Dieguez C. Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus. Biochem Biophys Res Commun 269: 41-45, 2000.
31. Must A, Spadano J, Coakley EH, Field AE, Colditz G, and Dietz WH. The disease burden associated with overweight and obesity. JAMA 282: 1523-1529, 1999.
32. Nyirenda MJ, Lindsay RS, Kenyon CJ, Burchell A, and Seckl JR. Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest 101: 2174-2181, 1998.
33. Nyirenda MJ, Welberg LA, and Seckl JR. Programming hyperglycacmia in the rat through prenatal exposure to glucocorticoids-fetal effect or maternal influence? J Endocrinol 170: 653-660, 2001.
34. Obici S, Feng Z, Tan J, Liu L, Karkanias G, and Rossetti L. Central melanocortin receptors regulate insulin action. J Clin Invest 108: 1079-1085, 2001.
35. Ozanne SE and Hales CN. The long-term consequences of intra-uterine protein malnutrition for glucose metabolism. Proc Nutr Soc 58: 615-619, 1999.
36. Plagemann A, Waas T, Harder T, Rittel F, Ziska T, and Rohde W. Hypothalamic neuropeptide Y levels in weaning offspring of low-protein malnourished mother rats. Neuropeptides 34: 1-6, 2000.
37. Radosevich PM, Lacy DB, Brown LL, Williams PE, and Abumrad NN. Central effects of beta-endorphins on glucose homeostasis in the conscious dog. Am J Physiol Endocrinol Metab 256: E322-E330, 1989.
38. Ravelli AC, Der Meulen JH, Osmond C, Barker DJ, and Bleker OP. Obesity at the age of 50 years in men and women exposed to famine prenatally. Am J Clin Nutr 70: 811-816, 1999.
39. Ravelli GP, Stein ZA, and Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 295: 349-353, 1976.
40. Ricci MR and Levin BE. Ontogeny of diet-Induced obesity in selectively-bred Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 285: R610-R618, 2003.
41. Rosenbloom AL, Joe JR, Young RS, and Winter WE. Emerging epidemic of type 2 diabetes in youth. Diabetes Care 22: 345-354, 1999.
42. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Knzlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, and Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585, 1998.
43. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte J, D, Woods SC, Seeley RJ, and Weigle DS. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45: 531-535, 1996.
44. Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P, and Baskin DG. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46: 2119-2123, 1997.
45. Storlien LH, James DE, Burleigh KM, Chisholm DJ, and Kraegen EW. Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure and obesity in rats. Am J Physiol Endocrinol Metab 251: E576-E583, 1986.
46. Sugden MC, Langdown ML, Munns MJ, and Holness MJ. Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinemia in the early-growth-retarded adult offspring. Eur J Endocrinol 145: 529-539, 2001.
47. Triscari J, Nauss-Karol C, Levin BE, and Sullivan AC. Changes in lipid metabolism in diet-induced obesity. Metabolism 34: 580-587, 1985.
48. Vazquez DM, Lopez JF, Van Hoers H, Watson SJ, and Levine S. Maternal deprivation regulates serotonin 1A and 2A receptors in the infant rat. Brain Res 855: 76-82, 2000.
49. Visscher TL and Seidell JC. The public health impact of obesity. Annu Rev Public Health 22: 355-375, 2001.
50. Welberg LA, Seckl JR, and Holmes MC. Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behavior. Neuroscience 104: 71-79, 2001.
51. Wortley KE, Chang GQ, Davydova Z, and Leihowitz SF. Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia. Am J Physiol Regul Integr Comp Physiol 284: R1454-R1465, 2003.
52. Xu AW, Kaelin CB, Takeda K, Akira S, Schwurtz MW, and Barsh GS. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 115: 951-958, 2005.