The long-term consequences of intra-uterine protein malnutrition for glucose metabolism

Proceedings of the Nutrition Society

Volumn 58, Issue 3, 1999, Pages 615-619

  Ozanne, Susan E ^a   Hales, C Nicholas ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

'Thrifty phenotype' hypothesis; Fetal growth; Hypertension; Insulin resistance; Non insulin dependent diabetes mellitus

Indexed keywords

GLUCOSE; INSULIN;

ANIMAL MODEL; CONFERENCE PAPER; DIABETES MELLITUS; FETUS; FETUS GROWTH; GLUCOSE METABOLISM; HYPERTENSION; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PROTEIN CONTENT; PROTEIN MALNUTRITION;

EID: 0032746837     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0029665199000804     Document Type: Conference Paper

References (27)

1. Barker DJP, Hales CN, Fall CHD, Osmond C, Phipps K & Clark PMS (1993) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36, 62-67.
2. Brown DC, Byrne CD, Clark PMS, Cox BD, Day NE, Hales CN, Shackleton JR, Wang TWM & Williams DRR (1991) Height and glucose tolerance in adult subjects. Diabetologia 34, 531-533.
3. Burns SP, Desai M, Cohen RD, Hales CN, Iles RA, Germain JP, Going TC & Bailey RA (1997) Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. Journal of Clinical Investigation 100, 1768-1774.
4. Desai M, Byrne CD, Zhang J, Petry CL, Lucas A & Hales CN (1996) Programming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein restricted diet. American Journal of Physiology 272, G1083-G1090.
5. Hales CN & Barker DJP (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35, 595-601.
6. Hales CN, Barker DJP, Clark PMS, Cox LJ, Fall C, Osmond C & Winter PD (1991) Fetal and infant growth and impaired glucose tolerance at age 64 years. British Medical Journal 303, 1019-1022.
7. Hales CN, Desai M, Ozanne SE & Crowther NJ (1996) Fishing in the stream of diabetes: From measuring insulin to the control of fetal organogenesis. Biochemical Society Transactions 24, 341-350.
8. Keller U, Schnell U, Sonnenberg GE, Gerber PP & Stauffacher W (1983) Role of glucagon in enhancing ketone body production in ketotic diabetic man. Diabetes 323, 387-391.
9. Kurosu H, Machama T, Okada T, Yamamoto T, Hoshino S, Fukui Y, Ui M, Hazeki O & Katada T (1997) Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosol peptide. Journal of Biological Chemistry 272, 24252-24256.
10. Law CM, Gordon GS, Shiell AW, Barker DJP & Hales CN (1995) Thinness at birth and glucose tolerance in seven-year-old children. Diabetic Medicine 12, 24-29.
11. O'Dea K (1991) Cardiovascular risk factors in Australian aborigines. Clinical and Experimental Pharmacology and Physiology 18, 85-88.
12. Okada T, Kawano Y, Sakakibara T, Hazeki O & Ui M (1994) Essential role of phosphatidyl inositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. Journal of Biological Chemistry 269, 3568-3573.
13. Ozanne SE, Nave BT, Wang CL, Shepherd PR, Prins J & Smith GD (1997) Poor fetal nutrition causes long term changes in expression of insulin signalling components in adipocytes. American Journal of Physiology 273, E46-E51.
14. Ozanne SE, Smith GD, Tikerpae J & Hales CN (1996a) Altered regulation of hepatic glucose output in the male offspring of protein-malnourished rat dams. American Journal of Physiology 270, E559-E564.
15. Ozanne SE, Wang CL, Coleman N & Smith GD (1996b) Altered muscle insulin sensitivity in the male offspring of protein-malnourished rats. American Journal of Physiology 271, E1128-E1134.
16. Ozanne SE, Wang CL, Dorling MW & Petry CJ (1998) Selective resistance to insulin in adipocytes from early growth retarded rats. Diabetologica 41, Suppl. 1, A44:166.
17. Petry CJ, Desai M, Ozanne SE & Hales CN (1997a) Early and late nutritional windows for diabetes susceptibility. Proceedings of the Nutrition Society 56, 233-242.
18. Petry CJ, Ozanne SE, Wang CL & Hales CN (1997b) Early protein restriction and obesity independently induced hypertension in year old rats. Clinical Science 93, 147-152.
19. Phillips DIW, Barker DJP, Hales CN, Hirst S & Osmond C (1994) Thinness at birth and insulin resistance in adult life. Diabetologia 37, 150-154.
20. Phillips DIW & Hales CN (1996) The intrauterine environment and susceptibility to non-insulin dependent diabetes and the insulin resistance syndrome. In The Diabetes Annual, vol. 10, pp. 1-13 [SM Marshall, PD Home and RA Rizza, editors]. Amsterdam: Elsevier.
21. Poulsen P, Vaag AA, Kyvik KO, Moller Jensen D & Beck-Nielsen H (1997) Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia 40, 439-446.
22. Ravelli ACJ, van der Meulen JHP, Michels RPJ, Osmond C, Barker DJP, Hales CN & Bleker OP (1998) Glucose tolerance in adults after prenatal exposure to the Dutch famine. Lancet 351, 173-177.
23. Shepherd PR, Crowther NJ, Desai M, Hales CN & Ozanne SE (1997) Altered adipocyte properties in the offspring of protein malnourished rats. British Journal of Nutrition 78, 121-129.
24. Shepherd PR, Withers DJ & Siddle K (1998) Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochemical Journal 333, 471-490.
25. Snoeck A, Remacle C, Reusens B & Hoet JJ (1990) Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas. Biology of the Neonate 57, 107-118.
26. Yajnik CS, Fall CHD, Vaidya U, Pandit AN, Bavdekar A, Bhat DS, Osmond C, Hales CN & Barker DJP (1995) Fetal growth and glucose and insulin metabolism in four year old Indian children. Diabetic Medicine 12, 330-336.
27. World Health Organization (1985) Diabetes mellitus. A Report of a WHO Study Group. Technical Report Series no. 844, pp. 20-25. Geneva: WHO.