Maternal obesity alters adiposity and monoamine function in genetically predisposed offspring

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 283, Issue 5 52-5, 2002, Pages

  Levin, Barry E ^a,b   Dunn Meynell, Ambrose A ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Amygdala; Diet induced obesity; Hypothalamus; Insulin; Leptin; Neural plasticity; Norepinephrine; Serotonin

Indexed keywords

BRAIN MONOAMINE; LEPTIN; NISOXETINE; NORADRENALIN TRANSPORTER; PAROXETINE; SEROTONIN TRANSPORTER; TRITIUM;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; FAT INTAKE; GENETIC PREDISPOSITION; GENOTYPE; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; LACTATION; MATERNAL DISEASE; MONOAMINE METABOLISM; NERVE CELL PLASTICITY; NONHUMAN; OBESITY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROGENY; PROTEIN FUNCTION; THALAMUS MIDLINE NUCLEUS; THALAMUS VENTRAL NUCLEUS;

EID: 0036838623     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00402.2002     Document Type: Article

References (42)

1. Ahima RS, Bjorbaek C, Osei S, and Flier JS. Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 140: 2755-2762, 1999.
2. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
3. 2-adrenergic heteroreceptors in the rat hypothalamus. J Pharmacol Exp Ther 254: 236-244, 1990.
4. Bouchard C and Perusse L. Genetics of obesity. Annu Rev Nutr 13: 337-354, 1993.
5. Charnay Y, Cusin I, Vallet PG, Muzzin P, Rohner-Jeanrenaud F, and Bouras C. Intracerebroventricular infusion of leptin decreases serotonin transporter binding sites in the frontal cortex of the rat. Neurosci Lett 283: 89-92, 2000.
6. Currie PJ and Wilson LM. Central injection of 5-hydroxytryptamine reduces food intake in obese and lean mice. Neuroreport 3: 59-61, 1992.
7. Dryden S, Wang Q, Frankish HM, Pickavance L, and Williams G. The serotonin (5-HT) antagonist methysergide increases neuropeptide Y (NPY) synthesis and secretion in the hypothalamus of the rat. Brain Res 699: 12-18, 1995.
8. Figlewicz DP, Szot P, Israel PA, Payne C, and Dorsa DM. Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus. Brain Res 602: 161-164, 1993.
9. Grignaschi G, Sironi F, and Samanin R. The 5-HT1B receptor mediates the effect of d-fenfluramine on eating caused by intra-hypothalamic injection of neuropeptide Y. Eur J Pharmacol 274: 221-224, 1995.
10. Hamza MA, White PF, Craig WF, Ghoname ES, Ahmed HE, Proctor TJ, Noe CE, Vakharia AS, and Gajraj N. Percutaneous electrical nerve stimulation: a novel analgesic therapy for diabetic neuropathic pain. Diabetes Care 23: 365-370, 2000.
11. Hassanain M and Levin BE. Dysregulation of hypothalamic serotonin turnover in diet-induced obese rats. Brain Res 929: 175-180, 2002.
12. Heidenreich KA and Toledo SP. Insulin receptors mediate growth effects in cultured fetal neurons. I. Rapid stimulation of protein synthesis. Endocrinology 125: 1451-1457, 1989,
13. Heidenreich KA and Toledo SP. Insulin receptors mediate growth effects in cultured fetal neurons. II. Activation of a protein kinase that phosphorylates ribosomal protein S6. Endocrinology 125: 1458-1463, 1989.
14. Jones AP and Friedman MI. Obesity and adipocyte abnormalities in offspring of rats undernourished during pregnancy. Science 215: 1518-1519, 1982.
15. Jones AP, Olster DH, and States B. Maternal insulin manipulations in rats organize body weight and noradrenergic innervation of the hypothalamus in gonadally intact male offspring. Dev Brain Res 97: 16-21, 1996.
16. Jones AP, Pothos EN, Rada P, Olster DH, and Hoebel BG. Maternal hormonal manipulations in rats cause obesity and increase medial hypothalamic norepinephrine release in male offspring. Brain Res Dev Brain Res 88: 127-131, 1995.
17. Leibowitz SF, Brown O, Tretter JR, and Kirschgessner A. Norepinephrine, clonidine and tricyclic antidepressants selectively stimulate carbohydrate ingestion through noradrenergic system of the paraventricular nucleus. Pharmacol Biochem Behav 23: 541-550, 1985.
18. Leibowitz SF, Roissin P, and Rosenn M. Chronic norepinephrine injection into the hypothalamic paraventricular nucleus produces hyperphagia and increased body weight in the rat. Pharmacol Biochem Behav 21: 801-808, 1984.
19. Leibowitz SF, Weiss GF, and Suh JS. Medial hypothalamic nuclei mediate serotonin's inhibitory effect on feeding behavior. Pharmacol Biochem Behav 37: 735-742, 1990.
20. 3H]paraminoclonidine binding. Brain Res 512: 54-59, 1990.
21. Levin BE. Diet cycling and age alter weight gain and insulin levels in rats. Am J Physiol Regul Integr Comp Physiol 267: R527-R535, 1994.
22. Levin BE and Dunn-Meynell AA. Dysregulation of arcuate nucleus preproneuropeptide Y MRNA in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 272: R1365-R1370, 1997.
23. Levin BE and Dunn-Meynell AA. Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 282: R46-R54, 2002.
24. Levin BE, Dunn-Meynell AA, Balkan B, and Keesey RE. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 273: R725-R730, 1997.
25. Levin BE and Govek E. Gestational obesity accentuates obesity in obesity-prone progeny. Am J Physiol Regul Integr Comp Physiol 275: R1375-R1379, 1998.
26. Levin BE, Hogan S, and Sullivan AC. Initiation and perpetuation of obesity and obesity resistance in rats. Am J Physiol Regul Integr Comp Physiol 256: R766-R771, 1989.
27. Moll GH, Mehnert C, Wicker M, Bock N, Rothenberger A, Ruther E, and Huether G. Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood. Brain Res Dev Brain Res 119: 251-257, 2000.
28. Nataf V and Monier S. Effect of insulin and insulin-like growth factor I on the expression of the catecholaminergic phenotype by neural crest cells. Brain Res Dev Brain Res 69: 59-66, 1992.
29. Park S, Harrold JA, Widdowson PS, and Williams G. Increased binding at 5-HT(1A), 5-HT(1B), and 5-HT(2A) receptors and 5-HT transporters in diet-induced obese rats. Brain Res 847: 90-97, 1999.
30. Plagemann A, Harder T, Janert U, Rake A, Rittel F, Rohde W, and Dorner G. Malformations of hypothalamic nuclei in hyperinsulinemic offspring of rats with gestational diabetes. Dev Neurosci 21: 58-67, 1999.
31. Plagemann A, Harder T, Kohlhoff R, Rohde W, and Dorner G. Overweight and obesity in infants of mothers with long-term insulin-dependent diabetes or gestational diabetes. Int J Obes Relat Metab Disord 21: 451-456, 1997.
32. Plagemann A, Harder T, Lindner R, Melchior K, Rake A, Rittel F, Rohde W, and Dorner G. Alterations of hypothalamic catecholamines in the newborn offspring of gestational diabetic mother rats. Brain Res 109: 201-209, 1998.
33. Plagemann A, Harder T, Rake A, Janert U, Melchior K, Rohde W, and Dorner G. Morphological alterations of hypothalamic nuclei due to intrahypothalamic hyperinsulinism in newborn rats. Int J Dev Neurosci 17: 37-44, 1999.
34. Plagemann A, Harder T, Rake A, Melchior K, Rittel F, Rohde W, and Dorner G. Hypothalamic insulin and neuropeptide Y in the offspring of gestational diabetic mother rats. Neuroreport 9: 4069-4073, 1998.
35. Plagemann A, Heidrich I, Gotz F, Rohde W, and Dorner G. Lifelong enhanced diabetes susceptibility and obesity after temporary intrahypothalamic hyperinsulinism during brain organization. Exp Clin Endocrinol 99: 91-95, 1992.
36. Plagemann A, Rittel F, Harder T, Wass T, Ziska T, and Rohde W. Hypothalamic galanin levels in weanling rats exposed to maternal low-protein diet. Nutr Res 20: 977-983, 2001.
37. Puro DG and Agardh E. Insulin-mediated regulation of neuronal maturation. Science 225; 1170-1172, 1984.
38. Rowland NE and Carlton J. Effects of fenfluramine on food intake, body weight, gastric emptying and brain monoamines in Syrian hamsters. Brain Res Bull 17: 575-581, 1986.
39. Scarpace PJ, Matheny M, Pollock BH, and Tumer N. Leptin increases uncoupling protein expression and energy expenditure. Am J Physiol Endocrinol Metab 273: E226-E230, 1997.
40. Shanley LJ, Irving AJ, and Harvey J. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J Neurosci 21: RC186, 2001.
41. 2-adrenoceptor modulation of 5-HT biosynthesis in the rat brain. Neurosci Lett 139: 57-65, 1992.
42. Zippel UH, Plagemann AH, and Plagemann AS. Long-term effects of early postnatally administered interleukin-1β on the hypothalamic-pituitary-adrenal (HPA) axis in rats. Nutr Neuronsci 4: 143-152, 2001.