Autoantibodies in the pathogenesis of mixed connective tissue disease

Rheumatic Disease Clinics of North America

Volumn 31, Issue 3, 2005, Pages 437-450

  Greidinger, Eric L ^a,b   Hoffman, Robert W ^a,b  

^a UNIVERSITY OF MIAMI   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; B LYMPHOCYTE; CELL STIMULATION; DISEASE ASSOCIATION; HUMAN; IMMUNE SYSTEM; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; INNATE IMMUNITY; MIXED CONNECTIVE TISSUE DISEASE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE ACTIVATION;

AUTOANTIBODIES; B-LYMPHOCYTES; HUMANS; MIXED CONNECTIVE TISSUE DISEASE; PROGNOSIS; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; T-LYMPHOCYTES; TIME FACTORS;

EID: 23444451416     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rdc.2005.04.004     Document Type: Review

References (76)

1. J.M. Amigues, A. Cantagrel, and M. Abbal Comparative study of 4 diagnosis criteria sets for mixed connective tissue disease in patients with anti-RNP antibodies. Autoimmunity Group of the Hospitals of Toulouse J Rheumatol 23 12 1996 2055 2062
2. G.C. Sharp, W.S. Irvin, and E.M. Tan Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA) Am J Med 52 1972 148 159
3. R.W. Hoffman T cells in the pathogenesis of systemic lupus erythematosus Clin Immunol 113 1 2004 4 13
4. P.G. Vlachoyiannopoulos, A. Guialis, and G. Tzioufas Predominance of IgM anti-U1RNP antibodies in patients with systemic lupus erythematosus Br J Rheumatol 35 6 1996 534 541
5. R.M. de Wildt, R. Ruytenbeek, and W.J. van Venrooij Heavy chain CDR3 optimization of a germline encoded recombinant antibody fragment predisposed to bind the U1A protein Protein Eng 10 7 1997 835 841
6. S. Fatenejad, M. Bennett, and J. Moslehi Influence of antigen organization on the development of lupus autoantibodies Arthritis Rheum 41 4 1998 603 612
7. E.L. Greidinger, and R.W. Hoffman The appearance of U1 RNP antibody specificities in sequential autoimmune human antisera follows a characteristic order that implicates the U1-70 kd and B′/B proteins as predominant U1 RNP immunogens Arthritis Rheum 44 2 2001 368 375
8. A. Murakami, K. Kojima, and K. Ohya A new conformational epitope generated by the binding of recombinant 70-kd protein and U1 RNA to anti-U1 RNP autoantibodies in sera from patients with mixed connective tissue disease Arthritis Rheum 46 12 2002 3273 3282
9. M.T. McClain, C.S. Lutz, and K.M. Kaufman Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response Proc Natl Acad Sci USA 101 10 2004 3551 3556
10. P.J. Utz, M. Hottelet, and W.J. van Venrooij Association of phosphorylated serine/arginine (SR) splicing factors with the U1-small ribonucleoprotein (snRNP) autoantigen complex accompanies apoptotic cell death J Exp Med 187 4 1998 547 560
11. E.L. Greidinger, M.F. Foecking, and S. Ranatunga Apoptotic U1-70 kd is antigenically distinct from the intact form of the U1-70-kd molecule Arthritis Rheum 46 5 2002 1264 1269
12. M.J. Mamula, R.J. Gee, and J.I. Elliott Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins J Biol Chem 274 32 1999 22321 22327
13. K. Skriner, W.H. Sommergruber, and V. Tremmel Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease J Clin Invest 100 1 1997 127 135
14. Y.N. Setty, C.B. Pittman, and A.S. Mahale Sicca symptoms and anti-SSA/Ro antibodies are common in mixed connective tissue disease J Rheumatol 29 3 2002 487 489
15. K. Ikeda, Y. Takasaki, and K. Hirokawa Clinical significance of antibodies to TS1-RNA in patients with mixed connective tissue disease J Rheumatol 30 5 2003 998 1005
16. G.R. Komatireddy, G.S. Wang, and G.C. Sharp Antiphospholipid antibodies among anti-U1-70 kDa autoantibody positive patients with mixed connective tissue disease J Rheumatol 24 2 1997 319 322
17. U.S. Deshmukh, J.E. Lewis, and F. Gaskin Immune responses to Ro60 and its peptides in mice. I. The nature of the immunogen and endogenous autoantigen determine the specificities of the induced autoantibodies J Exp Med 189 3 1999 531 540
18. G. Steiner, O. Shovman, and K. Skriner Induction of anti-RA33 hnRNP autoantibodies and transient spread to U1-A snRNP complex of spliceosome by idiotypic manipulation with anti-RA33 antibody preparation in mice Clin Exp Rheumatol 20 4 2002 517 524
19. B. Thiede, C. Dimmler, and F. Siejak Predominant identification of RNA-binding proteins in Fas-induced apoptosis by proteome analysis J Biol Chem 276 28 2001 26044 26050
20. S.A. Rutjes, A. van der Heijden, and P.J. Utz Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis J Biol Chem 274 35 1999 24799 24807
21. E.M. Tan Antinuclear antibodies: diagnostic markers and clues to the basis of systemic autoimmunity Pediatr Infect Dis J 7 5 Suppl 1988 S3 S9
22. A. Rosen, and L. Casciola-Rosen Clearing the way to mechanisms of autoimmunity Nat Med 7 6 2001 664 665
23. L. Casciola-Rosen, F. Andrade, and D. Ulanet Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity J Exp Med 190 6 1999 815 826
24. R.W. Hoffman, T. Gazitt, and M.F. Foecking U1 RNA induces innate immunity signaling Arthritis Rheum 50 9 2004 2891 2896
25. M. De Silva-Udawatta, S.R. Kumar, and E.L. Greidinger Cloned human TCR from patients with autoimmune disease can respond to two structurally distinct autoantigens J Immunol 172 6 2004 3940 3947
26. C. Zimmermann, G. Steiner, and K. Skriner The concurrence of rheumatoid arthritis and limited systemic sclerosis: clinical and serologic characteristics of an overlap syndrome Arthritis Rheum 41 11 1998 1938 1945
27. G. Riemekasten, J. Marell, and G. Trebeljahr A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus J Clin Invest 102 4 1998 754 763
28. M.A. Burdt, R.W. Hoffman, and S.L. Deutscher Long-term outcome in mixed connective tissue disease: longitudinal clinical and serologic findings Arthritis Rheum 42 5 1999 899 909
29. M.T. McClain, E.C. Rapp, and J.B. Harley Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1 J Med Virol 70 2 2003 253 257
30. M.M. Newkirk, W.J. van Venrooij, and G.S. Marshall Autoimmune response to U1 small nuclear ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection Arthritis Res 3 4 2001 253 258
31. B.C. Marshall, R.A. McPherson, and E. Greidinger Lack of autoantibody production associated with cytomegalovirus infection Arthritis Res 4 5 2002 R6
32. J.A. James, B.R. Neas, and K.L. Moser Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure Arthritis Rheum 44 5 2001 1122 1126
33. M.R. Arbuckle, M.T. McClain, and M.V. Rubertone Development of autoantibodies before the clinical onset of systemic lupus erythematosus N Engl J Med 349 16 2003 1526 1533
34. L.J. Mason, C.T. Ravirajan, and A. Rahman Is alpha-actinin a target for pathogenic anti-DNA antibodies in lupus nephritis? Arthritis Rheum 50 3 2004 866 870
35. E.L. Greidinger, M.F. Foecking, and J. Magee A major B cell epitope present on the apoptotic but not the intact form of the U1-70-kDa ribonucleoprotein autoantigen J Immunol 172 1 2004 709 716
36. I. Baumann, W. Kolowos, and R.E. Voll Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus Arthritis Rheum 46 1 2002 191 201
37. P.K. Potter, J. Cortes-Hernandez, and P. Quartier Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells J Immunol 170 6 2003 3223 3232
38. D. Laderach, S. Koutouzov, and J.F. Bach Concomitant early appearance of anti-ribonucleoprotein and anti-nucleosome antibodies in lupus prone mice J Autoimmun 20 2 2003 161 170
39. F. Monneaux, H. Dumortier, and G. Steiner Murine models of systemic lupus erythematosus: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Fas(lpr) and (NZB x NZW)F(1) lupus mice Int Immunol 13 9 2001 1155 1163
40. M. Okawa-Takatsuji, S. Aotsuka, and S. Uwatoko The B cell repertoire in patients with systemic autoimmune diseases: analysis of Epstein-Barr virus (EBV)-inducible circulating precursors that produce autoantibodies against nuclear ribonucleoprotein (nRNP) Clin Exp Immunol 90 3 1992 415 421
41. M.M. Holyst, D.L. Hill, and S.O. Hoch Analysis of human T cell and B cell responses against U small nuclear ribonucleoprotein 70-kd, B, and D polypeptides among patients with systemic lupus erythematosus and mixed connective tissue disease Arthritis Rheum 40 8 1997 1493 1503
42. J. Yan, and M.J. Mamula Autoreactive T cells revealed in the normal repertoire: escape from negative selection and peripheral tolerance J Immunol 168 7 2002 3188 3194
43. C.L. Keech, A.D. Farris, and D. Beroukas Cognate T cell help is sufficient to trigger anti-nuclear autoantibodies in naive mice J Immunol 166 9 2001 5826 5834
44. E.L. Greidinger, M.F. Foecking, and K.R. Schafermeyer T cell immunity in connective tissue disease patients targets the RNA binding domain of the U1-70kDa small nuclear ribonucleoprotein J Immunol 169 6 2002 3429 3437
45. R.W. Hoffman, G.C. Sharp, and S.L. Deutscher Analysis of anti-U1 RNA antibodies in patients with connective tissue disease. Association with HLA and clinical manifestations of disease Arthritis Rheum 38 12 1995 1837 1844
46. R.W. Hoffman, L.J. Rettenmaier, and Y. Takeda Human autoantibodies against the 70-kd polypeptide of U1 small nuclear RNP are associated with HLA-DR4 among connective tissue disease patients Arthritis Rheum 33 5 1990 666 673
47. F. Monneaux, J.P. Briand, and S. Muller B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein Eur J Immunol 30 8 2000 2191 2200
48. F. Heil, H. Hemmi, and H. Hochrein Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 Science 303 5663 2004 1526 1529
49. S. Balachandran, P.C. Roberts, and L.E. Brown Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection Immunity 13 1 2000 129 141
50. T. Lovgren, M.L. Eloranta, and U. Bave Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG Arthritis Rheum 50 6 2004 1861 1872
51. E.L. Greidinger, T. Gazitt, and K.F. Jaimes Human T cell clones specific for heterogeneous nuclear ribonucleoprotein A2 autoantigen from connective tissue disease patients assist in autoantibody production Arthritis Rheum 50 7 2004 2216 2222
52. B.F. Hoyer, K. Moser, and A.E. Hauser Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice J Exp Med 199 11 2004 1577 1584
53. E.L. Greidinger Apoptosis in lupus pathogenesis Front Biosci 6 2001 D1392 D1402
54. A.J. Szalai, C.T. Weaver, and M.A. McCrory Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene Arthritis Rheum 48 6 2003 1602 1611
55. T.W. Du Clos C-reactive protein reacts with the U1 small nuclear ribonucleoprotein J Immunol 143 8 1989 2553 2559
56. J.S. Navratil, S.C. Watkins, and J.J. Wisnieski The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells J Immunol 166 5 2001 3231 3239
57. P.L. Cohen, R. Caricchio, and V. Abraham Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase J Exp Med 196 1 2002 135 140
58. M.C. Bickerstaff, M. Botto, and W.L. Hutchinson Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity Nat Med 5 6 1999 694 697
59. D. Alarcon-Segovia, J.A. Tumlin, and R.A. Furie LJP 394 Investigator Consortium. LJP 394 for the prevention of renal flare in patients with systemic lupus erythematosus: results from a randomized, double-blind, placebo-controlled study Arthritis Rheum 48 2 2003 442 454
60. T. Fujiwaki, R. Urashima, and Y. Urushidani Neonatal lupus erythematosus associated with maternal mixed connective tissue disease Pediatr Int 45 2 2003 210 213
61. J.P. Buyon, and R.M. Clancy Neonatal lupus syndromes Curr Opin Rheumatol 15 5 2003 535 541
62. E.L. Greidinger, L. Casciola-Rosen, and S.M. Morris Autoantibody recognition of distinctly modified forms of the U1-70-kd antigen is associated with different clinical disease manifestations Arthritis Rheum 43 4 2000 881 888
63. M. Okawa-Takatsuji, S. Aotsuka, and S. Uwatoko Increase of cytokine production by pulmonary artery endothelial cells induced by supernatants from monocytes stimulated with autoantibodies against U1-ribonucleoprotein Clin Exp Rheumatol 17 6 1999 705 712
64. N.S. Gendi, K.I. Welsh, and W.J. Van Venrooij HLA type as a predictor of mixed connective tissue disease differentiation. Ten-year clinical and immunogenetic followup of 46 patients Arthritis Rheum 38 2 1995 259 266
65. + T cells in broncho-alveolar lavage fluid from patients with diffuse lung disease Tohoku J Exp Med 196 4 2002 231 240
66. J. Margaux, G. Hayem, and E. Palazzo Clinical usefulness of antibodies to U1snRNP proteins in mixed connective tissue disease and systemic lupus erythematosus Rev Rhum Engl Ed 65 6 1998 378 386
67. R.M. Hoet, I. Koornneef, and D.J. de Rooij Changes in anti-U1 RNA antibody levels correlate with disease activity in patients with systemic lupus erythematosus overlap syndrome Arthritis Rheum 35 10 1992 1202 1210
68. E. Simmons-O'Brien, S. Chen, and R. Watson One hundred anti-Ro (SS-A) antibody positive patients: a 10-year follow-up Medicine (Baltimore) 74 3 1995 109 130
69. S.E. Sonesson, S. Salomonsson, and L.A. Jacobsson Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies Arthritis Rheum 50 4 2004 1253 1261
70. K. Skriner, W.H. Sommergruber, and V. Tremmel Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease J Clin Invest 100 1 1997 127 135
71. R. Cervera, J.C. Piette, J. Font Euro-Phospholipid Project Group Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients Arthritis Rheum 46 4 2002 1019 1027
72. G.R. Komatireddy, G.S. Wang, and G.C. Sharp Antiphospholipid antibodies among anti-U1-70 kDa autoantibody positive patients with mixed connective tissue disease J Rheumatol 24 2 1997 319 322
73. L.L. Mendonca, O. Amengual, and T. Atsumi Most anticardiolipin antibodies in mixed connective tissue disease are beta2-glycoprotein independent J Rheumatol 25 1 1998 189 190
74. M. Richter Cohen, G. Steiner, and J.S. Smolen Erosive arthritis in systemic lupus erythematosus: analysis of a distinct clinical and serological subset Br J Rheumatol 37 4 1998 421 424
75. J.S. Smolen, and G. Steiner Mixed connective tissue disease: to be or not to be? Arthritis Rheum 41 5 1998 768 777
76. M.W. Boule, C. Broughton, and F. Mackay Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes J Exp Med 199 12 2004 1631 1640