Clinical significance of antibodies to TS1-RNA in patients with mixed connective tissue disease

Journal of Rheumatology

Volumn 30, Issue 5, 2003, Pages 998-1005

  Ikeda, Keigo ^a   Takasaki, Yoshinari ^b   Hirokawa, Kaoru ^b   Takeuchi, Ken ^b   Hashimoto, Hiroshi ^b  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

Antibody; Mixed connective tissue disease; Systemic lupus erythematosus; TS1 RNA; U1RNP

Indexed keywords

DNA ANTIBODY; IMMUNOGLOBULIN A ANTIBODY; RIBONUCLEOPROTEIN ANTIBODY; RNA; SMOOTH MUSCLE ANTIBODY; TS1 RNA ANTIBODY; U1 RIBONUCLEOPROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DERMATOMYOSITIS; DISEASE ACTIVITY; DISEASE COURSE; FEMALE; HELA CELL; HUMAN; HUMAN CELL; HYPERTENSION; IMMUNOPRECIPITATION; MAJOR CLINICAL STUDY; MIXED CONNECTIVE TISSUE DISEASE; POLYMYOSITIS; PRIORITY JOURNAL; PROTEINURIA; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS;

ADULT; ANTIBODIES, ANTINUCLEAR; FEMALE; HELA CELLS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIXED CONNECTIVE TISSUE DISEASE; PRECIPITIN TESTS; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; RNA; SEVERITY OF ILLNESS INDEX;

EID: 0038076233     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Tan EM. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 1989;44:93-152.
2. Eilat D, Lotan C. The reaction of human SLE antibodies with native, single stranded RNA: analysis of nucleotide sequence specificities and correlation with Sm and nRNP activities. Clin Exp Immunol 1982;49:283-9.
3. Eilat D, Hochberg M, Fischel R, Laskov R. Antibodies to RNA from autoimmune NZB/NZW mice recognize a similar antigenic determinant and show large idiotypic diversity. Proc Natl Acad Sci USA 1982;79:3818-22.
4. Lamon EW, Bennett JC. Antibodies to homologous RNA in the rabbit following stimulation by exogenous RNA. Proc Soc Exp Biol Med 1970;134:968-70.
5. Wilusz J, Keene JD. Autoantibodies specific for U1 RNA and initiator methionine tRNA. J Biol Chem 1986;261:5467-72.
6. Deutscher SL, Keene JD. A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody. Proc Natl Acad Sci USA 1988;85:3299-303.
7. van Venrooij WJ, Hoet R, Castrop R, et al. Anti-(U1) small nuclear RNA antibodies in anti-small nuclear ribonucleoprotein sera from patients with connective tissue diseases. J Clin Invest 1990;86:2154-60.
8. Hoet RM, De Weerd P, Gunnewiek JK, et al. Epitope regions on U1 small nuclear RNA recognized by anti-U1RNA-specific autoantibodies. J Clin Invest 1992;90:1753-62.
9. Boulanger C, Chabot B, Menard HA, et al. Autoantibodies in human anti-Ro sera specifically recognize deproteinized hY5 Ro RNA. Clin Exp Immunol 1995;99:29-36.
10. Bunn CC, Mathews MB. Autoreactive epitope defined as the anticodon region of alanine transfer RNA. Science 1987;238:1169-9.
11. Becker HF, Corda Y, Mathéws MB, et al. Iosine and N1-methylinosine within a synthetic oligomer mimicking the anticodon loop of human tRNA (A1a) are major epitopes for anti-PL-12 myositis autoantibodies. RNA 1999;5:865-75.
12. Brouwer R, Vree Egberts W, Jongen PH, et al. Frequent occurrence of anti-tRNA (His) autoantibodies that recognize a conformational epitope in sera of patients with myositis. Arthritis Rheum 1998;41:2059-67.
13. Uchiumi T, Traut RR, Elkon K, Kominami R. A human autoantibody specific for a unique conserved region of 28S ribosomal RNA inhibits the interaction of elongation factors 1a and 2 with ribosomes. J Biol Chem 1991;266:2054-62.
14. Sun Y, Fong KY, Chung MC, Yao ZJ. Peptide mimicking antigenic and immunogenic epitope of double-stranded DNA in systemic lupus erythematosus. Int Immunol 2001;13:223-32.
15. Hoet RM, Koornneef I, de Rooij DJ, et al. Changes in anti-U1 RNA antibody levels correlate with disease activity in patients with systemic lupus erythematosus overlap syndrome. Arthritis Rheum 1992;35:1202-10.
16. Tsai DE, Kenan DJ, Keene JD. In vitro selection of RNA epitopes using autoimmune patients serum. J Immunol 1993;150:1137-45.
17. Hirokawa K, Takasaki Y, Takeuchi K, et al. Anti-TS1-RNA: Characterization of a novel antibody against the sequence-specific RNA by a random RNA selection in patients with Sjögren's syndrome. J Rheumatol 2002;29:931-7.
18. Sharp GC, Irvin WS, Tan EM, et al. Mixed connective tissue disease syndrome associated with a specific antibody to an extractable nuclear antigen. Am J Med 1972;52:148-59.
19. Ohtsuka E, Nonaka S, Shingu M, et al. Sjögren's syndrome and mixed connective tissue disease. Clin Exp Rheumatol 992;10:339-44.
20. Kasukawa R, Tojo T, Miyawaki S. Mixed connective tissue disease - preliminary diagnostic criteria. Jpn J Rheumatol 1988;1:263-7.
21. Smolen JS, Steiner G. Mixed connective tissue disease: to be or not to be? Arthritis Rheum 1998;41:768-77.
22. Burdt MA, Hoffman RW, Deutscher SL, et al. Long-term outcome in mixed connective tissue disease: longitudinal clinical and serological findings. Arthritis Rheum 1999;42:899-909.
23. Vitali C, Bombardieri S, Moutsopoulos HM, et al. Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum 1993;36:340-7.
24. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
25. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteira for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980;23:581-90.
26. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
27. Bohan A, Peter JB. Polymyositis and dermatomyositis (first of 2 parts). N Engl J Med 1975;292:344-7.
28. Ohosone Y, Ishida M, Takahashi Y, et al. Spectrum and clinical significance of autoantibodies against transfer RNA. Arthritis Rheum 1998;41:1625-31.
29. Sharp GC. Diagnostic criteria for classification of MCTD. In: Kasukawa R, Sharp GC, editors. Mixed connective tissue diseases and antinuclear antibodies. Amsterdam: Elsevier; 1987:23-32.
30. Alarcon-Segovia D, Villareal M. Classification and diagnostic criteria for mixed connective tissue disease. In: Kasukawa R, Sharp GC, editors. Mixed connective tissue diseases and antinuclear antibodies. Amsterdam: Elsevier; 1987:33-40.
31. Kahn MF, Appelboom T. Syndrome de Sharp. In: Kahn MF, Peltier AP, Meyer O, Piette JC, editors. Les maladies systemiques. 3rd ed. Paris: Flammarion; 1991:545-56.
32. Kasukawa R, Tojo T, Miyawaki S. Preliminary diagnostic criteria for classification of mixed connective tissue disease. In: Kasukawa R, Sharp GC, editors. Mixed connective tissue diseases and antinuclear antibodies. Amsterdam: Elsevier; 1987:41-7.
33. Chang YN, Kenan DJ, Keene JD, et al. Direct interactions between autoantigen La and human immunodeficiency virus leader RNA. J Virol 1994;68:7008-20.
34. Keene JD, Query CC. Nuclear RNA-binding proteins. Prog Nucl Acids Res Mol Biol 1991;41:179-202.
35. Pettersson I, Wang G, Smith El, et al. The use of immunoblotting and immunoprecipitation of (U) small nuclear ribonucleoproteins in the analysis of sera of patients with mixed connective tissue disease and systemic lupus erythematosus. A cross-sectional, longitudinal study. Arthritis Rheum 1986;29:986-96.
36. Snowden N, Hay E, Holt PJL, Berstein R. Clinical course of patients with anti-RNP antibodies. J Rheumatol 1993;20:1256-8.
37. de Rooji DJ, Habets WJ, van de Putte LB, et al. Use of recombinant RNP peptides 70K and A in an ELISA for measurement of antibodies in mixed connective tissue disease: a longitudinal follow up of 18 patients. Ann Rheum Dis 1990;49:391-5.