Analysis of human T cell and B cell responses against U small nuclear ribonucleoprotein 70-kd, B, and D polypeptides among patients with systemic lupus erythematosus and mixed connective tissue disease

Arthritis and Rheumatism

Volumn 40, Issue 8, 1997, Pages 1493-1503

  Holyst, Margaret Mary ^a   Hill, Don L ^a   Hoch, Sallie O ^b   Hoffman, Robert W ^a,c  

^a UNIVERSITY OF MISSOURI   (United States)

^b AGOURON PHARMACEUTICALS INC   (United States)

^c MA427 HSC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HYBRID PROTEIN; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; POLYPEPTIDE; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CELL CLONE; CELLULAR IMMUNITY; CLINICAL ARTICLE; FEMALE; HUMAN; HUMORAL IMMUNITY; MALE; MIXED CONNECTIVE TISSUE DISEASE; PRIORITY JOURNAL; SEROLOGY; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

ADULT; ANTIBODY FORMATION; AUTOANTIBODIES; B-LYMPHOCYTES; CLONE CELLS; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOBLOTTING; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; MIXED CONNECTIVE TISSUE DISEASE; PEPTIDES; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 0030924449     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780400818     Document Type: Article

References (27)

1. Tan EM: Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 52:148-151, 1989
2. Pettersson I, Hinterberger M, Mimori T, Gottleib E, Steitz JA: The structure of mammalian small nuclear ribonucleoproteins: identification of multiple protein and anti-Sm autoantibodies. J Biol Chem 259:5907-5914, 1984
3. Zieve G, Ward RA: Cell biology of the snRNP particles. Crit Rev Biochem Mol Biol 25:1-46, 1990
4. Pettersson I, Wang G, Smith EI, Wigzell H, Hedfors E, Horn J, Sharp GC: The use of immunoblotting and immunoprecipitation of (U) small nuclear ribonucleoproteins in the analysis of sera of patients with mixed connective tissue disease and systemic lupus ervthematosus: a cross-sectional, longitudinal study. Arthritis Rheum 29:986-996, 1986
5. Hoffman RW, Rettenmaier LJ, Takeda Y, Hewett JE, Pettersson I, Nyman U, Luger AM, Sharp GC: Human autoantibodies against the 70-kd polypeptide of U1 small nuclear RNP are associated with HLA-DR4 among connective tissue disease patients. Arthritis Rheum 33:666-673, 1990
6. Kaneoka H, Hsu K-C, Takeda Y, Sharp GC, Hoffman RW: Molecular genetic analysis of HLA-DR and HLA-DQ genes among anti-U1-70-kd autoantibody positive connective tissue disease patients. Arthritis Rheum 35:83-94, 1992
7. Olsen ML, Arnett FC, Reveille JD: Contrasting molecular patterns of MHC class II alleles associated with the anti-Sm and anti-RNP precipitin autoantibodies in systemic lupus erythematosus. Arthritis Rheum 36:94-104, 1993
8. Hoffman RW, Takeda Y, Sharp GC, Lee DR, Hill DL, Kaneoka H, Caldwell CW: Human T cell clones reactive against U-small nuclear ribonucleoprotein autoantigens from connective tissue disease patients and healthy individuals. J Immunol 151:6460-6469, 1993
9. Hoffman RW, Kaneoka H, Hsu K-C, Takeda Y, Caldwell CW, Sharp GC: Molecular analysis of the human immune response to the U1-70kD antigen (abstract). Mol Biol Rep 15:132, 1991
10. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277, 1982
11. Porter JF, Kingsland LC, Lindberg DAB III, Shah I, Benge JM, Hazelwood SE, Kay DR, Homma M, Akizuki M, Takano M, Sharp GC: The AI/RHEUM knowledge-based computer consultant system in rheumatology: performance in the diagnosis of 59 connective tissue disease patients from Japan. Arthritis Rheum 31:219-226, 1988
12. Nyman U, Lundberg I, Hedfors E, Pettersson I: Recombinant 70-kD protein used for determination of autoantigenic epitopes recognized by anti-RNP sera. Clin Exp Immunol 81:52-58, 1990
13. Rokeach LA, Haselby JA, Hoch SO: Molecular cloning of a cDNA encoding the human Sm-D autoantigen. Immunology 85:4832-4836, 1988
14. Rokeach LA, Jannatipour M, Haselby JA, Hoch SO: Primary structure of a human small nuclear ribonucleoprotein polypeptide as deduced by cDNA analysis. J Biol Chem 264:5024-5030, 1989
15. Hoffman RW, Sharp GC, Deutscher SL: Analysis of anti-U1 RNA antibodies in patients with connective tissue disease: association with HLA and clinical manifestations of disease. Arthritis Rheum 38:1837-1844, 1995
16. Hoffman RW, Cassidy JT, Takeda Y, Smith-Jones EI, Wang GS, Sharp GC: U1-70-kd autoantibody-positive mixed connective tissue disease in children: a longitudinal clinical and serologic analysis. Arthritis Rheum 36:1599-1602, 1993
17. Hoffman RW, Bluestone JA, Leo O, Shaw S: Lysis of anti-T3 bearing murine hybridoma cells by human allospecific cytotoxic T cell clones and inhibition of that lysis by anti-T3 and anti-LFA-1 antibodies. J Immunol 135:5-8, 1985
18. Vieira P, de Waal-Malefyt R, Dang M-N, Johnson KE, Kastelein R, Fiorentino DF, de Vries JF, Roncarolo M-G, Mosmann TR, Moore KW: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRF1. Immunology 88:1172-1176, 1991
19. McKenzie ANJ, Culpepper JA, de Waal Malefyt R, Briere F, Punnonen J, Aversa G, Sato A, Dang W, Cocks GB, Menon S, de Vries JE, Banchereau J, Zurawski GR: Interleukin-13, a T cell-derived cytokine that regulates human monocyte and B cell function. Proc Natl Acad Sci U S A 90:3735-3739, 1993
20. Daniel WW: Applied Nonparametric Statistics. Second edition. New York, PWS-Kent Publishing Co, 1990
21. O'Brien RM, Cram DS, Coppel RL, Harrison LC: T-cell epitopes on the 70-kDa protein of the (U1)RNP complex in autoimmune rheumatologic disorders. J Autoimmun 3:747-757, 1990
22. Okubo M, Yamamoto K, Kato T, Matsuura N, Nishimaki T, Kasukawa K, Ito K, Mizushima Y, Nishioka K: Detection and epitope analysis of autoantigen-reactive T cells to the U1-small nuclear ribonucleoprotein A protein in autoimmune disease patients. J Immunol 151:1108-1115, 1993
23. Wolff-Vorbeck G, Hackl W, Fenning S, Krawinkel U, Luhrmann R, Peter HH, Schlesier M: Characterization of an HLA-DR4-restricted T cell clone recognizing a protein moiety of small nuclear ribonucleoproteins (UsnRNP). Clin Exp Immunol 95:378-384, 1994
24. Fenning S, Wolff-Vorbeck G, Hackl W, Krawinkel U, Luhrmann R, Northemann W, Peter HH, Schlesier M: T cell lines recognizing the 70-kD protein of U1 small nuclear ribonucleoprotein (U1snRNP). Clin Exp Immunol 101:408-413, 1995
25. Ebner C, Schenk S, Szepfalusi Z, Hoffmann K, Ferreira F, Wilheim M, Sceiner O, Kraft D: Multiple T cell specificities for Bet v I, the major birch pollen allergen, within single individuals: studies using specific T cell clones and overlapping peptides. Eur J Immunol 23:1523-1527, 1993
26. Paliard X, de Waal Malefijt R, Yssel H, Blanchard D, Chretien I, Abrams J, de Vries J, Spits H: Simultaneous production of IL-2, IL-4, and IFN-γ by activated human CD4+ and CD8+ T cell clones. J Immunol 141:849-855, 1988
27. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T cells. Nature 383:787-793, 1996