Corticosteroids for alcoholic hepatitis - What's next?

Journal of Hepatology

Volumn 43, Issue 3, 2005, Pages 526-533

  Mathurin, Philippe ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; INFLIXIMAB; PENTOXIFYLLINE; PLACEBO; PREDNISOLONE; PROPYLTHIOURACIL; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ALCOHOL LIVER DISEASE; CLINICAL TRIAL; DEVICE; DISEASE SEVERITY; DRUG EFFICACY; DRUG RESPONSE; ENTERIC FEEDING; HUMAN; LIVER SUPPORT; META ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SURVIVAL;

ADRENAL CORTEX HORMONES; HEPATITIS, ALCOHOLIC; HUMANS; REPRODUCIBILITY OF RESULTS; SURVIVAL ANALYSIS;

EID: 23444450032     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.06.003     Document Type: Review

References (93)

1. P. Mathurin, and T. Poynard Pharmacological treatment for alcoholic hepatitis and cirrhosis: present practice and future strategies D. Sherman V. Preedy R. Watson Ethanol and the liver: mechanisms and management 2002 Harwood Academic Publisher Switzerland 592 613
2. S. Naveau, S. Chollet-Martin, S. Dharancy, P. Mathurin, P. Jouet, and M.A. Piquet A double blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis Hepatology 39 2004 1390 1397
3. P. Mathurin, C. Mendenhall, R.L. Carithers Jr, M.J. Ramond, W.C. Maddrey, and P. Garstide Corticosteroids improve short term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials J Hepatol 36 2002 480 487
4. M.J. Ramond, T. Poynard, B. Rueff, P. Mathurin, C. Theodore, and J.C. Chaput A randomized trial of prednisolone in patients with severe alcoholic hepatitis N Engl J Med 326 1992 507 512
5. R.L. Carithers Jr, H.F. Herlong, A.M. Diehl, E.W. Shaw, B. Combes, and H.J. Fallon Methylprednisolone therapy in patients with severe alcoholic hepatitis: a randomized multicenter trial Ann Int Med 110 1989 685 690
6. S.F. Stewart, and C.P. Day The management of alcoholic liver disease J Hepatol 38 2003 S12 S13
7. J. Roman, A. Colell, C. Blasco, J. Caballeria, A. Pares, and J. Rodes Differential role of ethanol and acetaldehyde in the induction of oxydative stress in Hep G2 cells: effect on transcription factors AP-1 and NF-KB Hepatology 30 1999 1473 1480
8. S. Kamimura, and H. Tsukamoto Cytokine gene expression by kupffer cells in experimental alcoholic liver disease Hepatology 21 1995 1304 1309
9. M.G. Neuman, N.H. Shear, S. Bellentani, and C. Tiribelli Role of cytokines in ethanol-induced cytotoxicity in vitro in Hep G2 cells Gastroenterology 115 1998
10. J. Hansen, D.L. Cherwitz, and J.I. Allen The role of tumor necrosis factor alpha in acute endotoxin-induced hepatotoxicity in ethanol-fed rats Hepatology 20 1994 461 474
11. Y. Adachi, B.U. Bradford, W. Gao, H.K. Bojes, and R.G. Thurman Inactivation of kupffer cells prevents liver injury in rats following long-term exposure to ethanol Hepatology 20 1994 453 460
12. M. Yin, M.D. Wheeler, H. Kono, B.U. Bradford, R.M. Gallucci, and M.I. Luster Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice Gastroenterology 117 1999 942 950
13. W. Olinger, H.P. Dinges, K. Zatloukal, S. Mair, F. Gollowitsch, and H. Denk Immunohistochemical detection of tumor necrosis factor-alpha, other cytokines and adhesion molecules in human livers with alcoholic hepatitis Virchows Archiv A Pathol Anat 423 1993 169 176
14. T. Poynard, D. Thabut, A. Chryssostalis, J. Taieb, and V. Ratziu Anti-tumor necrosis factor-alpha therapy in severe alcoholic hepatitis: are large randomized trials still possible? J Hepatol 38 2003 518 520
15. W.C. Maddrey Alcoholic hepatitis: clinicopathologic features and therapy Semin Liv Dis 8 1988 91 102
16. W.J. Powell Jr, and G. Klastin Duration of survival in patients with Laennec's cirrhosis. Influence of alcohol withdrawal, and possible effects of recent changes in general management of the disease Am J Med 44 1968 406 420
17. A. Pares, J. Caballeria, M. Bruguera, M. Torres, and J. Rodes Histological course of alcoholic hepatitis. Influence of abstinence, sex and extent of hepatic damage J Hepatol 2 1986 33 42
18. N. Pande, R. Resnick, W. Yee, V.F. Eckardt, and J.L. Shurberg Cirrhotic portal hypertension: morbidity of continued alcoholism Gastroenterology 74 1978 64 69
19. W.C. Maddrey, J.K. Boitnott, M.S. Bedine, F.L. Weber, E. Mezey, and R.I. White Corticosteroid therapy of alcoholic hepatitis Gastroenterology 75 1978 193 199
20. R.A. Helman, M.H. Temko, S.W. Nye, and H.J. Fallon Natural history and evaluation of prednisolone therapy Ann Intern Med 74 1971 311 321
21. H.P. Porter, F.R. Simon, C.E. Pope, W. Volwiler, and F. Fenster Corticosteroid therapy in severe alcoholic hepatitis N Engl J Med 284 1971 1350 1355
22. J.L. Campra, E.M. Hamlin, R.J. Kirshbaum, M. Olivier, A.G. Redeker, and T.B. Reynolds Prednisone therapy of acute alcoholic hepatitis Ann Int Med 79 1973 625 631
23. B.L. Blitzer, M.G. Mutchnick, P.H. Joshi, M.M. Phillips, J.M. Fessel, and H.O. Conn Adrenocorticosteroid therapy in alcoholic hepatitis: a prospective, double-blind randomized study Am J Dig Dis 22 1977 477 484
24. H.R. Lesesne, E.M. Bozymski, and H.J. Fallon Treatment of alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements Gastroenterology 74 1978 169 173
25. J.B. Shumaker, R.H. Resnick, J.T. Galambos, H. Makopour, and F.L. Iber A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis Am J Gastroenterol 69 1978 443 449
26. A. Theodossi, A.L.W.F. Eddleston, and R. Williams Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis Gut 23 1982 75 79
27. W. Depew, T. Boyer, M. Omata, A. Redeker, and T. Reynolds Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy Gastroenterology 78 1980 524 529
28. P. Bories, J.Y. Guedj, D. Mirouze, A. Yousfi, and H. Michel Traitement de l'hépatite alcoolique aiguë par la prednisolone Presse Med 16 1987 769 772
29. C.L. Mendenhall, S. Anderson, P. Garcia-Pont, S. Goldberg, T. Kiernan, and L.B. Seef Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone N Engl J Med 311 1984 1464 1470
30. T.F. Imperiale, and A.J. McCullough Do corticosteroids reduce mortality from alcoholic hepatitis? Ann Int Med 113 1990 299 307
31. P. Mathurin, V. Duchatelle, M.J. Ramond, C. Degott, P. Bedossa, and S. Erlinger Survival and prognostic factors in patients with severe biopsy-proven alcoholic hepatitis treated by prednisolone: randomized trial, new cohort, and simulation Gastroenterology 110 1996 1847 1853
32. J.P. Daures, P. Peray, P. Bories, P. Blanc, A. Youfsi, and H. Michel Place de la corticothérapie dans le traitement des hépatites alcooliques aiguës. Résultats d'une méta-analyse Gastroenterol Clin Biol 15 1991 223 228
33. E. Christensen, and C. Gludd Glucocorticosteroids are ineffective in alcoholic hepatitis: A meta-analysis adjusting for confounding variables Gut 37 1995 113 118
34. T.F. Imperiale, J. O'Connor, and A.J. McCullough Corticosteroids are effective in patients with severe alcoholic patients Am J Gastroenterol 94 1999 3066 3067
35. T. Poynard, M. Munteanu, V. Ratziu, Y. Benhamou, V. Di Martino, and J. Taieb Truth survival in clinical research: an evidence based requiem? Ann Int Med 136 2002 888 895
36. T.F. Imperiale Meta-analysis: when and how Hepatology 29 1999 26S 31S
37. J. Taïeb, P. Mathurin, C. Elbim, P. Cluzel, M. Arce-Vicioso, and B. Bernard Blood neutrophil functions and cytokine synthesis in severe alcoholic hepatitis. Effect of corticosteroids J Hepatol 32 2000 579 586
38. L. Spahr, L. Rubbia-Brandt, J. Pugin, E. Giostra, J.L. Frossard, and B. Borisch Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood J Hepatol 35 2001 582 589
39. P. Mathurin, M. Abdelnour, M.J. Ramond, N. Carbonnell, L. Fartoux, and L. Serfaty Early change in bilirubin levels (ECBL) is an important prognostic factor in severe biopsy-proven alcoholic hepatitis (AH) treated by prednisolone Hepatology 38 2003 1363 1369
40. L. Spahr, L. Rubbia-Brandt, J.L. Frossard, E. Giostra, A.L. Rougemont, and J. Pugin Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized pilot study J Hepatol 37 2002 448 455
41. C. Duvoux, C. Radier, F. Roudot-Thoraval, F. Maille, M.C. Anglade, and J.T. Tran Van-Nhieu Low-grade steatosis and major changes in portal flow as new prognostic factors in steroid-treated alcoholic patients Hepatology 40 2004 1370 1378
42. P. Cales, C. Masliah, B. Bernard, P.P. Garnier, C. Silvain, and N. Szostak-Talbodec Early administration of vapreotide for variceal bleeding in patients with cirrhosis N Engl J Med 344 2001 23 28
43. A. Louvet, F. Texier, S. Dharancy, J. Boitard, P. Deltenre, and F. Gonzalez A prognostic model predicting the death at 6 months of patients with severe alcoholic hepatitis Hepatology 40 2004 274A
44. H. Orrego, J.E. Blake, L.M. Blendis, K.V. Compton, and Y. Israel Long-term treatment of alcoholic liver disease with propylthiouracil N Engl J Med 317 1987 1421 1427
45. S. Worrall, J. de Jersey, B.C. Shanley, and P. Wilce Antibodies against acetaldehyde-modified epitopes: presence in alcoholic, non-alcoholic liver disease and control subjects Alcohol Alcohol 25 1990 509 517
46. J. Ho, J. Buchweitz, R. Roth, and P. Ganey Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes J Leukoc Biol 59 1996 716 724
47. S.J. Weiss Tissue destruction by neutrophils N Engl J Med 320 1989 365 376
48. A.P. Bautista, N.B. D'Souza, C.H. Lang, and J.J. Spitzer Modulation of f-met-leu-phe-induced chemotactic activity and superoxyde production of neutrophils during chronic ethanol intoxication Alcohol Clin Exp 16 1992 788 794
49. A.A. Nanjii, B. Griniuviene, L.K. Yacoub, F. Fogt, and S.R. Tahan Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease: relationship to entoxemia and TNF alpha messenger RNA Exp Mol Pathol 62 1995 42 51
50. A.P. Bautista Chronic intoxication enhances the expression of CD18 adhesion molecules on rat neutrophils and release of a chemotactic factor by kupffer cells Alcohol Clin Exp Res 19 1995 285 290
51. P. Bedossa, T. Poynard, S. Naveau, E.D. Martin, H. Agostini, and J.C. Chaput Observer variation in assessment of liver biopsies of alcoholic patients Alcohol Clin Exp Res 12 1988 173 178
52. R.G. Thurman, Y. Limuro, K.T. Knecht, H.D. Connor, Y. Adachi, and C. Wall Role of Kupffer cells, endotoxin and free radicals in hepatotoxicity due to prolonged alcohol consumption: studies in female and male rats J Nutr 127 1997 903S 906S
53. R.G. Thurman Alcoholic liver injury involves activation of kupffer cells by endotoxin Am J Physiol 275 1998 G605 G611
54. Y. Adachi, L.E. Moore, B.U. Bradford, W. Gao, and R.G. Thurman Antibiotics prevent liver injury in rats following long-term exposure to ethanol Gastroenterology 108 1995 218 224
55. P. Mathurin, Q.G. Deng, A. Keshavarzian, S. Choudhary, E.W. Holmes, and H. Tsukamoto Exacerbation of alcoholic liver injury by enteral endotoxin in rats Hepatology 32 2000 1008 1017
56. A.A. Nanji, U. Khettry, and S.M. Sadrzadeh Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease Proc Soc Exp Biol Med 205 1994 243 247
57. A.A. Nanji, U. Khettry, S.M.H. Sadrzadeh, and T. Yamanaka Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2 Am J Pathol 142 1993 367 373
58. A. Kershavarzian, E.W. Holmes, M. PAtel, F. Ider, J.Z. Fields, and S. Pethkar Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage Am J Gastroenterol 1 1999 200 207
59. A. Parlesak, C. Schafer, T. Schutz, J.C. Bode, and C. Bode Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol- induced liver disease J Hepatol 32 2000 742 747
60. A. Khoruts, L. Stahnke, C.J. McClain, G. Logan, and J.I. Allen Circulating tumor necrosis factor, interleukin-1 and interleukin 6 concentrations in cirrhotic alcoholic patients Hepatology 13 1991 267 276
61. A. Nanji, U. Khettry, and S. Sadrzadeh Lactobacillus feeding reduces endotoxinemia and severity of experimental alcoholic liver disease Proc Soc Exp Biol Med 205 1994 243 247
62. A.A. Nanji, L. Miao, P. Thomas, A. Rahemtulla, S. Khwaja, and S. Zhao Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat Gastroenterology 112 1997 943 951
63. N. Enomoto, K. Ikejima, B. Bradford, C. Rivera, H. Kono, and D.A. Brenner Alcohol causes both tolerance and sensitization of rat kupffer cells via mechanisms dependent on endotoxin Gastroenterology 115 1998 443 451
64. M. Yin, B.U. Bradford, M.D. Wheeler, T. Uesugui, M. Froh, and S.M. Goyert Reduced liver injury in CD14-deficient mice J Immunol 166 2001 4737 4742
65. T. Uesugi, M. Froh, G.E. Arteel, B.U. Bradford, and R.G. Thurman Toll-Like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice Hepatology 23 2001 101 108
66. A.A. Nanji, S. Zhao, S.M.H. Sadrzadeh, and D.J. Waxman Use of reverse transcription-polymerase chain reaction to evaluate in vivo cytokine gene expression in rats fed ethanol for long periods Hepatology 19 1994 1483 1487
67. Y. Limuro, R.M. Gallucci, M.I. Luster, H. Khono, and R.G. Thurman Antibodies to tumor necrosis factor alpha attenuate hepatic necrosis and inflammation due to chornic exposure to ethanol in rats Hepatology 26 1997 1530 1537
68. N. Sheron, G. Bird, J. Koskinas, B. Portmann, M. Ceska, and I. Lindley Circulating and tissue levels of the neutrophil chemotaxin IL8 are elevated in severe acute alcoholic hepatitis, and tissue level correlate with neutrophil infiltration Hepatology 18 1993 41 46
69. G.L.A. Bird, N. Sheron, A.K.J. Goka, G.J. Alexander, and R.S. Williams Increased plasma tumor necrosis factor in severe alcoholic hepatitis Ann Int Med 112 1990 917 920
70. M.E. Felver, E. Mezey, M. McGuire, M.C. Mitchell, H.F. Herlong, and G.A. Veech Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis Alcohol Clin Exp Res 14 1990 255 259
71. J.C. Fernandez-Checa, N. Kaplowitz, C. Garcia-Ruiz, A. Collel, M. Miranda, and M. Mari GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect Am J Physiol 273 1997 G7 G17
72. V. Goossens, J. Grooten, K. De Vos, and W. Fiers Direct evidence for tumor necrosis factor induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity Proc Natl Sci USA 92 1995 8115 8119
73. G. Chaudri, and I.A. Clark Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor J Immulol 143 1989 1290 1294
74. C. Garcia-Ruiz, A. Collel, A. Morales, N. Kaplowitz, and J.C. Fernandez-Checa Role of oxidative express generated from the mitochondrial electron transport chain and mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor-kappa B: studies with isolated mitochondria and rat hepatocytes Mol Pharmacol 48 1995 825 834
75. J.C. Fernandez-Checa, N. Kaplowitz, C. Garcia-Ruiz, and A. Colell Mitochondrial glutathione: importance and transport Semin Liv Dis 18 1998 389 401
76. J.C. Fernandez-Checa, M. Ookhtens, and N. Kaplowitz Effect of chronic ethanol feeding on rat hepatocytic glutathion: compartmentation, efflux and response to incubation with ethanol J Clin Invest 80 1987 57 62
77. J.C. Fernandez-Checa, M. Ookhtens, and N. Kaplowitz Effects of chronic ethanol feeding on rat hepatocytic glutathione: relationship of cytosolic glutathione to efflux and mitochondrial sequestration J Clin Invest 83 1988 1247 1252
78. C. Garcia-Ruiz, A. Morales, A. Ballesta, J. Rodes, N. Kaplowitz, and J.C. Fernandez-Checa Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes J Clin Invest 94 1994 193 201
79. R. Jalan, S. Sen, C. Steiner, D. Kapoor, A. Alisa, and R. Williams Extracorporeal liver support with molecular absorbents recirculating system in patients with severe alcoholic hepatitis J Hepatol 38 2003 24 31
80. E. Cabre, P. Rodriguez-Iglesias, J. Caballeria, J.C. Quer, J.L. Sanchez-Lombrana, and A. Pares Short- and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: a multicenter randomized trial Hepatology 32 2000 36 42
81. H. Tsukamoto, S.W. French, N. Benson, G. Delgado, G.A. Rao, and E.C. Lzrkin Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet Hepatology 5 1985 224 232
82. H. Tsukamoto, C. Towner, L.M. Ciofalo, and S.W. French Ethanol induced liver fibrosis in rats fed high fat diet Hepatology 6 1986 814 822
83. H. Tsukamoto, S. Cheng, and W.S. Blanner Effects of dietary polyunsaturated fat on ethanol-induced Ito cell activation Am J Pysiol 270 1996 G581 G586
84. H. Tsukamoto Animal models of alcoholic liver injury Clin Liver Dis 2 1998 739 752
85. M.A. Alvarez, E. Cabre, V. Lorenzo-Zuniga, S. Montoliu, R. Planas, and M.A. Gassul Combining steroids with enteral nutrition: a better therapeutic strategy for severe alcoholic hepatitis: results of a pilot study Eur J Gastroenterol Hepatol 16 2004 1375 1380
86. G.M. Doherty, C.J. Jensen, H.R. Alexander, C.M. Buresh, and J.A. Norton Pentoxifylline suppression of tumor necrosis factor gene transcription Surgery 110 1991 192 198
87. J. Han, B. Thompson, and B. Beutler Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor for analysis at separate points in the signaling pathway J Exp Med 172 1990 391 394
88. E. Akriviadis, R. Botla, W. Briggs, S. Han, T. Reynolds, and O. Shakil Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial Gastroenterology 119 2000 1637 1648
89. R.P. Mookerjee, S. Sen, N.A. Davies, S.J. Hodges, R. Williams, and R. Jalan Tumor necrosis factor is an important mediator of portal and systemic haemodynamic derangements in alcoholic hepatitis Gut 52 2003 1182 1187
90. H. Tilg, R. Jalan, A. Kaser, N.A. Davies, and F.A. Offner HodgesSJ.Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis J Hepatol 38 2003 419 425
91. L. Blendis, and I. Dotan Anti-TNF therapy for severe acute alcoholic hepatitis: what went wrong? Gastroenterology 127 2004 1637 1639
92. Y. Yamada, I. Kirillova, J.J. Peschon, and N. Fausto Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type 1 tumor necrosis factor receptor Proc Natl Acad Sci USA 94 1997 1441 1445
93. M. Peters, G. Blinn, T. Jostock, P. Schirmacher, K.H. Meyer zum Buschenfelde, and P.R. Galle Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration Gastroenterology 119 2000 1663 1671