Recombinant human bone morphogenetic protein (rhBMP) induced heterotopic bone development in vivo and in vitro

Proceedings of the Society for Experimental Biology and Medicine

Volumn 211, Issue 3, 1996, Pages 265-272

  Volek Smith, Holly ^a   Urist, Marshall R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ASCORBIC ACID; BONE MORPHOGENETIC PROTEIN; CALCIUM; CELLULOSE ACETATE; DNA; GLYCOSAMINOGLYCAN; PHOSPHATE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SULFATE; SULFUR 35; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MATRIX; CARTILAGE; CONCENTRATION RESPONSE; CONNECTIVE TISSUE; CONTROLLED STUDY; HETEROTOPIC OSSIFICATION; MALE; NONHUMAN; RAT; TISSUE TRANSPLANTATION;

ANIMALIA; RECTUS; TRITIUM;

EID: 0029934670     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-211-43970     Document Type: Article

References (35)

1. Urist MR, Nogami H. Morphogenetic substratum for differentiation of cartilage in tissue culture. Nature 225:1051-1052, 1970.
2. Nogami H, Urist MR. A substratum of bone matrix for differentiation of mesenchymal cells into chondro-osseus tissues in vitro. Exp Cell Res 63:404-410, 1970.
3. Nogami H, Urist MR. Explants, transplants, and implants of a cartilage and bone morphogenetic matrix. Clin Orthop 103:235-251, 1974.
4. Nogami H, Urist MR. Substrata prepared from bone matrix for chondrogenesis in tissue culture. J Cell Biol 62:510-519, 1974.
5. Urist MR, Terashima Y, Stamos C. Cartilage tissue differentiation from mesenchymal cells derived from mature muscles in tissue culture. In Vitro 14(8):697-706, 1978.
6. Nogami H, Oohira A, Terashima Y, Urist MR. Radioactive isotope labelled diffusible components of a bone morphogenetic protein. Clin Orthop 122:307-314, 1977.
7. Nathanson MA. Transdifferentiation of skeletal muscle into cartilage: Transformation or differentiation? Curr Top Dev Biol 20:39-62, 1986.
8. Nathanson MA. In vitro proteoglycan synthesis in response to extracts of demineralized bone. Clin Orthop 299:263-281, 1994.
9. Nakagawa M, Urist MR. Chrondrogenesis in tissue cultures of muscle under the influence of a diffusible component of bone matrix. Proc Soc Exp Biol Med 154:568-572, 1977.
10. Sato K, Urist MR. Bone morphogenetic protein-induced cartilage development in tissue culture. Clin Orthop 183:180-187, 1984.
11. Kataoka H, Urist MR. Transplant of bone marrow and muscle-derived connective tissue cultures in diffusion chambers for bioassay of bone morphogenetic protein. Clin Orthop 286:262-270, 1974.
12. Terashima Y, Urist MR. BrdU-inhibition of substratum controlled chondrogenesis. Proc Soc Exp Biol Med 146:855-858, 1974.
13. Terashima Y, Urist MR. Chondrogenesis in outgrowths of muscle tissue onto modified bone matrix in tissue culture. Clin Orthop 127:248-255, 1977.
14. Urist MR, Iwata H. Preservation and biodegradation of the morphogenetic property of bone matrix. J Theor Biol 38:155-167, 1973.
15. Urist MR, Granstein R, Nogami H, Svenson L, Murphy R. Transmembrane bone morphogenesis across multiple-walled chambers: New evidence of a diffusible bone morphogenetic property. AMA Arch Surg 112:612-619, 1977.
16. Katoh R, Urist MR. Surface adhesion and attachment factors in bone morphogenetic protein-induced chondrogenesis in vitro. Clin Orthop 295:295-304, 1993.
17. Kawamura M, Urist MR. Growth factors, mitogens, cytokines, and bone morphogenetic protein in induced chodrogenesis in tissue culture. Dev Biol 130(2):435-442, 1988.
18. Murray SS, Murray EJB, Glackin CA, Urist MR. Bone morphogenetic protein inhibits differentiation and affects expression of helix-loop-helix regulatory molecules in myoblastic cells. J Cell Biochem 53:1-10, 1993.
19. Hanamura H, Higuchi Y, Nakagawa M, Iwata H, Urist MR. Solubilized bone morphogenetic protein (BMP) from mouse osteosarcoma and rat demineralized bone matrix. Clin Orthop 148:281-290, 1980.
20. Takahashi S, Urist MR. Differentiation of cartilage in three substrata under the influence of an aggregate of morphogenetic protein and other bone tissue non collagenous proteins (BMP/ iNCP). Clin Orthop 207:227-238, 1986.
21. Urist MR. The search for and discovery of bone morphogenetic protein (BMP). In: Urist MR, Burwell RG, O'Conner BT, Eds. Bone Grafts, Derivatives and Substitutes. London: Butterworth Heinemann, pp315-362, 1994.
22. Reddi AH. Regulation of cartilage and bone differentiation by bone morphogenetic proteins. Curr Opin Cell Biol 4(5):850-855, 1992.
23. 3H1OT1/2 and 3T3 cells. Growth Factors 9:57-71, 1993.
24. Israel DI, Nove J, Kerns KM, Moutsatsos IK, Kaufman RJ. Expression and characterization of bone morphogenetic protein-2 in Chinese hamsters ovary cells. Growth Factors 7:139-150, 1992.
25. Thies RS, Bauduy M, Ashton BA, Kurtzberg L, Wozney JM, Rosen V. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stroma cells. Endocrinology 130:1318-1324, 1992.
26. 3H1OT1/2 is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun 172:295-299, 1990.
27. Yamaguchi A, Katagiri T, Ikeda T, Wozney JM, Rosen V, Wang FA, Kahn AJ, Suda T, Yoshiki S. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 113(3):681-687.
28. Healy GM, Parker RC. An improved chemically defined basal medium (CMRL). J Cell Biol 30:531-538, 1966.
29. Urist MR. Heterotopic bone formation. In: Urist MR, Ed. Fundamental and Clinical Bone Physiology. Philadelphia: J. B. Lippincott, pp369-393, 1980.
30. Tenebaum HD, Heersche JNM. Differentiation of osteoblasts and formation of mineralized bone in vitro. Calcif Tissue Int 34:76-79, 1982.
31. Tenebaum HD, Limeback H, McCulloch CAG, Mamujee H, Sukhu B, Torontali M. Osteogenic phase-specific co-regulation of collagen synthesis and mineralization by β-glycerophosphatase in chick periosteal cultures. Bone 13:129-138, 1992.
32. Firschein HE, Urist MR. The induction of alkaline phosphatase by extraskeletal implants of bone matrix. Calcif Tissue Res 7:108-113, 1971.
33. Bellows CG, Aubin JE, Heersche JNM, Antosz ME. Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations. Calcif Tissue Int 38:143-154, 1986.
34. Zimmermann B, Wachtel JC, Vormann J. Kinetics of β-glycerophosphatase-induced endochondral mineralization in vitro. Calcium accumulation, alkaline phosphatase activity, and effects of levamisole. Calcif Tissue Int 51:54-61, 1992.
35. Rickard DJ, Sullivan TA, Shenker BJ, LeBoy PS, Cazhdan HI. Induction of rapid osteoblast differentiation of rat bone marrow stromal cell cultures by dexamathasone and BMP-2. Dev Biol 161:218-228, 1994.