Dose response to a single intramuscular injection of recombinant adeno- associated virus-erythropoietin in monkeys

Journal of Surgical Research

Volumn 90, Issue 2, 2000, Pages 102-108

  Rudich, Steven M ^a   Zhou, Shangzhen ^b   Srivastava, Ranjana ^b   Escobedo, Jaime A ^b   Perez, Richard V ^a   Manning, William C ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Adeno associated virus vector; Cynomolgus monkeys; Erythropoietin; Gene therapy

Indexed keywords

ERYTHROPOIETIN; RECOMBINANT ERYTHROPOIETIN; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANEMIA; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; DOSE RESPONSE; HEMATOCRIT; MONKEY; NONHUMAN; PRIORITY JOURNAL;

EID: 0034657760     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2000.5859     Document Type: Article

References (19)

1. Krantz S. B. Erythropoietin. Blood. 77:1991;419.
2. Nissenson A. R. Erythropoietin: Biology, clinical use, and impact on patients: An international symposium. Am. J. Kid. Dis. 18:1991;1.
3. Gimenez L. F., Scheel P. J. Clinical applications of recombinant erythropoietin in renal dialysis patients. Hematol. Oncol. Clin. North Am. 8:1994;913.
4. Rizzuto G., Cappelletti M., Maione D., Savino R., Lazzaro D., Costa P., Mathiesen I., Cortese R., Ciliberto G., Laufer R., La Monica N., Fattori E. Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc. Natl. Acad. Sci. USA. 96:1999;6417.
5. Klinman D. M., Conover J., Leiden J. M., Rosenberg A. S., Sechler J. M. G. Safe and effective regulation of hematocrit by gene gun administration of an erythropoietin-encoding DNA plasmid. Hum. Gene Ther. 10:1999;659.
6. Serguera C., Bohl D., Rolland E., Prevost P., Heard J. M. Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymer-encapsulated engineered cells. Hum. Gene Ther. 10:1999;375.
7. Regulier E., Schneider B. L., Deglon N., Beuzard Y., Aebischer P. Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts. Gene Ther. 5:1998;1014.
8. Osborne W. R. A., Ramesh N., Lau S., Clowes M. M., Dale D. C., Clowes A. W. Gene therapy for long-term expression of erythropoietin in rats. Proc. Natl. Acad. Sci. USA. 92:1995;8055.
9. Dai Y., Roman M., Naviaux R. K., Verma I. M. Gene therapy via primary myoblasts: Long-term expression of factor IX protein following transplantation in vivo. Proc. Natl. Acad. Sci. USA. 89:1992;10892.
10. Kessler P. D., Podsakoff G. M., Chen X., McQuiston S. A., Colosi P. C., Matelis L. A., Kurtzman G. J., Byrne B. J. Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein. Proc. Natl. Acad. Sci. USA. 93:1996;14082.
11. Svensson E. C., Black H. B., Dugger D. L., Tripathy S. K., Goldwasser E., Hao Z., Chu L., Leiden J. M. Long-term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication-defective adenoviral vector. Hum. Gene Ther. 8:1997;1797.
12. Zhou S., Murphy J. E., Escobedo J. A., Dwarki V. J. Adeno-associated virus-mediated delivery of erythropoietin leads to sustained elevation of hematocrit in nonhuman primates. Gene Ther. 5:1998;665.
13. Srivastava A., Bruno E., Briddell R., Cooper R., Srivastava C., van Besien K., Hoffman R. Parvovirus B19-induced perturbation of human megakaryocytopoiesis in vitro. Blood. 76:1990;1997.
14. Tripathy S. K., Goldwasser E., Lu M. M., Barr E., Leiden J. M. Long term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector. Proc. Natl. Acad. Sci. USA. 91:1996;10876.
15. Hamamori Y., Samal B., Tian J., Kedes L. Persistent erythropoiesis by myoblast transfer of erythropoietin cDNA. Hum. Gene Ther. 5:1994;1349.
16. Naffakh N., Henri A., Villeval J. L., Rouyer P., Moullier P., Blumenfeld N., Danos O., Vainchenker W., Heard J. M., Beuzard Y. Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts. Proc. Natl. Acad. Sci. USA. 92:1995;3194.
17. + T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J. Exp. Med. 181:1995;1081.
18. Rinsch C., Regulier E., Deglon N., Dalle B., Beuzard Y., Aebischer P. A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension. Hum. Gene Ther. 8:1997;1881.
19. Hamamori, Y, Samal, B, Tian, J, and, Kedes, L. Myoblast transfer of human erythropoietin gene in a mouse model of renal failure, J. Clin. Invest. 95, 1808, 1995.