메뉴 건너뛰기




Volumn 27, Issue 2, 2004, Pages 63-73

Dopaminergic Properties and Experimental Anti-Parkinsonian Effects of IPX750 in Rodent Models of Parkinson Disease

Author keywords

Anti parkinsonian effects; Dopamine; Dopamine receptors; Glycoconjugate; IPX 750; Parkinson disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; APOMORPHINE; CYCLIC AMP; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 5 RECEPTOR; DOPAMINE DERIVATIVE; DOPAMINE GLUCONAMIDE; DOPAMINE GLUCONAMINE; DOPAMINE TRANSPORTER; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; IPX 750; IPX 760; OXIDOPAMINE; UNCLASSIFIED DRUG;

EID: 2342513603     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002826-200403000-00004     Document Type: Article
Times cited : (17)

References (62)
  • 1
    • 0030896968 scopus 로고    scopus 로고
    • A neural substrate of prediction and reward
    • Schultz W, Daylan P, Montague PR. A neural substrate of prediction and reward. Science. 1997;275:1593-1599.
    • (1997) Science , vol.275 , pp. 1593-1599
    • Schultz, W.1    Daylan, P.2    Montague, P.R.3
  • 2
    • 0032482336 scopus 로고    scopus 로고
    • A new image for fear and emotion
    • Hyman SE. A new image for fear and emotion. Nature. 1998;393:417-418.
    • (1998) Nature , vol.393 , pp. 417-418
    • Hyman, S.E.1
  • 3
    • 0037176848 scopus 로고    scopus 로고
    • Levodopa strengths and weaknesses
    • Jankovic J. Levodopa strengths and weaknesses. Neurology. 2002;58: S19-S32.
    • (2002) Neurology , vol.58
    • Jankovic, J.1
  • 4
    • 0034846033 scopus 로고    scopus 로고
    • Imaging neurochemical endophenotypes: Promises and pitfalls
    • Martinez D, Broft A, Laruelle M. Imaging neurochemical endophenotypes: promises and pitfalls. Pharmacogenomics. 2001;2:223-237.
    • (2001) Pharmacogenomics , vol.2 , pp. 223-237
    • Martinez, D.1    Broft, A.2    Laruelle, M.3
  • 5
    • 0037383621 scopus 로고    scopus 로고
    • Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells
    • Mori S, Takanaga H, Ohtsuki S, et al. Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003;23:432-440.
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 432-440
    • Mori, S.1    Takanaga, H.2    Ohtsuki, S.3
  • 6
    • 0035010852 scopus 로고    scopus 로고
    • Regulatory pathways and uptake of L-DOPA by capillary cerebral endothelial cells, astrocytes, and neuronal cells
    • Sampaio-Maia B, Serrao MP, Soares-da-Silva P. Regulatory pathways and uptake of L-DOPA by capillary cerebral endothelial cells, astrocytes, and neuronal cells. Am. J. Physiol. Cell Physiol. 2001;280:C333-C342.
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Sampaio-Maia, B.1    Serrao, M.P.2    Soares-Da-Silva, P.3
  • 7
    • 0035845753 scopus 로고    scopus 로고
    • Functional feature of a novel model of blood brain barrier: Studies on permeation of test compounds
    • Cestelli A, Catania C, D'Agostino S, et al. Functional feature of a novel model of blood brain barrier: studies on permeation of test compounds. J Control Release. 2001;76:139-147.
    • (2001) J Control Release , vol.76 , pp. 139-147
    • Cestelli, A.1    Catania, C.2    D'Agostino, S.3
  • 8
    • 2342598433 scopus 로고    scopus 로고
    • 2003. U.S. Patent Serial No. 2006,548,484
    • Christian ST. 2003. U.S. Patent Serial No. 2006,548,484.
    • Christian, S.T.1
  • 9
    • 0041819572 scopus 로고    scopus 로고
    • Synthesis of glycosyl derivatives as dopamine prodrugs: Interaction with glucose carrier GLUT-1
    • Fernandez C, Nieto O, Fontcnla JA, et al. Synthesis of glycosyl derivatives as dopamine prodrugs: interaction with glucose carrier GLUT-1. Org Biomol Chem. 2003;1:767-771.
    • (2003) Org Biomol Chem , vol.1 , pp. 767-771
    • Fernandez, C.1    Nieto, O.2    Fontcnla, J.A.3
  • 10
    • 0043072342 scopus 로고    scopus 로고
    • Synthesis and biological studies of glycosyl dopamine derivatives as potential antiparkinsonian agents
    • Fernandez C, Nieto O, Rivas E, et al. Synthesis and biological studies of glycosyl dopamine derivatives as potential antiparkinsonian agents. Carbohydr Res. 2000;327:353-365.
    • (2000) Carbohydr Res , vol.327 , pp. 353-365
    • Fernandez, C.1    Nieto, O.2    Rivas, E.3
  • 11
    • 0037732576 scopus 로고    scopus 로고
    • Glycosyl derivatives of dopamine and L-dopa as anti-Parkinson prodrugs: Synthesis, pharmacological activity and in vitro stability studies
    • Bonina F, Puglia C, Rimoli MG, et al. Glycosyl derivatives of dopamine and L-dopa as anti-Parkinson prodrugs: synthesis, pharmacological activity and in vitro stability studies. J Drug Target. 2003;11:25-36.
    • (2003) J Drug Target , vol.11 , pp. 25-36
    • Bonina, F.1    Puglia, C.2    Rimoli, M.G.3
  • 13
    • 0038720473 scopus 로고    scopus 로고
    • Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons
    • Centonze D, Grande C, Usielllo A, et al. Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons. J Neurosci. 2003;23:6245-6254.
    • (2003) J Neurosci , vol.23 , pp. 6245-6254
    • Centonze, D.1    Grande, C.2    Usielllo, A.3
  • 14
    • 0034659598 scopus 로고    scopus 로고
    • Dynamic dopamine receptor interactions in the core and shell of nucleus accumbens differentially coordinate the expression of unconditioned motor behaviors
    • Canales JJ, Iversen SD. Dynamic dopamine receptor interactions in the core and shell of nucleus accumbens differentially coordinate the expression of unconditioned motor behaviors. Synapse. 2000;36:297-306.
    • (2000) Synapse , vol.36 , pp. 297-306
    • Canales, J.J.1    Iversen, S.D.2
  • 15
    • 0034212912 scopus 로고    scopus 로고
    • Toward understanding the biology of a complex phenotype: Rat strain and substrain differences in the sersorimotor gating-disruptive effects of dopamine agonists
    • Swerdlow NR, Martinez ZA, Hanlon FM, et al. Toward understanding the biology of a complex phenotype: Rat strain and substrain differences in the sersorimotor gating-disruptive effects of dopamine agonists. J Neurosci. 2000;20:4325-4336.
    • (2000) J Neurosci , vol.20 , pp. 4325-4336
    • Swerdlow, N.R.1    Martinez, Z.A.2    Hanlon, F.M.3
  • 16
    • 0025193479 scopus 로고
    • Human dopamine D1 receptor encoded by an intronless gene on chromosome 5
    • Sunahara RK, Niznik HB, Weiner DM, et al. Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature. 1990;347:80-83.
    • (1990) Nature , vol.347 , pp. 80-83
    • Sunahara, R.K.1    Niznik, H.B.2    Weiner, D.M.3
  • 17
    • 0025854737 scopus 로고
    • Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
    • Sunahara RK, Guan HC, O'Dowd BF, et al. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991;350:614-619.
    • (1991) Nature , vol.350 , pp. 614-619
    • Sunahara, R.K.1    Guan, H.C.2    O'Dowd, B.F.3
  • 18
    • 0032856319 scopus 로고    scopus 로고
    • Glucose transport in brain and retina: Implications in the management and complications of diabetes
    • Kumagai AK. Glucose transport in brain and retina: Implications in the management and complications of diabetes. Diabetes Metab Res Rev. 1999;15:261-273.
    • (1999) Diabetes Metab Res Rev , vol.15 , pp. 261-273
    • Kumagai, A.K.1
  • 19
    • 0031731915 scopus 로고    scopus 로고
    • Glucose transporter expression in brain: Relationship to cerebral glucose utilization
    • Vannucci SJ, Clark RR, Koehler-Stec E, et al. Glucose transporter expression in brain: Relationship to cerebral glucose utilization. Dev Neurosci. 1998;20:369-379.
    • (1998) Dev Neurosci , vol.20 , pp. 369-379
    • Vannucci, S.J.1    Clark, R.R.2    Koehler-Stec, E.3
  • 20
    • 0024804812 scopus 로고    scopus 로고
    • Cloning of the cDNA and gene for the human D2 dopamine receptor
    • Grandy DK, Marchionni MA, Makam H, et al. Cloning of the cDNA and gene for the human D2 dopamine receptor. Proc Natl Acad Sci U S A. 1998;86:9762-9766.
    • (1998) Proc Natl Acad Sci U S A , vol.86 , pp. 9762-9766
    • Grandy, D.K.1    Marchionni, M.A.2    Makam, H.3
  • 21
    • 0031712750 scopus 로고    scopus 로고
    • Functional differentiation of multiple dopamine D1-like receptors by NNC 01-0012
    • Sugamori KS, Hamadanizadeh SA, Scheideler MA, et al. Functional differentiation of multiple dopamine D1-like receptors by NNC 01-0012. J Neurochem. 1998;71:1685-1693.
    • (1998) J Neurochem , vol.71 , pp. 1685-1693
    • Sugamori, K.S.1    Hamadanizadeh, S.A.2    Scheideler, M.A.3
  • 22
    • 0034604541 scopus 로고    scopus 로고
    • Dopamine D5 receptor agonist high affinity and constitutive activity profile conferred by carboxyl-terminal tail sequence
    • Demchyshyn LL, McConkey F, Niznik HB. Dopamine D5 receptor agonist high affinity and constitutive activity profile conferred by carboxyl-terminal tail sequence. J Biol Chem. 2002;275:23446-23455.
    • (2002) J Biol Chem , vol.275 , pp. 23446-23455
    • Demchyshyn, L.L.1    McConkey, F.2    Niznik, H.B.3
  • 23
    • 0028847305 scopus 로고
    • Deriving the therapeutic concentrations of clozapine and haloperidol: The apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing ligand
    • Seeman P, Van Tol HH. Deriving the therapeutic concentrations of clozapine and haloperidol: The apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing ligand. Eur J Pharmacol. 1995;291:59-66.
    • (1995) Eur J Pharmacol , vol.291 , pp. 59-66
    • Seeman, P.1    Van Tol, H.H.2
  • 24
    • 0028120970 scopus 로고
    • Pharmacological heterogeneity of the cloned and native human dopamine transporter: Dissociation of [3H]WIN 35,428 and [3H]-GBR 12,935 binding
    • Pristupa ZB, Wilson JM, Hoffman BJ, et al. Pharmacological heterogeneity of the cloned and native human dopamine transporter: Dissociation of [3H]WIN 35,428 and [3H]-GBR 12,935 binding. Mol Pharmacol. 1994;45:125-135.
    • (1994) Mol Pharmacol , vol.45 , pp. 125-135
    • Pristupa, Z.B.1    Wilson, J.M.2    Hoffman, B.J.3
  • 25
    • 0031855610 scopus 로고    scopus 로고
    • Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter
    • Pristupa ZB, McConkey F, Liu F, et al. Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter. Synapse. 1998;30:79-87.
    • (1998) Synapse , vol.30 , pp. 79-87
    • Pristupa, Z.B.1    McConkey, F.2    Liu, F.3
  • 26
    • 0032826958 scopus 로고    scopus 로고
    • Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice
    • Le W, Conneely OM, Zou L, et al. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice. Exp Neurol. 1999;159:451-458.
    • (1999) Exp Neurol , vol.159 , pp. 451-458
    • Le, W.1    Conneely, O.M.2    Zou, L.3
  • 27
  • 30
    • 0034719439 scopus 로고    scopus 로고
    • Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: Synthesis and evaluation as dopamine transporter ligands
    • Choi SW, Elmaleh DR, Hanson RN, et al. Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: Synthesis and evaluation as dopamine transporter ligands. J Med Chem. 2000;43:205-213.
    • (2000) J Med Chem , vol.43 , pp. 205-213
    • Choi, S.W.1    Elmaleh, D.R.2    Hanson, R.N.3
  • 31
    • 0019273946 scopus 로고
    • Studies on uptake of phenyl glycosides as inhibitors of D-glucose uptake by Rhesus monkey kidney cells
    • Arita H, Kawanami J. Studies on uptake of phenyl glycosides as inhibitors of D-glucose uptake by Rhesus monkey kidney cells. J Bio Chem. 1980;88:1399-1406.
    • (1980) J Bio Chem , vol.88 , pp. 1399-1406
    • Arita, H.1    Kawanami, J.2
  • 32
    • 0029984998 scopus 로고    scopus 로고
    • Critical reevaluation of spiperone and benzamide binding to dopamine D2 receptors: Evidence for identical binding sites
    • Malmberg A, Jerning E, Mohell N. Critical reevaluation of spiperone and benzamide binding to dopamine D2 receptors: Evidence for identical binding sites. Eur J Pharmacol. 1996;303:123-128.
    • (1996) Eur J Pharmacol , vol.303 , pp. 123-128
    • Malmberg, A.1    Jerning, E.2    Mohell, N.3
  • 33
    • 0034109940 scopus 로고    scopus 로고
    • 2 receptors. Implications for atypical antipsychotic action
    • 2 receptors. Implications for atypical antipsychotic action. J Psychiatry Neurosci. 2000;25:161-166.
    • (2000) J Psychiatry Neurosci , vol.25 , pp. 161-166
    • Kapur, S.1    Seeman, P.2
  • 34
    • 0032692692 scopus 로고    scopus 로고
    • Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury
    • Le W, Conneely OM, He Y, et al. Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury. J Neurochem. 1999;73:2218-2221.
    • (1999) J Neurochem , vol.73 , pp. 2218-2221
    • Le, W.1    Conneely, O.M.2    He, Y.3
  • 35
    • 0031805754 scopus 로고    scopus 로고
    • Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
    • Castillo SO, Baffi JS, Palkovits M, et al. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol Cell Neurosci. 1998;11:36-46.
    • (1998) Mol Cell Neurosci , vol.11 , pp. 36-46
    • Castillo, S.O.1    Baffi, J.S.2    Palkovits, M.3
  • 36
    • 0031002024 scopus 로고    scopus 로고
    • Dopamine neuron agenesis in Nurr1-deficient mice
    • Zetterstrom RH, Solomin L, Jansson L, et al. Dopamine neuron agenesis in Nurr1-deficient mice. Science. 1997;276:248-250.
    • (1997) Science , vol.276 , pp. 248-250
    • Zetterstrom, R.H.1    Solomin, L.2    Jansson, L.3
  • 37
    • 0032584085 scopus 로고    scopus 로고
    • Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
    • Saucedo-Cardenas O, Quintana-Hau JD, Le WD, et al. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc Natl Acad Sci USA. 1998;95:4013-4018.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4013-4018
    • Saucedo-Cardenas, O.1    Quintana-Hau, J.D.2    Le, W.D.3
  • 38
    • 0032826958 scopus 로고    scopus 로고
    • Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice
    • Le W, Conneely OM, Zou L, et al. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice. Exp Neurol. 1999;159:451-458.
    • (1999) Exp Neurol , vol.159 , pp. 451-458
    • Le, W.1    Conneely, O.M.2    Zou, L.3
  • 39
    • 0036945244 scopus 로고    scopus 로고
    • Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine
    • Pedrosa R, Soares-da-Silva P. Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine. Br J Pharmacol. 2002;137:1305-1313.
    • (2002) Br J Pharmacol , vol.137 , pp. 1305-1313
    • Pedrosa, R.1    Soares-Da-Silva, P.2
  • 40
    • 0035937522 scopus 로고    scopus 로고
    • Dopamine induced protein damage in mitochondrial-synaptosomal fraction of rat brain
    • Khan FH, Saha M, Chakrabarti S. Dopamine induced protein damage in mitochondrial-synaptosomal fraction of rat brain. Brain Res. 2001;895:245-249.
    • (2001) Brain Res , vol.895 , pp. 245-249
    • Khan, F.H.1    Saha, M.2    Chakrabarti, S.3
  • 41
    • 0036309549 scopus 로고    scopus 로고
    • Catechol ortho-quinones: The electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases
    • Cavalieri EL, Li KM, Balu N, et al. Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases. Carcinogenesis. 2002;23:1071-1077.
    • (2002) Carcinogenesis , vol.23 , pp. 1071-1077
    • Cavalieri, E.L.1    Li, K.M.2    Balu, N.3
  • 42
    • 0037072567 scopus 로고    scopus 로고
    • The neuroprotectant ebselen inhibits oxidative DNA damage induced by dopamine in the presence of copper ions
    • Li Y, Cao Z. The neuroprotectant ebselen inhibits oxidative DNA damage induced by dopamine in the presence of copper ions. Neurosci Lett. 2002;330:69-73.
    • (2002) Neurosci Lett , vol.330 , pp. 69-73
    • Li, Y.1    Cao, Z.2
  • 43
    • 0035052491 scopus 로고    scopus 로고
    • Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line
    • Paris I, Dagnino-Subiabre A, Marcelain K, et al. Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line. J Neurochem. 2001;77:519-529.
    • (2001) J Neurochem , vol.77 , pp. 519-529
    • Paris, I.1    Dagnino-Subiabre, A.2    Marcelain, K.3
  • 44
    • 0037632905 scopus 로고    scopus 로고
    • Dopamine-dependent cytotoxicity of tetrahydrobiopterin: A possible mechanism for selective neurodegeneration in Parkinson's disease
    • Choi HJ, Kim SW, Lee SY, et al. Dopamine-dependent cytotoxicity of tetrahydrobiopterin: a possible mechanism for selective neurodegeneration in Parkinson's disease. J Neurochem. 2003;86:143-152.
    • (2003) J Neurochem , vol.86 , pp. 143-152
    • Choi, H.J.1    Kim, S.W.2    Lee, S.Y.3
  • 45
    • 0033558324 scopus 로고    scopus 로고
    • Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: Evidence against a role for extracellular dopamine
    • LaVoie MJ, Hastings TG. Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine. J Neurosci. 1999;19:1484-1491.
    • (1999) J Neurosci , vol.19 , pp. 1484-1491
    • LaVoie, M.J.1    Hastings, T.G.2
  • 47
    • 0035699645 scopus 로고    scopus 로고
    • Hydrogen peroxide supports hepatocyte P450 catalysed xenobiotic/drug metabolic activation to form cytotoxic reactive intermediates
    • Chan TS, Moridani M, Siraki A, et al. Hydrogen peroxide supports hepatocyte P450 catalysed xenobiotic/drug metabolic activation to form cytotoxic reactive intermediates. Adv Exp Med Biol. 2001;500:233-236.
    • (2001) Adv Exp Med Biol , vol.500 , pp. 233-236
    • Chan, T.S.1    Moridani, M.2    Siraki, A.3
  • 48
    • 0035145551 scopus 로고    scopus 로고
    • Antiapoptotic role of NFκB in the autooxidized dopamine-induced apoptosis of PC12 cells
    • Lee HJ, Kim SH, Kim KW, et al. Antiapoptotic role of NFκB in the autooxidized dopamine-induced apoptosis of PC12 cells. J Neurochem. 2001; 76:602-609.
    • (2001) J Neurochem , vol.76 , pp. 602-609
    • Lee, H.J.1    Kim, S.H.2    Kim, K.W.3
  • 49
    • 0033942804 scopus 로고    scopus 로고
    • Neuroblastoma cells expressing the noradrenaline transporter are destroyed more selectively by 6-fluorodopamine than by 6-hydroxydopamine
    • Seitz G, Stegmann HB, Jager HH, et al. Neuroblastoma cells expressing the noradrenaline transporter are destroyed more selectively by 6-fluorodopamine than by 6-hydroxydopamine. J Neurochem. 2000;75:511-520.
    • (2000) J Neurochem , vol.75 , pp. 511-520
    • Seitz, G.1    Stegmann, H.B.2    Jager, H.H.3
  • 50
    • 0033965940 scopus 로고    scopus 로고
    • Dopamine toxicity in neuroblastoma cells: Role of glutathione depletion by L-BSO and apoptosis
    • Stokes AH, Lewis DY, Lash LH, et al. Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis. Brain Res. 2000;858:1-8.
    • (2000) Brain Res , vol.858 , pp. 1-8
    • Stokes, A.H.1    Lewis, D.Y.2    Lash, L.H.3
  • 52
    • 0036166979 scopus 로고    scopus 로고
    • Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys
    • Lyras L, Zeng BY, McKenzie G, et al. Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys. J Neural Transm. 2002;109:53-67.
    • (2002) J Neural Transm , vol.109 , pp. 53-67
    • Lyras, L.1    Zeng, B.Y.2    McKenzie, G.3
  • 53
    • 0342369569 scopus 로고    scopus 로고
    • Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: Potential implication in relation to the pathogenesis of Parkinson's disease
    • Soto-Otero R, Mendez-Alvarez E, Hermida-Ameijeiras A, et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000;74:1605-1612.
    • (2000) J Neurochem , vol.74 , pp. 1605-1612
    • Soto-Otero, R.1    Mendez-Alvarez, E.2    Hermida-Ameijeiras, A.3
  • 54
    • 0026588309 scopus 로고
    • Chronic dietary pergolide preserves nigro-striatal neuronal integrity in aged Fischer-344 rats
    • Felten DL, Felten SY, Fuller RW, et al. Chronic dietary pergolide preserves nigro-striatal neuronal integrity in aged Fischer-344 rats. Neurobiol Aging. 1992;13:339-351.
    • (1992) Neurobiol Aging , vol.13 , pp. 339-351
    • Felten, D.L.1    Felten, S.Y.2    Fuller, R.W.3
  • 55
    • 0030897345 scopus 로고    scopus 로고
    • Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole
    • Carvey PM, Pieri S, Ling ZD. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neurol Transm. 1997;104:209-228.
    • (1997) J Neurol Transm , vol.104 , pp. 209-228
    • Carvey, P.M.1    Pieri, S.2    Ling, Z.D.3
  • 56
    • 0031716026 scopus 로고    scopus 로고
    • Dopamine agonists and neuroprotection in Parkinson's disease
    • Olanow CW, Jenner P, Brooks D. Dopamine agonists and neuroprotection in Parkinson's disease. Ann Neurol. 1998;44(Suppl. 1):S167-S174.
    • (1998) Ann Neurol , vol.44 , Issue.SUPPL. 1
    • Olanow, C.W.1    Jenner, P.2    Brooks, D.3
  • 57
    • 0031927090 scopus 로고    scopus 로고
    • Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: Mechanisms of neuroprotective treatment against oxidative stress
    • Sawada H, Ibi M, Kihara T, et al. Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress. Ann Neurol. 1998;44:110-119.
    • (1998) Ann Neurol , vol.44 , pp. 110-119
    • Sawada, H.1    Ibi, M.2    Kihara, T.3
  • 58
    • 0033525427 scopus 로고    scopus 로고
    • Neuroprotection by pramipexole against dopamine-and levodopa-induced cytotoxicity
    • Zou LL, Jankovic J, Rowe D, et al. Neuroprotection by pramipexole against dopamine-and levodopa-induced cytotoxicity. Life Sci. 1999;64:1275-1285.
    • (1999) Life Sci , vol.64 , pp. 1275-1285
    • Zou, L.L.1    Jankovic, J.2    Rowe, D.3
  • 59
    • 0033554203 scopus 로고    scopus 로고
    • Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist
    • Iida M, Miyazaki I, Tanaka K, et al. Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res. 1999;839:51-59.
    • (1999) Brain Res , vol.839 , pp. 51-59
    • Iida, M.1    Miyazaki, I.2    Tanaka, K.3
  • 60
    • 0030996245 scopus 로고    scopus 로고
    • Neuroprotective effects of the dopamine agonists pramipexole and bromocriptine in 3-acetylpyridine-treated rats
    • Sethy VH, Wu H, Oostveen JA, et al. Neuroprotective effects of the dopamine agonists pramipexole and bromocriptine in 3-acetylpyridine-treated rats. Brain Res. 1997;754:181-186.
    • (1997) Brain Res , vol.754 , pp. 181-186
    • Sethy, V.H.1    Wu, H.2    Oostveen, J.A.3
  • 61
    • 0036189532 scopus 로고    scopus 로고
    • Protection of dopaminergic neurons in primary culture by lisuride
    • Gille G, Rausch WD, Hung ST, et al. Protection of dopaminergic neurons in primary culture by lisuride. J Neural Transm. 2002;109:157-169.
    • (2002) J Neural Transm , vol.109 , pp. 157-169
    • Gille, G.1    Rausch, W.D.2    Hung, S.T.3
  • 62
    • 0031214452 scopus 로고    scopus 로고
    • Attenuation of oxidative neuronal necrosis by a dopamine D1 agonist in mouse cortical cell cultures
    • Noh JS, Gwag BJ. Attenuation of oxidative neuronal necrosis by a dopamine D1 agonist in mouse cortical cell cultures. Exp Neurol. 1997;146:604-608.
    • (1997) Exp Neurol , vol.146 , pp. 604-608
    • Noh, J.S.1    Gwag, B.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.