Hydrogen peroxide supports hepatocyte P450 catalysed xenobiotic/drug metabolic activation to form cytotoxic reactive intermediates

Advances in Experimental Medicine and Biology

Volumn 500, Issue , 2001, Pages 233-236

  Chan, T S ^a   Moridani, M ^a   Siraki, A ^a   Scobie, H ^a   Beard, K ^a   Eghbal, M A ^a   Galati, G ^a   O'Brien, P J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); CAFFEIC ACID DERIVATIVE; CATALASE; CATECHOLAMINE; CYTOCHROME P450; DIHYDROCAFFEIC ACID; DOPAMINE; GLUTATHIONE; HYDROGEN PEROXIDE; HYDROQUINONE; META TYRAMINE; MONOAMINE OXIDASE INHIBITOR; OXIDOREDUCTASE; POLYPHENOL; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL TISSUE; CATALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; LIVER CELL; LIVER MICROSOME; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

ANIMALIA; GYMNOMYZA SAMOENSIS;

EID: 0035699645     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-0667-6_34     Document Type: Conference Paper

References (12)

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3. Cytochrome P450 dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes
4. Hydrogen peroxide supports human and rat cytochrome P450 IA2-catalysed 2-amino-3-methylimidazo[4,5]quinoline bioactivation to mutagenic metabolites: Significance of cytochrome P450 peroxygenase
5. Hydroperoxides and superoxides in microsomal oxidations
6. Tissue sulfhydryl groups
7. LM compared with peroxidase catalysis
8. Oxidation of α-methyldopa and other catechols by cytochrome P450-generated superoxide anion: Possible mechanism of methyldopa hepatitis
9. 3+, in the N-oxygenation of amines by cytochrome P450 enzymes
10. 2. A review
11. Peroxidases
12. The crystal structure of chloroperoxidase: A heme-peroxidase-cytochrome P450 functional hybrid