Critical reevaluation of spiperone and benzamide binding to dopamine D2 receptors: Evidence for identical binding sites

European Journal of Pharmacology

Volumn 303, Issue 1-2, 1996, Pages 123-128

  Malmberg, Åsa ^a,b   Jerning, Eva ^a   Mohell, Nina ^a  

^a Astro Arcus AB ^*  (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Dopamine D2 receptor; Nemonapride; Receptor binding, in vitro; 125I NCQ 298; 3H Raclopride; 3H Spiperone; 3H YM 09151 2

Indexed keywords

BENZAMIDE DERIVATIVE; BUTACLAMOL; DOPAMINE 2 RECEPTOR; EMONAPRIDE; N [(1 ETHYL 2 PYRROLIDINYL)METHYL] 3 IODO 5,6 DIMETHOXYSALICYLAMIDE; RACLOPRIDE; RADIOLIGAND; RECEPTOR SUBTYPE; SPIPERONE;

ANIMAL TISSUE; ARTICLE; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; CORPUS STRIATUM; HUMAN; MALE; METHODOLOGY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

EID: 0029984998     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00080-5     Document Type: Article

References (20)

1. 50) of an enzymatic reaction, Biochem. Pharmacol. 22, 3099.
2. 2 receptor ligand, Eur. J. Pharmacol. 201, 1.
3. 2 receptors, Psychopharmacology 103, 6.
4. Hulme, E.G. and N.J M. Birdsall, 1992, Strategy and tactics in receptor-binding studies, in: Receptor-Ligand Interactions: A Practical Approach, ed. B.C. Hulme (Oxford University Press, New York, NY) p. 63.
5. 125I]NCQ-298: methodological considerations of high affinity binding, J. Recept. Res. 15, 503.
6. 2 receptors, Life Sci. 49, 617.
7. 3H-raclopride, Biochem. Pharmacol. 34, 2251.
8. 3 receptors, Mol. Pharmacol. 43, 749.
9. Markwell, M.A.K., S.M. Haas, L.L. Bieber and N.E. Tolbert, 1978, A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples, Anal. Biochem. 87, 206.
10. 3 receptors, Eur. J. Pharmacol. 238, 121.
11. Munson, P.J. and D. Rodbard, 1980, LIGAND: a versatile computerized approach for characterization of ligand-binding systems, Anal. Biochem. 107, 220.
12. 3H]-YM-09151-2, Naunyn-Schmiedeberg's Arch. Pharmacol. 329, 333.
13. Ögren, S.O. and T. Högberg, 1988, Novel dopamine D-2 antagonists for the treatment of schizophrenia, ISI Atlas Sci. Pharmacol. 2, 141.
14. Seeman, P., 1987, Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1, 133.
15. Seeman, P. and D. Grigoriadis, 1987, Dopamine receptors in brain and periphery, Neurochem. Int. 10, 1.
16. 3H]spiperone depend on tissue concentration: analysis and examples, J. Neurochem. 43, 221.
17. 2 receptor reveals different densities for dopamine receptor antagonist ligands. Implications for human brain positron emission tomography, Eur. J. Pharmacol. 227, 139.
18. 2 receptors in rat striatal membranes: methodological considerations and demonstration of the identical nature of the binding sites for the two ligands, Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 115.
19. 3 dopamine receptors in a range of tissues and under different conditions, J. Neurochem. 64, 940.
20. 3H]spiperone in striaturn, J. Pharmacol. Exp. Ther. 227, 592.