p38 mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Faslpr mice

Journal of the American Society of Nephrology

Volumn 14, Issue 1, 2003, Pages 57-67

  Iwata, Yasunori ^a   Wada, Takashi ^a   Furuichi, Kengo ^a   Sakai, Norihiko ^a   Matsushima, Kouji ^b   Yokoyama, Hitoshi ^a   Kobayashi, Ken ichi ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; COMPLEMENTARY DNA; CYTOKINE; DNA ANTIBODY; FAS ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY INJURY; LUPUS ERYTHEMATOSUS; LYMPHADENOPATHY; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEINURIA; SURVIVAL RATE; T LYMPHOCYTE;

EID: 0037218943     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000037402.83851.5F     Document Type: Article

References (36)

1. Herlaar E, Brown Z: p38 MAPK signaling cascades in inflammatory disease. Mol Medicine Today 5: 439-447, 1999
2. Wang XS, Diener K, Manthey CL, Wang S, Rosenzweig B, Bray J, Delaney J, Cole CN, Chan-Hui PY, Mantlo N, Lichenstein HS, Zukowski M, Yao Z: Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. J Biol Chem 272: 23668-23674, 1997
3. Rovin GH, Wilmer WA, Danne M, Dickerso JA, Dixon CL, Lu L: The mitogen-activated protein kinase p38 is necessary for interleukin 1β-induced monocyte chemoattractant protein 1 expression by human mesangial cells. Cytokine 11: 118-126, 1999
4. Goebeler M, Kilian K, Gillizer R, Kunz M, Yoshimura T, Broecker EB, Rapp UR, Ludwig S: The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-α-induced expression of monocyte-chemoattractant protein-1 in endothelial cells. Blood 93:857-865, 1999
5. Ganju RK, Dutt P, Wu L, Newman W, Avraham H, Avraham S, Groopman JE: β-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK. Blood 91: 791-797, 1998
6. Nakamura H, Kawakami A, Yamasaki S, Kawabe Y, Nakamura T, Eguchi K: Expression of mitogen activated protein kinases in labial salivary glands with Sjögren's syndrome. Ann Rheum Dis 58: 382-385, 1999
7. Schett G, Tohidast-Akrad M, Smolen JS, Schmid BJ, Steiner CW, Bitzan P, Zenz P, Redlich K, Xu Q, Steiner G: Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal regulated kinases, c-JUN N terminal kinase, and p38 mitogen activated protein kinase, in sinovial tissue and cells in rheumatoid arthritis. Arthritis Rheum 43: 2501-2512, 2000
8. Theophiloulos AN, Dixon FJ: Murine models of systemic erythematosus. Adv Immunol 37: 269-290, 1985
9. Yui MA, Brissette WH, Brennan DC, Wuthrich RP, Kelley VR: Increased macrophage colony-stimulating factor in neonatal and adult autoimmune MRL-lpr mice. Am J Patho 139: 255-261, 1991
10. Yokoyama H, Kreft B, Kelley VR: Biphasic increase in circulating and renal TNF-α in MRL-lpr mice with differing regulatory mechanisms. Kidney Int 47: 122-130, 1995
11. Wada T, Naito T, Griffiths RS, Coffman TM, Kelley VR: Systemic autoimmune nephritogenic components induce CSF-1 and TNF-α in MRL kidneys. Kidney Int 52: 934-941, 1997
12. Naito T, Yokoyama H, Moore KJ, Dranoff G, Mulligan RC, Kelley VR: Macrophage growth factors introduced into the kidney initiate renal injury. Mol Med 2: 297-312, 1996
13. Moore KJ, Yeh K, Naito T, Kelley VR: TNF-α enhances colony-stimulating factor-1 induced macrophage accumulation in autoimmune renal disease. J Immunol 157: 427-432, 1996
14. lpr kidneys are dependent on multiple T-cell subsets. Kidney Int 59: 565-578, 2001
15. Nick JA, Avdi NJ, Young SK, Lehman LA, McDonald PP, Frasch SC, Billstrom MA, Henson PM, Johnson GL, Worthen GS: Selective activation and functional significance of p38 alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils. J Clin Invest 103: 851-868, 1999
16. Campell KS: Signal transduction from the B cell antigen-receptor. Curr Opin Immunol 3: 256-264, 1999
17. Yamamoto N, Sakai F, Yamazaki H, Nakahara K, Okuhara M: Effect of FR167653, a cytokine suppressive agent, on endotoxin-induced disseminated intravascular coagulation. Eur J Phamacol 314: 137-142, 1996
18. Yamamoto N, Sakai F, Yamazaki H, Sato N, Nakahara K, Okuhara M: FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor-α, ameliorates endotoxin-induced shock. Eur J Phamacol 327: 169-75, 1997
19. Kobayashi J, Takeyoshi I, Ohwada S, Iwanami K, Matsumoto K, Muramoto M, Morishita Y: The effects of FR167653 in extended liver resection with ischemia in dogs. Hepatology 28: 459-465, 1998
20. Takahashi S, Keto Y, Fujita T, Uchiyama T, Yamamoto A: FR167653, a p38 mitogen-activated protein kinase inhibitor, prevents: Helicobacter pylori-induced gastritis in Mongolian gerbils. J Pharmacol Exp Ther 296: 48-56, 2001
21. Wada T, Furuichi K, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, Kobayashi K, Mukaida N, Matushima K, Yokoyama H: A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wister-Kyoto rats. J Am Soc Nphrol 11: 1534-1541, 2000
22. Wada T, Furuichi K, Sakai N, Hisada Y, Kobayashi K, Mukaida N, Tomosugi N, Matushima K, Yokoyama H: Involvement of p38 mitogen-activated protein kinase followed by chemokine expression in crescentic glomerulonephritis. Am J Kidney Dis 38: 1169-1177, 2001
23. Pertosa G, Grandaliano G, Gesualdo L, Ranieri E, Monno R, Schena FP: Interleukin-6, interleukin-8 and monocyte chemotactic peptide-1 gene expression and protein synthesis are independently modulated by hemodialysis membranes. Kidney Int 54: 570-579, 1998
24. Wada T, Yokoyama H, Su SB, Mukaida N, Iwano M, Dohi K, Takahashi Y, Sasaki T, Furuichi K, Segawa C, Hisada Y, Ohta S, Tkasawa K, Kobayashi K: Monitoring urinary levels of monocyte chemoattractant and activating factor reflects disease activity of lupus nephritis. Kidney Int 49: 761-767, 1996
25. lpr mice. J Exp Med 190: 1813-24, 1999
26. Terada Y, Nakashima O, Inoshita S, Kuwahara M, Sasaki S, Marumo F: Mitogen-activated protein kinase cascade and transcription factors: The opposite role of MKK3/6-p38K and MKK1-MAPK. Nephrol Dial Transplant 14[Suppl 1]:45-47, 1999
27. Schneider A, Panzer U, Zahner G, Wenzel U, Wolf G, Thaiss F, Helmchen U, Stahl RAK: Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-β. Kidney Int 56: 135-144, 1999
28. Wang SN, Lapage J, Hirschberg R: Glomerular ultrafiltration and apical tubular action of IGF-1, TGF-beta, and HGF in nephrotic syndrome. Kidney Int 56: 1247-1251, 1999
29. Bishop GA, Hsing Y, Hostiger BS, Jalukar SV, Ramirez LM, Tomai MA: Molecular mechanism of B lymphocyte activation by the immune response modifier R-848. J Immunol 165: 5552-5557, 2000
30. Chan OT, Madio MP, Sclomchik MJ: The central and multiple roles of B cells in lupus pathogenesis. Immunol Rev 169: 107-121, 1999
31. Tian, Wei, Zhang Z, Cohen DM: MAPK signaling and the kidney. Am J Phisyol Renal Physiol 279: F593-604, 2000
32. Bokemeyer D, Gugllelmi KE, McGinty A, Sorokin A, Lianos EA, Dunn MJ: Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats. J Clin Invest 100: 582-588, 1997
33. Wilson KP: The structural basis for the specificity of pyridinilimidazole inhibitors of p38 MAP kinase. Chem. Biol 4: 423-431, 1997
34. Bardger AM, Griswold DE, Kapadia R, Blake S, Swift BA, Hoffman SJ, Stroup GB, Webb E, Rieman DJ, Gowen M, Boehm JC, Adams JL, Lee JC: Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Arthritis Rheum 43: 175-183, 2000
35. Kawano T, Ogushi F, Tani K, Endo T, Ohmoto Y, Hayashi Y, Sone S: Comparison of suppressive effects of a new anti-inflammatoru compaund, FR167653, on production of PGE2 and inflammatory cytokines, human monocytes, and alveolar macrophages in response to endotoxin. J Leukoc Biol 65: 80-86, 1999
36. Tomosoni S, Noris M, Zapela S, Gotti E, Casiraghi F, Bonazzola S, Benigni A, Remmuzzi G: Upregulation of renal systemic cyclooxygenase-2 in patients with active lupus nephritis. J Am Soc Nephrol 9: 1202-1212, 1998