Localization of a yeast early Golgi mannosyltransferase, Och1p, involves retrograde transport

Journal of Cell Biology

Volumn 132, Issue 6, 1996, Pages 985-998

  Harris, Sandra L ^a   Waters, M Gerard ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA FRUCTOFURANOSIDASE; EPITOPE; HEMAGGLUTININ; HYBRID PROTEIN; MANNOSYLTRANSFERASE; MEMBRANE PROTEIN;

ARTICLE; AUTORADIOGRAPHY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GOLGI COMPLEX; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; BETA-FRUCTOFURANOSIDASE; BIOLOGICAL TRANSPORT; CELL COMPARTMENTATION; ENDOPEPTIDASES; FUNGAL PROTEINS; GLYCOSIDE HYDROLASES; GLYCOSYLATION; GLYCOSYLTRANSFERASES; GOLGI APPARATUS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HEMAGGLUTININS, VIRAL; MANNOSYLTRANSFERASES; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; VACUOLES;

EID: 0029864907     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.132.6.985     Document Type: Article

References (112)

1. Achstetter, T., and D.H. Wolf. 1985. Hormone processing and membrane-bound proteinases in yeast. EMBO (Eur. Mol. Biol. Organ.) J. 4:173-177.
2. Aoki, D., N. Lee, N. Yamagughi, C. Dubois, and M.N. Fukuda. 1992. Golgi retention of a trans-Golgi membrane protein, galactosyltransferase, requires cysteine and histidine residues within the membrane-anchoring domain. Proc Natl. Acad. Sci. USA. 89:4319-4323.
3. Armstrong, J., and S. Patel. 1991. The Golgi sorting domain of coronavirus E1 protein. J. Cell. Sci. 98:567-575.
4. Bacon, R.A., A. Salminen, H. Ruohola, P. Novick, and S Ferro-Novick 1989. The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants. J. Cell Biol. 109:1015-1022.
5. Ballou, C E 1990. Isolation, characterization, and properties of Saccharomyces cerevisiae mnn mutants with nonconditional protein glycosylation defects. Methods Enzymol. 185:440-470.
6. Ballou, L., E. Alvarado, P.K Tsai, A. Dell, and C.E. Ballou. 1989. Protein glycosylation defects in the Saccharomyces cerevisiae mnn7 mutant class. Support for the stop signal proposed for regutation of outer chain elongation. J. Biol. Chem. 264:11857-11864.
7. Banfield, D.K., M.J Lewis, C. Rabouille, G. Warren, and H.R.B. Pelham. 1994. Localization of Sed5, a putative vesicle targeting molecule, to the cis-Golgi network involves both its transmembrane and cytoplasmic domains. J. Cell Biol 127:357-371.
8. Boehm, J., H.D. Ulrich, R. Ossjg, and H.D. Schmitt. 1994. Kex2-dependent invertase secretion as a tool to study the targeting of transmembrane proteins which are involved in ER to Golgi transport in yeast. EMBO (Eur. Mol Biol. Organ.) J. 13:3696-3710.
9. Bowser, R., and P. Novick. 1991. Sec15 protein, an essential component of the exocytotic apparatus, is associated with the plasma membrane and with a soluble 19.5S particle J. Cell Biol. 112:1117-1131.
10. Bretscher, M.S., and S. Munro. 1993. Cholesterol and the Golgi apparatus. Science (Wash DC) 261:1280-1282.
11. Bryant, N J , and A. Boyd. 1993. Immunoisolation of Kex2p-containing organelles from yeast demonstrates colocalisation of three processing proteinases to a single Golgi subcompartment. J. Cell Sci. 106:815-822.
12. Burke, J., J M. Pettitt, D. Humphris, and P.A. Gleeson 1994. Medial-Golgi retention of N-acetylglucosaminyltransferase I. Contribution from all domams of the enzyme. J. Biol. Chem 269:12049-12059.
13. Carlson, M., and D. Botstein. 1981. Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase. Cell. 28:145-154.
14. Chapman, R.E., and S. Munro 1994. The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway. EMBO (Eur. Mol. Biol. Organ.) J. 13:4896-4907.
15. Colley, K.J , E.U. Lee, and J.C. Paulson. 1992. The signal anchor and stem regions of the β-galactoside α-2,6-sialyltransferase may each act to localize the enzyme to the Golgi apparatus. J. Biol. Chem. 267:7784-7793.
16. Cooper, A., and H. Bussey. 1992 Yeast Kex1p is a Golgi-associated membrane protein: deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane. J. Cell Biol. 119.1459-1468.
17. Cosson, P , and F Letourneur. 1994. Coatomer interaction with di-lysine endoplasmic reticulum retention motifs. Science (Wash. DC) 263:1629-1631.
18. Cunningham, K.W., and W.T. Wickner. 1989. Yeast KEX2 protease and mannosyltransferase I are localized to distinct compartments of the secretory pathway. Yeast. 5:25-33.
19. Dahdal, R Y , and K J. Colley. 1993. Specific sequences in the signal anchor of the β-galactosidc α-2,6-sialyltransferase are not essential for Golgi localization. Membrane flanking sequences may specify Golgi retention. J. Biol Chem. 268:26310-26319.
20. Deng, W.P., and J A. Nickoloff. 1992. Site-directed mutagenesis of virtually any plasmid by eliminating a unique site. Anal. Biochem 200:81-88.
21. +-ATPase in mutants lacking one subunit of the enzyme. J. Biol. Chem. 268 16845-16851.
22. Eakle, K.A., M. Bernstein, and S.D. Emr. 1988. Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product. Mol Cell. Biol. 8:4098-4109.
23. Eible, R. 1992. A simple and efficient procedure for transformation of yeasts. Biotechniques. 13:18-20.
24. Esmon, B., P. Novick, and R. Schekman. 1981. Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast. Cell. 25: 451-460.
25. Franzusoff, A., and R. Schekman. 1989. Functional compartments of the yeast Golgi apparatus are defined by the sec7 mutation. EMBO (Eur. Mol. Biol Organ.) J. 8:2695-2702.
26. Franzusoff, A., K. Redding, J. Crosby, R.S. Fuller, and R Schekman. 1991. Localization of components involved in protein transport and processing through the yeast Golgi apparatus J. Cell Biol. 112:27-37.
27. Fuller, R.S., R.E Sterne, and J. Thorner. 1988. Enzymes required for yeast prohormone processing. Annu. Rev. Physiol. 50.345-362.
28. Gaynor, E.C., S. te Heesen, T R. Graham, M. Aebi, and S.D Emr. 1994. Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast. J. Cell Biol. 127:653-665.
29. Goldstein, A., and J.O. Lampen. 1975. β-D-Fructofuranoside fructohydrolase from yeast. Methods Enzymol. 42:504-511.
30. Gonatas, J.O., S.G.E. Mezitis, A. Stiebert, B. Fleisher, and N.K. Gonatas. 1989. MG 160, a novel sialoglycoprotein of the medial cisternae of the Golgi apparatus. J. Biol. Chem. 264:646-653.
31. Graham, T.R., and S.D. Emr. 1991. Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant. J Cell Biol. 114:207-218.
32. Graham, T.R., and V.A. Krasnov. 1995. Sorting of yeast α-1,3 mannosyltiansferase is mediated by a luminal domain interaction, and a transmembrane domain signal that can confer clathrin-dependent Golgi localization to a secreted protein. Mol. Biol. Cell. 6:809-824.
33. Graham, T.R., M. Seeger, G-S. Payne, V.L. MacKay, and S.D. Emr. 1994. Clathrin-dependent localization of α-1,3-mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. J. Cell Biol. 127:667-678.
34. Groesch, M.E., H Ruohola, R. Bacon, G. Rossi, and S. Ferro-Novick. 1990. Isolation of a functional vesicular intermediate that mediates ER to Golgi transport in yeast. J. Cell Biol. 111:45-53.
35. Grove, S N., C.E Bracker, and D.J. Morré. 1968. Cytomembrane differentiation in the endoplasmic reticulum-Golgi apparatus-vesicle complex Science (Wash. DC) 101:171-173.
36. Hanahan, D. 1983. Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 166:557-580
37. Harlow, E., and D. Lane. 1988. Antibodies. A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
38. Henning, B.A., G.S. Zubenko, A. Halsilik, and E.W. Jones. 1981. Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 78:435-439.
39. Hobman, T.C . L. Woodward, and M.G. Farquhar. 1995. Targeting of a heterodimeric membrane protein complex to the Goigi: Rubella virus E2 glycoprotein contains a transmembrane Golgi retention signal. Mol Biol. Cell 6:7-20
40. Hoe, M.H , P. Slusarewicz, T. Misteli, R Watson, and G. Warren. 1995. Evidence for recycling of the resident medial/trans Golgi enzyme N-acetylglucosaminyltransferase I, in IdID cells. J. Biol. Chem 270: 25057-25063.
41. Hosobuchi, M , T. Kreis, and R. Schekman. 1992. SEC21 is a gene required for ER to Golgi protein transport that encodes a subunit of a yeast coatomer. Nature (Lond.). 360.603-605.
42. Jackson, M.R., T Nilsson, and P.A. Peterson. 1990. Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum. EMBO (Eur. Mol. Biol. Organ.) J. 9:3153-3162.
43. Jackson, M.R., T. Nilsson, and P.A. Peterson. 1993. Retrieval of transmembrane proteins to the endoplasmic reticulum J. Cell Biol 121:317-333
44. Johnson, L.M., V A. Bankaitis, and S D Emr. 1987. Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease Cell. 48.875-885.
45. Julius, D , R. Schekman, and J. Thorner. 1984. Glycosylation and processing of prepro-α-factor through the yeast secretory pathway. Cell. 36: 309-318.
46. Kaiser, C.A., D Preuss, P. Grisafi, and D. Bolstein. 1987 Many random sequences functionally replace the secretion signal sequence of yeast invertase. Science (Wash. DC). 235:312-317
47. Khonsky, D.J., P.K. Herman, and S.D. Emr. 1990. The fungal vacuole: composition, function, and biogenesis. Microbiol. Rev 54:266-292.
48. Kramer, B., W. Kramer, and H.-J. Fritz. 1984. Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli. Cell. 38:879-887.
49. Kurjan, J., and I. Herskowitz. 1982. Structure of a yeast pheromone gene (MFα): a putative α-factor precursor contains four tandem copies of mature α-factor. Cell 30:933-943.
50. 4. Nature (Lond.). 227:680-685.
51. Letourneur, F., E.C. Gaynor, S. Hennecke, C. Demolliere, R. Duden, S.D. Emr, H. Riezman, and P. Cosson. 1994. Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell. 79:1199-1207.
52. Lewis, M.J., and H.R. Pelham. 1992. Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum. Cell. 68:353-364.
53. Locker, J.K., D.-J.E Opstelten, M. Ericsson, M.C. Horzinek, and P.J.M. Rottier. 1995 Oligomenzation of a trans-Golgi/trans-Golgi network retained protein occurs in the Golgi complex and may be part of its retention. J. Biol. Chem. 270:8815-8821.
54. Lussier, M., A.-M. Sdicu, T. Ketals, and H. Bussey. 1995. Localization and targeting of the Saccharomyces cerevisiae Kre2p/Mnt1p α-1,2-mannosyltransferase to a medial-Golgi compartment. J. Cell Biol. 131:913-927.
55. Machamer, C.E. 1991. Golgi retention signals: do membranes hold the key? Trends Cell Biol. 1 141-144.
56. Machamer, C.E 1993. Targeting and retention of Golgi membrane proteins. Curr. Opin. Cell Biol. 5:606-612.
57. Machamer, C.E., and J.K. Rose. 1987. A specific transmembrane domain of a coronavirus E1 glycoprotein is required for its retention in the Golgi region. J. Cell Biol 105.1205-1214.
58. Masibay, A.S., P. V. Balaji, E E. Boeggeman, and P.K. Quasba. 1993. Mutational analysis of the Golgi retention signal of bovine β-1,4-galactosyltransferase. J. Biol. Chem. 268:9908-9916.
59. Matsuoka, Y., S.-Y Chen, and R.W. Compans. 1994. A signal for Golgi retention in the Bunyavirus G1 glycoprotein. J. Biol. Chem 269:22565-22573.
60. Meisenbock, G., and J.E. Rothman. 1995. The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack. J. Cell Biol. 129:309-313.
61. Miller, J.H. 1972. Experiments in Molecular Genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
62. Munro, S. 1991. Sequences within and adjacent to the transmembrane segment of α-2,6-sialyltransferase specify Golgi retention. EMBO (Eur. Mol. Biol. Organ.) J. 10:3577-3588.
63. Munro, S., and H.R. Pelham 1987. A C-terminal signal prevents secretion of luminal ER proteins. Cell 48 899-907.
64. Nakanishi-Shindo, Y., K.I. Nakayama, A. Tanaka, Y. Toda, and Y Jigami. 1993. Structure of the N-linked oligosaccharides that show the complete loss of α-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae. J. Biol. Chem. 268:26338-26345.
65. Nakayama, K., T. Nagasu, Y. Shimma, J. Kuromitsu, and Y. Jigami 1992. OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides. EMBO (Eur. Mol. Biol. Organ) J. 11:2511-2519.
66. Nilsson, T., J.M. Lucocq, D. Mackay, and G. Warren. 1991. The membrane spanning domain of β-1,4-galactosyltransferase specifies trans Golgi localization EMBO (Eur. Mol. Biol. Organ.) J. 10:3567-3575
67. Nilsson, T., P. Slusarewicz, M.H. Hoe, and G. Warren. 1993. Kin recognition. A model for the retention of Golgi enzymes. FEBS (Fed. Eur. Biochem Soc) Lett. 330:1-4.
68. Nilsson, T., M.H. Hoe, P. Slusarewicz, C. Rabouille, R. Watson, F. Hunte, G. Watzele, E.G. Berger, and G. Warren. 1994. Kin recognition between medial Golgi enzymes in HeLa cells. EMBO (Eur. Mol. Biol. Organ.) J. 13:562-574.
69. Nothwehr, S.F., C.J. Roberts, and T.H. Stevens. 1993. Membrane protein retention in the yeast Golgi apparatus: dipeptidyl aminopeptidase A is retained by a cytoplasmic signal containing aromatic residues. J. Cell Biol. 121:1197-1209
70. Nothwehr, S.F., E Conibear, and T.H. Stevens. 1995 Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane. J. Cell Biol 129:35-46.
71. Novick, P., S. Ferro, and R. Schekman. 1981. Order of events in the yeast secretory pathway. Cell. 25:461-469.
72. Orci, L., R. Montesano, P. Meda, F Malaisse-Lagae, D. Brown, A Perrelet, and P. Vassalli. 1981. Heterogeneous distribution of filipin-cholesterol complexes across the cisternae of the Golgi apparatus. Proc. Natl. Acad. Sci. USA 78:293-297.
73. Pastan, I., V. Chaudary, and D.J. FitzGerald. 1992. Recombinant toxins as novel therapeutic agents. Annu. Rev. Biochem. 61:331-354
74. Pelham, H.R , K.G Hardwick, and M J. Lewis. 1988. Sorting of soluble ER proteins in yeast. EMBO (Eur. Mol. Biol. Organ) J. 7:1757-1762.
75. Pelham, H.R.B., L.M. Roberts, and J.M. Lord. 1992. Toxin entry. how reversible is the secretory pathway? Trends Cell Biol. 2:183-185.
76. Peter, F., P.N. Van, and H.-D Soling. 1992. Different sorting of Lys-Asp-Glu-Leu proteins in rat liver. J. Biol. Chem 267:10631-10637.
77. Raschke, W.C., K.A. Kern, C. Antalis, and C.E. Ballou. 1973. Genetic control of yeast mannan structure. Isolation and characterization of mannan mutants. J. Biol. Chem. 248:4660-4666.
78. Redding, K., C. Holcomb, and R.S. Fuller. 1991. Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae. J. Cell Biol. 113:527-538.
79. Robinson, J S., D.J. Klionsky, L M. Banta, and S.D. Emr. 1988. Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol. Cell Biol. 8:4936-4948.
80. Romero, P.A., and A. Herscovics. 1989. Glycoprotein biosynthesis in Saccharomyces cerevisiae. Characterization of α-1,6-mannosyltransferase which initiates outer chain formation. J. Biol. Chem 264:1946-1950.
81. Rose, M., F. Winston, and P. Hieter. 1990. Methods in yeast genetics. A laboratory course manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
82. Rothstein, R 1991. Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194:281-301.
83. 2-terminal fragment that includes the cytoplasmic and transmembrane domain is sufficient for Golgi retention. J. Biol. Chem. 267:9241-9247.
84. Saiki, R., D.H. Gelfand, S. Stoffel, R. Higuuchi, G.T. Horn, K.B. Mullis, and H.A. Erlich. 1988. Primer-directed enzymatic amplification of DNA with thermostable DNA polymerase. Science (Wash DC). 239. 487-491.
85. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
86. Schauer, I., S. Emr, C. Gross, and R. Schekman 1985. Invertase signal and mature sequence substitutions that delay intercompartmental transport of active enzyme. J. Cell. Biol. 100:1664-1675.
87. Schiestl, R H., and R.D. Gietz. 1989. High efficiency transformation of intact yeast cells using single stranded nucleic acid as a earner. Curr. Genet. 16:339-346.
88. Schröder, S., F. Schimmoller, B. Singer-Krüger, and H. Riezman. 1995. The Golgi-localization of yeast Emp47p depends on its di-lysine motif but is not affected by the ret1-1 mutation in α-COP. J. Cell Biol. 131: 895-912.
89. Schwcintck, T., C. Lorenz, and J.F. Ernst. 1995. Golgi localization in yeast is mediated by the membrane anchor region of rat liver sialyltransferase. J. Biol. Chem. 270:5483-5489.
90. Schweizer, A., J. Rohrer, H.-P. Hauri, and S. Kornfeld. 1994. Retention of p63 in an ER-Goigi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers. J. Cell Biol 126:25-39
91. Seeger, M., and G.S. Payne. 1992. A role for clathrin in the sorting of vacuolar proteins in the Golgi complex of yeast. EMBO (Eur. Mol. Biol. Organ.) J. 11:2811-2818.
92. Seeger, M., and G.S. Payne. 1992. Selective and immediate effects of clathrin heavy chain mutations on Golgi membrane protein retention in Saccharomyces cerevisiae. J. Cell Biol. 118:531-540.
93. Seetharam, S., V.K. Chaudhary, D. FitzGerald, and I. Pastan. 1991. Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL J. Biol. Chem. 266:17376-17381.
94. Semenza, J C., K.G. Hardwick, N. Dean, and H.R. Pelham. 1990. ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway. Cell. 61:349-1357.
95. Sikorski, R.S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics. 122:19-27.
96. Slusarewicz, P., T. Nilsson, N. Hui, R. Watson, and G. Warren. 1994. Isolation of a matrix that binds medial Golgi enzymes. J. Cell Biol 124:405-413.
97. Swift, A.M., and C.E. Machamer. 1991. A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein. J. Cell Biol. 115:19-30.
98. Tang, B.L., S.H. Wong, S.H. Low, and W. Hong. 1992. The transmembrane domain of N-glucosaminyltransferase I contains a Golgi retention signal. J Biol Chem. 267:10122-10126
99. Teasdale, R.D., G. D'Agostaro, and P.A. Gleeson. 1992. The signal for Golgi retention of bovine β-1,4-galactosyltransferase is in the transmembrane domain [erratum appears in 1992 J. Biol Chem. 267:13113]. J. Biol. Chem 267:4084-4096.
100. Teasdale, R.D . F. Matheson, and P.A. Gleeson. 1994. Post-translational modifications distinguish cell surface from Golgi-retamed β-1,4 galactosyltransferase molecules. Golgi localization involves active retention. Glycobiology. 4:917-928.
101. Townsley, F.M., and H.R. Pelham. 1994. The KKXX signal mediates retrieval of membrane proteins from the Golgi to the ER in yeast. Eur. J. Cell Biol. 64:211-216.
102. Trimble, R.B., F. Maley, and F.K. Chu. 1983. Glycoprotein biosynthesis in yeast. Protein conformation affects processing of high mannose oligosaccharides on carboxypeptidase Y and invertase. J. Biol. Chem. 258: 2562-2567.
103. Waters, M.G., T. Serafini, and J.E. Rothman. 1991. 'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles. Nature (Lond.). 349:248-251
104. Weisz, O.A , A.M. Swift, and C.E Machamer. 1993. Oligomerization of a membrane protein correlates with its retention in the Golgi complex. J. Cell Biol. 122:1185-1196.
105. Whitters, E.A., T.P. McGee, and V.A. Bankaitis. 1994. Purification and characterization of a late Golgi compartment from Saccharomyces cerevisiae. J. Biol. Chem. 269.28106-28117.
106. Wilcox, C.A., K. Redding, R. Wright, and R.S. Fuller. 1992. Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole. Mol. Biol. Cell. 3:1353-1371.
107. Wilsbach, K., and G.S. Payne. 1993. Dynamic retention of TGN membrane proteins in Saccharomyces cerevisiae. Trends Cell Biol. 3:426-431.
108. Wilsbach, K., and G.S. Payne. 1993. Vps1p, a member of the dynamin GTP-ase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiae. EMBO (Eur. Mol. Biol. Organ.) J. 12:3049-3059.
109. Wilson, D W , M J. Lewis, and H R. Pelham. 1993. pH-dependent binding of KDEL to its receptor in vitro. J. Biol. Chem. 268:7465-7468.
110. Wilson, I.A., H.L Niman, R.A. Houghten, M L. Cherenson, M.L. Connolly, and R.A. Lerner. 1984. The structure of an antigenic determinant in a protein. Cell. 37:767-778.
111. Wong, S.H., S.H. Low, and W. Hong. 1992. The 17-residue transmembrane domain of β-galactoside α-2,6-sialyltransferase is sufficient for Golgi retention. J. Cell Biol. 117:245-258.
112. Yuan, L., J G. Barriocanal, J.S. Bonifacino, and I.V. Sandoval. 1987. Two integral membrane proteins located in the cis-middle and trans-part of the Golgi system acquire sialylated N-linked carbohydrates and display different turnovers and sensitivity to cAMP-dependent phosphorylation. J Cell Biol. 105:215-227.