The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11β-hydroxylase) inhibitors

Journal of Steroid Biochemistry and Molecular Biology

Volumn 96, Issue 3-4, 2005, Pages 259-270

  Müller Vieira, Ursula ^a   Angotti, Marc ^a   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Adrenocortical tumor cell line NCI H295R; Congestive heart failure; CYP11B1; CYP11B2; Inhibitor screening; Myocardial fibrosis; Renin angiotensin aldosterone system; Selective inhibition

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; ANDROGEN; CYTOCHROME P450 INHIBITOR; FADROZOLE; HYDROCORTISONE; KETOCONAZOLE; STEROID; STEROID 11BETA MONOOXYGENASE;

ADRENAL CORTEX TUMOR; ALDOSTERONE RELEASE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; ISOTOPE LABELING; PROTEIN EXPRESSION; STEROIDOGENESIS; SUPERNATANT; TUMOR CELL;

ADRENAL CORTEX; ALDOSTERONE; ALDOSTERONE SYNTHASE; AROMATASE INHIBITORS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FADROZOLE; HUMANS; STEROID 11-BETA-HYDROXYLASE; STEROIDS;

EID: 23144467136     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2005.04.032     Document Type: Article

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