Synthesis of amidinohydrazones and evaluation of their inhibitory effect towards aldosterone synthase (CYP11B2) and the formation of selected steroids

Archiv der Pharmazie

Volumn 337, Issue 7, 2004, Pages 411-416

  Voets, Marieke ^a   Müller Vieira, Ursula ^a   Marchais Oberwinkler, Sandrine ^a   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Aldosterone synthase; Amidinohydrazones; CYP11B2; Formation of steroids; Nonsteroidal inhibitors

Indexed keywords

2 (2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINECARBOXIMIDAMIDE NITRATE; 2 (3,4 DIHYDRONAPHTHALEN 1 YLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (5 METHOXY 2,3 DIHYDRO 1H INDEN 1 YLIDENE)HYDRAZINECARBOXIMIDAMIDE SULFATE; 2 (6 METHOXY 3,4 DIHYDRONAPHTHALEN 1(2H) YLIDENE)HYDRAZINECARBOXIMIDAMIDE SULFATE; 2 (7 METHOXY 3,4 DIHYDRONAPHTHALEN 1(2H) YLIDENE)HYDRAZINECARBOXIMIDAMIDE SULFATE; 2 (9H FLUOREN 9 YLIDENE)HYDRAZINECARBOXIMIDAMIDE SULFATE; 2 [(3 METHOXYPHENYL)(PHENYL)METHYLENE]HYDRAZINECARBOXIMIDAMIDE; 2 [5 (PYRIDIN 3 YLMETHOXY) 2,3 DIHYDRO 1H INDEN 1 YLIDENE] HYDRAZINECARBOXIMIDAMIDE SULFATE; 2 [6 (3 PYRIDIN 3 YLMETHOXY) 3,4 DIHYDRONAPHTHALEN 1(2H) YLIDENE]HYDRAZINECARBOXIMIDAMIDE SULFATE; 2 [7 (3 PYRIDIN 3 YLMETHOXY) 3,4 DIHYDRONAPHTHALEN 1(2H) YLIDENE]HYDRAZINECARBOXIMIDAMIDE SULFATE; 2 [BIS(3 METHOXYPHENYL)METHYLENE]HYDRAZINECARBOXIMIDAMIDE NITRATE; 2 [PHENYL[3 (PYRIDIN 3 YLMETHOXY)PHENYL]METHYLENE]HYDRAZINECARBOXIMIDAMIDE; 9H FLUOREN 9 ONE SEMICARBAZONE; ALDOSTERONE ANTAGONIST; ALDOSTERONE SYNTHASE INHIBITOR; ANDROSTENEDIONE; CYTOCHROME P450 INHIBITOR; HYDRAZONE DERIVATIVE; HYDROCORTISONE; PRASTERONE; STEROID HORMONE ANTAGONIST; UNCLASSIFIED DRUG;

ADRENAL CORTEX TUMOR; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL LINE; YEAST;

ALDOSTERONE; ALDOSTERONE SYNTHASE; AMIDINES; ANDROSTENEDIONE; CELL LINE, TUMOR; DEHYDROEPIANDROSTERONE; DRUG DESIGN; HUMANS; HYDRAZONES; HYDROCORTISONE; SCHIZOSACCHAROMYCES; STEROIDS;

EID: 4544306650     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200400872     Document Type: Article

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