Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: Potent inhibitors of aldosterone synthase

Journal of Medicinal Chemistry

Volumn 48, Issue 6, 2005, Pages 1796-1805

  Ulmschneider, Sarah ^a   Müller Vieira, Ursula ^a   Mitrenga, Markus ^a   Hartmann, Rolf W ^a   Oberwinkler Marchais, Sandrine ^a   Klein, Christian D ^a   Bureik, Matthias ^a   Bernhardt, Rita ^a   Antes, Iris ^b   Lengauer, Thomas ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE FOR INFORMATICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 [(E) (5 BROMO 2,3 DIHYDRO 1H INDEN 1 YLIDENE)METHYL] 1H IMIDAZOLE HYDROCHLORIDE; 5 [(E) 3,4 DIHYDRONAPHTHALEN 1 (2H) YLIDENEMETHYL] 1H IMIDAZOLE; 5 [(Z) (5 BROMO 2,3 DIHYDRO 1H INDEN 1 YLIDENE)METHYL] 1H IMIDAZOLE OXALATE; 5 [(Z) 3,4 DIHYDRONAPHTHALEN 1 (2H) YLIDENEMETHYL] 1H IMIDAZOLE OXALATE; ALDOSTERONE SYNTHASE; AROMATASE; CHEMICAL COMPOUND; CYTOCHROME P450 17; FADROZOLE; IMIDAZOLYLMETHYLENEDRONAPHTHALENES; IMIDAZOLYLMETHYLENEINDANES; KETOCONAZOLE; STEROID 11BETA MONOOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; DRUG SELECTIVITY; FRIEDEL CRAFTS REACTION; MITOCHONDRION; NONHUMAN; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SYNTHESIS; WITTIG REACTION; YEAST;

ALDOSTERONE SYNTHASE; ANIMALS; AROMATASE; AROMATASE INHIBITORS; ARYL HYDROCARBON HYDROXYLASES; CATTLE; CELL LINE; HUMANS; IMIDAZOLES; INDANS; INDENES; MODELS, MOLECULAR; SCHIZOSACCHAROMYCES; STEREOISOMERISM; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 20144370140     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049600p     Document Type: Article

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