Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): Screening in fission yeast and evaluation of selectivity in V79 cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 81, Issue 2, 2002, Pages 173-179

  Ehmer, Peter B ^a   Bureik, Matthias ^a   Bernhardt, Rita ^a   Müller, Ursula ^a   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Aldosterone synthase; Congestive heart failure; CYP11B1; CYP11B2; Fission yeast; Inhibitor screening; Myocardial fibrosis; Renin angiotensin aldosterone system; Schizosaccharomyces pombe; Selective inhibition; Steroid 11 hydroxylase

Indexed keywords

1 [4 PYRI(METHYL)TETRALIN]; 2 [4 [1 (N',N' DIMETHYLCARBAMOYL)IMIDAZOLYL]METHYLENE] 1 TETRALON; 20 HYDROXYIMINOPREGNA 5,14 DIENE 3BETA OL; 4' METHOXY 4 [1 (1H IMIDAZOLYL)ETHYL]BIPHENYL; 5 (1 IMIDAZOLYLCARBAMOYLOXY) 5,6,7,8 TETRAHYDROQUINOLINE; 5 CHLORO 1 (1 IMIDAZOLYL)INDANE; 5 HYDROXY 2 (4 PYRIDYLMETHYL)INDANE; 7 BROMO 1 (1 IMIDAZOLYL)TETRALIN; 7 CHLORO 1 (1 IMIDAZOLYL)TETRALIN; ALDOSTERONE SYNTHASE; ENZYME INHIBITOR; HYDROCORTISONE; SPIRONOLACTONE; STEROID 11BETA MONOOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; NONHUMAN; PROTEIN EXPRESSION; SCHIZOSACCHAROMYCES POMBE; YEAST;

ALDOSTERONE SYNTHASE; ANIMALS; CELL LINE; CRICETINAE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; RECOMBINANT PROTEINS; SCHIZOSACCHAROMYCES; SUBSTRATE SPECIFICITY;

SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 0036345081     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(02)00056-0     Document Type: Article

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