YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells

Japanese Journal of Pharmacology

Volumn 79, Issue 2, 1999, Pages 213-220

  Ideyama, Yukitaka ^a   Kudoh, Masafumi ^a   Tanimoto, Kyoko ^a   Susaki, Yoko ^a   Nanya, Taiki ^a   Nakahara, Takahito ^a   Ishikawa, Hiroko ^a   Fujikura, Takashi ^a   Akaza, Hideyuki ^b   Shikama, Hisataka ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Adrenal androgen; Adrenocortical cell; CYP17; Ketoconazole; YM116

Indexed keywords

2 (1H IMIDAZOL 4 YLMETHYL) 9H CARBAZOLE; ANDROGEN; ANDROSTENEDIONE; CARBAZOLE DERIVATIVE; CB 7630; HYDROCORTISONE; HYDROXYPROGESTERONE; KETOCONAZOLE; LIAROZOLE; LYASE INHIBITOR; MICROSOME ENZYME; PRASTERONE; PROGESTERONE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; UNCLASSIFIED DRUG;

ADRENAL CORTEX CARCINOMA; ADRENAL CORTEX CELL; ADRENAL GLAND; ANDROGEN SYNTHESIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; MICROSOME; TESTIS;

EID: 0033061665     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.79.213     Document Type: Article

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