Cloning and characterization of the novel chimeric gene TEL/PTPRR in acute myelogenous leukemia with inv(12)(p13q13)

Cancer Research

Volumn 65, Issue 15, 2005, Pages 6612-6621

  Nakamura, Fumihiko ^a,b   Nakamura, Yuichi ^d   Maki, Kazuhiro ^a   Sato, Yuko ^c   Mitani, Kinuko ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HELIX LOOP HELIX PROTEIN; ISOPROTEIN; MUTANT PROTEIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE R; RECEPTOR SUBTYPE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CELL PROLIFERATION; CHIMERA; CHROMOSOME 12P; CHROMOSOME INVERSION; CONTROLLED STUDY; DIMERIZATION; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EXON; FEMALE; GENE; GENE EXPRESSION; GENE FUSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PTPRR GENE; RNA TRANSLATION; SIGNAL TRANSDUCTION; TEL GENE;

ADULT; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CERCOPITHECUS AETHIOPS; CHROMOSOMES, HUMAN, PAIR 12; CLONING, MOLECULAR; CONSENSUS SEQUENCE; COS CELLS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; INVERSION, CHROMOSOME; LEUKEMIA, MYELOCYTIC, ACUTE; MICE; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; NUCLEAR PROTEINS; ONCOGENE PROTEINS, FUSION; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS C-ETS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS;

EID: 23044455955     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-4631     Document Type: Article

References (52)

1. Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994; 77:307-16.
2. Poirel H, Oury C, Carron C, et al. The TEL gene products: nuclear phosphoproteins with DNA binding properties. Oncogene 1997;14:349-57.
3. Gu X, Shin BH, Akbarali Y, et al. Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6. J Biol Chem 200l;276:9421-36.
4. Kim CA, Phillips ML, Kim W, et al. Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression. EMBO J 2001;20: 4173-82.
5. Kwiatkowski BA, Bastian LS, Bauer TR Jr, Tsai S, Zielinska-Kwiatkowska AG, Hickstein DD. The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity. J Biol Chem 1998;273:17525-30.
6. Potter MD, Buijs A, Kreider B, van Rompaey L, Grosveld G. Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6. Blood 2000;95:3341-8.
7. Wang L, Hiebert SW. TEL contacts multiple corepressors and specifically associates with his tone deacetylase-3. Oncogene 2001;20:3716-25.
8. Lopez RG, Carron C, Oury C, Gardellin P, Bernard O, Ghysdael J. TEL is a sequence-specific transcriptional represser. J Biol Chem 1999;274:30132-8.
9. Martinez R, Golub TR. Transcriptional repression of 1d1 by the leukemogenic ETS protein TEL [abstract]. Blood 2000;96:453a.
10. Fenrick R, Wang L, Nip J, et al. TEL, a putative tumor suppressor, modulates cell growth and cell morphology of Ras-transformed cells while repressing the transcription of stromelysin-1. Mol Cell Biol 2000;20:5828-39.
11. L. J Biol Chem 2003;278:46378-86.
12. Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH. Yolk sac angiogenesis defect and intraembryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J 1997;16:4374-83.
13. Wang LC, Swat W, Fujiwara Y, et al. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev 1998;12:2392-402.
14. Hock H, Meade E, Medeiros S, et al. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev 2004;18:2336-41.
15. van Rompaey L, Potter M, Adams C, Grosveld G. Tel induces a G1 arrest and suppresses Ras-induced transformation. Oncogene 2000;19:5244-50.
16. Carroll M, Tomasson MH, Barker GF, Golub TR, Gilliland DG. The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways. Proc Natl Acad Sci U S A 1996;93: 14845-50.
17. Jousset C, Carron C, Boureux A, et al. A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the PDGFRβ oncoprotein. EMBO J 1997;16:69-82.
18. Eguchi M, Eguchi-Ishimae M, Tojo A, et al. Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12:15)(p13;q25). Blood 1999; 93:1355-63.
19. Papadopoulos P, Ridge SA, Boucher CA, Stocking C, Wiedemann LM. The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res 1995;55:34-8.
20. Golub TR, Goga A, Barker GF, et al. Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol Cell Biol 1996;16:4107-16.
21. Lacronique V, Boureux A, Valle VD, et al. A TEL-JAK2 fusion protein with constitutive kinuse activity in human leukemia. Science 1997;278:1309-12.
22. Peeters P, Raynaud SD, Cools J, et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 1997;90:2535-40.
23. Kuno Y, Abe A, Emi N, et al. Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12). Blood 2001;97:1050-5.
24. Cazzaniga G, Tosi S, Aloisi A, et al. The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25:p13): molecular cloning of both reciprocal transcripts. Blood 1999;94: 4370-3.
25. Golub TR, Barker GF, Bohlander SK, et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 1995;92:4917-21.
26. Romana SP, Mauchauffe M, Le Coniat M, et al. The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 1995;85:3662-70.
27. Hiebert SW, Sun W, Davis JN, et al. The t(12;21) converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol 1996;16:1349-55.
28. Fears S, Gavin M, Zhang DE, et al. Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter. Proc Natl Acad Sci U S A 1997;94:1949-54.
29. Fenrick R, Araann JM, Lutterbach B, et al. Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Mol Cell Biol 1999;19: 6566-74.
30. Buijs A, Sherr S, van Baal S, et al. Translocation (12;22)(p13:q11) in myeloproliferative disorders results in fusion of ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene 1995;10:1511-9.
31. Buijs A, van Rompaey L, Molijn AC, et al. The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity. Mol Cell Biol 2000;20: 9281-93.
32. Peeters P, Wlodarska I, Baens M, et al. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Cancer Res 1997;57:564-9.
33. Cazzaniga G, Daniotti M, Tosi S, et al. The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case. Cancer Res 2001; 61:4666-70.
34. Chase A, Reiter A, Burci L, et al. Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). Blood 1999;93:1025-31.
35. Gunji H, Waga K, Nakamura F, et al. TEL/AML1 shows dominant-negative effects over TEL as well as AML1. Biochem Biophys Res Commun 2004;322:623-30.
36. Baens M, Peeters P, Guo C, Aerssens J, Marynen P. Genomic organization of TEL: the human ETS-variant gene 6. Genome Res 1996;6:404-13.
37. Rowley JD, Diaz MO, Espinosa R III, et al. Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: Identification of 11q23 translocation breakpoints with a yeast artificial chromosome. Proc Natl Acad Sci U S A 1990;87:9358-62.
38. Bohlander SK, Espinosa R III, Fernald AA, Rowley JD, Le Beau MM, Diaz MO. Sequence-independent amplification and labeling of yeast artificial chromosomes for fluorescence in situ hybridization. Cytogenet Cell Genet 1994;65:108-10.
39. Arai H, Maki K, Waga K, et al. Functional regulation of TEL by p38-induced phosphorylation. Biochem Biophys Res Commun 2002;299:116-25.
40. Waga K, Nakamura Y, Maki K, et al. Leukemia-related transcription factor TEL accelerates differentiation of friend erythroleukemia cells. Oncogene 2003; 22:59-68.
41. Sasaki K, Nakamura Y, Maki K, et al. Functional analysis of a dominant-negative ΔETS TEL/ETV6 isoform. Biochem Biophys Res Commun 2004;317: 1128-37.
42. Maki K, Arai H, Waga K, et al. Leukemia-related transcription factor TEL is negatively regulated through extracellular signal-regulated kinase-induced phosphorylation. Mol Cell Biol 2004;24:3227-37.
43. Tanaka T, Tanaka K, Ogawa S, et al. An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J 1995;14:341-50.
44. Wood LD, Irvin BJ, Nucifora G, Luce KS, Hiebert SW. Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor. Proc Natl Acad Sci U S A 2003;100:3257-62.
45. Chakrabarti SR, Sood R, Nandi S, Nucifora G. Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies. Proc Natl Acad Sci U S A 2000;97: 13281-5.
46. Hendriks W, Schepens J, Brugman C, Zeeuwen P, Wieringa B. A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J 1995;305: 499-504.
47. Ogata M, Sawada M, Fujino Y, Hamaoka T. cDNA cloning and characterization of a novel receptor-type protein tyrosine phosphatase expressed predominantly in the brain. J Biol Chem 1995;270:2337-43.
48. Shiozuka K, Watanabe Y, Ikeda T, Hashimoto S, Kawashima H. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase. Gene 1995;162: 279-84.
49. Augustine KA, Silbiger SM, Bucay N, et al. Protein tyrosine phosphatase (PC12, Br7, S1) family: expression characterization in the adult human and mouse. Anat Rec 2000;258:221-34.
50. van den Maagdenberg AM, Bachner D, Schepens JT, et al. The mouse Ptprr gene encodes two protein tyrosine phosphatases, PTP-SL and PTPBR7, that display distinct patterns of expression during neural development. Eur J Neurosci 1999;11:3832-44.
51. Miura Y, Kirito K, Komatsu N. Regulation of both erythroid and megakaryocytic differentiation of a human leukemia cell line, UT-7. Acta Haematol 1998; 99:180-4.
52. Schick N, Oakeley EJ, Hynes NE, Badache A. TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity. J Biol Chem 2004;279:38787-96.